LOCUS       NM_175857                578 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens keratin associated protein 8-1 (KRTAP8-1), mRNA.
ACCESSION   NM_175857
VERSION     NM_175857.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 578)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 578)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 578)
  AUTHORS   Matsunaga,R., Abe,R., Ishii,D., Watanabe,S.I., Kiyoshi,M.,
            Nocker,B., Tsuchiya,M. and Tsumoto,K.
  TITLE     Bidirectional binding property of high glycine-tyrosine
            keratin-associated protein contributes to the mechanical strength
            and shape of hair
  JOURNAL   J Struct Biol 183 (3), 484-494 (2013)
   PUBMED   23791804
  REMARK    GeneRIF: The helical arrangement of intermediate filament proteins
            found in the orthocortex, which is uniquely distributed on the
            convex fiber side of the hair, is regulated by KAP8.1
REFERENCE   4  (bases 1 to 578)
  AUTHORS   Rogers,M.A., Langbein,L., Winter,H., Ehmann,C., Praetzel,S. and
            Schweizer,J.
  TITLE     Characterization of a first domain of human high glycine-tyrosine
            and high sulfur keratin-associated protein (KAP) genes on
            chromosome 21q22.1
  JOURNAL   J Biol Chem 277 (50), 48993-49002 (2002)
   PUBMED   12359730
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. This record has been curated by NCBI staff in
            collaboration with Michael Rogers. The reference sequence was
            derived from AP000244.1.
            
            On May 17, 2019 this sequence version replaced NM_175857.3.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AJ457064.1, AB096961.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000329621.6/ ENSP00000332805.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-578               AP000244.1         51829-52406         c
FEATURES             Location/Qualifiers
     source          1..578
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="21"
                     /map="21q22.11"
     gene            1..578
                     /gene="KRTAP8-1"
                     /gene_synonym="KAP8.1"
                     /note="keratin associated protein 8-1"
                     /db_xref="GeneID:337879"
                     /db_xref="HGNC:HGNC:18935"
     exon            1..578
                     /gene="KRTAP8-1"
                     /gene_synonym="KAP8.1"
                     /inference="alignment:Splign:2.1.0"
     CDS             55..246
                     /gene="KRTAP8-1"
                     /gene_synonym="KAP8.1"
                     /note="high glycine-tyrosine keratin-associated protein
                     8.1"
                     /codon_start=1
                     /product="keratin-associated protein 8-1"
                     /protein_id="NP_787053.1"
                     /db_xref="CCDS:CCDS13607.1"
                     /db_xref="GeneID:337879"
                     /db_xref="HGNC:HGNC:18935"
                     /translation="MLCDNFPGAVFPGCYWGSYGYPLGYSVGCGYGSTYSPVGYGFGY
                     GYNGCGAFGYRRYSPFALY"
ORIGIN      
        1 atcccactga ggaaacgcac tctgttgcta cctaagccct ccactcccga caccatgctc
       61 tgcgacaact tccccggggc tgtcttccca ggatgctact ggggcagcta tggctacccg
      121 ctgggatata gcgttggctg tggctatggc agcacctact ctccagtggg ctatggcttc
      181 ggctatggct acaacggctg tggggctttc ggctacagga gatactcgcc atttgctctc
      241 tactgattgg ctgaaatccc cgaggtgtag catcttctct cccttgaagg ctgagcccca
      301 catctccagg ttccccccgt atccactcct tcagtcctca tttgctcatc aacctcagag
      361 acactgcttt ccaacttacc tcgagtccca ggggaggaaa atgaaaaagc agacgcttcc
      421 tcaagctgcc tcccctggct gatgttctct gggacatttt cggaaatttg acctcccact
      481 tgtcatgagc tacttttgaa ttttccatga cactcatgac ttgtgatgaa gtcatggata
      541 tgtctatcaa aatctcaata aatttgtctc agctggta
//
