LOCUS       NM_001257305             845 bp    mRNA    linear   PRI 13-OCT-2024
DEFINITION  Homo sapiens keratin associated protein 1-4 (KRTAP1-4), mRNA.
ACCESSION   NM_001257305 XM_003846286 XM_003846480 XM_003846598
VERSION     NM_001257305.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 845)
  AUTHORS   Zody,M.C., Garber,M., Adams,D.J., Sharpe,T., Harrow,J.,
            Lupski,J.R., Nicholson,C., Searle,S.M., Wilming,L., Young,S.K.,
            Abouelleil,A., Allen,N.R., Bi,W., Bloom,T., Borowsky,M.L.,
            Bugalter,B.E., Butler,J., Chang,J.L., Chen,C.K., Cook,A., Corum,B.,
            Cuomo,C.A., de Jong,P.J., DeCaprio,D., Dewar,K., FitzGerald,M.,
            Gilbert,J., Gibson,R., Gnerre,S., Goldstein,S., Grafham,D.V.,
            Grocock,R., Hafez,N., Hagopian,D.S., Hart,E., Norman,C.H.,
            Humphray,S., Jaffe,D.B., Jones,M., Kamal,M., Khodiyar,V.K.,
            LaButti,K., Laird,G., Lehoczky,J., Liu,X., Lokyitsang,T.,
            Loveland,J., Lui,A., Macdonald,P., Major,J.E., Matthews,L.,
            Mauceli,E., McCarroll,S.A., Mihalev,A.H., Mudge,J., Nguyen,C.,
            Nicol,R., O'Leary,S.B., Osoegawa,K., Schwartz,D.C., Shaw-Smith,C.,
            Stankiewicz,P., Steward,C., Swarbreck,D., Venkataraman,V.,
            Whittaker,C.A., Yang,X., Zimmer,A.R., Bradley,A., Hubbard,T.,
            Birren,B.W., Rogers,J., Lander,E.S. and Nusbaum,C.
  TITLE     DNA sequence of human chromosome 17 and analysis of rearrangement
            in the human lineage
  JOURNAL   Nature 440 (7087), 1045-1049 (2006)
   PUBMED   16625196
REFERENCE   2  (bases 1 to 845)
  AUTHORS   Shimomura,Y., Aoki,N., Schweizer,J., Langbein,L., Rogers,M.A.,
            Winter,H. and Ito,M.
  TITLE     Polymorphisms in the human high sulfur hair keratin-associated
            protein 1, KAP1, gene family
  JOURNAL   J Biol Chem 277 (47), 45493-45501 (2002)
   PUBMED   12228244
  REMARK    GeneRIF: no polymorphic alleles were found for the hKAP1.4 and
            hKAP1.5 genes in Japanese and Caucasian individuals
REFERENCE   3  (bases 1 to 845)
  AUTHORS   Rogers,M.A., Langbein,L., Winter,H., Ehmann,C., Praetzel,S.,
            Korn,B. and Schweizer,J.
  TITLE     Characterization of a cluster of human high/ultrahigh sulfur
            keratin-associated protein genes embedded in the type I keratin
            gene domain on chromosome 17q12-21
  JOURNAL   J Biol Chem 276 (22), 19440-19451 (2001)
   PUBMED   11279113
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC007455.7.
            
            On Apr 19, 2021 this sequence version replaced NM_001257305.1.
            
            Summary: The main structural proteins of mammalian hair fiber are
            the hair keratins (see MIM 601077) and the keratin-associated
            proteins (KAPs), which form a rigid and resistant hair shaft
            through extensive disulfide bond crosslinking with the abundant
            cysteines of hair keratins (Shimomura et al., 2002 [PubMed
            12228244]).[supplied by OMIM, Jan 2009].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000377747.5/ ENSP00000366976.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-845               AC007455.7         20003-20847
FEATURES             Location/Qualifiers
     source          1..845
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q21.2"
     gene            1..845
                     /gene="KRTAP1-4"
                     /gene_synonym="KAP1.4; KRTAP1.4"
                     /note="keratin associated protein 1-4"
                     /db_xref="GeneID:728255"
                     /db_xref="HGNC:HGNC:18904"
                     /db_xref="MIM:608821"
     exon            1..845
                     /gene="KRTAP1-4"
                     /gene_synonym="KAP1.4; KRTAP1.4"
                     /inference="alignment:Splign:2.1.0"
     CDS             118..483
                     /gene="KRTAP1-4"
                     /gene_synonym="KAP1.4; KRTAP1.4"
                     /note="keratin-associated protein 1.4; high sulfur
                     keratin-associated protein 1.4"
                     /codon_start=1
                     /product="keratin-associated protein 1-4"
                     /protein_id="NP_001244234.1"
                     /db_xref="CCDS:CCDS58548.1"
                     /db_xref="GeneID:728255"
                     /db_xref="HGNC:HGNC:18904"
                     /db_xref="MIM:608821"
                     /translation="MASCSTSGTCGSSCCQPSCCETSCCQPSCCQTSSCGTGCGIGGG
                     IGYGQEGSGGSVSTRIRWCHPDCHVEGTCLPPCYLVSCTPPSCCQLHHAEASCCRPSY
                     CGQSCCRPACCCHCCEPTC"
ORIGIN      
        1 gaaaaggtgt tgggtaaata tgcagctcta gggaacatat caaaggacag atatagaagg
       61 tacagcccaa actcagaaac ctctcttaac acagctctca acccaactcc tgacaccatg
      121 gccagctgtt ccaccagtgg gacctgtggc tccagctgct gccagccaag ctgctgtgaa
      181 actagctgct gccagccaag ctgctgccag accagctcct gcggaaccgg ctgtggcatt
      241 ggtggtggca ttggctatgg ccaggagggc agcggtggat ctgtgagcac ccgtatcagg
      301 tggtgccacc cagattgcca cgtggagggc acctgcctgc ccccctgcta cctggtaagc
      361 tgcacacccc catcctgctg ccagctgcac cacgccgagg cctcctgctg ccgcccgtcc
      421 tactgtggac agtcctgctg ccgcccagcc tgctgctgcc actgctgtga gcccacctgc
      481 taaaagccag gttgctgatc gcttaagaat gaaaggggaa gcacagcaaa attgtgctga
      541 tttctgaaga actgttcgat tttacttgga tgctaagtac catgatgttg ttaagctgct
      601 cagagataat gaaactccta gttaggacac tgtggatgtg ccgaattcac ttactgaaag
      661 atgtatcaat cagtgttctg gatagcttgc gttgcttgag cagaggacca ggatggaata
      721 gttcatcatt tcagtgacat ctctgctccc ccaactctct cttgatgctc atgcatcttc
      781 agacctggtt tttccttgaa tatctctgat taatccaaat aaaatgtttt aatgtgcaaa
      841 gcaaa
//
