LOCUS       NM_001165252             875 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens keratin associated protein 2-3 (KRTAP2-3), mRNA.
ACCESSION   NM_001165252 XM_001127094
VERSION     NM_001165252.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 875)
  AUTHORS   Takahashi,K., Podyma-Inoue,K.A., Saito,M., Sakakitani,S.,
            Sugauchi,A., Iida,K., Iwabuchi,S., Koinuma,D., Kurioka,K.,
            Konishi,T., Tanaka,S., Kaida,A., Miura,M., Hashimoto,S., Okada,M.,
            Uchihashi,T., Miyazono,K. and Watabe,T.
  TITLE     TGF-beta generates a population of cancer cells residing in G1
            phase with high motility and metastatic potential via KRTAP2-3
  JOURNAL   Cell Rep 40 (13), 111411 (2022)
   PUBMED   36170816
  REMARK    GeneRIF: TGF-beta generates a population of cancer cells residing
            in G1 phase with high motility and metastatic potential via
            KRTAP2-3.
REFERENCE   2  (bases 1 to 875)
  AUTHORS   Zody,M.C., Garber,M., Adams,D.J., Sharpe,T., Harrow,J.,
            Lupski,J.R., Nicholson,C., Searle,S.M., Wilming,L., Young,S.K.,
            Abouelleil,A., Allen,N.R., Bi,W., Bloom,T., Borowsky,M.L.,
            Bugalter,B.E., Butler,J., Chang,J.L., Chen,C.K., Cook,A., Corum,B.,
            Cuomo,C.A., de Jong,P.J., DeCaprio,D., Dewar,K., FitzGerald,M.,
            Gilbert,J., Gibson,R., Gnerre,S., Goldstein,S., Grafham,D.V.,
            Grocock,R., Hafez,N., Hagopian,D.S., Hart,E., Norman,C.H.,
            Humphray,S., Jaffe,D.B., Jones,M., Kamal,M., Khodiyar,V.K.,
            LaButti,K., Laird,G., Lehoczky,J., Liu,X., Lokyitsang,T.,
            Loveland,J., Lui,A., Macdonald,P., Major,J.E., Matthews,L.,
            Mauceli,E., McCarroll,S.A., Mihalev,A.H., Mudge,J., Nguyen,C.,
            Nicol,R., O'Leary,S.B., Osoegawa,K., Schwartz,D.C., Shaw-Smith,C.,
            Stankiewicz,P., Steward,C., Swarbreck,D., Venkataraman,V.,
            Whittaker,C.A., Yang,X., Zimmer,A.R., Bradley,A., Hubbard,T.,
            Birren,B.W., Rogers,J., Lander,E.S. and Nusbaum,C.
  TITLE     DNA sequence of human chromosome 17 and analysis of rearrangement
            in the human lineage
  JOURNAL   Nature 440 (7087), 1045-1049 (2006)
   PUBMED   16625196
REFERENCE   3  (bases 1 to 875)
  AUTHORS   Rogers,M.A., Langbein,L., Winter,H., Ehmann,C., Praetzel,S.,
            Korn,B. and Schweizer,J.
  TITLE     Characterization of a cluster of human high/ultrahigh sulfur
            keratin-associated protein genes embedded in the type I keratin
            gene domain on chromosome 17q12-21
  JOURNAL   J Biol Chem 276 (22), 19440-19451 (2001)
   PUBMED   11279113
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC100808.10 and BC063625.1.
            
            On May 17, 2019 this sequence version replaced NM_001165252.1.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC063625.1, CN311461.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000391418.3/ ENSP00000375237.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-22                AC100808.10        101467-101488
            23-875              BC063625.1         1-853
FEATURES             Location/Qualifiers
     source          1..875
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q21.2"
     gene            1..875
                     /gene="KRTAP2-3"
                     /gene_synonym="KAP2.3; KAP2.4; KRTAP2-4; KRTAP2.3;
                     KRTAP2.4"
                     /note="keratin associated protein 2-3"
                     /db_xref="GeneID:730755"
                     /db_xref="HGNC:HGNC:18906"
     exon            1..875
                     /gene="KRTAP2-3"
                     /gene_synonym="KAP2.3; KAP2.4; KRTAP2-4; KRTAP2.3;
                     KRTAP2.4"
                     /inference="alignment:Splign:2.1.0"
     CDS             65..451
                     /gene="KRTAP2-3"
                     /gene_synonym="KAP2.3; KAP2.4; KRTAP2-4; KRTAP2.3;
                     KRTAP2.4"
                     /note="high sulfur keratin-associated protein 2.4;
                     keratin-associated protein 2.3; Keratin-associated protein
                     2-4; Keratin-associated protein 2.4"
                     /codon_start=1
                     /product="keratin-associated protein 2-3"
                     /protein_id="NP_001158724.1"
                     /db_xref="CCDS:CCDS54123.1"
                     /db_xref="GeneID:730755"
                     /db_xref="HGNC:HGNC:18906"
                     /translation="MTGSCCGSTLSSLSYGGGCCQPCCCRDPCCCRPVTCQTTVCRPV
                     TCVPRCTRPICEPCRRPVCCDPCSLQEGCCRPITCCPSSCTAVVCRPCCWATTCCQPV
                     SVQSPCCRPPCGQPTPCSTTCRTSSC"
     regulatory      854..859
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KRTAP2-3"
                     /gene_synonym="KAP2.3; KAP2.4; KRTAP2-4; KRTAP2.3;
                     KRTAP2.4"
                     /note="hexamer: ATTATA"
     polyA_site      875
                     /gene="KRTAP2-3"
                     /gene_synonym="KAP2.3; KAP2.4; KRTAP2-4; KRTAP2.3;
                     KRTAP2.4"
                     /note="major polyA site"
ORIGIN      
        1 attcacacct gagaacatcc agctcctctc aacagcccaa cccacaccag cctcagacac
       61 caccatgacc ggctcctgct gcggctccac cttgtcctcc ctgagctacg ggggaggctg
      121 ctgccagccc tgctgctgcc gcgacccctg ctgctgccgc cccgtgacct gccagaccac
      181 cgtgtgccgc cccgtgacct gcgtgccccg ctgcacgcgc cccatctgcg agccctgccg
      241 ccgcccggtg tgctgcgacc cctgctccct gcaggaaggc tgctgccgcc ccatcacctg
      301 ctgcccctcg tcgtgcacgg ctgtggtgtg caggccctgc tgctgggcca ccacctgctg
      361 ccagcctgtg tctgtgcagt ccccctgctg ccggcctccc tgcggccagc cgaccccttg
      421 cagcaccacc tgcaggacct cctcctgctg agaccccacc tctcctctca acgcacgaaa
      481 cattcccagg tgcacagaag cttgtgcaga ctcttctacc ccttctggat cagatgagag
      541 actccacctt tgcagcctag ctgatcctca agcacgaatt caacaataac atcctatcta
      601 tttccccaca taattatgca gctaatcctg gccctctctg acaatcttga gaaaaattcc
      661 agctttcatc attcgaattc ctggcttgaa aaaaaaaacg agtaaataaa aatcaaagct
      721 cctcttgaat agaactctgt cccactgact catcaccctt ttttctactg tttcaaggtt
      781 ctcagatgag atttttttct tccaggataa tactatttgt atgctgtatt tttgcactgt
      841 aaaaaaaaat aaaattatat ttctggggaa gcaaa
//
