LOCUS       NM_033045               2092 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens keratin 84 (KRT84), mRNA.
ACCESSION   NM_033045
VERSION     NM_033045.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2092)
  AUTHORS   Liu,Y., Li,R. and Ren,G.
  TITLE     KRT84 is a potential tumor suppressor and good prognosis signature
            of oral squamous cell carcinoma
  JOURNAL   Biosci Rep 40 (4) (2020)
   PUBMED   32181476
  REMARK    GeneRIF: KRT84 is a potential tumor suppressor and good prognosis
            signature of oral squamous cell carcinoma.
REFERENCE   2  (bases 1 to 2092)
  AUTHORS   Schweizer,J., Bowden,P.E., Coulombe,P.A., Langbein,L., Lane,E.B.,
            Magin,T.M., Maltais,L., Omary,M.B., Parry,D.A., Rogers,M.A. and
            Wright,M.W.
  TITLE     New consensus nomenclature for mammalian keratins
  JOURNAL   J Cell Biol 174 (2), 169-174 (2006)
   PUBMED   16831889
REFERENCE   3  (bases 1 to 2092)
  AUTHORS   Rogers,M.A., Edler,L., Winter,H., Langbein,L., Beckmann,I. and
            Schweizer,J.
  TITLE     Characterization of new members of the human type II keratin gene
            family and a general evaluation of the keratin gene domain on
            chromosome 12q13.13
  JOURNAL   J Invest Dermatol 124 (3), 536-544 (2005)
   PUBMED   15737194
REFERENCE   4  (bases 1 to 2092)
  AUTHORS   Rogers,M.A., Winter,H., Langbein,L., Wolf,C. and Schweizer,J.
  TITLE     Characterization of a 300 kbp region of human DNA containing the
            type II hair keratin gene domain
  JOURNAL   J Invest Dermatol 114 (3), 464-472 (2000)
   PUBMED   10692104
REFERENCE   5  (bases 1 to 2092)
  AUTHORS   Heid,H.W., Werner,E. and Franke,W.W.
  TITLE     The complement of native alpha-keratin polypeptides of hair-forming
            cells: a subset of eight polypeptides that differ from epithelial
            cytokeratins
  JOURNAL   Differentiation 32 (2), 101-119 (1986)
   PUBMED   2431943
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff in
            collaboration with Michael Rogers. The reference sequence was
            derived from AC078865.22 and BC069647.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_033045.3.
            
            Summary: The protein encoded by this gene is a member of the
            keratin gene family. As a type II hair keratin, it is a basic
            protein which heterodimerizes with type I keratins to form hair and
            nails. The type II hair keratins are clustered in a region of
            chromosome 12q13 and are grouped into two distinct subfamilies
            based on structure similarity. One subfamily, consisting of KRTHB1,
            KRTHB3, and KRTHB6, is highly related. The other less-related
            subfamily includes KRTHB2, KRTHB4, and KRTHB5. All hair keratins
            are expressed in the hair follicle; this hair keratin is contained
            primarily in the filiform tongue papilla, among other hair
            keratins. [provided by RefSeq, Jul 2008].
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC069647.1, AK314030.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1968540,
                                           SAMEA1968968 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000257951.3/ ENSP00000257951.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 5' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-19                AC078865.22        27489-27507
            20-2092             BC069647.1         1-2073
FEATURES             Location/Qualifiers
     source          1..2092
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q13.13"
     gene            1..2092
                     /gene="KRT84"
                     /gene_synonym="HB4; KRTHB4"
                     /note="keratin 84"
                     /db_xref="GeneID:3890"
                     /db_xref="HGNC:HGNC:6461"
                     /db_xref="MIM:602766"
     exon            1..613
                     /gene="KRT84"
                     /gene_synonym="HB4; KRTHB4"
                     /inference="alignment:Splign:2.1.0"
     CDS             68..1870
                     /gene="KRT84"
                     /gene_synonym="HB4; KRTHB4"
                     /note="keratin, hair, basic, 4; type II hair keratin 4;
                     hard keratin, type II, 4; K84; type-II keratin Kb24; type
                     II hair keratin Hb4; keratin 84, type II"
                     /codon_start=1
                     /product="keratin, type II cuticular Hb4"
                     /protein_id="NP_149034.2"
                     /db_xref="CCDS:CCDS8825.1"
                     /db_xref="GeneID:3890"
                     /db_xref="HGNC:HGNC:6461"
                     /db_xref="MIM:602766"
                     /translation="MSCRSYRVSSGHRVGNFSSCSAMTPQNLNRFRANSVSCWSGPGF
                     RGLGSFGSRSVITFGSYSPRIAAVGSRPIHCGVRFGAGCGMGFGDGRGVGLGPRADSC
                     VGLGFGAGSGIGYGFGGPGFGYRVGGVGVPAAPSITAVTVNKSLLTPLNLEIDPNAQR
                     VKKDEKEQIKTLNNKFASFIDKVRFLEQQNKLLETKWSFLQEQKCIRSNLEPLFESYI
                     TNLRRQLEVLVSDQARLQAERNHLQDVLEGFKKKYEEEVVCRANAENEFVALKKDVDA
                     AFMNKSDLEANVDTLTQEIDFLKTLYMEEIQLLQSHISETSVIVKMDNSRDLNLDGII
                     AEVKAQYEEVARRSRADAEAWYQTKYEEMQVTAGQHCDNLRNIRNEINELTRLIQRLK
                     AEIEHAKAQRAKLEAAVAEAEQQGEATLSDAKCKLADLECALQQAKQDMARQLCEYQE
                     LMNAKLGLDIEIATYRRLLEGEESRLCEGVGPVNISVSSSRGGLVCGPEPLVAGSTLS
                     RGGVTFSGSSSVCATSGVLASCGPSLGGARVAPATGDLLSTGTRSGSMLISEACVPSV
                     PCPLPTQGGFSSCSGGRSSSVRFVSTTTSCRTKY"
     exon            614..822
                     /gene="KRT84"
                     /gene_synonym="HB4; KRTHB4"
                     /inference="alignment:Splign:2.1.0"
     exon            823..883
                     /gene="KRT84"
                     /gene_synonym="HB4; KRTHB4"
                     /inference="alignment:Splign:2.1.0"
     exon            884..979
                     /gene="KRT84"
                     /gene_synonym="HB4; KRTHB4"
                     /inference="alignment:Splign:2.1.0"
     exon            980..1144
                     /gene="KRT84"
                     /gene_synonym="HB4; KRTHB4"
                     /inference="alignment:Splign:2.1.0"
     exon            1145..1270
                     /gene="KRT84"
                     /gene_synonym="HB4; KRTHB4"
                     /inference="alignment:Splign:2.1.0"
     exon            1271..1491
                     /gene="KRT84"
                     /gene_synonym="HB4; KRTHB4"
                     /inference="alignment:Splign:2.1.0"
     exon            1492..1523
                     /gene="KRT84"
                     /gene_synonym="HB4; KRTHB4"
                     /inference="alignment:Splign:2.1.0"
     exon            1524..2092
                     /gene="KRT84"
                     /gene_synonym="HB4; KRTHB4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agagggactc ccagctccag ctcacccatt ctacacttgc tcttttgctc ccaaccagga
       61 agccatcatg tcttgccgct cctaccgagt cagctctggt caccgggtgg gcaacttcag
      121 ctcttgttca gcaatgacac cacagaacct gaatcgcttc cgggccaact ctgtctcctg
      181 ttggagtggg cctggattcc ggggccttgg cagctttggt agtcggagtg tcatcacctt
      241 tggatcgtac tcaccccgga tagcagctgt aggctctcgg cccatccact gtggagtccg
      301 ctttggtgct ggctgtggga tgggttttgg tgatgggaga ggtgttggtc tggggcctag
      361 ggctgacagc tgtgttggtc tgggctttgg agctggcagt ggcattggct atggctttgg
      421 tggccctggc tttggttaca gagttggagg ggttggagtc ccagcagccc catctatcac
      481 agctgtgact gtgaacaaga gcctactgac ccccctcaac ctggagattg accccaatgc
      541 ccagagggtg aagaaggatg agaaggagca aatcaagacc ctcaacaaca agtttgcctc
      601 cttcattgac aaggttcggt tcctagagca gcagaataag ctcctagaga ccaagtggag
      661 cttcctccaa gagcagaaat gtatcaggag caatctggag ccactcttcg agagctacat
      721 caccaacctg cggaggcagt tggaggtgct ggtcagtgat caggcccggc tccaggctga
      781 gaggaaccac ctgcaggatg tcctagaggg cttcaagaag aagtatgaag aggaagtggt
      841 atgtcgggcc aatgctgaga atgagtttgt ggctctgaag aaggatgtgg atgcagcttt
      901 catgaacaag tctgatctcg aggccaacgt ggatacccta actcaggaaa ttgactttct
      961 aaaaacgctt tacatggagg aaatccagtt gctgcagtcg cacatctcag agacgtcggt
     1021 cattgtgaag atggacaaca gccgtgacct gaaccttgat gggatcattg ctgaggtcaa
     1081 ggcccagtat gaggaggtgg ccaggcgcag ccgggctgat gctgaggcct ggtaccagac
     1141 caagtatgaa gagatgcagg tgacagctgg ccaacactgt gacaacctgc gcaacatacg
     1201 gaacgagatc aacgaactga cccgcctgat ccagaggctt aaggcagaga ttgagcacgc
     1261 caaggctcag cgtgccaagt tggaggctgc agtggccgag gccgagcagc agggcgaggc
     1321 gaccctcagt gatgccaaat gcaagctggc agatctggag tgtgccctgc agcaggccaa
     1381 gcaggacatg gcgcggcagc tgtgcgagta ccaggagctg atgaatgcca agctgggcct
     1441 ggacatcgag atcgccacct acaggcgcct gctggagggc gaggagagcc ggctctgtga
     1501 aggtgttgga ccagtaaaca tatccgtcag cagctcccgg ggcggcctgg tgtgcgggcc
     1561 tgagcctttg gttgccggct ccaccctctc ccgcggcggg gtcaccttct caggtagcag
     1621 cagcgtctgt gccaccagtg gggtcctggc ttcctgtggc cccagcctgg gtggagcccg
     1681 ggtcgccccg gccactgggg acctgctgag cactggcaca aggagtggct ccatgctcat
     1741 cagcgaggcc tgtgtcccca gcgtcccctg ccccctgccc acccaggggg gcttcagcag
     1801 ctgcagcggc ggccgcagct ccagcgtccg ctttgtgtcc accaccacct cctgccggac
     1861 caagtactga gagcccagcc ccagacagct gctgcccaga gaagaaccag ctccacggct
     1921 cctgcttctg cccccagggt tcgtgggctc tgggcttgac ggtctccagc tcccctttct
     1981 gccaggaagc caccccttag cactcccccg attattctgc ctggccccat gtcctcttgg
     2041 aggatttttc tgccatgtag atgctccatt agcagttcca gctaagctgg ct
//
