LOCUS       NM_033184                764 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens keratin associated protein 2-4 (KRTAP2-4), mRNA.
ACCESSION   NM_033184
VERSION     NM_033184.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 764)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 764)
  AUTHORS   Yang,X., Coulombe-Huntington,J., Kang,S., Sheynkman,G.M., Hao,T.,
            Richardson,A., Sun,S., Yang,F., Shen,Y.A., Murray,R.R., Spirohn,K.,
            Begg,B.E., Duran-Frigola,M., MacWilliams,A., Pevzner,S.J.,
            Zhong,Q., Wanamaker,S.A., Tam,S., Ghamsari,L., Sahni,N., Yi,S.,
            Rodriguez,M.D., Balcha,D., Tan,G., Costanzo,M., Andrews,B.,
            Boone,C., Zhou,X.J., Salehi-Ashtiani,K., Charloteaux,B., Chen,A.A.,
            Calderwood,M.A., Aloy,P., Roth,F.P., Hill,D.E., Iakoucheva,L.M.,
            Xia,Y. and Vidal,M.
  TITLE     Widespread Expansion of Protein Interaction Capabilities by
            Alternative Splicing
  JOURNAL   Cell 164 (4), 805-817 (2016)
   PUBMED   26871637
REFERENCE   3  (bases 1 to 764)
  AUTHORS   Rogers,M.A., Langbein,L., Winter,H., Ehmann,C., Praetzel,S.,
            Korn,B. and Schweizer,J.
  TITLE     Characterization of a cluster of human high/ultrahigh sulfur
            keratin-associated protein genes embedded in the type I keratin
            gene domain on chromosome 17q12-21
  JOURNAL   J Biol Chem 276 (22), 19440-19451 (2001)
   PUBMED   11279113
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff in
            collaboration with Michael Rogers. The reference sequence was
            derived from AJ406930.1.
            
            On May 17, 2019 this sequence version replaced NM_033184.3.
            
            Summary: This protein is a member of the keratin-associated protein
            (KAP) family. The KAP proteins form a matrix of keratin
            intermediate filaments which contribute to the structure of hair
            fibers. KAP family members appear to have unique, family-specific
            amino- and carboxyl-terminal regions and are subdivided into three
            multi-gene families according to amino acid composition: the high
            sulfur, the ultrahigh sulfur, and the high tyrosine/glycine KAPs.
            This protein is a member of the high sulfur KAP family and the gene
            is localized to a cluster of KAPs at 17q12-q21. [provided by
            RefSeq, Jul 2008].
            
            ##Evidence-Data-START##
            Transcript is intronless :: AJ406930.1, BC101149.2 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000394015.3/ ENSP00000377583.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-764               AJ406930.1         1-764
FEATURES             Location/Qualifiers
     source          1..764
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q21.2"
     gene            1..764
                     /gene="KRTAP2-4"
                     /gene_synonym="KAP2.1B; KAP2.3; KAP2.4; KRTAP2-3;
                     KRTAP2.3; KRTAP2.4"
                     /note="keratin associated protein 2-4"
                     /db_xref="GeneID:85294"
                     /db_xref="HGNC:HGNC:18891"
     exon            1..764
                     /gene="KRTAP2-4"
                     /gene_synonym="KAP2.1B; KAP2.3; KAP2.4; KRTAP2-3;
                     KRTAP2.3; KRTAP2.4"
                     /inference="alignment:Splign:2.1.0"
     CDS             35..421
                     /gene="KRTAP2-4"
                     /gene_synonym="KAP2.1B; KAP2.3; KAP2.4; KRTAP2-3;
                     KRTAP2.3; KRTAP2.4"
                     /note="keratin associated protein 2.1B; keratin-associated
                     protein 2.4; high sulfur keratin-associated protein 2.4;
                     Keratin-associated protein 2-3; Keratin-associated protein
                     2.3"
                     /codon_start=1
                     /product="keratin-associated protein 2-4"
                     /protein_id="NP_149440.1"
                     /db_xref="CCDS:CCDS32648.1"
                     /db_xref="GeneID:85294"
                     /db_xref="HGNC:HGNC:18891"
                     /translation="MTGSCCGSTLSSLSYGGGCCQPCCCRDPCCCRPVTCQTTVCRPV
                     TCVPRCTRPICEPCRRPVCCDPCSLQEGCCRPITCCPSSCTAVVCRPCCWATTCCQPV
                     SVQSPCCRPPCGQPTPCSTTCRTSSC"
ORIGIN      
        1 aatagcccaa cccacaccag cctcagacac caccatgacc ggctcctgct gcggctccac
       61 cttgtcctcc ctgagctacg ggggaggctg ctgccagccc tgctgctgcc gcgacccctg
      121 ctgctgccgc cccgtgacct gccagaccac cgtgtgccgc cccgtgacct gcgtgccccg
      181 ctgcacgcgc cccatctgcg agccctgccg ccgcccggtg tgctgcgacc cctgctccct
      241 gcaggaaggc tgctgccgcc ccatcacctg ctgcccctcg tcgtgcacgg ctgtggtgtg
      301 caggccctgc tgctgggcca ccacctgctg ccagcctgtg tctgtgcagt ccccctgctg
      361 ccggcccccc tgcggccagc cgaccccttg cagcaccacc tgcaggacct cctcctgctg
      421 agaccccaat gcccccacag agcaatacac tgaagcctaa acatctatct ggtgttttta
      481 aaaagttaaa agaaaaatag attttttttc acaaggtgac aatagtgatt tttaccatct
      541 ggatacagcc tggtgtaagc agacgtccat taccaccctc acccacattt tcaggtgtct
      601 acatcagcct tagtcattat ggatagtaaa tcgaccttta agaattcctg gggtggactt
      661 tgcaaacaca ttctacaacc tgatggtttt tactgctcaa actgtcacca tcatcttttg
      721 caatgtgttg ctcactgttg tcaataaact aatttttcct ggca
//
