LOCUS       NM_001386841             812 bp    mRNA    linear   PRI 10-JUN-2024
DEFINITION  Homo sapiens keratin associated protein 4-1 (KRTAP4-1), transcript
            variant 1, mRNA.
ACCESSION   NM_001386841
VERSION     NM_001386841.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 812)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 812)
  AUTHORS   Kariya,N., Shimomura,Y. and Ito,M.
  TITLE     Size polymorphisms in the human ultrahigh sulfur hair
            keratin-associated protein 4, KAP4, gene family
  JOURNAL   J Invest Dermatol 124 (6), 1111-1118 (2005)
   PUBMED   15955084
REFERENCE   3  (bases 1 to 812)
  AUTHORS   Rogers,M.A., Langbein,L., Winter,H., Ehmann,C., Praetzel,S.,
            Korn,B. and Schweizer,J.
  TITLE     Characterization of a cluster of human high/ultrahigh sulfur
            keratin-associated protein genes embedded in the type I keratin
            gene domain on chromosome 17q12-21
  JOURNAL   J Biol Chem 276 (22), 19440-19451 (2001)
   PUBMED   11279113
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC006070.1.
            
            Summary: This protein is a member of the keratin-associated protein
            (KAP) family. The KAP proteins form a matrix of keratin
            intermediate filaments which contribute to the structure of hair
            fibers. KAP family members appear to have unique, family-specific
            amino- and carboxyl-terminal regions and are subdivided into three
            multi-gene families according to amino acid composition: the high
            sulfur, the ultrahigh sulfur, and the high tyrosine/glycine KAPs.
            This protein is a member of the ultrahigh sulfur KAP family and the
            gene is localized to a cluster of KAPs at 17q12-q21. [provided by
            RefSeq, Jul 2008].
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000398472.2/ ENSP00000381489.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-812               AC006070.1         122199-123010
FEATURES             Location/Qualifiers
     source          1..812
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q21.2"
     gene            1..812
                     /gene="KRTAP4-1"
                     /gene_synonym="KAP4.1; KAP4.10; KRTAP4-10; KRTAP4.10"
                     /note="keratin associated protein 4-1"
                     /db_xref="GeneID:85285"
                     /db_xref="HGNC:HGNC:18907"
     exon            1..812
                     /gene="KRTAP4-1"
                     /gene_synonym="KAP4.1; KAP4.10; KRTAP4-10; KRTAP4.10"
                     /inference="alignment:Splign:2.1.0"
     CDS             58..498
                     /gene="KRTAP4-1"
                     /gene_synonym="KAP4.1; KAP4.10; KRTAP4-10; KRTAP4.10"
                     /note="isoform 1 is encoded by transcript variant 1;
                     keratin associated protein 4-10; ultrahigh sulfur
                     keratin-associated protein 4.10"
                     /codon_start=1
                     /product="keratin-associated protein 4-1 isoform 1"
                     /protein_id="NP_001373770.1"
                     /db_xref="CCDS:CCDS92305.1"
                     /db_xref="GeneID:85285"
                     /db_xref="HGNC:HGNC:18907"
                     /translation="MVNSCCGSVCSDQGCDQGLCQETCCRPSCCQTTCCCPSCVVSSC
                     CRPSCSQTTCCQTTCCRPSCCHPVCCQTTCRPSCGVSSCCRPLCCQTTCHPSCGMSSC
                     CRPLCCQTTCRPSCGVSSCCRPLCCQTTCCRATCCRPSCCGSSC"
     regulatory      787..792
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KRTAP4-1"
                     /gene_synonym="KAP4.1; KAP4.10; KRTAP4-10; KRTAP4.10"
                     /note="hexamer: AATAAA"
     polyA_site      812
                     /gene="KRTAP4-1"
                     /gene_synonym="KAP4.1; KAP4.10; KRTAP4-10; KRTAP4.10"
                     /note="major polyA site"
ORIGIN      
        1 acattcgaaa aactcactgt cttggaaacc tacctagaac ctccaccctc tgacaccatg
       61 gttaactctt gttgtggctc tgtctgctct gaccagggct gtgatcaagg cctctgccaa
      121 gagacctgct gccgccccag ctgctgccag accacctgtt gctgccccag ctgtgttgta
      181 tccagctgct gccgcccatc ctgctctcag actacctgct gccagaccac ttgctgtcgc
      241 cccagctgct gccacccagt ctgttgtcag accacctgcc gccccagctg tggtgtgtcc
      301 agctgctgcc gcccactctg ctgtcagacc acctgccacc ccagctgtgg tatgtccagc
      361 tgctgccgtc cactctgttg tcagaccacc tgccgcccca gctgtggtgt gtccagctgc
      421 tgccgtccac tctgctgtca gaccacctgc tgccgtgcaa cttgctgccg ccccagctgc
      481 tgtggatcct cttgttgaac ctcatattgg actatcaacc atgagccagt caccatccca
      541 tgatatgaaa gtgtcattta tatcaacttg tccatgtgtt aaatggccat cagctttatt
      601 atcctgttat tccactaagt aactggtgaa agggcatcca tctacattta ataccactca
      661 tttttcccat ggatctcttc ccagcagcat tcagacctca gatgcatgat gcagttagac
      721 taagcctcta agtttctgac tgttatgctt gatttgacct tcaaaattac atattaactg
      781 ttcttcaata aatattatct taatatcagt aa
//
