LOCUS       NM_033185                735 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens keratin associated protein 3-3 (KRTAP3-3), mRNA.
ACCESSION   NM_033185
VERSION     NM_033185.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 735)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 735)
  AUTHORS   Rogers,M.A., Langbein,L., Winter,H., Ehmann,C., Praetzel,S.,
            Korn,B. and Schweizer,J.
  TITLE     Characterization of a cluster of human high/ultrahigh sulfur
            keratin-associated protein genes embedded in the type I keratin
            gene domain on chromosome 17q12-21
  JOURNAL   J Biol Chem 276 (22), 19440-19451 (2001)
   PUBMED   11279113
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff in
            collaboration with Michael Rogers. The reference sequence was
            derived from AC007455.7.
            
            On May 17, 2019 this sequence version replaced NM_033185.2.
            
            Summary: This protein is a member of the keratin-associated protein
            (KAP) family. The KAP proteins form a matrix of keratin
            intermediate filaments which contribute to the structure of hair
            fibers. KAP family members appear to have unique, family-specific
            amino- and carboxyl-terminal regions and are subdivided into three
            multi-gene families according to amino acid composition: the high
            sulfur, the ultrahigh sulfur, and the high tyrosine/glycine KAPs.
            This protein is a member of the high sulfur KAP family and the gene
            is localized to a cluster of KAPs at 17q12-q21. [provided by
            RefSeq, Jul 2008].
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC069099.1, AJ406933.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000391586.3/ ENSP00000375428.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-735               AC007455.7         56034-56768
FEATURES             Location/Qualifiers
     source          1..735
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q21.2"
     gene            1..735
                     /gene="KRTAP3-3"
                     /gene_synonym="KAP3.3; KRTAP3.3"
                     /note="keratin associated protein 3-3"
                     /db_xref="GeneID:85293"
                     /db_xref="HGNC:HGNC:18890"
     exon            1..735
                     /gene="KRTAP3-3"
                     /gene_synonym="KAP3.3; KRTAP3.3"
                     /inference="alignment:Splign:2.1.0"
     CDS             68..364
                     /gene="KRTAP3-3"
                     /gene_synonym="KAP3.3; KRTAP3.3"
                     /note="keratin-associated protein 3.3; high sulfur
                     keratin-associated protein 3.3"
                     /codon_start=1
                     /product="keratin-associated protein 3-3"
                     /protein_id="NP_149441.1"
                     /db_xref="CCDS:CCDS32643.1"
                     /db_xref="GeneID:85293"
                     /db_xref="HGNC:HGNC:18890"
                     /translation="MDCCASRGCSVPTGPATTICSSDKSCRCGVCLPSTCPHTVWLLE
                     PTCCDNCPPPCHIPQPCVPTCFLLNSCQPTPGLETLNLTTFTQPCCEPCLPRGC"
ORIGIN      
        1 attcacacct cagaagcctt atccttcttt tcaatcaaac ccataaatac cacagactct
       61 aatagccatg gattgctgtg cctctcgagg ctgcagtgtc cccaccgggc ctgccaccac
      121 catctgctcc tctgacaaat cctgccgctg tggagtctgc ctgcccagca cctgcccaca
      181 cacagtttgg ttactggagc ccacctgctg tgacaactgt cccccaccct gccacattcc
      241 tcagccctgc gtgcccacct gcttcctgct caactcctgc cagccaactc caggcctgga
      301 gaccctcaac ctcaccacct tcactcagcc ctgctgtgag ccctgcctcc caagaggctg
      361 ctaatggatg gctactttgc tcagtgcctg agattgaaaa agtcaacata gaagctttag
      421 cattcaccta tctcagtacc tacaactaat gtactctgct ttagaaattg gaacaaggat
      481 ggtactacca caatcacccc ctgcaaaaaa aaagagacca agaaactttc aatgaccatt
      541 cagctataac caactgcagt ttgaatcagt ggatgcctat agcttcctga agctgttcga
      601 ttccttcata ttaaagtgtc tctttctgtg ggtggtttgg gaattctgtt ttcagtcttg
      661 ggtggtatct ttctgaaaat taaggaagtt cttcatgatt atcctaataa attttacatc
      721 tctggcatag cacaa
//
