LOCUS       NM_198687               1643 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens keratin associated protein 10-4 (KRTAP10-4), mRNA.
ACCESSION   NM_198687
VERSION     NM_198687.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1643)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 1643)
  AUTHORS   Shibuya,K., Obayashi,I., Asakawa,S., Minoshima,S., Kudoh,J. and
            Shimizu,N.
  TITLE     A cluster of 21 keratin-associated protein genes within introns of
            another gene on human chromosome 21q22.3
  JOURNAL   Genomics 83 (4), 679-693 (2004)
   PUBMED   15028290
REFERENCE   3  (bases 1 to 1643)
  AUTHORS   Rogers,M.A., Langbein,L., Winter,H., Beckmann,I., Praetzel,S. and
            Schweizer,J.
  TITLE     Hair keratin associated proteins: characterization of a second high
            sulfur KAP gene domain on human chromosome 21
  JOURNAL   J Invest Dermatol 122 (1), 147-158 (2004)
   PUBMED   14962103
REFERENCE   4  (bases 1 to 1643)
  AUTHORS   Rogers,M.A., Langbein,L., Winter,H., Ehmann,C., Praetzel,S. and
            Schweizer,J.
  TITLE     Characterization of a first domain of human high glycine-tyrosine
            and high sulfur keratin-associated protein (KAP) genes on
            chromosome 21q22.1
  JOURNAL   J Biol Chem 277 (50), 48993-49002 (2002)
   PUBMED   12359730
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff in
            collaboration with Michael Rogers. The reference sequence was
            derived from AP001067.1.
            
            On Apr 18, 2014 this sequence version replaced NM_198687.1.
            
            Summary: This is an intronless gene located in a cluster of related
            genes on the q arm of chromosome 21. The proteins encoded by these
            genes form disulfide bonds with cysteine residues in hair keratins,
            thereby contributing to the structure and stability of hair fibers.
            [provided by RefSeq, Apr 2014].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000400374.4/ ENSP00000383225.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1643              AP001067.1         59182-60824
FEATURES             Location/Qualifiers
     source          1..1643
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="21"
                     /map="21q22.3"
     gene            1..1643
                     /gene="KRTAP10-4"
                     /gene_synonym="KAP10.4; KAP18-4; KRTAP10.4; KRTAP18-4;
                     KRTAP18.4"
                     /note="keratin associated protein 10-4"
                     /db_xref="GeneID:386672"
                     /db_xref="HGNC:HGNC:20521"
     exon            1..1643
                     /gene="KRTAP10-4"
                     /gene_synonym="KAP10.4; KAP18-4; KRTAP10.4; KRTAP18-4;
                     KRTAP18.4"
                     /inference="alignment:Splign:2.1.0"
     CDS             31..1236
                     /gene="KRTAP10-4"
                     /gene_synonym="KAP10.4; KAP18-4; KRTAP10.4; KRTAP18-4;
                     KRTAP18.4"
                     /note="keratin-associated protein 18.4; high sulfur
                     keratin-associated protein 10.4"
                     /codon_start=1
                     /product="keratin-associated protein 10-4"
                     /protein_id="NP_941960.2"
                     /db_xref="CCDS:CCDS42957.1"
                     /db_xref="GeneID:386672"
                     /db_xref="HGNC:HGNC:20521"
                     /translation="MSVCSSDLSYSSRVCLPGSCDSCSDSWQVDDCPESCCEPPCCAP
                     SCCAPAPCLSLVCTPVSRVSSPCCPVTCEPSPCQSGCTSSCTPSCCQQSSCQLACCAS
                     SPCQQACCVPVCCKTVCCKPVCCVPVCCGDSSCCQQSSCQSACCTSSPCQQACCVPIC
                     CKPVCSGISSSCCQQSSCVSCVSSPCCQAVCEPSPCQSGCISSCTPSCCQQSSCQPAC
                     CTSSSCQQACCVPVCCKTVCCKPVCSEDSSSCCQQSSCQPACCTSSPCQQACCVPVCC
                     KPVCCKPVCSVPICSGASSLCCQQSSCQPACCTSSQSQQGCCVPVCCKPVSCVPVCSG
                     ASSSCCQQSSCQPACCTTSCCRPSSSVSLLCRPVCRPACCVPVPSCCAPTSSCQPSCC
                     RPASCVSLL"
     regulatory      1613..1618
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KRTAP10-4"
                     /gene_synonym="KAP10.4; KAP18-4; KRTAP10.4; KRTAP18-4;
                     KRTAP18.4"
     polyA_site      1643
                     /gene="KRTAP10-4"
                     /gene_synonym="KAP10.4; KAP18-4; KRTAP10.4; KRTAP18-4;
                     KRTAP18.4"
ORIGIN      
        1 agctcaaccc ccagcacagc agcatccacc atgtccgtct gctccagcga cctgagctac
       61 agcagccgcg tctgccttcc tggttcctgt gactcttgct ccgactcctg gcaggtggac
      121 gactgcccag agagctgctg cgagcccccc tgctgcgccc ccagctgctg cgccccggcc
      181 ccctgcctga gcctggtctg caccccagtg agccgtgtgt ccagcccctg ctgcccagtg
      241 acctgtgagc ccagcccctg ccaatcaggc tgcaccagct cctgcacgcc ctcgtgctgc
      301 cagcagtcta gctgccagct ggcttgctgt gcctcctccc cctgccagca ggcctgctgc
      361 gtgcccgtct gctgcaagac tgtctgctgc aagcctgtgt gctgtgtgcc cgtctgctgt
      421 ggggattctt catgctgcca gcagtctagc tgccagtcag cttgctgcac ctcctccccc
      481 tgccagcagg cctgctgtgt gcccatctgc tgcaagcctg tctgctctgg gatttcctct
      541 tcgtgctgcc agcagtctag ctgtgtgagc tgtgtgtcca gcccctgctg ccaggcggtc
      601 tgtgagccca gcccctgcca atcaggctgc atcagctcct gcacgccctc gtgctgccag
      661 cagtctagct gccagccggc ttgctgcacc tcctcctcct gccagcaggc ctgctgcgtg
      721 cccgtctgct gcaagactgt ctgctgcaag cctgtgtgct ctgaggattc ctcttcatgc
      781 tgccagcagt ctagctgcca gccggcttgc tgcacctcct ctccctgcca gcaggcttgc
      841 tgtgtgcctg tctgctgcaa gcctgtgtgc tgcaagcctg tctgctctgt gcccatctgc
      901 tctggggctt cctctctgtg ctgccagcag tctagctgcc agccagcttg ctgcacctcc
      961 tcccaaagcc agcagggctg ctgcgtgccc gtctgctgca agcctgtgag ctgtgtgcct
     1021 gtttgctctg gggcttcctc ttcatgctgc cagcaatcta gctgccagcc agcttgctgc
     1081 accacctcct gctgcagacc ctcctcctcc gtgtccctcc tctgccgccc cgtgtgcagg
     1141 cccgcctgct gcgtgcccgt cccttcctgc tgtgctccca cctcctcctg ccaacccagc
     1201 tgctgccgcc cagcctcctg cgtgtccctc ctctgacgcc ccgtgtgctc ccgcccagcc
     1261 tgctgaggcc tccgctcagg tcagaagccc agctgctgat ggacacgccc cccagtgcca
     1321 gccaggctca ggtcccacct gaaagctgat agtcgcgtcc tgaattgctc ctgcactttg
     1381 accatttcct ggtgtctgct gttgagctgg acaatggaag aactgaaagt ctatactcaa
     1441 tgctgcagcc ctcttgcggg gggagggggg cgcttctaga aagttcccat ggcagtggcc
     1501 tcccctccat atctcccacc tctcatgagg gtcagttcag ccttgacccg tgaggtctct
     1561 gtcctcctgg ctcagagccg cagagccttc tttggacgcc ctcaagctga ccaataaagg
     1621 ccctgagact gcaatggcgc tga
//
