LOCUS       NM_033062                776 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens keratin associated protein 4-2 (KRTAP4-2), mRNA.
ACCESSION   NM_033062
VERSION     NM_033062.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 776)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 776)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 776)
  AUTHORS   Chen,S., Fragoza,R., Klei,L., Liu,Y., Wang,J., Roeder,K., Devlin,B.
            and Yu,H.
  TITLE     An interactome perturbation framework prioritizes damaging missense
            mutations for developmental disorders
  JOURNAL   Nat Genet 50 (7), 1032-1040 (2018)
   PUBMED   29892012
REFERENCE   4  (bases 1 to 776)
  AUTHORS   Yang,X., Coulombe-Huntington,J., Kang,S., Sheynkman,G.M., Hao,T.,
            Richardson,A., Sun,S., Yang,F., Shen,Y.A., Murray,R.R., Spirohn,K.,
            Begg,B.E., Duran-Frigola,M., MacWilliams,A., Pevzner,S.J.,
            Zhong,Q., Wanamaker,S.A., Tam,S., Ghamsari,L., Sahni,N., Yi,S.,
            Rodriguez,M.D., Balcha,D., Tan,G., Costanzo,M., Andrews,B.,
            Boone,C., Zhou,X.J., Salehi-Ashtiani,K., Charloteaux,B., Chen,A.A.,
            Calderwood,M.A., Aloy,P., Roth,F.P., Hill,D.E., Iakoucheva,L.M.,
            Xia,Y. and Vidal,M.
  TITLE     Widespread Expansion of Protein Interaction Capabilities by
            Alternative Splicing
  JOURNAL   Cell 164 (4), 805-817 (2016)
   PUBMED   26871637
REFERENCE   5  (bases 1 to 776)
  AUTHORS   Rogers,M.A., Langbein,L., Winter,H., Ehmann,C., Praetzel,S.,
            Korn,B. and Schweizer,J.
  TITLE     Characterization of a cluster of human high/ultrahigh sulfur
            keratin-associated protein genes embedded in the type I keratin
            gene domain on chromosome 17q12-21
  JOURNAL   J Biol Chem 276 (22), 19440-19451 (2001)
   PUBMED   11279113
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff in
            collaboration with Michael Rogers. The reference sequence was
            derived from AC006070.1.
            
            On May 17, 2019 this sequence version replaced NM_033062.3.
            
            Summary: This protein is a member of the keratin-associated protein
            (KAP) family. The KAP proteins form a matrix of keratin
            intermediate filaments which contribute to the structure of hair
            fibers. KAP family members appear to have unique, family-specific
            amino- and carboxyl-terminal regions and are subdivided into three
            multi-gene families according to amino acid composition: the high
            sulfur, the ultrahigh sulfur, and the high tyrosine/glycine KAPs.
            This protein is a member of the ultrahigh sulfur KAP family and the
            gene is localized to a cluster of KAPs at 17q12-q21. [provided by
            RefSeq, Jul 2008].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript represented the
            more frequently occurring allele. The genomic coordinates used for
            the transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AJ406934.1, BC127252.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000377726.3/ ENSP00000366955.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-776               AC006070.1         128889-129664
FEATURES             Location/Qualifiers
     source          1..776
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q21.2"
     gene            1..776
                     /gene="KRTAP4-2"
                     /gene_synonym="KAP4.2; KRTAP4.2"
                     /note="keratin associated protein 4-2"
                     /db_xref="GeneID:85291"
                     /db_xref="HGNC:HGNC:18900"
     exon            1..776
                     /gene="KRTAP4-2"
                     /gene_synonym="KAP4.2; KRTAP4.2"
                     /inference="alignment:Splign:2.1.0"
     CDS             58..468
                     /gene="KRTAP4-2"
                     /gene_synonym="KAP4.2; KRTAP4.2"
                     /note="keratin-associated protein 4.2; ultrahigh sulfur
                     keratin-associated protein 4.2"
                     /codon_start=1
                     /product="keratin-associated protein 4-2"
                     /protein_id="NP_149051.2"
                     /db_xref="CCDS:CCDS11384.1"
                     /db_xref="GeneID:85291"
                     /db_xref="HGNC:HGNC:18900"
                     /translation="MVNSCCGSVCSDQGCGLENCCRPSCCQTTCCRTTCCRPSCCVSS
                     CCRPQCCQSVCCQPTCCSPSCCQTTCCRTTCCRPSCCVSSCFRPQCCQSVYCQPTCCR
                     PSCGQTTCCRTTCYRPSCCVSTCCRPTCSSGSCC"
ORIGIN      
        1 aaaccttcca aacccacctt cctggaaatc cacccagaac ctccaccctc tgacaccatg
       61 gtcaactcct gttgtggctc tgtgtgctct gaccagggct gtggcctaga gaactgctgc
      121 cgtcccagct gctgccagac cacctgctgc aggaccacct gctgccgccc cagctgctgt
      181 gtgtccagct gctgcagacc gcagtgctgc cagtctgtgt gctgccagcc cacctgctgc
      241 agccccagct gctgccagac cacttgctgc aggaccacct gctgccgtcc cagctgctgt
      301 gtgtccagct gcttcagacc ccagtgctgc cagtctgtgt actgccagcc cacctgctgc
      361 cgccccagct gtggccagac cacctgctgc aggaccacct gctaccgccc cagctgctgt
      421 gtgtccacct gctgccgccc aacctgctct agtggctctt gctgctgatg ccctcaccta
      481 tactcacctg cctttattaa ccagcattct tgatatgatc cacctgtgaa ctgaatcatg
      541 caaggccaat tggacaacct cagttccaac caattcttgg attgagtttg gcctccaaat
      601 atgctcacca aacactatgt tgctaccctc taccaaatga atacaagttt gaattttctc
      661 tgaaatatgt caaccccatg ttccctgaat tgaaatattt gctctctacc ataatttatc
      721 acatggagct attcctctat cttaaataaa ttttaatttt tgaggcatac aaataa
//
