LOCUS       NM_032524               1100 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens keratin associated protein 4-4 (KRTAP4-4), mRNA.
ACCESSION   NM_032524
VERSION     NM_032524.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1100)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 1100)
  AUTHORS   Kariya,N., Shimomura,Y. and Ito,M.
  TITLE     Size polymorphisms in the human ultrahigh sulfur hair
            keratin-associated protein 4, KAP4, gene family
  JOURNAL   J Invest Dermatol 124 (6), 1111-1118 (2005)
   PUBMED   15955084
REFERENCE   3  (bases 1 to 1100)
  AUTHORS   Rogers,M.A., Langbein,L., Winter,H., Ehmann,C., Praetzel,S.,
            Korn,B. and Schweizer,J.
  TITLE     Characterization of a cluster of human high/ultrahigh sulfur
            keratin-associated protein genes embedded in the type I keratin
            gene domain on chromosome 17q12-21
  JOURNAL   J Biol Chem 276 (22), 19440-19451 (2001)
   PUBMED   11279113
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff in
            collaboration with Michael Rogers. The reference sequence was
            derived from AC100808.10 and AJ406936.1.
            
            On May 17, 2019 this sequence version replaced NM_032524.1.
            
            Summary: This protein is a member of the keratin-associated protein
            (KAP) family. The KAP proteins form a matrix of keratin
            intermediate filaments which contribute to the structure of hair
            fibers. KAP family members appear to have unique, family-specific
            amino- and carboxyl-terminal regions and are subdivided into three
            multi-gene families according to amino acid composition: the high
            sulfur, the ultrahigh sulfur, and the high tyrosine/glycine KAPs.
            This protein is a member of the ultrahigh sulfur KAP family and the
            gene is localized to a cluster of KAPs at 17q12-q21. [provided by
            RefSeq, Jul 2008].
            
            ##Evidence-Data-START##
            Transcript is intronless :: AJ406936.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000390661.5/ ENSP00000375076.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-17                AC100808.10        833-849
            18-1096             AJ406936.1         1-1079
            1097-1100           AC100808.10        1929-1932
FEATURES             Location/Qualifiers
     source          1..1100
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q21.2"
     gene            1..1100
                     /gene="KRTAP4-4"
                     /gene_synonym="KAP4.13; KAP4.4; KRTAP4-13; KRTAP4.13;
                     KRTAP4.4"
                     /note="keratin associated protein 4-4"
                     /db_xref="GeneID:84616"
                     /db_xref="HGNC:HGNC:16928"
     exon            1..1100
                     /gene="KRTAP4-4"
                     /gene_synonym="KAP4.13; KAP4.4; KRTAP4-13; KRTAP4.13;
                     KRTAP4.4"
                     /inference="alignment:Splign:2.1.0"
     CDS             58..558
                     /gene="KRTAP4-4"
                     /gene_synonym="KAP4.13; KAP4.4; KRTAP4-13; KRTAP4.13;
                     KRTAP4.4"
                     /note="keratin associated protein 4.4; keratin-associated
                     protein 4-13; keratin-associated protein 4.13; ultrahigh
                     sulfur keratin-associated protein 4.4; ultrahigh sulfur
                     keratin-associated protein 4.13"
                     /codon_start=1
                     /product="keratin-associated protein 4-4"
                     /protein_id="NP_115913.1"
                     /db_xref="CCDS:CCDS11383.1"
                     /db_xref="GeneID:84616"
                     /db_xref="HGNC:HGNC:16928"
                     /translation="MVNSCCGSVCSDQGCGLENCCRPSYCQTTCCRTTCCRPSCCVSS
                     CCRPQCCQTTCCRTTCCHPSCCVSSCCRPQCCQSVCCQPTCCRPQCCQTTCCRTTCCR
                     PSCCRPQCCQSVCCQPTCCCPSYCVSSCCRPQCCQTTCCRTTCCRPSCCVSRCYRPHC
                     GQSLCC"
     regulatory      1075..1080
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KRTAP4-4"
                     /gene_synonym="KAP4.13; KAP4.4; KRTAP4-13; KRTAP4.13;
                     KRTAP4.4"
                     /note="hexamer: AATAAA"
     polyA_site      1100
                     /gene="KRTAP4-4"
                     /gene_synonym="KAP4.13; KAP4.4; KRTAP4-13; KRTAP4.13;
                     KRTAP4.4"
                     /note="major polyA site"
ORIGIN      
        1 aagccttcca aaccctcctt cctggaaacc cacccagaac ctccaccctc tgacaccatg
       61 gtcaactcct gttgtggctc tgtgtgctct gaccagggct gtggcctaga gaactgctgc
      121 cgtcccagct actgccagac cacctgctgc aggaccacct gctgccgccc cagctgctgt
      181 gtgtccagct gctgcagacc ccagtgctgc cagaccacct gctgcaggac cacctgctgc
      241 caccccagct gctgtgtgtc cagctgctgc agaccccagt gctgccagtc tgtgtgctgc
      301 cagcccacct gctgcagacc ccaatgctgc cagactacct gctgtaggac cacctgctgc
      361 cgccccagct gctgcaggcc ccagtgctgc cagtctgtgt gctgccagcc cacctgctgc
      421 tgccccagct actgtgtgtc cagctgctgc agaccccagt gctgccagac cacctgctgc
      481 agaaccacct gctgccgccc cagctgctgt gtgtccaggt gctacaggcc ccattgtggc
      541 cagtctctat gctgctagcc catctgctgg caaaccacct gctacaggac cacctgctgc
      601 caccccagct attgcatttc cagctgctgc cagccttcct gcagtatctc tagcagcagt
      661 agctcctcct gctgtggctt cagctgctgc aggctctcct gctgcatctc cagttgctgc
      721 cgccccaact gctgccagac catgtgctgc cgcccaacct gctctagtgc ttcttgctgc
      781 tgaggctgtc atctggactc accagattct catcaaccag cattcttgat gtagctcatc
      841 tatgagctga gttatgggaa gctagttgga aaacttcagt tccaaccaat tcttagattg
      901 aatctggcct ccaaatatat gctcccccca cattttacct ctctaccaaa tgaacataag
      961 ttgtaatttg ctctgaaatc tgtcaactat cttaattgaa atatttgctc tctgccataa
     1021 tttctcatat ggagctattc cattttaaac aaatatttat ctaaataaat cttaaataaa
     1081 ttttcaggca tagaaatata
//
