LOCUS       NM_181684                739 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens keratin associated protein 12-2 (KRTAP12-2), mRNA.
ACCESSION   NM_181684
VERSION     NM_181684.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 739)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 739)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 739)
  AUTHORS   Yang,X., Coulombe-Huntington,J., Kang,S., Sheynkman,G.M., Hao,T.,
            Richardson,A., Sun,S., Yang,F., Shen,Y.A., Murray,R.R., Spirohn,K.,
            Begg,B.E., Duran-Frigola,M., MacWilliams,A., Pevzner,S.J.,
            Zhong,Q., Wanamaker,S.A., Tam,S., Ghamsari,L., Sahni,N., Yi,S.,
            Rodriguez,M.D., Balcha,D., Tan,G., Costanzo,M., Andrews,B.,
            Boone,C., Zhou,X.J., Salehi-Ashtiani,K., Charloteaux,B., Chen,A.A.,
            Calderwood,M.A., Aloy,P., Roth,F.P., Hill,D.E., Iakoucheva,L.M.,
            Xia,Y. and Vidal,M.
  TITLE     Widespread Expansion of Protein Interaction Capabilities by
            Alternative Splicing
  JOURNAL   Cell 164 (4), 805-817 (2016)
   PUBMED   26871637
REFERENCE   4  (bases 1 to 739)
  AUTHORS   Shibuya,K., Obayashi,I., Asakawa,S., Minoshima,S., Kudoh,J. and
            Shimizu,N.
  TITLE     A cluster of 21 keratin-associated protein genes within introns of
            another gene on human chromosome 21q22.3
  JOURNAL   Genomics 83 (4), 679-693 (2004)
   PUBMED   15028290
REFERENCE   5  (bases 1 to 739)
  AUTHORS   Rogers,M.A., Langbein,L., Winter,H., Beckmann,I., Praetzel,S. and
            Schweizer,J.
  TITLE     Hair keratin associated proteins: characterization of a second high
            sulfur KAP gene domain on human chromosome 21
  JOURNAL   J Invest Dermatol 122 (1), 147-158 (2004)
   PUBMED   14962103
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. This record has been curated by NCBI staff in
            collaboration with Michael Rogers. The reference sequence was
            derived from AJ566389.1.
            
            On May 17, 2019 this sequence version replaced NM_181684.2.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AJ566389.1, AB076362.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000360770.3/ ENSP00000354001.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-739               AJ566389.1         10-748
FEATURES             Location/Qualifiers
     source          1..739
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="21"
                     /map="21q22.3"
     gene            1..739
                     /gene="KRTAP12-2"
                     /gene_synonym="KAP12.2; KRTAP12.2"
                     /note="keratin associated protein 12-2"
                     /db_xref="GeneID:353323"
                     /db_xref="HGNC:HGNC:20530"
     exon            1..739
                     /gene="KRTAP12-2"
                     /gene_synonym="KAP12.2; KRTAP12.2"
                     /inference="alignment:Splign:2.1.0"
     CDS             42..482
                     /gene="KRTAP12-2"
                     /gene_synonym="KAP12.2; KRTAP12.2"
                     /note="keratin-associated protein 12.2; high sulfur
                     keratin-associated protein 12.2"
                     /codon_start=1
                     /product="keratin-associated protein 12-2"
                     /protein_id="NP_859012.1"
                     /db_xref="CCDS:CCDS42965.1"
                     /db_xref="GeneID:353323"
                     /db_xref="HGNC:HGNC:20530"
                     /translation="MCHTSCSSGCQPACCAPSPCQPACCVPSSCQASCCVPVGCQSSV
                     CVPVSFKPAVCLPVSCQSSVCVPMSFKSAVCVPVSCQSSVCVPVSCRPIVCAAPSCQS
                     SLCVPVSCRPVVYAAPSCQSSGCCQPSCTSVLCRPISYSISSCC"
ORIGIN      
        1 tcactgccct ctgcctcgac cttatccagc cacacgccac catgtgtcat accagctgct
       61 cctcgggctg ccagccagcc tgctgcgcgc ccagcccctg ccagccagcc tgttgtgtgc
      121 ccagctcctg ccaggcatcc tgctgtgtgc ctgtgggctg ccagtcctcc gtgtgtgtgc
      181 ccgtgagctt caagccagcc gtgtgcctgc ccgtgagctg ccagtcttct gtgtgtgtgc
      241 ccatgagctt caagtcagct gtgtgcgtgc ccgtgagctg ccagtcttct gtgtgtgtgc
      301 ctgtgagctg caggcccatt gtgtgtgcag ccccctcctg ccagtcctcc ctgtgcgtgc
      361 ctgtgagctg caggcctgtc gtgtatgcgg ctccgtcctg ccagtcctct gggtgctgcc
      421 agccctcctg caccagcgtc ctctgcagac ccatctccta cagtatctct tcctgctgct
      481 gagcatgaat ctccagaccc gctgctccca gtgcagatga ggccacacct gtacactccc
      541 tggatgagtc ctcagttggt cttctgcaca tggtgcaggt gaaaagcatg ctcagttgaa
      601 ccctctgaat tctggattga gaatgtgaca gaatgatctg gagcccttgc tgaccttgcc
      661 catcccccca gggaagtctg gggtcccaga gtcattctct gaccccatga gagccaaata
      721 aaccagcttt ccccatgca
//
