LOCUS       NM_198689               1578 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens keratin associated protein 10-7 (KRTAP10-7), mRNA.
ACCESSION   NM_198689
VERSION     NM_198689.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1578)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 1578)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 1578)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1578)
  AUTHORS   Chen,S., Fragoza,R., Klei,L., Liu,Y., Wang,J., Roeder,K., Devlin,B.
            and Yu,H.
  TITLE     An interactome perturbation framework prioritizes damaging missense
            mutations for developmental disorders
  JOURNAL   Nat Genet 50 (7), 1032-1040 (2018)
   PUBMED   29892012
REFERENCE   5  (bases 1 to 1578)
  AUTHORS   Sahni,N., Yi,S., Taipale,M., Fuxman Bass,J.I.,
            Coulombe-Huntington,J., Yang,F., Peng,J., Weile,J., Karras,G.I.,
            Wang,Y., Kovacs,I.A., Kamburov,A., Krykbaeva,I., Lam,M.H.,
            Tucker,G., Khurana,V., Sharma,A., Liu,Y.Y., Yachie,N., Zhong,Q.,
            Shen,Y., Palagi,A., San-Miguel,A., Fan,C., Balcha,D., Dricot,A.,
            Jordan,D.M., Walsh,J.M., Shah,A.A., Yang,X., Stoyanova,A.K.,
            Leighton,A., Calderwood,M.A., Jacob,Y., Cusick,M.E.,
            Salehi-Ashtiani,K., Whitesell,L.J., Sunyaev,S., Berger,B.,
            Barabasi,A.L., Charloteaux,B., Hill,D.E., Hao,T., Roth,F.P.,
            Xia,Y., Walhout,A.J.M., Lindquist,S. and Vidal,M.
  TITLE     Widespread macromolecular interaction perturbations in human
            genetic disorders
  JOURNAL   Cell 161 (3), 647-660 (2015)
   PUBMED   25910212
REFERENCE   6  (bases 1 to 1578)
  AUTHORS   Levy,S., Sutton,G., Ng,P.C., Feuk,L., Halpern,A.L., Walenz,B.P.,
            Axelrod,N., Huang,J., Kirkness,E.F., Denisov,G., Lin,Y.,
            MacDonald,J.R., Pang,A.W., Shago,M., Stockwell,T.B., Tsiamouri,A.,
            Bafna,V., Bansal,V., Kravitz,S.A., Busam,D.A., Beeson,K.Y.,
            McIntosh,T.C., Remington,K.A., Abril,J.F., Gill,J., Borman,J.,
            Rogers,Y.H., Frazier,M.E., Scherer,S.W., Strausberg,R.L. and
            Venter,J.C.
  TITLE     The diploid genome sequence of an individual human
  JOURNAL   PLoS Biol 5 (10), e254 (2007)
   PUBMED   17803354
REFERENCE   7  (bases 1 to 1578)
  AUTHORS   Shibuya,K., Obayashi,I., Asakawa,S., Minoshima,S., Kudoh,J. and
            Shimizu,N.
  TITLE     A cluster of 21 keratin-associated protein genes within introns of
            another gene on human chromosome 21q22.3
  JOURNAL   Genomics 83 (4), 679-693 (2004)
   PUBMED   15028290
REFERENCE   8  (bases 1 to 1578)
  AUTHORS   Rogers,M.A., Langbein,L., Winter,H., Beckmann,I., Praetzel,S. and
            Schweizer,J.
  TITLE     Hair keratin associated proteins: characterization of a second high
            sulfur KAP gene domain on human chromosome 21
  JOURNAL   J Invest Dermatol 122 (1), 147-158 (2004)
   PUBMED   14962103
REFERENCE   9  (bases 1 to 1578)
  AUTHORS   Rogers,M.A., Langbein,L., Winter,H., Ehmann,C., Praetzel,S. and
            Schweizer,J.
  TITLE     Characterization of a first domain of human high glycine-tyrosine
            and high sulfur keratin-associated protein (KAP) genes on
            chromosome 21q22.1
  JOURNAL   J Biol Chem 277 (50), 48993-49002 (2002)
   PUBMED   12359730
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AB076354.1 and AJ566385.1.
            
            On May 17, 2019 this sequence version replaced NM_198689.2.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AB076354.1, BC119643.2 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000609664.2/ ENSP00000476821.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1168              AB076354.1         1-1168
            1169-1578           AJ566385.1         195-604
FEATURES             Location/Qualifiers
     source          1..1578
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="21"
                     /map="21q22.3"
     gene            1..1578
                     /gene="KRTAP10-7"
                     /gene_synonym="KAP10.7; KAP18.7; KRTAP18-7"
                     /note="keratin associated protein 10-7"
                     /db_xref="GeneID:386675"
                     /db_xref="HGNC:HGNC:22970"
     exon            1..1578
                     /gene="KRTAP10-7"
                     /gene_synonym="KAP10.7; KAP18.7; KRTAP18-7"
                     /inference="alignment:Splign:2.1.0"
     CDS             26..1138
                     /gene="KRTAP10-7"
                     /gene_synonym="KAP10.7; KAP18.7; KRTAP18-7"
                     /note="keratin associated protein 18-7; high sulfur
                     keratin-associated protein 10.7"
                     /codon_start=1
                     /product="keratin-associated protein 10-7"
                     /protein_id="NP_941962.1"
                     /db_xref="CCDS:CCDS74803.1"
                     /db_xref="GeneID:386675"
                     /db_xref="HGNC:HGNC:22970"
                     /translation="MAASTMSVCSSDLSYGSRVCLPGSCDSCSDSWQVDDCPESCCEP
                     PCCAPAPCLSLVCTPVSYVSSPCCRVTCEPSPCQSGCTSSCTPSCCQQSSCQLACCAS
                     SPCQQACCVPVCCKTVCCKPVYCVPVCSGDSSCCQQSSCQSACCTSSPCQQACCVPIC
                     CKPVCSGISSSCCQQSSCVSCVSSPCCQAVCEPSPCQSGCISSCTPSCCQQSSCKPAC
                     CTSSPCQQACCVPVCCKPVCCVPTCSDDSGSCCQPACCTSSQSQQGCCVPVCCKPVCC
                     VPVCSGASTSCCQQSSCQPACCTTSCCRPSSSVSLLCRPVCRPACCVPVPSCCAPTSS
                     CQASCCRPASCVSLLCRPACSRPACCGPTSTQKSSC"
ORIGIN      
        1 catctcctcc agttcaatcc ccagcatggc tgcgtccact atgtctgtct gctccagcga
       61 cctgagctac ggcagccgcg tctgccttcc tggttcctgt gactcttgct ccgactcctg
      121 gcaggtggac gactgcccag agagctgctg cgagcccccc tgctgcgccc cggccccctg
      181 cctgagcctg gtctgcaccc cagtgagcta tgtgtccagc ccctgctgcc gagtgacctg
      241 tgagcccagc ccctgccaat caggctgcac cagctcctgc acgccctcgt gctgccagca
      301 gtctagctgc cagctggctt gctgtgcctc ctccccctgc cagcaggcct gctgcgtgcc
      361 cgtctgctgc aagactgtct gctgcaagcc tgtgtactgt gtgcctgtct gcagtgggga
      421 ttcttcatgc tgccagcagt ctagctgcca gtcagcttgc tgcacctcct ccccctgcca
      481 gcaggcctgc tgtgtgccca tctgctgcaa gcctgtctgc tctgggattt cctcttcgtg
      541 ctgccagcag tctagctgtg tgagctgtgt gtccagtccc tgctgccagg cggtctgtga
      601 gcccagcccc tgccaatcag gctgcatcag ctcctgcacg ccctcgtgct gccagcagtc
      661 tagctgcaag ccggcttgct gcacctcctc cccttgccag caggcctgct gtgtgcctgt
      721 ctgctgcaag cccgtctgct gtgtgcccac ctgctctgat gattccggtt catgctgcca
      781 gccagcttgc tgcacctcct cccaaagcca gcagggctgc tgcgtgcccg tctgctgtaa
      841 gcctgtgtgc tgtgtgcccg tctgctctgg ggcttccact tcatgctgcc agcagtctag
      901 ctgccagccg gcttgctgca ccacctcctg ctgcagaccc tcctcctccg tgtccctcct
      961 ctgccgcccc gtgtgcaggc ccgcctgctg cgtgcccgtc ccctcctgct gcgcccccac
     1021 ctcctcctgc caggccagct gctgccgccc agcctcctgt gtgtctctcc tttgccgccc
     1081 cgcatgctcc cgcccggcct gctgtggccc cacctcaacc cagaagtcca gctgctgagt
     1141 gatctcctta agatcatcca aagcctgagt gctcactgcc acctgcaccc ctggattctt
     1201 tacccttgac ggctctccac atcccgctcc taagccctgc agtggacgtc agtggtcagc
     1261 tggccatcca gtgtgcgctt ctcctcctag aagcagctca gctgtttctc caagtcttga
     1321 ctttccccca attacccagc cctgcttccc cagcaacagg tgggcagtga ccccagcaag
     1381 gccagcgggt gctcccaggc catagcccgg tgtggggaga aatgagggta gacaggtacc
     1441 aactgggttt ctcgtcactg tcccagctca gtggcgagcc ctgctcctcc cctgctgtgg
     1501 gcctgggcct ctttctctgt cttccctgac cacgggagca ggtcagaccc ttctaataaa
     1561 ctcctttcct aaaaagta
//
