LOCUS       NM_198695                876 bp    mRNA    linear   PRI 03-APR-2024
DEFINITION  Homo sapiens keratin associated protein 10-8 (KRTAP10-8), mRNA.
ACCESSION   NM_198695
VERSION     NM_198695.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 876)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 876)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 876)
  AUTHORS   Chen,S., Fragoza,R., Klei,L., Liu,Y., Wang,J., Roeder,K., Devlin,B.
            and Yu,H.
  TITLE     An interactome perturbation framework prioritizes damaging missense
            mutations for developmental disorders
  JOURNAL   Nat Genet 50 (7), 1032-1040 (2018)
   PUBMED   29892012
REFERENCE   4  (bases 1 to 876)
  AUTHORS   Yang,X., Coulombe-Huntington,J., Kang,S., Sheynkman,G.M., Hao,T.,
            Richardson,A., Sun,S., Yang,F., Shen,Y.A., Murray,R.R., Spirohn,K.,
            Begg,B.E., Duran-Frigola,M., MacWilliams,A., Pevzner,S.J.,
            Zhong,Q., Wanamaker,S.A., Tam,S., Ghamsari,L., Sahni,N., Yi,S.,
            Rodriguez,M.D., Balcha,D., Tan,G., Costanzo,M., Andrews,B.,
            Boone,C., Zhou,X.J., Salehi-Ashtiani,K., Charloteaux,B., Chen,A.A.,
            Calderwood,M.A., Aloy,P., Roth,F.P., Hill,D.E., Iakoucheva,L.M.,
            Xia,Y. and Vidal,M.
  TITLE     Widespread Expansion of Protein Interaction Capabilities by
            Alternative Splicing
  JOURNAL   Cell 164 (4), 805-817 (2016)
   PUBMED   26871637
REFERENCE   5  (bases 1 to 876)
  AUTHORS   Sahni,N., Yi,S., Taipale,M., Fuxman Bass,J.I.,
            Coulombe-Huntington,J., Yang,F., Peng,J., Weile,J., Karras,G.I.,
            Wang,Y., Kovacs,I.A., Kamburov,A., Krykbaeva,I., Lam,M.H.,
            Tucker,G., Khurana,V., Sharma,A., Liu,Y.Y., Yachie,N., Zhong,Q.,
            Shen,Y., Palagi,A., San-Miguel,A., Fan,C., Balcha,D., Dricot,A.,
            Jordan,D.M., Walsh,J.M., Shah,A.A., Yang,X., Stoyanova,A.K.,
            Leighton,A., Calderwood,M.A., Jacob,Y., Cusick,M.E.,
            Salehi-Ashtiani,K., Whitesell,L.J., Sunyaev,S., Berger,B.,
            Barabasi,A.L., Charloteaux,B., Hill,D.E., Hao,T., Roth,F.P.,
            Xia,Y., Walhout,A.J.M., Lindquist,S. and Vidal,M.
  TITLE     Widespread macromolecular interaction perturbations in human
            genetic disorders
  JOURNAL   Cell 161 (3), 647-660 (2015)
   PUBMED   25910212
REFERENCE   6  (bases 1 to 876)
  AUTHORS   Shibuya,K., Obayashi,I., Asakawa,S., Minoshima,S., Kudoh,J. and
            Shimizu,N.
  TITLE     A cluster of 21 keratin-associated protein genes within introns of
            another gene on human chromosome 21q22.3
  JOURNAL   Genomics 83 (4), 679-693 (2004)
   PUBMED   15028290
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AB076355.1 and AL773602.1.
            
            On Jun 4, 2009 this sequence version replaced NM_198695.1.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AB076355.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000334662.2/ ENSP00000335565.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-98                AB076355.1         1-98
            99-99               AL773602.1         47027-47027
            100-876             AB076355.1         100-876
FEATURES             Location/Qualifiers
     source          1..876
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="21"
                     /map="21q22.3"
     gene            1..876
                     /gene="KRTAP10-8"
                     /gene_synonym="KAP10.8; KRTAP18-8; KRTAP18.8"
                     /note="keratin associated protein 10-8"
                     /db_xref="GeneID:386681"
                     /db_xref="HGNC:HGNC:20525"
     exon            1..876
                     /gene="KRTAP10-8"
                     /gene_synonym="KAP10.8; KRTAP18-8; KRTAP18.8"
                     /inference="alignment:Splign:2.1.0"
     CDS             23..802
                     /gene="KRTAP10-8"
                     /gene_synonym="KAP10.8; KRTAP18-8; KRTAP18.8"
                     /note="keratin associated protein 18-8; keratin-associated
                     protein 18.8; high sulfur keratin-associated protein 10.8"
                     /codon_start=1
                     /product="keratin-associated protein 10-8"
                     /protein_id="NP_941968.2"
                     /db_xref="CCDS:CCDS13713.1"
                     /db_xref="GeneID:386681"
                     /db_xref="HGNC:HGNC:20525"
                     /translation="MADACCTRTYVIAASTMSVCSSDVGHVSRVSSPSTCTGSSWQVD
                     NCQESCCEPRSCASSCCTPSCCAPAPCLALVCAPVSCEPSPCQSGCTDSCTPSCCQQS
                     SCQPACCTSSPCQQACCVPVCCKSNCCKPVCCVSICSGASSPCCQQSSCQSACCTFSP
                     CQQACCVPICCKPICCVPVCSGASSLCCQKSSCQPACCTTSCCRPSSSVSLLCRPVCR
                     PACCVPVPSCCVPASSCQPSCCHPASCLSFLCRPACSRLAC"
ORIGIN      
        1 accacccagt ccagcaccca ccatggctga cgcctgctgc accaggacgt atgtgattgc
       61 tgcatccacc atgtctgtct gctccagtga cgtgggccat gtcagccgag tctcctcccc
      121 cagcacctgc actggctcct cctggcaggt ggacaattgc caggaaagct gctgcgagcc
      181 ccgctcctgt gcctccagct gctgtacccc tagctgctgt gccccagccc cctgcctggc
      241 cctggtctgt gccccagtga gctgtgagcc cagcccctgc caatcaggct gcaccgactc
      301 ctgcacacct tcatgctgcc agcagtctag ctgccagccg gcttgctgca cctcctcccc
      361 ctgccaacag gcctgctgtg tgcctgtgtg ctgcaagtcc aactgctgca agcccgtgtg
      421 ctgcgtgtcc atctgctctg gagcttcctc cccatgctgc cagcagtcta gctgccagtc
      481 agcttgctgc accttctccc catgccaaca ggcctgctgt gtgcccatct gctgcaagcc
      541 catctgctgt gtgcctgtct gctctggggc ttcctctctg tgctgccaga agtctagctg
      601 ccagccggct tgctgcacca cctcctgctg cagaccctcc tcctccgtgt ccctcctctg
      661 ccgccctgtg tgccggcctg cctgctgtgt gcctgtcccc tcctgttgtg tccctgcctc
      721 ctcctgccag cccagctgct gccacccggc ctcctgcctg tccttcctct gccgccccgc
      781 gtgctcccgc ctggcctgct gaggcctctg ctcaggccag gagtccagct gctgatgggc
      841 acgtccccca gggccagccg gctccggtcc tgtcct
//
