LOCUS       NM_181606                721 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens keratin associated protein 7-1 (KRTAP7-1), mRNA.
ACCESSION   NM_181606 XM_001724754 XM_927228 XM_941037
VERSION     NM_181606.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 721)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 721)
  AUTHORS   Zhang,Z.D., Frankish,A., Hunt,T., Harrow,J. and Gerstein,M.
  TITLE     Identification and analysis of unitary pseudogenes: historic and
            contemporary gene losses in humans and other primates
  JOURNAL   Genome Biol 11 (3), R26 (2010)
   PUBMED   20210993
REFERENCE   3  (bases 1 to 721)
  AUTHORS   Rogers,M.A., Langbein,L., Winter,H., Ehmann,C., Praetzel,S. and
            Schweizer,J.
  TITLE     Characterization of a first domain of human high glycine-tyrosine
            and high sulfur keratin-associated protein (KAP) genes on
            chromosome 21q22.1
  JOURNAL   J Biol Chem 277 (50), 48993-49002 (2002)
   PUBMED   12359730
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            KF510536.1, AB096962.1 and AJ457063.1.
            
            On May 17, 2019 this sequence version replaced NM_181606.2.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AB096962.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000621162.1/ ENSP00000479656.1
            polymorphic pseudogene :: PMID: 20210993
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-27                KF510536.1         278-304             c
            28-398              AB096962.1         1-371
            399-721             AJ457063.1         249-571
FEATURES             Location/Qualifiers
     source          1..721
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="21"
                     /map="21q22.11"
     gene            1..721
                     /gene="KRTAP7-1"
                     /gene_synonym="KAP7.1"
                     /note="keratin associated protein 7-1"
                     /db_xref="GeneID:337878"
                     /db_xref="HGNC:HGNC:18934"
     exon            1..721
                     /gene="KRTAP7-1"
                     /gene_synonym="KAP7.1"
                     /inference="alignment:Splign:2.1.0"
     CDS             62..325
                     /gene="KRTAP7-1"
                     /gene_synonym="KAP7.1"
                     /note="high tyrosine-glycine keratin-associated protein
                     7.1"
                     /codon_start=1
                     /product="keratin-associated protein 7-1"
                     /protein_id="NP_853637.2"
                     /db_xref="CCDS:CCDS74780.1"
                     /db_xref="GeneID:337878"
                     /db_xref="HGNC:HGNC:18934"
                     /translation="MTRYFCCGSYFPGYPIYGTNFHGTFRATPLNCVVPLGSPLNYGC
                     GCNGYSSLGYSFGGSNINNLGGCYGGSFYRPWGSGSGFGYSTY"
     regulatory      696..701
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KRTAP7-1"
                     /gene_synonym="KAP7.1"
                     /note="hexamer: AATAAA"
     polyA_site      721
                     /gene="KRTAP7-1"
                     /gene_synonym="KAP7.1"
                     /note="major polyA site"
ORIGIN      
        1 attaacactt gggtaactta cccttcacaa tccatctaaa tccttctcaa ttgctgccac
       61 catgactcgt tacttctgct gtggaagcta cttcccagga taccctatct atgggaccaa
      121 cttccatggg accttcagag ccaccccctt gaactgtgtt gtgcctctgg gctctcccct
      181 gaactatggc tgtggatgca atggctacag ctccctgggc tacagctttg gtggtagcaa
      241 catcaacaac ctgggcggct gctatggtgg tagcttctat aggccatggg gctctggctc
      301 tggctttggc tacagcacct actgatggac caatggctcc agtgactaca ggactctcaa
      361 ttaattctct gcacagaaca acctgaagag caatgactgt cttcctacct tcccatgtgc
      421 ttgggtgata catcttccat cttcttgctg acttcttgct gtggtctttg tctttgatgc
      481 tgttggacaa gtcacccagg actcaggtgc tgaactgata ctcatctaca gacaaaggaa
      541 gcaagatgca tttttttggt catacttgaa ttttaacagt gaaaaagtag tttgcctccc
      601 atggttgctc tgctcatgta ttattagctt ctacatcaac attaatgtat tacaaattgg
      661 gtgtgggtag taaggggatt ttctgtcagt ctcttaataa atctatttcc ttcagcataa
      721 a
//
