LOCUS       NM_198693               1149 bp    mRNA    linear   PRI 10-FEB-2024
DEFINITION  Homo sapiens keratin associated protein 10-2 (KRTAP10-2),
            transcript variant 1, mRNA.
ACCESSION   NM_198693 XM_942388
VERSION     NM_198693.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1149)
  AUTHORS   Shibuya,K., Obayashi,I., Asakawa,S., Minoshima,S., Kudoh,J. and
            Shimizu,N.
  TITLE     A cluster of 21 keratin-associated protein genes within introns of
            another gene on human chromosome 21q22.3
  JOURNAL   Genomics 83 (4), 679-693 (2004)
   PUBMED   15028290
REFERENCE   2  (bases 1 to 1149)
  AUTHORS   Rogers,M.A., Langbein,L., Winter,H., Beckmann,I., Praetzel,S. and
            Schweizer,J.
  TITLE     Hair keratin associated proteins: characterization of a second high
            sulfur KAP gene domain on human chromosome 21
  JOURNAL   J Invest Dermatol 122 (1), 147-158 (2004)
   PUBMED   14962103
REFERENCE   3  (bases 1 to 1149)
  AUTHORS   Rogers,M.A., Langbein,L., Winter,H., Ehmann,C., Praetzel,S. and
            Schweizer,J.
  TITLE     Characterization of a first domain of human high glycine-tyrosine
            and high sulfur keratin-associated protein (KAP) genes on
            chromosome 21q22.1
  JOURNAL   J Biol Chem 277 (50), 48993-49002 (2002)
   PUBMED   12359730
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff in
            collaboration with Michael Rogers. The reference sequence was
            derived from AB076348.1 and AJ566381.1.
            
            On May 17, 2019 this sequence version replaced NM_198693.3.
            
            Summary: This gene encodes a member of the high sulfur-type
            keratin-associated protein (KAP) family. The KAP proteins form a
            matrix of keratin intermediate filaments which contribute to the
            structure of hair fibers. This gene is located in a cluster of
            similar genes on 21q22.3. Alternatively-spliced transcript variants
            have been identified. [provided by RefSeq, Jan 2015].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the functional protein.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AB076348.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000391621.1/ ENSP00000375479.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1071              AB076348.1         1-1071
            1072-1149           AJ566381.1         373-450
FEATURES             Location/Qualifiers
     source          1..1149
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="21"
                     /map="21q22.3"
     gene            1..1149
                     /gene="KRTAP10-2"
                     /gene_synonym="KAP10.2; KAP18-2; KAP18.2; KRTAP10.2;
                     KRTAP18-2; KRTAP18.2"
                     /note="keratin associated protein 10-2"
                     /db_xref="GeneID:386679"
                     /db_xref="HGNC:HGNC:22967"
     exon            1..1149
                     /gene="KRTAP10-2"
                     /gene_synonym="KAP10.2; KAP18-2; KAP18.2; KRTAP10.2;
                     KRTAP18-2; KRTAP18.2"
                     /inference="alignment:Splign:2.1.0"
     CDS             48..815
                     /gene="KRTAP10-2"
                     /gene_synonym="KAP10.2; KAP18-2; KAP18.2; KRTAP10.2;
                     KRTAP18-2; KRTAP18.2"
                     /note="keratin-associated protein 18.2; high sulfur
                     keratin-associated protein 10.2; keratin-associated
                     protein 18-2"
                     /codon_start=1
                     /product="keratin-associated protein 10-2"
                     /protein_id="NP_941966.1"
                     /db_xref="CCDS:CCDS42955.1"
                     /db_xref="GeneID:386679"
                     /db_xref="HGNC:HGNC:22967"
                     /translation="MAASTMSICSSACTNSWQVDDCPESCCELPCGTPSCCAPAPCLT
                     LVCTPVSCVSSPCCQAACEPSACQSGCTSSCTPSCCQQSSCQPACCTSSPCQQACCVP
                     VCCKPVCCVPVCCGASSCCQQSSCQPACCASSSCQQSCRVPVCCKAVCCVPTCSESSS
                     SCCQQSSCQPACCTSSPCQQSCCVSVCCKPVCCKSICCVPVCSGASSPCCQQSSCQPA
                     CCTSSCCRPSSSVSLLCRPVCSRPASCSFSSGQKSSC"
ORIGIN      
        1 tcactcactc acacacctcc cccagctcac ctcctcccca ctccagcatg gccgcctcca
       61 ccatgtccat ctgctccagc gcctgcacca actcctggca ggtggacgac tgcccagaga
      121 gctgctgtga gctcccctgc ggcaccccca gctgctgtgc cccagccccc tgcctgaccc
      181 tggtctgcac cccagtgagc tgtgtgtcca gcccctgctg ccaggcggcc tgtgagccca
      241 gcgcctgcca atcaggctgc accagctcct gcacgccctc gtgctgccag cagtctagct
      301 gccagccggc ttgctgcacc tcctccccct gccagcaggc ctgctgcgtg cccgtctgct
      361 gcaagcctgt gtgctgtgtg cccgtctgct gtggggcttc ttcatgctgc cagcagtcta
      421 gctgccagcc agcttgctgt gcctcttcct cctgccagca gtcctgccgt gtgcctgtct
      481 gctgcaaagc tgtgtgctgc gtgcccacct gctctgagtc atcctcttca tgctgccagc
      541 agtctagctg ccagccggct tgctgcacct cctccccgtg tcagcagtcc tgctgtgtgt
      601 ccgtctgctg caagcctgtc tgctgcaagt ccatctgctg tgtacctgtt tgctctgggg
      661 cttcctctcc gtgctgccag cagtctagct gccagccagc ttgctgcacc tcctcctgct
      721 gcagaccctc ctcctctgtg tccctcctct gccgccccgt gtgctcccgc ccagcctcct
      781 gcagcttttc ctcaggccaa aagtctagct gctgatggcc atgtccccca gggccagccg
      841 ggctcaggcc ccacctccct gccagtcctt ggacctccca gcccacccag cctcagcaca
      901 gctcagcaca gaaggagcag ccccagccac agccgcccag ccccggggtc tcagatgctc
      961 actggctcct ctctgacctc ccgccgggcg ggcgagccct ggcttctcct cacggtgctt
     1021 cctggctgca gaccacaacc ctccgctggt cgctggtcgc tggttgggga tgggccctcc
     1081 tgacctgggt ctcaccccca ggagcgtcac cctctgcctc tgagcaccaa taaagcgtct
     1141 gcggcccca
//
