LOCUS       NM_030967                910 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens keratin associated protein 1-1 (KRTAP1-1), mRNA.
ACCESSION   NM_030967
VERSION     NM_030967.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 910)
  AUTHORS   Park,J.H., Lim,S.W., Myung,W., Park,I., Jang,H.J., Kim,S.,
            Lee,M.S., Chang,H.S., Yum,D., Suh,Y.L., Kim,J.W. and Kim,D.K.
  TITLE     Whole-genome sequencing reveals KRTAP1-1 as a novel genetic variant
            associated with antidepressant treatment outcomes
  JOURNAL   Sci Rep 11 (1), 4552 (2021)
   PUBMED   33633223
  REMARK    GeneRIF: Whole-genome sequencing reveals KRTAP1-1 as a novel
            genetic variant associated with antidepressant treatment outcomes.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 910)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 910)
  AUTHORS   Fujimoto,S., Takase,T., Kadono,N., Maekubo,K. and Hirai,Y.
  TITLE     Krtap11-1, a hair keratin-associated protein, as a possible crucial
            element for the physical properties of hair shafts
  JOURNAL   J Dermatol Sci 74 (1), 39-47 (2014)
   PUBMED   24439038
  REMARK    GeneRIF: Krtap11-1 may play an important role on keratin-bundle
            assembly in the hair cortex.
REFERENCE   4  (bases 1 to 910)
  AUTHORS   Shimomura,Y., Aoki,N., Schweizer,J., Langbein,L., Rogers,M.A.,
            Winter,H. and Ito,M.
  TITLE     Polymorphisms in the human high sulfur hair keratin-associated
            protein 1, KAP1, gene family
  JOURNAL   J Biol Chem 277 (47), 45493-45501 (2002)
   PUBMED   12228244
  REMARK    GeneRIF: polymorphisms in Japanese and Caucasian individuals
REFERENCE   5  (bases 1 to 910)
  AUTHORS   Shimomura,Y., Aoki,N., Rogers,M.A., Langbein,L., Schweizer,J. and
            Ito,M.
  TITLE     hKAP1.6 and hKAP1.7, two novel human high sulfur keratin-associated
            proteins are expressed in the hair follicle cortex
  JOURNAL   J Invest Dermatol 118 (2), 226-231 (2002)
   PUBMED   11841537
REFERENCE   6  (bases 1 to 910)
  AUTHORS   Rogers,M.A., Langbein,L., Winter,H., Ehmann,C., Praetzel,S.,
            Korn,B. and Schweizer,J.
  TITLE     Characterization of a cluster of human high/ultrahigh sulfur
            keratin-associated protein genes embedded in the type I keratin
            gene domain on chromosome 17q12-21
  JOURNAL   J Biol Chem 276 (22), 19440-19451 (2001)
   PUBMED   11279113
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff in
            collaboration with Michael Rogers. The reference sequence was
            derived from AB052934.1 and AC007455.7.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_030967.2.
            
            Summary: This protein is a member of the keratin-associated protein
            (KAP) family. The KAP proteins form a matrix of keratin
            intermediate filaments which contribute to the structure of hair
            fibers. KAP family members appear to have unique, family-specific
            amino- and carboxyl-terminal regions and are subdivided into three
            multi-gene families according to amino acid composition: the high
            sulfur, the ultrahigh sulfur, and the high tyrosine/glycine KAPs.
            This protein is a member of the high sulfur KAP family and the gene
            is localized to a cluster of KAPs at 17q12-q21. [provided by
            RefSeq, Jul 2008].
            
            ##Evidence-Data-START##
            Transcript is intronless :: AB052934.1, AJ406926.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000306271.5/ ENSP00000305975.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-892               AB052934.1         12-903
            893-910             AC007455.7         9640-9657
FEATURES             Location/Qualifiers
     source          1..910
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q21.2"
     gene            1..910
                     /gene="KRTAP1-1"
                     /gene_synonym="HB2A; hKAP1.7; KAP1.1; KAP1.1A; KAP1.1B;
                     KAP1.6; KAP1.7; KRTAP1.1; KRTAP1A"
                     /note="keratin associated protein 1-1"
                     /db_xref="GeneID:81851"
                     /db_xref="HGNC:HGNC:16772"
                     /db_xref="MIM:608819"
     exon            1..910
                     /gene="KRTAP1-1"
                     /gene_synonym="HB2A; hKAP1.7; KAP1.1; KAP1.1A; KAP1.1B;
                     KAP1.6; KAP1.7; KRTAP1.1; KRTAP1A"
                     /inference="alignment:Splign:2.1.0"
     CDS             54..587
                     /gene="KRTAP1-1"
                     /gene_synonym="HB2A; hKAP1.7; KAP1.1; KAP1.1A; KAP1.1B;
                     KAP1.6; KAP1.7; KRTAP1.1; KRTAP1A"
                     /note="keratin associated protein 1A; keratin associated
                     protein 1.7; keratin-associated protein 1.1;
                     keratin-associated protein 1.6; high sulfur
                     keratin-associated protein 1.1"
                     /codon_start=1
                     /product="keratin-associated protein 1-1"
                     /protein_id="NP_112229.1"
                     /db_xref="CCDS:CCDS42324.1"
                     /db_xref="GeneID:81851"
                     /db_xref="HGNC:HGNC:16772"
                     /db_xref="MIM:608819"
                     /translation="MACCQTSFCGFPSCSTSGTCGSSCCQPSCCETSSCQPRCCETSC
                     CQPSCCQTSFCGFPSFSTGGTCDSSCCQPSCCETSCCQPSCYQTSSCGTGCGIGGGIG
                     YGQEGSSGAVSTRIRWCRPDCRVEGTCLPPCCVVSCTPPSCCQLHHAEASCCRPSYCG
                     QSCCRPVCCCYCSEPTC"
     regulatory      868..873
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KRTAP1-1"
                     /gene_synonym="HB2A; hKAP1.7; KAP1.1; KAP1.1A; KAP1.1B;
                     KAP1.6; KAP1.7; KRTAP1.1; KRTAP1A"
                     /note="hexamer: AATAAA"
     polyA_site      893
                     /gene="KRTAP1-1"
                     /gene_synonym="HB2A; hKAP1.7; KAP1.1; KAP1.1A; KAP1.1B;
                     KAP1.6; KAP1.7; KRTAP1.1; KRTAP1A"
                     /note="major polyA site"
ORIGIN      
        1 ataattcaga aactcctcca agcaacccaa ccttcagatc aactcctgac accatggcct
       61 gctgtcagac cagcttctgt ggatttccca gctgctccac cagtgggacc tgcggctcca
      121 gctgctgcca gccaagctgc tgtgagacca gctcctgcca gccacgctgc tgtgagacca
      181 gctgctgcca gccaagctgc tgccagacca gcttctgtgg atttcctagc ttctcaaccg
      241 gtgggacttg tgactctagc tgctgccagc caagctgctg tgaaactagc tgctgccagc
      301 caagctgcta ccagaccagc tcctgcggaa ctggctgtgg cattggtggt ggcattggct
      361 atggccagga gggcagcagt ggagctgtga gcacccgtat caggtggtgc cgcccagact
      421 gccgtgtgga gggtacctgc ctgcccccct gctgcgtggt gagctgcaca cccccatcct
      481 gctgccagct gcaccacgcc gaggcctcct gctgccgccc atcctactgt ggacagtcct
      541 gttgccgccc agtctgctgc tgctactgct ctgagcccac ttgttgaaaa cctccttctg
      601 ctggggatcc tgataagatg gcaccttaaa actagccaaa ttagaatcct aacaatcttc
      661 tgaactccag tacctataac tgggcttgca acctctcatc acacagccac ataaattccc
      721 taggaagtaa attcatttac aatggaagac caaaaatttt tcctagacct ggttgtcagc
      781 caaagtccta caatgtgaaa agagttagat actattttac tataaatatc acctgaaata
      841 tttcaacagt tattgggact taaatttaat aaaagttttc atctcttcaa tgatgaagtt
      901 gttgtttgaa
//
