LOCUS       NM_198696               1006 bp    mRNA    linear   PRI 10-FEB-2024
DEFINITION  Homo sapiens keratin associated protein 10-3 (KRTAP10-3), mRNA.
ACCESSION   NM_198696
VERSION     NM_198696.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1006)
  AUTHORS   Shibuya,K., Obayashi,I., Asakawa,S., Minoshima,S., Kudoh,J. and
            Shimizu,N.
  TITLE     A cluster of 21 keratin-associated protein genes within introns of
            another gene on human chromosome 21q22.3
  JOURNAL   Genomics 83 (4), 679-693 (2004)
   PUBMED   15028290
REFERENCE   2  (bases 1 to 1006)
  AUTHORS   Rogers,M.A., Langbein,L., Winter,H., Beckmann,I., Praetzel,S. and
            Schweizer,J.
  TITLE     Hair keratin associated proteins: characterization of a second high
            sulfur KAP gene domain on human chromosome 21
  JOURNAL   J Invest Dermatol 122 (1), 147-158 (2004)
   PUBMED   14962103
REFERENCE   3  (bases 1 to 1006)
  AUTHORS   Rogers,M.A., Langbein,L., Winter,H., Ehmann,C., Praetzel,S. and
            Schweizer,J.
  TITLE     Characterization of a first domain of human high glycine-tyrosine
            and high sulfur keratin-associated protein (KAP) genes on
            chromosome 21q22.1
  JOURNAL   J Biol Chem 277 (50), 48993-49002 (2002)
   PUBMED   12359730
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff in
            collaboration with Michael Rogers. The reference sequence was
            derived from AP001067.1, AB076350.1 and AJ566383.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_198696.2.
            
            Summary: This gene encodes a member of the keratin-associated
            protein (KAP) family. The KAP proteins form a matrix of keratin
            intermediate filaments which contribute to the structure of hair
            fibers. KAP family members appear to have unique, family-specific
            amino- and carboxyl-terminal regions and are subdivided into three
            multi-gene families according to amino acid composition: the high
            sulfur, the ultrahigh sulfur, and the high tyrosine/glycine KAPs.
            This gene encodes a member of the high sulfur KAP family. It is
            localized to a cluster of intronless KAPs at 21q22.3 which are
            located within the introns of the C21orf29 gene. [provided by
            RefSeq, Jul 2008].
            
            ##Evidence-Data-START##
            Transcript is intronless :: AB076350.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000391620.2/ ENSP00000375478.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-35                AP001067.1         44214-44248         c
            36-175              AB076350.1         1-140
            176-590             AP001067.1         43659-44073         c
            591-773             AJ566383.1         15-197
            774-1006            AP001067.1         43243-43475         c
FEATURES             Location/Qualifiers
     source          1..1006
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="21"
                     /map="21q22.3"
     gene            1..1006
                     /gene="KRTAP10-3"
                     /gene_synonym="KAP10.3; KAP18-3; KAP18.3; KRTAP10.3;
                     KRTAP18-3; KRTAP18.3"
                     /note="keratin associated protein 10-3"
                     /db_xref="GeneID:386682"
                     /db_xref="HGNC:HGNC:22968"
     exon            1..1006
                     /gene="KRTAP10-3"
                     /gene_synonym="KAP10.3; KAP18-3; KAP18.3; KRTAP10.3;
                     KRTAP18-3; KRTAP18.3"
                     /inference="alignment:Splign:2.1.0"
     CDS             81..746
                     /gene="KRTAP10-3"
                     /gene_synonym="KAP10.3; KAP18-3; KAP18.3; KRTAP10.3;
                     KRTAP18-3; KRTAP18.3"
                     /note="keratin-associated protein 18.3; high sulfur
                     keratin-associated protein 10.3; keratin-associated
                     protein 18-3"
                     /codon_start=1
                     /product="keratin-associated protein 10-3"
                     /protein_id="NP_941969.2"
                     /db_xref="CCDS:CCDS42956.1"
                     /db_xref="GeneID:386682"
                     /db_xref="HGNC:HGNC:22968"
                     /translation="MATSTMSVCSSAYSDSWQVDACPESCCEPPCCATSCCAPAPCLT
                     LVCTPVSCVSSPCCQAACEPSPCQSGCTSSCTPSCCQQSSCQPACCTSSPCQQACCVP
                     VCCKPVCCVPVCCKPVCCKPICCVPVCSGASSSCCQQSSRQPACCTTSCCRPSSSVSL
                     LCRPVCRSTCCVPIPSCCAPASTCQPSCCRPASCVSLLCRPTCSRLSSACCGLSSGQK
                     SSC"
ORIGIN      
        1 cgatcactca ctcactccct cactcactcc cacactcact cactcacgtc tcccccagct
       61 cacctcctcc ccaccccagc atggccacgt ctaccatgtc cgtctgctcc agcgcttact
      121 ctgactcctg gcaggtggac gcctgcccag agagctgctg tgagcccccc tgctgcgcca
      181 ccagctgctg cgccccggcc ccctgcctga ccctggtctg caccccagtg agctgtgtgt
      241 ccagcccctg ctgccaggcg gcctgtgagc ccagcccctg ccagtcaggc tgcaccagct
      301 cctgcacgcc ctcgtgctgc cagcagtcta gctgccagcc agcttgctgc acatcctccc
      361 cctgccagca ggcctgctgc gtgcctgtct gctgcaagcc agtctgctgt gtgcccgtct
      421 gctgcaagcc tgtctgctgc aagcccatct gctgtgtgcc cgtctgctct ggggcttcct
      481 cttcatgctg ccagcagtct agccgccagc cggcttgctg caccacctcc tgctgcagac
      541 cctcctcctc cgtgtccctc ctctgccgcc ccgtgtgcag gtccacctgc tgtgtgccca
      601 tcccctcctg ctgtgcccct gcctccacct gccagcccag ctgctgccgc ccggcctcct
      661 gcgtgtccct cctctgccgc cccacgtgct cccgcctctc ttccgcgtgc tgcggcctct
      721 cctcaggcca gaagtccagc tgctgacggg caggtcccgt ttctccagag ttgttccagg
      781 gccatctctg acttccgaaa atccttgcag ccctgagccc tgtctgagtc tcctctgccc
      841 atagccactg cacctccagc cagcaatgct gagctttcat gccgattccc tccaggcatg
      901 catctctccc acaccctcat ctccatgctg gccagccggt ggtcactgtg tcctgcccca
      961 tgtgagtgat cagtctgtca acaaataaag tcaccaatgt gccctc
//
