LOCUS       NM_021046               1185 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens keratin associated protein 5-8 (KRTAP5-8), mRNA.
ACCESSION   NM_021046
VERSION     NM_021046.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1185)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 1185)
  AUTHORS   Yahagi,S., Shibuya,K., Obayashi,I., Masaki,H., Kurata,Y., Kudoh,J.
            and Shimizu,N.
  TITLE     Identification of two novel clusters of ultrahigh-sulfur
            keratin-associated protein genes on human chromosome 11
  JOURNAL   Biochem Biophys Res Commun 318 (3), 655-664 (2004)
   PUBMED   15144888
REFERENCE   3  (bases 1 to 1185)
  AUTHORS   Perez,C., Auriol,J., Gerst,C., Bernard,B.A. and Egly,J.M.
  TITLE     Genomic organization and promoter characterization of two human UHS
            keratin genes
  JOURNAL   Gene 227 (2), 137-148 (1999)
   PUBMED   10023043
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AB126077.1, AP000867.5 and BX099510.1.
            
            On May 17, 2019 this sequence version replaced NM_021046.2.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AB126077.1, DRR138516.364866.1
                                        [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000398534.4/ ENSP00000420723.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-315               AB126077.1         1-315
            316-316             AP000867.5         66237-66237
            317-1025            AB126077.1         317-1025
            1026-1183           BX099510.1         361-518
            1184-1185           AP000867.5         67105-67106
FEATURES             Location/Qualifiers
     source          1..1185
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q13.4"
     gene            1..1185
                     /gene="KRTAP5-8"
                     /gene_synonym="KRTAP5-2; KRTAP5.8; UHSKerB"
                     /note="keratin associated protein 5-8"
                     /db_xref="GeneID:57830"
                     /db_xref="HGNC:HGNC:23603"
     exon            1..1185
                     /gene="KRTAP5-8"
                     /gene_synonym="KRTAP5-2; KRTAP5.8; UHSKerB"
                     /inference="alignment:Splign:2.1.0"
     CDS             32..595
                     /gene="KRTAP5-8"
                     /gene_synonym="KRTAP5-2; KRTAP5.8; UHSKerB"
                     /note="keratin, ultrahigh sulfur, B; UHS KERB-like
                     protein; UHS KerB; UHS keratin B; keratin-associated
                     protein 5.8; keratin, ultra high-sulfur matrix protein B;
                     ultrahigh sulfur keratin-associated protein 5.8"
                     /codon_start=1
                     /product="keratin-associated protein 5-8"
                     /protein_id="NP_066384.2"
                     /db_xref="CCDS:CCDS41683.1"
                     /db_xref="GeneID:57830"
                     /db_xref="HGNC:HGNC:23603"
                     /translation="MGCCGCSGGCGSGCGGCGSGCGGCGSSCCVPICCCKPVCCCVPA
                     CSCSSCGSCGGSKGGRGSCGGSKGDCGSCGGSKGGCGSCGCSQCSCYKPCCCSSGCGS
                     SCCQSSCCKPCCSQSSCCKPCSCSSGCGSSCCQSSCCKPCCSQSSCCKPCCCSSGCGS
                     SCCQSSCCKPCCSQSSCCVPICCQCKI"
     regulatory      1162..1167
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KRTAP5-8"
                     /gene_synonym="KRTAP5-2; KRTAP5.8; UHSKerB"
                     /note="hexamer: AATAAA"
     polyA_site      1185
                     /gene="KRTAP5-8"
                     /gene_synonym="KRTAP5-2; KRTAP5.8; UHSKerB"
                     /note="major polyA site"
ORIGIN      
        1 ctacctgctc caccctcaac ccaccagaac catgggctgc tgtggctgct ctggaggctg
       61 tggctccggc tgtgggggct gcggctctgg ctgtggggga tgtggctcta gctgctgtgt
      121 gcccatctgc tgctgcaagc ccgtgtgctg ctgtgtgcca gcctgttcct gctccagctg
      181 tggctcctgt gggggctcca aggggggccg tggctcctgt gggggctcca agggggactg
      241 tggctcctgt gggggctcca agggaggctg tggttcttgt ggctgctccc agtgcagctg
      301 ctataagccc tgctgttgct cctcaggctg tgggtcatcc tgctgccagt ccagctgctg
      361 caaaccctgc tgttcccagt ccagctgttg taagccctgc agctgctctt caggctgtgg
      421 gtcatcctgc tgccagtcca gctgctgcaa gccctgctgt tcccagtcca gctgctgtaa
      481 gccctgctgc tgctcttcag gctgtgggtc atcctgctgc cagtccagct gctgcaagcc
      541 ctgctgttcc cagtccagct gctgtgtccc aatttgctgc cagtgcaaga tctgaggctc
      601 tgcctacaaa tctcagctgg tcccacagat ctgggctctc caggaatgac tgtagctgtg
      661 tcctgaattc ctgaagcaca tctctgagtc tgtcctcctc tggactaagg cagcctagcg
      721 tccagggctc agtactcagc tgctcagcct ctgaggtcat gagggcttct ggcatgctgg
      781 gtgctgccca tcaaccctcc cagaatcccc tcttcctttc ctgacctcat cacttcaacc
      841 ttctcagggc ttcaagatcc cacatccctg ggcccctcct gtgagcctgc tggaaacaca
      901 ctgaaactgg aatcctccga cctgctgccg cctctccccg gtccctgcaa cctcctggct
      961 cctccaccct tcatcttcat cctgcctgag ctgccacagc tccgattgtt tttggagttg
     1021 acctagagga ctcagaatta ttagagaccc caggatcctc tcctgaggag gaggggcgcc
     1081 cagtctcctc ttctacctct gacctggcct tgtttctttc cccagggctt cgccttgtaa
     1141 gtgcctaggc tgaatcttct aaataaatac gatccacacc tccca
//
