LOCUS       NP_149034                600 aa            linear   PRI 28-APR-2025
DEFINITION  keratin, type II cuticular Hb4 [Homo sapiens].
ACCESSION   NP_149034
VERSION     NP_149034.2
DBSOURCE    REFSEQ: accession NM_033045.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 600)
  AUTHORS   Liu,Y., Li,R. and Ren,G.
  TITLE     KRT84 is a potential tumor suppressor and good prognosis signature
            of oral squamous cell carcinoma
  JOURNAL   Biosci Rep 40 (4) (2020)
   PUBMED   32181476
  REMARK    GeneRIF: KRT84 is a potential tumor suppressor and good prognosis
            signature of oral squamous cell carcinoma.
REFERENCE   2  (residues 1 to 600)
  AUTHORS   Schweizer,J., Bowden,P.E., Coulombe,P.A., Langbein,L., Lane,E.B.,
            Magin,T.M., Maltais,L., Omary,M.B., Parry,D.A., Rogers,M.A. and
            Wright,M.W.
  TITLE     New consensus nomenclature for mammalian keratins
  JOURNAL   J Cell Biol 174 (2), 169-174 (2006)
   PUBMED   16831889
REFERENCE   3  (residues 1 to 600)
  AUTHORS   Rogers,M.A., Edler,L., Winter,H., Langbein,L., Beckmann,I. and
            Schweizer,J.
  TITLE     Characterization of new members of the human type II keratin gene
            family and a general evaluation of the keratin gene domain on
            chromosome 12q13.13
  JOURNAL   J Invest Dermatol 124 (3), 536-544 (2005)
   PUBMED   15737194
REFERENCE   4  (residues 1 to 600)
  AUTHORS   Rogers,M.A., Winter,H., Langbein,L., Wolf,C. and Schweizer,J.
  TITLE     Characterization of a 300 kbp region of human DNA containing the
            type II hair keratin gene domain
  JOURNAL   J Invest Dermatol 114 (3), 464-472 (2000)
   PUBMED   10692104
REFERENCE   5  (residues 1 to 600)
  AUTHORS   Heid,H.W., Werner,E. and Franke,W.W.
  TITLE     The complement of native alpha-keratin polypeptides of hair-forming
            cells: a subset of eight polypeptides that differ from epithelial
            cytokeratins
  JOURNAL   Differentiation 32 (2), 101-119 (1986)
   PUBMED   2431943
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff in
            collaboration with Michael Rogers. The reference sequence was
            derived from AC078865.22 and BC069647.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Sep 5, 2001 this sequence version replaced NP_149034.1.
            
            Summary: The protein encoded by this gene is a member of the
            keratin gene family. As a type II hair keratin, it is a basic
            protein which heterodimerizes with type I keratins to form hair and
            nails. The type II hair keratins are clustered in a region of
            chromosome 12q13 and are grouped into two distinct subfamilies
            based on structure similarity. One subfamily, consisting of KRTHB1,
            KRTHB3, and KRTHB6, is highly related. The other less-related
            subfamily includes KRTHB2, KRTHB4, and KRTHB5. All hair keratins
            are expressed in the hair follicle; this hair keratin is contained
            primarily in the filiform tongue papilla, among other hair
            keratins. [provided by RefSeq, Jul 2008].
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC069647.1, AK314030.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1968540,
                                           SAMEA1968968 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000257951.3/ ENSP00000257951.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..600
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q13.13"
     Protein         1..600
                     /product="keratin, type II cuticular Hb4"
                     /note="keratin, hair, basic, 4; type II hair keratin 4;
                     hard keratin, type II, 4; K84; type-II keratin Kb24; type
                     II hair keratin Hb4; keratin 84, type II"
                     /calculated_mol_wt=64712
     Region          1..165
                     /region_name="Head"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9NSB2.2)"
     Region          16..161
                     /region_name="Keratin_2_head"
                     /note="Keratin type II head; pfam16208"
                     /db_xref="CDD:465068"
     Region          165..475
                     /region_name="Filament"
                     /note="Intermediate filament protein; pfam00038"
                     /db_xref="CDD:459643"
     Region          166..200
                     /region_name="Coil 1A"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9NSB2.2)"
     Region          201..210
                     /region_name="Linker 1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9NSB2.2)"
     Region          211..311
                     /region_name="Coil 1B"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9NSB2.2)"
     Region          312..328
                     /region_name="Linker 12"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9NSB2.2)"
     Region          329..472
                     /region_name="Coil 2"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9NSB2.2)"
     Region          473..600
                     /region_name="Tail"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9NSB2.2)"
     CDS             1..600
                     /gene="KRT84"
                     /gene_synonym="HB4; KRTHB4"
                     /coded_by="NM_033045.4:68..1870"
                     /db_xref="CCDS:CCDS8825.1"
                     /db_xref="GeneID:3890"
                     /db_xref="HGNC:HGNC:6461"
                     /db_xref="MIM:602766"
ORIGIN      
        1 mscrsyrvss ghrvgnfssc samtpqnlnr fransvscws gpgfrglgsf gsrsvitfgs
       61 yspriaavgs rpihcgvrfg agcgmgfgdg rgvglgprad scvglgfgag sgigygfggp
      121 gfgyrvggvg vpaapsitav tvnkslltpl nleidpnaqr vkkdekeqik tlnnkfasfi
      181 dkvrfleqqn klletkwsfl qeqkcirsnl eplfesyitn lrrqlevlvs dqarlqaern
      241 hlqdvlegfk kkyeeevvcr anaenefval kkdvdaafmn ksdleanvdt ltqeidflkt
      301 lymeeiqllq shisetsviv kmdnsrdlnl dgiiaevkaq yeevarrsra daeawyqtky
      361 eemqvtagqh cdnlrnirne ineltrliqr lkaeiehaka qrakleaava eaeqqgeatl
      421 sdakckladl ecalqqakqd marqlceyqe lmnaklgldi eiatyrrlle geesrlcegv
      481 gpvnisvsss rgglvcgpep lvagstlsrg gvtfsgsssv catsgvlasc gpslggarva
      541 patgdllstg trsgsmlise acvpsvpcpl ptqggfsscs ggrsssvrfv stttscrtky
//
