LOCUS       NM_033061                995 bp    mRNA    linear   PRI 25-JUL-2022
DEFINITION  Homo sapiens keratin associated protein 4-7 (KRTAP4-7), mRNA.
ACCESSION   NM_033061 XM_001725767 XM_002343514
VERSION     NM_033061.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 995)
  AUTHORS   Zody MC, Garber M, Adams DJ, Sharpe T, Harrow J, Lupski JR,
            Nicholson C, Searle SM, Wilming L, Young SK, Abouelleil A, Allen
            NR, Bi W, Bloom T, Borowsky ML, Bugalter BE, Butler J, Chang JL,
            Chen CK, Cook A, Corum B, Cuomo CA, de Jong PJ, DeCaprio D, Dewar
            K, FitzGerald M, Gilbert J, Gibson R, Gnerre S, Goldstein S,
            Grafham DV, Grocock R, Hafez N, Hagopian DS, Hart E, Norman CH,
            Humphray S, Jaffe DB, Jones M, Kamal M, Khodiyar VK, LaButti K,
            Laird G, Lehoczky J, Liu X, Lokyitsang T, Loveland J, Lui A,
            Macdonald P, Major JE, Matthews L, Mauceli E, McCarroll SA, Mihalev
            AH, Mudge J, Nguyen C, Nicol R, O'Leary SB, Osoegawa K, Schwartz
            DC, Shaw-Smith C, Stankiewicz P, Steward C, Swarbreck D,
            Venkataraman V, Whittaker CA, Yang X, Zimmer AR, Bradley A, Hubbard
            T, Birren BW, Rogers J, Lander ES and Nusbaum C.
  TITLE     DNA sequence of human chromosome 17 and analysis of rearrangement
            in the human lineage
  JOURNAL   Nature 440 (7087), 1045-1049 (2006)
   PUBMED   16625196
REFERENCE   2  (bases 1 to 995)
  AUTHORS   Kariya N, Shimomura Y and Ito M.
  TITLE     Size polymorphisms in the human ultrahigh sulfur hair
            keratin-associated protein 4, KAP4, gene family
  JOURNAL   J Invest Dermatol 124 (6), 1111-1118 (2005)
   PUBMED   15955084
REFERENCE   3  (bases 1 to 995)
  AUTHORS   Rogers MA, Langbein L, Winter H, Ehmann C, Praetzel S, Korn B and
            Schweizer J.
  TITLE     Characterization of a cluster of human high/ultrahigh sulfur
            keratin-associated protein genes embedded in the type I keratin
            gene domain on chromosome 17q12-21
  JOURNAL   J Biol Chem 276 (22), 19440-19451 (2001)
   PUBMED   11279113
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. This record has been curated by NCBI staff in
            collaboration with Michael Rogers. The reference sequence was
            derived from AC100808.10.
            
            On Aug 11, 2021 this sequence version replaced NM_033061.3.
            
            Summary: This protein is a member of the keratin-associated protein
            (KAP) family. The KAP proteins form a matrix of keratin
            intermediate filaments which contribute to the structure of hair
            fibers. KAP family members appear to have unique, family-specific
            amino- and carboxyl-terminal regions and are subdivided into three
            multi-gene families according to amino acid composition: the high
            sulfur, the ultrahigh sulfur, and the high tyrosine/glycine KAPs.
            This protein is a member of the ultrahigh sulfur KAP family and the
            gene is localized to a cluster of KAPs at 17q12-q21. [provided by
            RefSeq, Mar 2009].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BP225848.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000391417.6/ ENSP00000375236.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-995               AC100808.10        76437-77431         c
FEATURES             Location/Qualifiers
     source          1..995
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q21.2"
     gene            1..995
                     /gene="KRTAP4-7"
                     /gene_synonym="KAP4.7; KRTAP4.7"
                     /note="keratin associated protein 4-7"
                     /db_xref="GeneID:100132476"
                     /db_xref="HGNC:HGNC:18898"
     exon            1..995
                     /gene="KRTAP4-7"
                     /gene_synonym="KAP4.7; KRTAP4.7"
                     /inference="alignment:Splign:2.1.0"
     CDS             58..525
                     /gene="KRTAP4-7"
                     /gene_synonym="KAP4.7; KRTAP4.7"
                     /note="Ultrahigh sulfur keratin-associated protein 4.7"
                     /codon_start=1
                     /product="putative keratin-associated protein 4-X"
                     /protein_id="NP_149050.3"
                     /db_xref="CCDS:CCDS45673.1"
                     /db_xref="GeneID:100132476"
                     /db_xref="HGNC:HGNC:18898"
                     /translation="MVSSCCGSVCSDQGCSQDLCQETCCRPSCCQTTCCRTTCYRPSC
                     CVSSCCRPQCCQSVCCQPTCCRPTCCETTCCHPRCCISSCCRPSCCMSSCCKPQCCQS
                     VCCQPTCCRPSCCRPCCCLRPVCGRVSCHTTCYRPTCVISTCPRPLCCASSCC"
ORIGIN      
        1 aaacccaaga acttcactct cttggaaacc cacccagatc ctccccgttc tgacaccatg
       61 gtcagctcct gttgtggctc cgtgtgctct gaccagggct gcagccaaga cctctgtcag
      121 gagacctgct gccgccccag ctgctgtcag accacctgtt gcaggaccac ctgctaccgc
      181 cccagctgtt gtgtgtccag ctgctgcagg ccccagtgct gccagtctgt gtgctgccaa
      241 cccacctgct gtcgccccac ctgctgtgag acgacctgct gccaccctag gtgctgcatc
      301 tccagctgct gccgccccag ctgctgtatg tccagctgct gcaagcccca gtgctgccag
      361 tctgtgtgct gccagcccac ctgctgccgc cccagctgct gccgcccctg ctgctgcctg
      421 cgtccagtct gtggccgagt ctcctgccac accacttgct atcgcccaac ctgtgtcatc
      481 tccacctgtc cccgcccctt gtgctgtgcc tcctcttgct gctgagccca ctgccctggc
      541 tcacgtcccc cttcaccact ggcccacaga tgtagaccct tctactgtgc tgaccattag
      601 gatacatgaa gtggggttga tgtcattcaa taggatggac cttatgcttc caaagagccc
      661 accaccattt cactgactct gtgagaacat tctggttcat tttaaactcc ctcctttgct
      721 ttctttttct tctggtggtg gcaccaaatg tgaattaatt tgtaatacac tagctaagaa
      781 attattccaa tcttctgatt tccttatttt ctttatcact ttaaggtaca gattctcctt
      841 ctcagtgagg tagatattat ctgcaggacc agttttgtca ctgatgttgc accctcagat
      901 ccagccaccc aattgtattc tgtgtttctc ctagggtgaa tttcttatgc tttgttgtat
      961 ctctgctttc taataaactt ttctgcactt aagaa
//
