LOCUS       NM_198694               1150 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens keratin associated protein 10-5 (KRTAP10-5), mRNA.
ACCESSION   NM_198694
VERSION     NM_198694.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1150)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 1150)
  AUTHORS   Chen,S., Fragoza,R., Klei,L., Liu,Y., Wang,J., Roeder,K., Devlin,B.
            and Yu,H.
  TITLE     An interactome perturbation framework prioritizes damaging missense
            mutations for developmental disorders
  JOURNAL   Nat Genet 50 (7), 1032-1040 (2018)
   PUBMED   29892012
REFERENCE   3  (bases 1 to 1150)
  AUTHORS   Shibuya,K., Obayashi,I., Asakawa,S., Minoshima,S., Kudoh,J. and
            Shimizu,N.
  TITLE     A cluster of 21 keratin-associated protein genes within introns of
            another gene on human chromosome 21q22.3
  JOURNAL   Genomics 83 (4), 679-693 (2004)
   PUBMED   15028290
REFERENCE   4  (bases 1 to 1150)
  AUTHORS   Rogers,M.A., Langbein,L., Winter,H., Beckmann,I., Praetzel,S. and
            Schweizer,J.
  TITLE     Hair keratin associated proteins: characterization of a second high
            sulfur KAP gene domain on human chromosome 21
  JOURNAL   J Invest Dermatol 122 (1), 147-158 (2004)
   PUBMED   14962103
REFERENCE   5  (bases 1 to 1150)
  AUTHORS   Rogers,M.A., Langbein,L., Winter,H., Ehmann,C., Praetzel,S. and
            Schweizer,J.
  TITLE     Characterization of a first domain of human high glycine-tyrosine
            and high sulfur keratin-associated protein (KAP) genes on
            chromosome 21q22.1
  JOURNAL   J Biol Chem 277 (50), 48993-49002 (2002)
   PUBMED   12359730
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff in
            collaboration with Michael Rogers. The reference sequence was
            derived from AP001067.1.
            
            On Apr 18, 2014 this sequence version replaced NM_198694.2.
            
            Summary: This is an intronless gene located in a cluster of related
            genes on the q arm of chromosome 21. The proteins encoded by these
            genes form disulfide bonds with cysteine residues in hair keratins,
            thereby contributing to the structure and stability of hair fibers.
            [provided by RefSeq, Apr 2014].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000400372.1/ ENSP00000383223.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1150              AP001067.1         64908-66057         c
FEATURES             Location/Qualifiers
     source          1..1150
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="21"
                     /map="21q22.3"
     gene            1..1150
                     /gene="KRTAP10-5"
                     /gene_synonym="KAP10.5; KAP18-5; KAP18.5; KRTAP10.5;
                     KRTAP18-5; KRTAP18.1; KRTAP18.5"
                     /note="keratin associated protein 10-5"
                     /db_xref="GeneID:386680"
                     /db_xref="HGNC:HGNC:22969"
     exon            1..1150
                     /gene="KRTAP10-5"
                     /gene_synonym="KAP10.5; KAP18-5; KAP18.5; KRTAP10.5;
                     KRTAP18-5; KRTAP18.1; KRTAP18.5"
                     /inference="alignment:Splign:2.1.0"
     CDS             27..842
                     /gene="KRTAP10-5"
                     /gene_synonym="KAP10.5; KAP18-5; KAP18.5; KRTAP10.5;
                     KRTAP18-5; KRTAP18.1; KRTAP18.5"
                     /note="keratin-associated protein 18.5; high sulfur
                     keratin-associated protein 10.5"
                     /codon_start=1
                     /product="keratin-associated protein 10-5"
                     /protein_id="NP_941967.3"
                     /db_xref="CCDS:CCDS42958.1"
                     /db_xref="GeneID:386680"
                     /db_xref="HGNC:HGNC:22969"
                     /translation="MAACTMSVCSSACSDSWRVDDCPESCCEPPCGTAPCLTLVCTPV
                     SCVSSPCCQAACEPSPCQSGCTSSCTPSCCQPACCASSPCQQACCVPVCCKPVCCLPT
                     CSKDSSSCCQQSSCQPTCCASSSCQQSCCVPVCCKPVCCVPTCSEDSSSCCQHSSCQP
                     TCCTSSPCQQSCYVPVCCKPVCCKPICCVPVCSGASTSCCQQSSCQPACCTTSCCRPS
                     SSVSLLCRPICRPACCLPISSCCAPASSYQASCCRPASCVSLLCRPACSPLAC"
     regulatory      1127..1132
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KRTAP10-5"
                     /gene_synonym="KAP10.5; KAP18-5; KAP18.5; KRTAP10.5;
                     KRTAP18-5; KRTAP18.1; KRTAP18.5"
     polyA_site      1150
                     /gene="KRTAP10-5"
                     /gene_synonym="KAP10.5; KAP18-5; KAP18.5; KRTAP10.5;
                     KRTAP18-5; KRTAP18.1; KRTAP18.5"
ORIGIN      
        1 ccagctcacg tcttccccac cccagcatgg ccgcgtgcac catgtccgtc tgctccagcg
       61 cttgctctga ctcctggcga gtggacgact gcccagagag ctgctgtgag cccccctgcg
      121 gcaccgcccc ctgcctgacc ctggtctgca ccccagtgag ctgtgtgtcc agcccctgct
      181 gccaggcggc ctgtgagccc agcccctgcc aatcaggctg caccagctcc tgcacgccct
      241 cgtgctgcca gccggcttgc tgcgcctcct ccccctgcca gcaggcctgc tgcgtgcccg
      301 tctgctgcaa gcctgtgtgc tgcctgccca cctgctctaa ggattcctct tcatgctgcc
      361 agcagtctag ctgccagcca acttgctgtg cctcttcctc ctgccagcag tcctgctgtg
      421 tgcctgtctg ctgcaagccc gtgtgctgtg tgcccacctg ttctgaggat tcctcttcat
      481 gctgccagca ttctagctgc cagccgactt gctgcacctc ctccccctgc cagcagtcct
      541 gctacgtgcc tgtctgttgc aagcctgtct gctgcaaacc catctgctgt gtgcccgtct
      601 gctctggggc ttccacttca tgctgccagc agtctagctg tcagccggct tgctgcacca
      661 cctcctgctg cagaccctcc tcctccgtgt ccctcctctg ccgccccata tgcaggcccg
      721 cctgctgcct gcccatctcc tcctgctgtg cccctgcctc ctcctaccag gccagctgct
      781 gccgcccggc ctcctgcgtg tccctcctct gccgccccgc gtgctccccc ctggcctgct
      841 gaggcctctg ctcaggccag gagtccagtt gctgatgtgc acatccccca gggccaactg
      901 gtcctgactc gggttaggag gttgcccccg cttgggacgg ggcccccatg tgctgaggtg
      961 acccccccct ccatactccc aggaatctcc atcctcgaag ctccccagct cctgcctccc
     1021 agcaggggcc cacctgcctg ttgggtcccc tgtcctccct cccagcttct ctgccccatg
     1081 tcacttggcc tcgacttgaa cctgtcagca cctcctcctg ctccccaata aactcccctt
     1141 ggtcgcctga
//
