LOCUS       NM_033032                733 bp    mRNA    linear   PRI 31-DEC-2022
DEFINITION  Homo sapiens keratin associated protein 2-2 (KRTAP2-2), mRNA.
ACCESSION   NM_033032 XM_001127069 XM_001714719 XM_930081
VERSION     NM_033032.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 733)
  AUTHORS   Zody MC, Garber M, Adams DJ, Sharpe T, Harrow J, Lupski JR,
            Nicholson C, Searle SM, Wilming L, Young SK, Abouelleil A, Allen
            NR, Bi W, Bloom T, Borowsky ML, Bugalter BE, Butler J, Chang JL,
            Chen CK, Cook A, Corum B, Cuomo CA, de Jong PJ, DeCaprio D, Dewar
            K, FitzGerald M, Gilbert J, Gibson R, Gnerre S, Goldstein S,
            Grafham DV, Grocock R, Hafez N, Hagopian DS, Hart E, Norman CH,
            Humphray S, Jaffe DB, Jones M, Kamal M, Khodiyar VK, LaButti K,
            Laird G, Lehoczky J, Liu X, Lokyitsang T, Loveland J, Lui A,
            Macdonald P, Major JE, Matthews L, Mauceli E, McCarroll SA, Mihalev
            AH, Mudge J, Nguyen C, Nicol R, O'Leary SB, Osoegawa K, Schwartz
            DC, Shaw-Smith C, Stankiewicz P, Steward C, Swarbreck D,
            Venkataraman V, Whittaker CA, Yang X, Zimmer AR, Bradley A, Hubbard
            T, Birren BW, Rogers J, Lander ES and Nusbaum C.
  TITLE     DNA sequence of human chromosome 17 and analysis of rearrangement
            in the human lineage
  JOURNAL   Nature 440 (7087), 1045-1049 (2006)
   PUBMED   16625196
REFERENCE   2  (bases 1 to 733)
  AUTHORS   Rogers MA, Langbein L, Winter H, Ehmann C, Praetzel S, Korn B and
            Schweizer J.
  TITLE     Characterization of a cluster of human high/ultrahigh sulfur
            keratin-associated protein genes embedded in the type I keratin
            gene domain on chromosome 17q12-21
  JOURNAL   J Biol Chem 276 (22), 19440-19451 (2001)
   PUBMED   11279113
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC100808.10.
            
            On Aug 13, 2020 this sequence version replaced NM_033032.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000398477.1/ ENSP00000381494.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-733               AC100808.10        106351-107083
FEATURES             Location/Qualifiers
     source          1..733
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q21.2"
     gene            1..733
                     /gene="KRTAP2-2"
                     /gene_synonym="KAP2.1; KAP2.2; KRTAP2-1; KRTAP2.1A;
                     KRTAP2.1B"
                     /note="keratin associated protein 2-2"
                     /db_xref="GeneID:728279"
                     /db_xref="HGNC:HGNC:18905"
     exon            1..733
                     /gene="KRTAP2-2"
                     /gene_synonym="KAP2.1; KAP2.2; KRTAP2-1; KRTAP2.1A;
                     KRTAP2.1B"
                     /inference="alignment:Splign:2.1.0"
     CDS             20..391
                     /gene="KRTAP2-2"
                     /gene_synonym="KAP2.1; KAP2.2; KRTAP2-1; KRTAP2.1A;
                     KRTAP2.1B"
                     /note="Keratin-associated protein 2-1; High sulfur
                     keratin-associated protein 2.1; Keratin-associated protein
                     2.1"
                     /codon_start=1
                     /product="putative keratin-associated protein
                     ENSP00000381495"
                     /protein_id="NP_149021.2"
                     /db_xref="CCDS:CCDS54122.1"
                     /db_xref="GeneID:728279"
                     /db_xref="HGNC:HGNC:18905"
                     /translation="MTGSCCGSTFSSLSYGGGCCQPCCCRDPCCCRPVTCQTTVCRPV
                     TCVPRCTRPICEPCRRPVCCDPCSLQEGCCRPITCCPSSCTAVVCRPCCWATTCCQPV
                     SVQSPCGQPTPCSTTCRTSSC"
     regulatory      706..711
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KRTAP2-2"
                     /gene_synonym="KAP2.1; KAP2.2; KRTAP2-1; KRTAP2.1A;
                     KRTAP2.1B"
                     /note="hexamer: AATAAA"
     polyA_site      733
                     /gene="KRTAP2-2"
                     /gene_synonym="KAP2.1; KAP2.2; KRTAP2-1; KRTAP2.1A;
                     KRTAP2.1B"
                     /note="major polyA site"
ORIGIN      
        1 accagcctca gacaccacca tgaccggctc ctgctgcggc tccaccttct cctccctgag
       61 ctacggggga ggctgctgcc agccctgctg ctgccgcgac ccctgctgct gccgccccgt
      121 gacctgccag accaccgtgt gccgccccgt gacctgcgtg ccccgctgca cgcgccccat
      181 ctgcgagccc tgccgccgcc cggtgtgctg cgacccctgc tccctgcagg aaggctgctg
      241 ccgccccatc acctgctgcc cctcgtcgtg cacggctgtg gtgtgcaggc cctgctgctg
      301 ggccaccacc tgctgccagc ctgtgtctgt gcagtccccc tgcggccagc cgaccccttg
      361 cagcaccacc tgcaggacct cctcctgctg agccaccacc tgctgccagc ctgtgtctgt
      421 gcagtccccc tgcggccagc cgaccccttg cagcaccacc tgcaggacct cctcctgctg
      481 agcagcccgt tatcacgaag ggcccctcag aagatggcca ggtccatccc gctgcccctc
      541 agggcttcac cgcagagcaa tacacgtttc cttgagaagc ccatttctca tctcttcata
      601 ctagctcaca ctatgcattg aagacacctt ttcagaccaa ccacagatga gaaatacttt
      661 tcctaggact ccagtctaac tcctatatca tgttgtctgc tttctaataa actcaatact
      721 cctaccatag aaa
//
