LOCUS       NM_031957               1183 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens keratin associated protein 1-5 (KRTAP1-5), mRNA.
ACCESSION   NM_031957
VERSION     NM_031957.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1183)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 1183)
  AUTHORS   Yachie,N., Petsalaki,E., Mellor,J.C., Weile,J., Jacob,Y., Verby,M.,
            Ozturk,S.B., Li,S., Cote,A.G., Mosca,R., Knapp,J.J., Ko,M., Yu,A.,
            Gebbia,M., Sahni,N., Yi,S., Tyagi,T., Sheykhkarimli,D., Roth,J.F.,
            Wong,C., Musa,L., Snider,J., Liu,Y.C., Yu,H., Braun,P.,
            Stagljar,I., Hao,T., Calderwood,M.A., Pelletier,L., Aloy,P.,
            Hill,D.E., Vidal,M. and Roth,F.P.
  TITLE     Pooled-matrix protein interaction screens using Barcode Fusion
            Genetics
  JOURNAL   Mol Syst Biol 12 (4), 863 (2016)
   PUBMED   27107012
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1183)
  AUTHORS   Shimomura,Y., Aoki,N., Schweizer,J., Langbein,L., Rogers,M.A.,
            Winter,H. and Ito,M.
  TITLE     Polymorphisms in the human high sulfur hair keratin-associated
            protein 1, KAP1, gene family
  JOURNAL   J Biol Chem 277 (47), 45493-45501 (2002)
   PUBMED   12228244
  REMARK    GeneRIF: no polymorphic alleles were found for the hKAP1.4 and
            hKAP1.5 genes in Japanese and Caucasian individuals
REFERENCE   4  (bases 1 to 1183)
  AUTHORS   Rogers,M.A., Langbein,L., Winter,H., Ehmann,C., Praetzel,S.,
            Korn,B. and Schweizer,J.
  TITLE     Characterization of a cluster of human high/ultrahigh sulfur
            keratin-associated protein genes embedded in the type I keratin
            gene domain on chromosome 17q12-21
  JOURNAL   J Biol Chem 276 (22), 19440-19451 (2001)
   PUBMED   11279113
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff in
            collaboration with Michael Rogers. The reference sequence was
            derived from AC007455.7 and AJ406928.1.
            
            On Nov 23, 2018 this sequence version replaced NM_031957.1.
            
            Summary: This protein is a member of the keratin-associated protein
            (KAP) family. The KAP proteins form a matrix of keratin
            intermediate filaments which contribute to the structure of hair
            fibers. KAP family members appear to have unique, family-specific
            amino- and carboxyl-terminal regions and are subdivided into three
            multi-gene families according to amino acid composition: the high
            sulfur, the ultrahigh sulfur, and the high tyrosine/glycine KAPs.
            This protein is a member of the high sulfur KAP family and the gene
            is localized to a cluster of KAPs at 17q12-q21. [provided by
            RefSeq, Jul 2008].
            
            ##Evidence-Data-START##
            Transcript is intronless :: AJ406928.1, BC069533.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000361883.6/ ENSP00000355302.5
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-6                 AC007455.7         22990-22995
            7-1183              AJ406928.1         1-1177
FEATURES             Location/Qualifiers
     source          1..1183
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q21.2"
     gene            1..1183
                     /gene="KRTAP1-5"
                     /gene_synonym="KAP1.5; KRTAP1.5"
                     /note="keratin associated protein 1-5"
                     /db_xref="GeneID:83895"
                     /db_xref="HGNC:HGNC:16777"
                     /db_xref="MIM:608822"
     exon            1..1183
                     /gene="KRTAP1-5"
                     /gene_synonym="KAP1.5; KRTAP1.5"
                     /inference="alignment:Splign:2.1.0"
     CDS             54..578
                     /gene="KRTAP1-5"
                     /gene_synonym="KAP1.5; KRTAP1.5"
                     /note="keratin associated protein 1.5; high sulfur
                     keratin-associated protein 1.5"
                     /codon_start=1
                     /product="keratin-associated protein 1-5"
                     /protein_id="NP_114163.1"
                     /db_xref="CCDS:CCDS42321.1"
                     /db_xref="GeneID:83895"
                     /db_xref="HGNC:HGNC:16777"
                     /db_xref="MIM:608822"
                     /translation="MTCCQTSFCGYPSFSISGTCGSSCCQPSCCETSCCQPRSCQTSF
                     CGFPSFSTSGTCSSSCCQPSCCETSCCQPSCCETSCCQPSCCQISSCGTGCGIGGGIS
                     YGQEGSSGAVSTRIRWCRPDSRVEGTYLPPCCVVSCTPPSCCQLHHAQASCCRPSYCG
                     QSCCRPVCCCEPTC"
     regulatory      1163..1168
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KRTAP1-5"
                     /gene_synonym="KAP1.5; KRTAP1.5"
                     /note="hexamer: ATTATA"
     polyA_site      1183
                     /gene="KRTAP1-5"
                     /gene_synonym="KAP1.5; KRTAP1.5"
                     /note="major polyA site"
ORIGIN      
        1 aaacctcaga aactcctcca agcaacctaa ctcttaaccc aacttctgac accatgacct
       61 gctgccagac cagcttctgt ggatatccca gcttctccat cagtgggacc tgtggctcca
      121 gctgctgcca gccaagctgc tgtgagacca gctgctgcca gccacgcagc tgccagacta
      181 gcttctgcgg atttcccagc ttctcaacca gtgggacctg cagctccagt tgctgccagc
      241 caagctgctg tgagaccagc tgctgccagc caagctgctg tgagaccagc tgctgccagc
      301 caagctgctg ccagatcagc tcctgcggaa ctggctgtgg cattggtggt ggcatcagct
      361 atggccagga gggcagcagt ggagctgtga gcacccgtat caggtggtgc cgcccagaca
      421 gtcgtgtgga gggcacctac ctacccccct gctgtgtggt gagctgcacg cccccatcct
      481 gctgccaact gcaccatgcc caggcctcct gctgccgccc gtcctactgt ggacagtcct
      541 gctgccgccc agtctgctgc tgtgagccca cttgctgaaa gccagtttgc ttattttcaa
      601 ttgcctaggt cacagtgtct ctgaactgtt catcccttga ccacctctgg accactaaca
      661 agttctcaga ctttgcattg cttgtgatgg agactactaa gtatatgagc tcacaattct
      721 atctgattcc attctacaat gaataccttg acccttcact ggggacacag aaatgctaca
      781 aagccacctg ctgatcatca atttgcttgg gatatactat ttctgatatt tctgcaggat
      841 taaaaattac tgacatgttg tggaatttat ccatgagaac tatccacaag tctaatgttt
      901 ccatgcttta taatctattt tatcttgttt acctaaaatt ttttgcaaca tcaaagacac
      961 caaattatag ccaagtgaca ttcctcaagt caccagagag aatggaagct catcacccaa
     1021 cattcagctt ctaagaagta ggctggactt tccacatttt aacatctgat ccatcccttg
     1081 gtttttggat cataatgatc ttgcctgctg gatatttcag ttatatctgt gatacaatgt
     1141 cttctgtcat ttcttaataa atattatata ctaggcaaag aaa
//
