LOCUS       NM_181607                662 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens keratin associated protein 19-1 (KRTAP19-1), mRNA.
ACCESSION   NM_181607
VERSION     NM_181607.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 662)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 662)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 662)
  AUTHORS   Rogers,M.A., Langbein,L., Winter,H., Ehmann,C., Praetzel,S. and
            Schweizer,J.
  TITLE     Characterization of a first domain of human high glycine-tyrosine
            and high sulfur keratin-associated protein (KAP) genes on
            chromosome 21q22.1
  JOURNAL   J Biol Chem 277 (50), 48993-49002 (2002)
   PUBMED   12359730
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC126284.1 and AJ457067.1.
            
            On May 17, 2019 this sequence version replaced NM_181607.2.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AJ457067.1, BC126286.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000390689.3/ ENSP00000375108.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-54                BC126284.1         12-65
            55-662              AJ457067.1         1-608
FEATURES             Location/Qualifiers
     source          1..662
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="21"
                     /map="21q22.11"
     gene            1..662
                     /gene="KRTAP19-1"
                     /gene_synonym="KAP19.1"
                     /note="keratin associated protein 19-1"
                     /db_xref="GeneID:337882"
                     /db_xref="HGNC:HGNC:18936"
     exon            1..662
                     /gene="KRTAP19-1"
                     /gene_synonym="KAP19.1"
                     /inference="alignment:Splign:2.1.0"
     CDS             51..323
                     /gene="KRTAP19-1"
                     /gene_synonym="KAP19.1"
                     /note="high tyrosine-glycine keratin-associated protein
                     19.1"
                     /codon_start=1
                     /product="keratin-associated protein 19-1"
                     /protein_id="NP_853638.1"
                     /db_xref="CCDS:CCDS13594.1"
                     /db_xref="GeneID:337882"
                     /db_xref="HGNC:HGNC:18936"
                     /translation="MSHYGSYYGGLGYSCGGFGGLGYGYGCGCGSFCRRGSGCGYGGY
                     GYGSGFGSYGYGSGFGGYGYGSGFGGYGYGCCRPSYNGGYGFSGFY"
     regulatory      645..650
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KRTAP19-1"
                     /gene_synonym="KAP19.1"
                     /note="hexamer: AATGAA"
     polyA_site      662
                     /gene="KRTAP19-1"
                     /gene_synonym="KAP19.1"
                     /note="major polyA site"
ORIGIN      
        1 acactcagga tcttgcctga acaacaaacc aactcaccac tcctgacacc atgagtcact
       61 acggcagcta ctacggaggc ctgggctaca gctgtggagg cttcggtggc ctgggctatg
      121 gctatggctg tggatgtggc agcttctgca gacggggttc tggctgtggc tatggaggct
      181 acggatatgg ctctggcttt ggaagctacg gatatggctc tggctttgga ggctacggat
      241 atggctctgg ctttggaggc tatggatatg gctgctgccg cccatcgtac aatggaggat
      301 acggattctc tggcttttat taaatgaatt gctgaaattg gaagcagagg agaaacctcc
      361 aaatgtgttt ggtcctgtcc cgtgctttca ttccaaaaat ccattctatt gccttcagca
      421 tcaatggaga gatatttagc tatgttaaat ctttaaaata gatttaagct gcttctgtga
      481 atatttgttg tctttttact ttcggagtcc gtcacctgaa atcatattca tgtataacta
      541 ctctaggttg ttcttctaaa tttgctttat ttttcttacc accattacct tgatgttatc
      601 tatcaagatc ctagcaaaaa cttgtatttt gcttttatct aataaatgaa gtaaagtata
      661 aa
//
