LOCUS       NM_031964                799 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens keratin associated protein 17-1 (KRTAP17-1), mRNA.
ACCESSION   NM_031964 XM_001127267
VERSION     NM_031964.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 799)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 799)
  AUTHORS   Oh Adib,C., Jones,B., Liao,H., Smith,F.J., Solomon,R., Egan,C.A.
            and Leachman,S.
  TITLE     Recurrent mutation in keratin 17 in a large family with
            pachyonychia congenita type 2
  JOURNAL   Arch Dermatol Res 300 (5), 211-214 (2008)
   PUBMED   18347808
  REMARK    GeneRIF: Recurrent mutation in a large family with pachyonychia
            congenita type 2
REFERENCE   3  (bases 1 to 799)
  AUTHORS   Rogers,M.A., Langbein,L., Winter,H., Ehmann,C., Praetzel,S.,
            Korn,B. and Schweizer,J.
  TITLE     Characterization of a cluster of human high/ultrahigh sulfur
            keratin-associated protein genes embedded in the type I keratin
            gene domain on chromosome 17q12-21
  JOURNAL   J Biol Chem 276 (22), 19440-19451 (2001)
   PUBMED   11279113
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff in
            collaboration with Michael Rogers. The reference sequence was
            derived from AC003958.3 and AJ406952.1.
            
            On May 17, 2019 this sequence version replaced NM_031964.1.
            
            Summary: This protein is a member of the keratin-associated protein
            (KAP) family. The KAP proteins form a matrix of keratin
            intermediate filaments which contribute to the structure of hair
            fibers. KAP family members appear to have unique, family-specific
            amino- and carboxyl-terminal regions and are subdivided into three
            multi-gene families according to amino acid composition: the high
            sulfur, the ultrahigh sulfur, and the high tyrosine/glycine KAPs.
            This protein is a member of the ultrahigh sulfur KAP family and the
            gene is localized to a cluster of KAPs at 17q12-q21. [provided by
            RefSeq, Jul 2008].
            
            ##Evidence-Data-START##
            Transcript is intronless :: AJ406952.1, BC069078.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000334202.5/ ENSP00000333993.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-15                AC003958.3         117226-117240
            16-794              AJ406952.1         1-779
            795-799             AC003958.3         118020-118024
FEATURES             Location/Qualifiers
     source          1..799
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q21.2"
     gene            1..799
                     /gene="KRTAP17-1"
                     /gene_synonym="KAP17.1; KRTAP16.1; KRTAP17.1"
                     /note="keratin associated protein 17-1"
                     /db_xref="GeneID:83902"
                     /db_xref="HGNC:HGNC:18917"
     exon            1..799
                     /gene="KRTAP17-1"
                     /gene_synonym="KAP17.1; KRTAP16.1; KRTAP17.1"
                     /inference="alignment:Splign:2.1.0"
     CDS             61..378
                     /gene="KRTAP17-1"
                     /gene_synonym="KAP17.1; KRTAP16.1; KRTAP17.1"
                     /note="keratin associated protein 16.1"
                     /codon_start=1
                     /product="keratin-associated protein 17-1"
                     /protein_id="NP_114170.1"
                     /db_xref="CCDS:CCDS11387.1"
                     /db_xref="GeneID:83902"
                     /db_xref="HGNC:HGNC:18917"
                     /translation="MGCCPGDCFTCCTQEQNCCEECCCQPGCCGCCGSCCGCGGSGCG
                     GSGCGGSCCGSSCCGSGCGGCGGCGGCGGGCCGSSCCGSSCCGSGCCGPVCCQPTPIC
                     DTK"
     regulatory      770..775
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KRTAP17-1"
                     /gene_synonym="KAP17.1; KRTAP16.1; KRTAP17.1"
                     /note="hexamer: AATAAA"
     polyA_site      799
                     /gene="KRTAP17-1"
                     /gene_synonym="KAP17.1; KRTAP16.1; KRTAP17.1"
                     /note="major polyA site"
ORIGIN      
        1 accgtcagtc gtggggaact ccggctgcgt taccgacctg cgagctgacg ggcccggacc
       61 atggggtgct gcccggggga ctgcttcacc tgctgcaccc aggagcaaaa ctgctgtgaa
      121 gagtgctgct gtcagccggg ctgctgtggc tgctgcggct cctgctgtgg ctgtgggggc
      181 tctggctgcg ggggctctgg ctgcgggggc agctgctgcg gatcgtcttg ctgtggatct
      241 ggctgcggag gctgtggagg ctgcggaggc tgcgggggtg gctgctgtgg atccagttgc
      301 tgtgggtcca gttgctgcgg ctccgggtgc tgtgggcctg tgtgctgcca gcccacacct
      361 atatgcgaca caaaatgaag acctttccct ccaccactga tgcagtccca ccgaaagcct
      421 ccatctgctc cagggggaca gcccctcgtg tccagaacct tccatacccc caagacagtg
      481 tcttgtcttt ctgtgatttg tagaggaggg cttgttctcc aacaccttct ctggtatttc
      541 aaggcaccga gaacaagagc catactctga tgaaacatta aaactcggtc acaactaagt
      601 gatcccaagc tcaagggtga atccccaata ctttacttat tcacatgaag ttcaatgtct
      661 tgtactataa gacatcctct tcttcaaggt gtctttggga ctgatcctcc gccctggctt
      721 tctgcagctt tgagatgcaa aaaaggtcca tcttctttgt gagcctctta ataaatttga
      781 gcatgctggc ataacctaa
//
