LOCUS       NM_033033               2644 bp    mRNA    linear   PRI 09-JUN-2024
DEFINITION  Homo sapiens keratin 82 (KRT82), mRNA.
ACCESSION   NM_033033
VERSION     NM_033033.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2644)
  AUTHORS   Erjavec,S.O., Gelfman,S., Abdelaziz,A.R., Lee,E.Y., Monga,I.,
            Alkelai,A., Ionita-Laza,I., Petukhova,L. and Christiano,A.M.
  TITLE     Whole exome sequencing in Alopecia Areata identifies rare variants
            in KRT82
  JOURNAL   Nat Commun 13 (1), 800 (2022)
   PUBMED   35145093
  REMARK    GeneRIF: Whole exome sequencing in Alopecia Areata identifies rare
            variants in KRT82.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2644)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 2644)
  AUTHORS   Bray,D.J., Walsh,T.R., Noro,M.G. and Notman,R.
  TITLE     Complete Structure of an Epithelial Keratin Dimer: Implications for
            Intermediate Filament Assembly
  JOURNAL   PLoS One 10 (7), e0132706 (2015)
   PUBMED   26181054
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2644)
  AUTHORS   Schweizer,J., Bowden,P.E., Coulombe,P.A., Langbein,L., Lane,E.B.,
            Magin,T.M., Maltais,L., Omary,M.B., Parry,D.A., Rogers,M.A. and
            Wright,M.W.
  TITLE     New consensus nomenclature for mammalian keratins
  JOURNAL   J Cell Biol 174 (2), 169-174 (2006)
   PUBMED   16831889
REFERENCE   5  (bases 1 to 2644)
  AUTHORS   Rogers,M.A., Edler,L., Winter,H., Langbein,L., Beckmann,I. and
            Schweizer,J.
  TITLE     Characterization of new members of the human type II keratin gene
            family and a general evaluation of the keratin gene domain on
            chromosome 12q13.13
  JOURNAL   J Invest Dermatol 124 (3), 536-544 (2005)
   PUBMED   15737194
REFERENCE   6  (bases 1 to 2644)
  AUTHORS   Rogers,M.A., Winter,H., Langbein,L., Wolf,C. and Schweizer,J.
  TITLE     Characterization of a 300 kbp region of human DNA containing the
            type II hair keratin gene domain
  JOURNAL   J Invest Dermatol 114 (3), 464-472 (2000)
   PUBMED   10692104
REFERENCE   7  (bases 1 to 2644)
  AUTHORS   Heid,H.W., Werner,E. and Franke,W.W.
  TITLE     The complement of native alpha-keratin polypeptides of hair-forming
            cells: a subset of eight polypeptides that differ from epithelial
            cytokeratins
  JOURNAL   Differentiation 32 (2), 101-119 (1986)
   PUBMED   2431943
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff in
            collaboration with Michael Rogers. The reference sequence was
            derived from AC078865.22.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Dec 2, 2019 this sequence version replaced NM_033033.3.
            
            Summary: The protein encoded by this gene is a member of the
            keratin gene family. As a type II hair keratin, it is a basic
            protein which heterodimerizes with type I keratins to form hair and
            nails. The type II hair keratins are clustered in a region of
            chromosome 12q13 and are grouped into two distinct subfamilies
            based on structure similarity. One subfamily, consisting of KRTHB1,
            KRTHB3, and KRTHB6, is highly related. The other less-related
            subfamily includes KRTHB2, KRTHB4, and KRTHB5. All hair keratins
            are expressed in the hair follicle; this keratin appears to be a
            hair cuticle-specific keratin. [provided by RefSeq, Jul 2008].
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ628419.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMEA2159764
                                           [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000257974.3/ ENSP00000257974.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-469               AC078865.22        6806-7274
            470-678             AC078865.22        9232-9440
            679-739             AC078865.22        11792-11852
            740-835             AC078865.22        12519-12614
            836-1000            AC078865.22        12992-13156
            1001-1126           AC078865.22        16133-16258
            1127-1347           AC078865.22        16909-17129
            1348-1379           AC078865.22        17351-17382
            1380-2644           AC078865.22        17946-19210
FEATURES             Location/Qualifiers
     source          1..2644
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q13.13"
     gene            1..2644
                     /gene="KRT82"
                     /gene_synonym="Hb-2; HB2; KRTHB2"
                     /note="keratin 82"
                     /db_xref="GeneID:3888"
                     /db_xref="HGNC:HGNC:6459"
                     /db_xref="MIM:601078"
     exon            1..469
                     /gene="KRT82"
                     /gene_synonym="Hb-2; HB2; KRTHB2"
                     /inference="alignment:Splign:2.1.0"
     CDS             59..1600
                     /gene="KRT82"
                     /gene_synonym="Hb-2; HB2; KRTHB2"
                     /note="keratin, hair, basic, 2; hard keratin, type II, 2;
                     K82; type-II keratin Kb22; type II hair keratin Hb2;
                     keratin 82, type II"
                     /codon_start=1
                     /product="keratin, type II cuticular Hb2"
                     /protein_id="NP_149022.3"
                     /db_xref="CCDS:CCDS8826.1"
                     /db_xref="GeneID:3888"
                     /db_xref="HGNC:HGNC:6459"
                     /db_xref="MIM:601078"
                     /translation="MSYHSFQPGSRCGSQSFSSYSAVMPRMVTHYAVSKGPCRPGGGR
                     GLRALGCLGSRSLCNVGFGRPRVASRCGGTLPGFGYRLGATCGPSACITPVTINESLL
                     VPLALEIDPTVQRVKRDEKEQIKCLNNRFASFINKVRFLEQKNKLLETKWNFMQQQRC
                     CQTNIEPIFEGYISALRRQLDCVSGDRVRLESELCSLQAALEGYKKKYEEELSLRPCV
                     ENEFVALKKDVDTAFLMKADLETNAEALVQEIDFLKSLYEEEICLLQSQISETSVIVK
                     MDNSRELDVDGIIAEIKAQYDDIASRSKAEAEAWYQCRYEELRVTAGNHCDNLRNRKN
                     EILEMNKLIQRLQQETENVKAQRCKLEGAIAEAEQQGEAALNDAKCKLAGLEEALQKA
                     KQDMACLLKEYQEVMNSKLGLDIEIATYRRLLEGEEHRLCEGIGPVNISVSSSKGAFL
                     YEPCGVSTPVLSTGVLRSNGGCSIVGTGELYVPCEPQGLLSCGSGRKSSMTLGAGGSS
                     PSHKH"
     exon            470..678
                     /gene="KRT82"
                     /gene_synonym="Hb-2; HB2; KRTHB2"
                     /inference="alignment:Splign:2.1.0"
     exon            679..739
                     /gene="KRT82"
                     /gene_synonym="Hb-2; HB2; KRTHB2"
                     /inference="alignment:Splign:2.1.0"
     exon            740..835
                     /gene="KRT82"
                     /gene_synonym="Hb-2; HB2; KRTHB2"
                     /inference="alignment:Splign:2.1.0"
     exon            836..1000
                     /gene="KRT82"
                     /gene_synonym="Hb-2; HB2; KRTHB2"
                     /inference="alignment:Splign:2.1.0"
     exon            1001..1126
                     /gene="KRT82"
                     /gene_synonym="Hb-2; HB2; KRTHB2"
                     /inference="alignment:Splign:2.1.0"
     exon            1127..1347
                     /gene="KRT82"
                     /gene_synonym="Hb-2; HB2; KRTHB2"
                     /inference="alignment:Splign:2.1.0"
     exon            1348..1379
                     /gene="KRT82"
                     /gene_synonym="Hb-2; HB2; KRTHB2"
                     /inference="alignment:Splign:2.1.0"
     exon            1380..2644
                     /gene="KRT82"
                     /gene_synonym="Hb-2; HB2; KRTHB2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atcatcctgc cccggttctt tcctccaggg ccgcatttct ctgcctctct ctcctgccat
       61 gtcgtaccac tctttccagc caggctccag gtgtggcagt cagagtttca gctcatactc
      121 ggctgtcatg ccccggatgg tcacccacta tgcagtgagc aaggggccat gccggcccgg
      181 gggtggtagg ggcctccgag ctctgggctg ccttggctca cggagcctgt gcaacgtggg
      241 ctttgggagg ccccgggtag cctccaggtg tggaggtacc ctgcctggct tcgggtaccg
      301 actgggagcc acctgtgggc cttctgcctg catcacccct gtcaccatca atgagagcct
      361 gctggtccca ctggcactgg agatagaccc gactgtgcag agggtaaaga gggatgagaa
      421 ggagcagatc aagtgcctca acaaccgttt cgcatctttc atcaacaagg tccgtttcct
      481 ggagcagaag aacaagctgc tggagaccaa gtggaacttc atgcagcagc agaggtgctg
      541 ccagaccaac atcgagccca tcttcgaggg ctatatcagc gcccttcggc ggcagctgga
      601 ctgtgtgtcc ggggaccgcg tgaggctaga gtcagagctc tgcagcctcc aggctgcact
      661 ggagggctac aagaaaaaat acgaagagga gctctccctg cgtccctgtg ttgagaatga
      721 gtttgttgcc ttgaagaagg acgtggacac agccttcctg atgaaggctg acctggagac
      781 caacgcagag gcactcgtgc aggagatcga cttcctgaaa agcctgtatg aggaggagat
      841 ctgcctgctc cagtctcaga tctctgagac ctcggtcatt gtgaagatgg acaacagccg
      901 ggagctggac gtggacggca tcatcgctga gatcaaggcg cagtatgacg acatcgccag
      961 ccgcagcaaa gccgaagcag aggcctggta ccagtgccgg tatgaggagc tgagagtcac
     1021 agctgggaac cactgtgaca acctccgcaa ccgtaagaac gagatcctgg aaatgaataa
     1081 actgatccag cggctgcagc aagaaaccga gaatgtcaaa gcccagcgct gcaaacttga
     1141 gggtgccata gctgaggcag agcagcaggg cgaggcggct ctcaatgatg ccaagtgcaa
     1201 gctggcaggg ctggaggagg ctctgcagaa ggccaagcag gacatggcct gcctgctcaa
     1261 ggaatatcag gaggtgatga actccaagct gggcctggac atcgagatcg ccacctacag
     1321 gcgcctgctg gagggtgaag agcacaggct gtgcgaaggc atcgggcccg tgaatatctc
     1381 agtgagcagc tccaaaggcg ccttcctgta cgagccatgt ggggtcagca cgcctgtcct
     1441 cagcactggc gtcctcagga gcaatggggg ctgcagcatc gtgggcactg gtgaactcta
     1501 tgtcccctgc gagccccagg ggctactgag ctgtgggagc gggcggaaat ccagcatgac
     1561 gctaggagct gggggcagct cccccagcca caagcattag catgatccga gacatccagg
     1621 agacagagcc cctgccccat ggccctggat gtcacactcc caccagggct gaagacaagg
     1681 atgttccaaa accccacctc cctttattga ctccacattc ccctccagtg ttccctcctt
     1741 gagagctgag ctgcccctag gacccctcct ttgcctcatg agtcaccttc cactcacctg
     1801 tgtgcagacc ctcagctagg cccagatggt ggggacagac ggcagagaaa gagcatgcat
     1861 tgctcttaac cgcagaatgg caataacccc caaaaggtca aatgggcaca ccacagttct
     1921 gctctgtgga tcatcccatg gaagtttcct cacaaagtca gctcctctcc caccacaggc
     1981 tcacactgcc cttactttag gctctcatgc ccctaagaaa agtgaatttc ctttaacacc
     2041 gcctgaaaca tgcacactgc aaatatcaaa aggagacacc cccaaatccc actctaaatt
     2101 ccaaagccaa gtgccacgat ttcaggatca gtcaggacct gccaatgtcc tctcagcaca
     2161 gagaatcaag aggtggcctt tgggcagtag atttactttc tcaggtatgt tgaacccaaa
     2221 ctgtgagaat aaatctttct cctgagctca cattggcagg tgatgtcagg ccaatgccta
     2281 gaacaaaggg caaagggata tggaatgttt actggacagt tggaaaacca aaaacagata
     2341 ccattttctc aatggaatca gttccccctc cacccatccc cttctgtaca tagccgcccc
     2401 ttcctgttcc ccaacccttt agctcctttt gctttgagtc tgatatgaca gtgatgtggg
     2461 gctgccccag ctgacttgga ggccctggct caggagctca tagatggagg aggtgtgggc
     2521 tgactacctc ccagaagccc ctcatgccaa gcctgtccca ctggggctcc agggcctctg
     2581 ccctgaacat ctgggcttct gttcaaaata aacctactct gttcatggat tatagcaatc
     2641 agga
//
