LOCUS       NM_198690               1286 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens keratin associated protein 10-9 (KRTAP10-9), mRNA.
ACCESSION   NM_198690
VERSION     NM_198690.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1286)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 1286)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1286)
  AUTHORS   Chen,S., Fragoza,R., Klei,L., Liu,Y., Wang,J., Roeder,K., Devlin,B.
            and Yu,H.
  TITLE     An interactome perturbation framework prioritizes damaging missense
            mutations for developmental disorders
  JOURNAL   Nat Genet 50 (7), 1032-1040 (2018)
   PUBMED   29892012
REFERENCE   4  (bases 1 to 1286)
  AUTHORS   Yang,X., Coulombe-Huntington,J., Kang,S., Sheynkman,G.M., Hao,T.,
            Richardson,A., Sun,S., Yang,F., Shen,Y.A., Murray,R.R., Spirohn,K.,
            Begg,B.E., Duran-Frigola,M., MacWilliams,A., Pevzner,S.J.,
            Zhong,Q., Wanamaker,S.A., Tam,S., Ghamsari,L., Sahni,N., Yi,S.,
            Rodriguez,M.D., Balcha,D., Tan,G., Costanzo,M., Andrews,B.,
            Boone,C., Zhou,X.J., Salehi-Ashtiani,K., Charloteaux,B., Chen,A.A.,
            Calderwood,M.A., Aloy,P., Roth,F.P., Hill,D.E., Iakoucheva,L.M.,
            Xia,Y. and Vidal,M.
  TITLE     Widespread Expansion of Protein Interaction Capabilities by
            Alternative Splicing
  JOURNAL   Cell 164 (4), 805-817 (2016)
   PUBMED   26871637
REFERENCE   5  (bases 1 to 1286)
  AUTHORS   Sahni,N., Yi,S., Taipale,M., Fuxman Bass,J.I.,
            Coulombe-Huntington,J., Yang,F., Peng,J., Weile,J., Karras,G.I.,
            Wang,Y., Kovacs,I.A., Kamburov,A., Krykbaeva,I., Lam,M.H.,
            Tucker,G., Khurana,V., Sharma,A., Liu,Y.Y., Yachie,N., Zhong,Q.,
            Shen,Y., Palagi,A., San-Miguel,A., Fan,C., Balcha,D., Dricot,A.,
            Jordan,D.M., Walsh,J.M., Shah,A.A., Yang,X., Stoyanova,A.K.,
            Leighton,A., Calderwood,M.A., Jacob,Y., Cusick,M.E.,
            Salehi-Ashtiani,K., Whitesell,L.J., Sunyaev,S., Berger,B.,
            Barabasi,A.L., Charloteaux,B., Hill,D.E., Hao,T., Roth,F.P.,
            Xia,Y., Walhout,A.J.M., Lindquist,S. and Vidal,M.
  TITLE     Widespread macromolecular interaction perturbations in human
            genetic disorders
  JOURNAL   Cell 161 (3), 647-660 (2015)
   PUBMED   25910212
REFERENCE   6  (bases 1 to 1286)
  AUTHORS   Shibuya,K., Obayashi,I., Asakawa,S., Minoshima,S., Kudoh,J. and
            Shimizu,N.
  TITLE     A cluster of 21 keratin-associated protein genes within introns of
            another gene on human chromosome 21q22.3
  JOURNAL   Genomics 83 (4), 679-693 (2004)
   PUBMED   15028290
REFERENCE   7  (bases 1 to 1286)
  AUTHORS   Rogers,M.A., Langbein,L., Winter,H., Beckmann,I., Praetzel,S. and
            Schweizer,J.
  TITLE     Hair keratin associated proteins: characterization of a second high
            sulfur KAP gene domain on human chromosome 21
  JOURNAL   J Invest Dermatol 122 (1), 147-158 (2004)
   PUBMED   14962103
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL773602.1, AB076356.1 and AJ566386.1.
            
            On May 17, 2019 this sequence version replaced NM_198690.2.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AB076356.1, BC131613.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000397911.5/ ENSP00000381009.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-30                AL773602.1         61943-61972
            31-408              AB076356.1         1-378
            409-1256            AL773602.1         62351-63198
            1257-1286           AJ566386.1         457-486
FEATURES             Location/Qualifiers
     source          1..1286
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="21"
                     /map="21q22.3"
     gene            1..1286
                     /gene="KRTAP10-9"
                     /gene_synonym="KAP10.9; KAP18.9; KRTAP18-9"
                     /note="keratin associated protein 10-9"
                     /db_xref="GeneID:386676"
                     /db_xref="HGNC:HGNC:22971"
     exon            1..1286
                     /gene="KRTAP10-9"
                     /gene_synonym="KAP10.9; KAP18.9; KRTAP18-9"
                     /inference="alignment:Splign:2.1.0"
     CDS             80..958
                     /gene="KRTAP10-9"
                     /gene_synonym="KAP10.9; KAP18.9; KRTAP18-9"
                     /note="keratin associated protein 18-9; keratin-associated
                     protein 10.9; keratin-associated protein 18.9; high sulfur
                     keratin-associated protein 10.9"
                     /codon_start=1
                     /product="keratin-associated protein 10-9"
                     /protein_id="NP_941963.2"
                     /db_xref="CCDS:CCDS42961.1"
                     /db_xref="GeneID:386676"
                     /db_xref="HGNC:HGNC:22971"
                     /translation="MAASTMSIRSSAYSDSWQVDDCPESCCEPPCCATSCCAPAPCLT
                     LVCTPVSRVSSPCCQVTCEPSPCQSGCTSSCTPSCCQQSSCQPAYCTSSPCQQACCVP
                     VCCKPVCCVPVCCGASSCCQQSSYQPACCASSSCQPACCVPVCCKPVCCAPTCSEDSY
                     SCCQQSSCQPACCTSSPCQQSYCVPVCCKPVCCKPICCVPVCSGASSLCCQQSGCQPA
                     CCTTSCCRPSSSVSLLCRPVCRPACCVPVSSCCAPTSSRQPSYCRQASCVSLLCRPVC
                     SRPACYSFSSGQKSSC"
ORIGIN      
        1 acacactcac aaactcactc actgacacac tcacacactc acttacacct cccccagctc
       61 acctcctccc caccccagca tggccgcgtc caccatgtcc atccgctcca gcgcttactc
      121 cgactcctgg caggtggacg actgcccaga gagctgctgt gagcccccct gctgcgccac
      181 cagctgctgc gccccggccc cctgcctgac cctggtctgc accccagtga gccgtgtatc
      241 cagcccctgc tgccaggtga cctgtgagcc cagcccctgc caatcaggct gcaccagctc
      301 ctgcacgccc tcgtgctgcc agcagtctag ctgccagccg gcttactgca cctcctcccc
      361 ctgccagcag gcctgctgcg tgcccgtctg ctgcaagcct gtgtgctgcg tgcccgtctg
      421 ctgtggggct tcttcgtgct gccaacagtc tagctaccag ccagcttgct gtgcctcttc
      481 ctcctgccag ccggcctgct gtgtgcccgt ctgctgcaaa cctgtgtgct gtgcgcccac
      541 ctgctctgag gattcctatt catgctgcca acagtctagc tgccagccag cttgctgcac
      601 ttcctccccc tgccagcagt cctactgtgt gcctgtctgc tgtaagcctg tctgctgcaa
      661 acccatctgc tgtgtgcctg tctgctctgg ggcttcctct ttgtgctgcc agcagtctgg
      721 ctgccagccg gcttgctgca ccacctcctg ctgcagaccc tcctcctctg tgtccctcct
      781 ctgccgccct gtgtgcaggc ccgcctgctg cgtgcccgtc tcctcctgct gtgcccccac
      841 ctcctcccgc cagcccagct attgccgcca ggcctcctgt gtgtcccttc tctgccgccc
      901 tgtgtgctcc cgcccggcct gctacagctt ctcctcaggc cagaagtcca gctgctgacg
      961 gtcatgtccc ccagggccag ccgggctcag gccccacctc cctgccagtc cttggacctc
     1021 ccagcccacc cagcctcagc acagctcaac acagaaggag cagccccagc cacagccgcc
     1081 cagccccggg gtctcagatg ctcactggct cctccctgac ctcccccccg ggcaggcgag
     1141 ccctggcttc tcctcacggt gcttcctggc tgcagaccac aaccctccgc tggtcgctgg
     1201 ttggggacgg gccctcctga cccgggtctc acccccagca gcgtcaccct ctgcccctga
     1261 gcaccaataa agcgtctgcg gcccca
//
