LOCUS       NM_031960               1162 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens keratin associated protein 4-8 (KRTAP4-8), transcript
            variant 1, mRNA.
ACCESSION   NM_031960 XM_001129949 XM_001129965 XM_001130332 XM_001130340
            XM_001721146 XM_001721148 XM_001722576 XM_002343515 XM_002347748
            XM_927495
VERSION     NM_031960.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1162)
  AUTHORS   Choi,H.I., Choi,G.I., Kim,E.K., Choi,Y.J., Sohn,K.C., Lee,Y.,
            Kim,C.D., Yoon,T.J., Sohn,H.J., Han,S.H., Kim,S., Lee,J.H. and
            Lee,Y.H.
  TITLE     Hair greying is associated with active hair growth
  JOURNAL   Br J Dermatol 165 (6), 1183-1189 (2011)
   PUBMED   21916889
REFERENCE   2  (bases 1 to 1162)
  AUTHORS   Zody,M.C., Garber,M., Adams,D.J., Sharpe,T., Harrow,J.,
            Lupski,J.R., Nicholson,C., Searle,S.M., Wilming,L., Young,S.K.,
            Abouelleil,A., Allen,N.R., Bi,W., Bloom,T., Borowsky,M.L.,
            Bugalter,B.E., Butler,J., Chang,J.L., Chen,C.K., Cook,A., Corum,B.,
            Cuomo,C.A., de Jong,P.J., DeCaprio,D., Dewar,K., FitzGerald,M.,
            Gilbert,J., Gibson,R., Gnerre,S., Goldstein,S., Grafham,D.V.,
            Grocock,R., Hafez,N., Hagopian,D.S., Hart,E., Norman,C.H.,
            Humphray,S., Jaffe,D.B., Jones,M., Kamal,M., Khodiyar,V.K.,
            LaButti,K., Laird,G., Lehoczky,J., Liu,X., Lokyitsang,T.,
            Loveland,J., Lui,A., Macdonald,P., Major,J.E., Matthews,L.,
            Mauceli,E., McCarroll,S.A., Mihalev,A.H., Mudge,J., Nguyen,C.,
            Nicol,R., O'Leary,S.B., Osoegawa,K., Schwartz,D.C., Shaw-Smith,C.,
            Stankiewicz,P., Steward,C., Swarbreck,D., Venkataraman,V.,
            Whittaker,C.A., Yang,X., Zimmer,A.R., Bradley,A., Hubbard,T.,
            Birren,B.W., Rogers,J., Lander,E.S. and Nusbaum,C.
  TITLE     DNA sequence of human chromosome 17 and analysis of rearrangement
            in the human lineage
  JOURNAL   Nature 440 (7087), 1045-1049 (2006)
   PUBMED   16625196
REFERENCE   3  (bases 1 to 1162)
  AUTHORS   Kariya,N., Shimomura,Y. and Ito,M.
  TITLE     Size polymorphisms in the human ultrahigh sulfur hair
            keratin-associated protein 4, KAP4, gene family
  JOURNAL   J Invest Dermatol 124 (6), 1111-1118 (2005)
   PUBMED   15955084
REFERENCE   4  (bases 1 to 1162)
  AUTHORS   Rogers,M.A., Langbein,L., Winter,H., Ehmann,C., Praetzel,S.,
            Korn,B. and Schweizer,J.
  TITLE     Characterization of a cluster of human high/ultrahigh sulfur
            keratin-associated protein genes embedded in the type I keratin
            gene domain on chromosome 17q12-21
  JOURNAL   J Biol Chem 276 (22), 19440-19451 (2001)
   PUBMED   11279113
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC100808.10.
            
            On May 17, 2019 this sequence version replaced NM_031960.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000333822.5/ ENSP00000328444.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1162              AC100808.10        63439-64600
FEATURES             Location/Qualifiers
     source          1..1162
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q21.2"
     gene            1..1162
                     /gene="KRTAP4-8"
                     /gene_synonym="KAP4.8; KRTAP4.8"
                     /note="keratin associated protein 4-8"
                     /db_xref="GeneID:728224"
                     /db_xref="HGNC:HGNC:17230"
     exon            1..1162
                     /gene="KRTAP4-8"
                     /gene_synonym="KAP4.8; KRTAP4.8"
                     /inference="alignment:Splign:2.1.0"
     CDS             59..616
                     /gene="KRTAP4-8"
                     /gene_synonym="KAP4.8; KRTAP4.8"
                     /note="isoform 1 is encoded by transcript variant 1;
                     keratin associated protein 4.8; ultrahigh sulfur
                     keratin-associated protein 4.8"
                     /codon_start=1
                     /product="keratin-associated protein 4-8 isoform 1"
                     /protein_id="NP_114166.1"
                     /db_xref="CCDS:CCDS45674.1"
                     /db_xref="GeneID:728224"
                     /db_xref="HGNC:HGNC:17230"
                     /translation="MVNSCCGSVCSDQGCGQDLCQETCCCPSCCQTTCCRTTCYRPSY
                     SVSCCCRPQCCQSVCCQPTCCRPSCCVSSCCKPQCCQSVCCQPTCCHPSCCISSCCRP
                     SCCVSSCCKPQCCQSVCCQPNCCRPSCSISSCCRPSCCESSCCRPCCCLRPVCGRVSC
                     HTTCYRPACVISTCPRPVCCASSCC"
ORIGIN      
        1 caaactcaag aactttactc tcttggaaac ccaaatagat ccttcaccct ctgacaccat
       61 ggtcaactcc tgttgtggct ccgtgtgctc tgaccaaggc tgtggccaag acctctgcca
      121 ggagacctgc tgctgcccca gctgctgtca gaccacctgc tgcaggacca cctgctaccg
      181 ccccagctac agtgtgtcct gctgctgcag accccagtgc tgccagtctg tgtgctgcca
      241 gcccacctgc tgtcgcccca gctgctgtgt gtccagctgc tgcaagcccc agtgctgcca
      301 gtctgtgtgc tgccagccca cctgctgcca ccctagctgc tgcatctcca gctgctgccg
      361 ccccagctgc tgtgtgtcca gctgctgcaa gccccagtgc tgccagtctg tgtgctgcca
      421 gcccaactgc tgccgcccca gctgcagcat ctccagctgc tgccgcccct cttgctgtga
      481 atccagctgc tgccgcccct gctgctgcct gcgtccagtc tgtggccgag tctcctgcca
      541 caccacttgc tatcgcccag cctgtgtcat ctccacctgc ccccgccccg tgtgctgcgc
      601 ctcctcttgc tgctgagccc actgccctgg ctcatctctc ccttcaccgc tggtccacaa
      661 atgtagacca ttcttctgtg ctgaatatta ggacacatgg agtgggattt atgtcattca
      721 gcagggtgga cctcatgtat ccaatgagcc catcaccatc ccgctgactc tgtgagaaca
      781 ttctggttca ttttaaactc cctcccttgc tttctttttc ttccagtcat ggcaccaaat
      841 acgaattaat ttgtaatcca ctagctaaga aattattcca atcctctaaa ttcctcattt
      901 tttaaaatca ttttgagcct acagaatatc cttcccaatt aggtacacat tatctccctt
      961 tcaaacatac tatttgtctg tcagcctttc agtcattctt ttcttttgga aaggtaggag
     1021 gctgcccctc ccgtgctctc ccgctttctc cctgctctct ctttctctca ctgttcaagt
     1081 ttgtcagaat ttttctattt tattagttct ttatctttat tgtgttcaca aaatatattg
     1141 tattaaactt ttcatttaga aa
//
