LOCUS       NM_198691               1215 bp    mRNA    linear   PRI 10-FEB-2024
DEFINITION  Homo sapiens keratin associated protein 10-1 (KRTAP10-1), mRNA.
ACCESSION   NM_198691
VERSION     NM_198691.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1215)
  AUTHORS   Fujikawa,H., Fujimoto,A., Farooq,M., Ito,M. and Shimomura,Y.
  TITLE     Characterization of the human hair shaft cuticle-specific
            keratin-associated protein 10 family
  JOURNAL   J Invest Dermatol 133 (12), 2780-2782 (2013)
   PUBMED   23702583
  REMARK    GeneRIF: hair shaft cuticle-specific KRTAP10-1 protein displays
            characteristics similar to the hair shaft cortex-specific KRTAP2
            proteins
REFERENCE   2  (bases 1 to 1215)
  AUTHORS   Shibuya,K., Obayashi,I., Asakawa,S., Minoshima,S., Kudoh,J. and
            Shimizu,N.
  TITLE     A cluster of 21 keratin-associated protein genes within introns of
            another gene on human chromosome 21q22.3
  JOURNAL   Genomics 83 (4), 679-693 (2004)
   PUBMED   15028290
REFERENCE   3  (bases 1 to 1215)
  AUTHORS   Rogers,M.A., Langbein,L., Winter,H., Beckmann,I., Praetzel,S. and
            Schweizer,J.
  TITLE     Hair keratin associated proteins: characterization of a second high
            sulfur KAP gene domain on human chromosome 21
  JOURNAL   J Invest Dermatol 122 (1), 147-158 (2004)
   PUBMED   14962103
REFERENCE   4  (bases 1 to 1215)
  AUTHORS   Rogers,M.A., Langbein,L., Winter,H., Ehmann,C., Praetzel,S. and
            Schweizer,J.
  TITLE     Characterization of a first domain of human high glycine-tyrosine
            and high sulfur keratin-associated protein (KAP) genes on
            chromosome 21q22.1
  JOURNAL   J Biol Chem 277 (50), 48993-49002 (2002)
   PUBMED   12359730
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff in
            collaboration with Michael Rogers. The reference sequence was
            derived from AB076347.1, AP001067.1 and AJ566380.1.
            
            On May 17, 2019 this sequence version replaced NM_198691.2.
            
            Summary: This gene encodes a member of the keratin-associated
            protein (KAP) family. The KAP proteins form a matrix of keratin
            intermediate filaments which contribute to the structure of hair
            fibers. KAP family members appear to have unique, family-specific
            amino- and carboxyl-terminal regions and are subdivided into three
            multi-gene families according to amino acid composition: the high
            sulfur, the ultrahigh sulfur, and the high tyrosine/glycine KAPs.
            This gene encodes a member of the high sulfur KAP family. It is
            localized to a cluster of intronless KAPs at 21q22.3 which are
            located within the introns of the C21orf29 gene. [provided by
            RefSeq, Jul 2008].
            
            ##Evidence-Data-START##
            Transcript is intronless :: AB076347.1, BC120960.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000400375.1/ ENSP00000383226.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-345               AB076347.1         1-345
            346-705             AP001067.1         24944-25303         c
            706-981             AB076347.1         706-981
            982-1011            AJ566380.1         97-126
            1012-1215           AP001067.1         24434-24637         c
FEATURES             Location/Qualifiers
     source          1..1215
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="21"
                     /map="21q22.3"
     gene            1..1215
                     /gene="KRTAP10-1"
                     /gene_synonym="KAP10.1; KAP18-1; KAP18.1; KRTAP10.1;
                     KRTAP18-1; KRTAP18.1"
                     /note="keratin associated protein 10-1"
                     /db_xref="GeneID:386677"
                     /db_xref="HGNC:HGNC:22966"
     exon            1..1215
                     /gene="KRTAP10-1"
                     /gene_synonym="KAP10.1; KAP18-1; KAP18.1; KRTAP10.1;
                     KRTAP18-1; KRTAP18.1"
                     /inference="alignment:Splign:2.1.0"
     CDS             46..894
                     /gene="KRTAP10-1"
                     /gene_synonym="KAP10.1; KAP18-1; KAP18.1; KRTAP10.1;
                     KRTAP18-1; KRTAP18.1"
                     /note="keratin-associated protein 18.1; high sulfur
                     keratin-associated protein 10.1; keratin-associated
                     protein 18-1"
                     /codon_start=1
                     /product="keratin-associated protein 10-1"
                     /protein_id="NP_941964.2"
                     /db_xref="CCDS:CCDS42954.1"
                     /db_xref="GeneID:386677"
                     /db_xref="HGNC:HGNC:22966"
                     /translation="MAASTMSVCSSACSDSWQVDACPESCCEPHCCALSCCAPAPCLT
                     LVCTPVSRVSSPCCQAACEPSPCQSGCTSSCTPSCCQQSSCQPACCTSSPCQQACCVP
                     VCCKPVCCLPTCSKDSSSCCQQSSCQPTCCASSSSQQSCCVPVCCKPVCYVPTCSEDS
                     SSCCQQSSCHPACCTSSPCQQACCVPVRCKPVCCKPICCVPVCSGASTSCCQQSSCQP
                     ACCTTSCCRPSSSVSLLCRPVCRPACCMPVSSCCAPASSCQASCCRPASCVSLLCRPA
                     CSRPAC"
ORIGIN      
        1 tcactcactc acacctcccg cagctcacct cctccccacc ccagcatggc cgcgtccacc
       61 atgtccgtct gctccagcgc ttgctccgac tcctggcagg tggatgcctg cccagagagc
      121 tgctgtgagc cccactgctg cgccctcagc tgctgcgccc cggccccctg cctgaccctg
      181 gtctgcaccc cagtgagccg tgtgtccagc ccctgctgcc aggcagcctg tgagcccagc
      241 ccctgccaat caggctgcac cagctcctgc acgccctcgt gctgccagca gtctagctgc
      301 cagccggctt gctgcacctc ctccccctgc cagcaggcct gctgcgtgcc cgtctgctgc
      361 aagcctgtgt gctgcctgcc cacctgctct aaggattcct cttcatgctg ccagcagtct
      421 agctgccagc caacttgctg tgcctcttcc tccagccagc agtcctgctg tgtgcctgtt
      481 tgctgcaagc ctgtgtgcta tgtgcccacc tgctctgagg attcctcttc atgctgccag
      541 cagtctagct gccatccagc ttgctgcacc tcctccccct gccagcaggc ctgctgcgtg
      601 cccgtccgtt gcaagcctgt ctgctgcaag cccatctgct gtgtgcccgt ctgctctggg
      661 gcttccactt catgctgcca gcagtctagc tgccagccgg cttgctgcac cacctcctgc
      721 tgcagaccct cctcctccgt gtccctcctc tgccgccctg tatgccggcc cgcctgctgt
      781 atgcctgtct cctcctgctg tgcccctgcc tcctcctgcc aggccagctg ctgccgcccg
      841 gcctcctgcg tgtccctcct ctgccgcccc gcgtgctccc gcccggcctg ctgaggcctc
      901 tgctcaggcc aggagtccag ctgctgatgg gcacccgccc tgggccagct gggctcagtt
      961 cctgacctgg gttaggtggc ttcccccacc taggacgggt ccccgtgtct cccctgtgct
     1021 gaggtgaccc cccctccttg ctcccaggag cctccatcct tgcagctccc cagctcttgc
     1081 cttccagcag gtgcccacct gcctgctagg tcccctgtcc tccctcccag cttctctgct
     1141 ctgggtcact tggcctcgac ttgaacctct cagcacctcc tcctgctccc caataaactc
     1201 tccttggtca cctga
//
