LOCUS       NM_030966                991 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens keratin associated protein 1-3 (KRTAP1-3), mRNA.
ACCESSION   NM_030966
VERSION     NM_030966.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 991)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 991)
  AUTHORS   Yachie,N., Petsalaki,E., Mellor,J.C., Weile,J., Jacob,Y., Verby,M.,
            Ozturk,S.B., Li,S., Cote,A.G., Mosca,R., Knapp,J.J., Ko,M., Yu,A.,
            Gebbia,M., Sahni,N., Yi,S., Tyagi,T., Sheykhkarimli,D., Roth,J.F.,
            Wong,C., Musa,L., Snider,J., Liu,Y.C., Yu,H., Braun,P.,
            Stagljar,I., Hao,T., Calderwood,M.A., Pelletier,L., Aloy,P.,
            Hill,D.E., Vidal,M. and Roth,F.P.
  TITLE     Pooled-matrix protein interaction screens using Barcode Fusion
            Genetics
  JOURNAL   Mol Syst Biol 12 (4), 863 (2016)
   PUBMED   27107012
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 991)
  AUTHORS   Shimomura,Y., Aoki,N., Schweizer,J., Langbein,L., Rogers,M.A.,
            Winter,H. and Ito,M.
  TITLE     Polymorphisms in the human high sulfur hair keratin-associated
            protein 1, KAP1, gene family
  JOURNAL   J Biol Chem 277 (47), 45493-45501 (2002)
   PUBMED   12228244
  REMARK    GeneRIF: polymorphisms in Japanese and Caucasian individuals
REFERENCE   4  (bases 1 to 991)
  AUTHORS   Rogers,M.A., Langbein,L., Winter,H., Ehmann,C., Praetzel,S.,
            Korn,B. and Schweizer,J.
  TITLE     Characterization of a cluster of human high/ultrahigh sulfur
            keratin-associated protein genes embedded in the type I keratin
            gene domain on chromosome 17q12-21
  JOURNAL   J Biol Chem 276 (22), 19440-19451 (2001)
   PUBMED   11279113
REFERENCE   5  (bases 1 to 991)
  AUTHORS   Zhumabaeva,B.D., Gening,L.V. and Gazarian,K.G.
  TITLE     [Cloning and structural characteristics of human hair keratin genes
            rich in sulfur]
  JOURNAL   Mol Biol (Mosk) 26 (4), 813-820 (1992)
   PUBMED   1279380
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff in
            collaboration with Michael Rogers. The reference sequence was
            derived from AC007455.7 and AJ406927.1.
            
            On May 17, 2019 this sequence version replaced NM_030966.1.
            
            Summary: This protein is a member of the keratin-associated protein
            (KAP) family. The KAP proteins form a matrix of keratin
            intermediate filaments which contribute to the structure of hair
            fibers. KAP family members appear to have unique, family-specific
            amino- and carboxyl-terminal regions and are subdivided into three
            multi-gene families according to amino acid composition: the high
            sulfur, the ultrahigh sulfur, and the high tyrosine/glycine KAPs.
            This protein is a member of the high sulfur KAP family and the gene
            is localized to a cluster of KAPs at 17q12-q21. [provided by
            RefSeq, Jul 2008].
            
            ##Evidence-Data-START##
            Transcript is intronless :: AJ406927.1, BC069161.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000344363.7/ ENSP00000344420.5
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-19                AC007455.7         15324-15342
            20-991              AJ406927.1         1-972
FEATURES             Location/Qualifiers
     source          1..991
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q21.2"
     gene            1..991
                     /gene="KRTAP1-3"
                     /gene_synonym="KAP1.2; KAP1.3; KAP1.6; KAP1.8A; KAP1.8B;
                     KAP1.9; KRTAP1.3"
                     /note="keratin associated protein 1-3"
                     /db_xref="GeneID:81850"
                     /db_xref="HGNC:HGNC:16771"
                     /db_xref="MIM:608820"
     exon            1..991
                     /gene="KRTAP1-3"
                     /gene_synonym="KAP1.2; KAP1.3; KAP1.6; KAP1.8A; KAP1.8B;
                     KAP1.9; KRTAP1.3"
                     /inference="alignment:Splign:2.1.0"
     CDS             54..557
                     /gene="KRTAP1-3"
                     /gene_synonym="KAP1.2; KAP1.3; KAP1.6; KAP1.8A; KAP1.8B;
                     KAP1.9; KRTAP1.3"
                     /note="keratin associated protein 1.6; keratin-associated
                     protein 1.8; keratin-associated protein 1.9"
                     /codon_start=1
                     /product="keratin-associated protein 1-3"
                     /protein_id="NP_112228.1"
                     /db_xref="CCDS:CCDS42323.1"
                     /db_xref="GeneID:81850"
                     /db_xref="HGNC:HGNC:16771"
                     /db_xref="MIM:608820"
                     /translation="MTCCQTSFCGYPSCSTSGTCGSSCCQPSCCETSCCQPSCCQTSF
                     CGFPSFSTSGTCSSSCCQPSCCETSCCQPSCCQTSSCGTGCGIGGGIGYGQEGSSGAV
                     STRIRWCRPDCRVEGTCLPPCCVVSCTPPTCCQLHHAEASCCRPSYCGQSCCRPVCCC
                     YSCEPTC"
ORIGIN      
        1 aaaactcaga aactcctcca agcaacccag acttcatacc agctcccaac accatgacct
       61 gctgccagac cagcttctgt ggatatccca gctgctccac cagtgggaca tgcggctcca
      121 gctgctgcca gccaagctgc tgtgagacca gctgctgcca gccaagctgc tgccagacca
      181 gcttctgcgg atttcctagc ttctcaacta gtgggacctg cagctccagt tgctgccagc
      241 caagctgctg tgagaccagc tgctgccagc caagctgctg ccagaccagc tcctgcggaa
      301 ctggctgtgg cattggtggt ggcattggct atggccagga gggcagcagt ggagctgtga
      361 gcacccgtat caggtggtgc cgcccagact gccgtgtgga gggtacctgc ctgcccccct
      421 gctgtgtggt gagctgcaca cccccaacct gctgccagct gcaccacgcc gaggcctcct
      481 gctgccgccc atcctactgt ggacagtcct gctgccgccc agtctgctgc tgctactcct
      541 gtgagcccac ctgctaaaag ccagtttgct gattttcaac ttgaaatttc cactttcagt
      601 tccattcatg aacgaattat ttcttcaagc acttatggac aacgaacaaa ttcttcaacc
      661 tttctttgtc tttcttatgg gggttaccaa atattttggc ctcagaatta tctgattcct
      721 ttcaattcca gaaagacctt actcttctct ctgaggacgc caaaatacaa atttgaccca
      781 agaaatgaaa aagccgattt accttgaaac tgagcctttg caagcattga agcccacgct
      841 ctgagtctca gcgccgacga gaccatggaa gagccatctg tccttctcag gacactcact
      901 tcctgtatcc caccgtcctg caaattgcac cccctatgaa agaggaataa tataccaagg
      961 tctaataaat tttaactatt ggtgcaacaa a
//
