LOCUS       NM_031958                608 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens keratin associated protein 3-1 (KRTAP3-1), mRNA.
ACCESSION   NM_031958
VERSION     NM_031958.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 608)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 608)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 608)
  AUTHORS   Rogers,M.A., Langbein,L., Winter,H., Ehmann,C., Praetzel,S.,
            Korn,B. and Schweizer,J.
  TITLE     Characterization of a cluster of human high/ultrahigh sulfur
            keratin-associated protein genes embedded in the type I keratin
            gene domain on chromosome 17q12-21
  JOURNAL   J Biol Chem 276 (22), 19440-19451 (2001)
   PUBMED   11279113
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff in
            collaboration with Michael Rogers. The reference sequence was
            derived from AC007455.7 and AJ406931.1.
            
            On Nov 23, 2018 this sequence version replaced NM_031958.1.
            
            Summary: This protein is a member of the keratin-associated protein
            (KAP) family. The KAP proteins form a matrix of keratin
            intermediate filaments which contribute to the structure of hair
            fibers. KAP family members appear to have unique, family-specific
            amino- and carboxyl-terminal regions and are subdivided into three
            multi-gene families according to amino acid composition: the high
            sulfur, the ultrahigh sulfur, and the high tyrosine/glycine KAPs.
            This protein is a member of the high sulfur KAP family and the gene
            is localized to a cluster of KAPs at 17q12-q21. [provided by
            RefSeq, Jul 2008].
            
            ##Evidence-Data-START##
            Transcript is intronless :: AJ406931.1, BC113077.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000391588.3/ ENSP00000375430.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-14                AC007455.7         41070-41083
            15-608              AJ406931.1         1-594
FEATURES             Location/Qualifiers
     source          1..608
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q21.2"
     gene            1..608
                     /gene="KRTAP3-1"
                     /gene_synonym="KAP3.1; KRTAP3.1"
                     /note="keratin associated protein 3-1"
                     /db_xref="GeneID:83896"
                     /db_xref="HGNC:HGNC:16778"
     exon            1..608
                     /gene="KRTAP3-1"
                     /gene_synonym="KAP3.1; KRTAP3.1"
                     /inference="alignment:Splign:2.1.0"
     CDS             55..351
                     /gene="KRTAP3-1"
                     /gene_synonym="KAP3.1; KRTAP3.1"
                     /note="keratin-associated protein 3.1; high sulfur
                     keratin-associated protein 3.1"
                     /codon_start=1
                     /product="keratin-associated protein 3-1"
                     /protein_id="NP_114164.1"
                     /db_xref="CCDS:CCDS32645.1"
                     /db_xref="GeneID:83896"
                     /db_xref="HGNC:HGNC:16778"
                     /translation="MYCCALRSCSVPTGPATTFCSFDKSCRCGVCLPSTCPHEISLLQ
                     PICCDTCPPPCCKPDTYVPTCWLLNNCHPTPGLSGINLTTYVQPGCESPCEPRC"
     regulatory      583..588
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KRTAP3-1"
                     /gene_synonym="KAP3.1; KRTAP3.1"
                     /note="hexamer: AATAAA"
     polyA_site      608
                     /gene="KRTAP3-1"
                     /gene_synonym="KAP3.1; KRTAP3.1"
                     /note="major polyA site"
ORIGIN      
        1 atcgagacac caacagactt ctctcaactc aacaaaaacc cacctcccat tgccatgtat
       61 tgctgtgctc tccgctcctg cagcgtcccc accggccctg ccaccacctt ctgctcattt
      121 gataaaagct gccgctgtgg agtctgccta cccagcacct gcccacatga gatcagcctc
      181 cttcagccca tctgctgtga cacctgcccc ccaccctgct gcaagcctga tacctatgtg
      241 ccaacttgct ggctgctcaa caactgtcac ccgactcccg gactgagtgg gatcaacctg
      301 accacctatg ttcagcctgg ctgtgagagt ccctgtgagc cccgctgtta accagccgag
      361 tctgcacagg ttccgtgagg tggctgccca atgtcctctg caccatctgg gcttcagcac
      421 tcactactgc ctacatcaag gctaaggcca tcccaatccc cggggccaag tcttgatgaa
      481 tcttcttaat tatttgcaca tttgggtacc attggagacc tcccttctgt cttttaggct
      541 atttcatcac tctttgagaa ataaccattt tgaccatttg ttaataaact ttattctggc
      601 ttagcaaa
//
