LOCUS       NM_181609                552 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens keratin associated protein 19-3 (KRTAP19-3), mRNA.
ACCESSION   NM_181609
VERSION     NM_181609.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 552)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 552)
  AUTHORS   Rogers,M.A., Langbein,L., Winter,H., Ehmann,C., Praetzel,S. and
            Schweizer,J.
  TITLE     Characterization of a first domain of human high glycine-tyrosine
            and high sulfur keratin-associated protein (KAP) genes on
            chromosome 21q22.1
  JOURNAL   J Biol Chem 277 (50), 48993-49002 (2002)
   PUBMED   12359730
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AP000567.2 and AF139541.1.
            
            On May 17, 2019 this sequence version replaced NM_181609.3.
            
            ##Evidence-Data-START##
            Transcript is intronless :: DRR138525.128055.1, AF139541.1
                                        [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000334063.6/ ENSP00000386376.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-56                AP000567.2         112214-112269       c
            57-484              AF139541.1         1-428
            485-486             AP000567.2         111784-111785       c
            487-550             AF139541.1         431-494
            551-552             AP000567.2         111718-111719       c
FEATURES             Location/Qualifiers
     source          1..552
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="21"
                     /map="21q22.11"
     gene            1..552
                     /gene="KRTAP19-3"
                     /gene_synonym="GTRHP; KAP19.3"
                     /note="keratin associated protein 19-3"
                     /db_xref="GeneID:337970"
                     /db_xref="HGNC:HGNC:18938"
     exon            1..552
                     /gene="KRTAP19-3"
                     /gene_synonym="GTRHP; KAP19.3"
                     /inference="alignment:Splign:2.1.0"
     CDS             57..302
                     /gene="KRTAP19-3"
                     /gene_synonym="GTRHP; KAP19.3"
                     /note="glycine/tyrosine-rich protein; GTHRP"
                     /codon_start=1
                     /product="keratin-associated protein 19-3"
                     /protein_id="NP_853640.1"
                     /db_xref="CCDS:CCDS13596.1"
                     /db_xref="GeneID:337970"
                     /db_xref="HGNC:HGNC:18938"
                     /translation="MSYYGSYYGGLGYGCGGFGGLGYGYGCGCGSFRRLGSGCGYGGY
                     GYGSGFGGYGYGSGFGGYGYGCYRPSYYGGYGFSGFY"
     regulatory      526..531
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KRTAP19-3"
                     /gene_synonym="GTRHP; KAP19.3"
                     /note="hexamer: AATAAA"
     polyA_site      552
                     /gene="KRTAP19-3"
                     /gene_synonym="GTRHP; KAP19.3"
                     /note="major polyA site"
ORIGIN      
        1 attcacactc aggaccttgc cttgagcagc aaaccaaact cactacccct gacaccatga
       61 gctactacgg cagctactat ggaggcctgg gctatggctg tggaggcttt ggtggcctgg
      121 gctatggcta tggctgtgga tgtggcagct tccgcagact gggttctggc tgtggctatg
      181 gaggctacgg atatggctct ggctttggag gctatggata tggctctggc ttcggaggct
      241 acggatatgg ctgctaccgc ccatcatact atggaggata tggattctct ggattctatt
      301 aaactactgc cccagcaaca caatgtgtga aattataaga ggactttccc agagctgact
      361 tcaatcattg gacaacaaag atcatgctgg agctatttgc acaaaagaat ttaacatctc
      421 agaatttcag gcaatttttt ttctctgtat acccacatct ctataataat cctagtattc
      481 tctacttttg cttttaaagc tgattgaatt atctgtttat cttccaataa aacattctat
      541 tttcaaacac aa
//
