LOCUS       NM_182507               3873 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens keratin 80 (KRT80), transcript variant 1, mRNA.
ACCESSION   NM_182507
VERSION     NM_182507.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3873)
  AUTHORS   Yun,W.J., Li,J., Yin,N.C., Zhang,C.Y., Cui,Z.G., Zhang,L. and
            Zheng,H.C.
  TITLE     The facilitating effects of KRT80 on chemoresistance, lipogenesis,
            and invasion of esophageal cancer
  JOURNAL   Cancer Biol Ther 25 (1), 2302162 (2024)
   PUBMED   38241178
  REMARK    GeneRIF: The facilitating effects of KRT80 on chemoresistance,
            lipogenesis, and invasion of esophageal cancer.
REFERENCE   2  (bases 1 to 3873)
  AUTHORS   Gao,X., Wang,G., Zhang,M., Zhang,X., Zhang,S. and Long,H.
  TITLE     LINC01485 contributes to colorectal cancer progression by targeting
            miR-383-5p/KRT80 axis
  JOURNAL   Environ Toxicol 39 (1), 398-408 (2024)
   PUBMED   37782686
  REMARK    GeneRIF: LINC01485 contributes to colorectal cancer progression by
            targeting miR-383-5p/KRT80 axis.
REFERENCE   3  (bases 1 to 3873)
  AUTHORS   Shi,K.H., Xue,H., Zhao,E.H., Xiao,L.J., Sun,H.Z. and Zheng,H.C.
  TITLE     KRT80 expression works as a biomarker and a target for
            differentiation in gastric cancer
  JOURNAL   Histol Histopathol 39 (1), 117-130 (2024)
   PUBMED   37129345
  REMARK    GeneRIF: KRT80 expression works as a biomarker and a target for
            differentiation in gastric cancer.
REFERENCE   4  (bases 1 to 3873)
  AUTHORS   Wei,X.Y., Zhao,J., Tong,H.B., Cheng,S.J., He,N. and Song,F.X.
  TITLE     Characters of KRT80 and its roles in neoplasms diseases
  JOURNAL   Cancer Med 12 (13), 13991-14003 (2023)
   PUBMED   37211956
  REMARK    GeneRIF: Characters of KRT80 and its roles in neoplasms diseases.
            Review article
REFERENCE   5  (bases 1 to 3873)
  AUTHORS   Zhang,F., Wang,G., Yan,W. and Jiang,H.
  TITLE     MiR-4268 suppresses gastric cancer genesis through inhibiting
            keratin 80
  JOURNAL   Cell Cycle 21 (19), 2051-2064 (2022)
   PUBMED   35748914
  REMARK    GeneRIF: MiR-4268 suppresses gastric cancer genesis through
            inhibiting keratin 80.
REFERENCE   6  (bases 1 to 3873)
  AUTHORS   Bray,D.J., Walsh,T.R., Noro,M.G. and Notman,R.
  TITLE     Complete Structure of an Epithelial Keratin Dimer: Implications for
            Intermediate Filament Assembly
  JOURNAL   PLoS One 10 (7), e0132706 (2015)
   PUBMED   26181054
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 3873)
  AUTHORS   Liu,Y., Cao,L., Li,Z., Zhou,D., Liu,W., Shen,Q., Wu,Y., Zhang,D.,
            Hu,X., Wang,T., Ye,J., Weng,X., Zhang,H., Zhang,D., Zhang,Z.,
            Liu,F., He,L. and Shi,Y.
  TITLE     A genome-wide association study identifies a locus on TERT for mean
            telomere length in Han Chinese
  JOURNAL   PLoS One 9 (1), e85043 (2014)
   PUBMED   24465473
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 3873)
  AUTHORS   Langbein,L., Eckhart,L., Rogers,M.A., Praetzel-Wunder,S. and
            Schweizer,J.
  TITLE     Against the rules: human keratin K80: two functional alternative
            splice variants, K80 and K80.1, with special cellular localization
            in a wide range of epithelia
  JOURNAL   J Biol Chem 285 (47), 36909-36921 (2010)
   PUBMED   20843789
  REMARK    GeneRIF: Alternative splice variants, K80 and K80.1 distribute
            differently in epithelia of hair and skin.
REFERENCE   9  (bases 1 to 3873)
  AUTHORS   Schweizer,J., Bowden,P.E., Coulombe,P.A., Langbein,L., Lane,E.B.,
            Magin,T.M., Maltais,L., Omary,M.B., Parry,D.A., Rogers,M.A. and
            Wright,M.W.
  TITLE     New consensus nomenclature for mammalian keratins
  JOURNAL   J Cell Biol 174 (2), 169-174 (2006)
   PUBMED   16831889
REFERENCE   10 (bases 1 to 3873)
  AUTHORS   Rogers,M.A., Edler,L., Winter,H., Langbein,L., Beckmann,I. and
            Schweizer,J.
  TITLE     Characterization of new members of the human type II keratin gene
            family and a general evaluation of the keratin gene domain on
            chromosome 12q13.13
  JOURNAL   J Invest Dermatol 124 (3), 536-544 (2005)
   PUBMED   15737194
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC021066.37, BC065180.1 and
            AJ717743.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_182507.2.
            
            Summary: Keratins are intermediate filament proteins responsible
            for the structural integrity of epithelial cells and are subdivided
            into epithelial keratins and hair keratins. This gene's expression
            profile shows that it encodes a type II epithelial keratin,
            although structurally the encoded protein is more like a type II
            hair keratin. This protein is involved in cell differentiation,
            localizing near desmosomal plaques in earlier stages of
            differentiation but then dispersing throughout the cytoplasm in
            terminally differentiating cells. The type II keratins are
            clustered in a region of chromosome 12q13. Two transcript variants
            encoding two different fully functional isoforms have been found
            for this gene.[provided by RefSeq, Oct 2010].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (K80, also known as a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC047308.1, AJ717743.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2147596 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000394815.3/ ENSP00000378292.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-14                AC021066.37        90188-90201
            15-1224             BC065180.1         1-1210
            1225-1632           AJ717743.1         1165-1572
            1633-3873           AC021066.37        110966-113206
FEATURES             Location/Qualifiers
     source          1..3873
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q13.13"
     gene            1..3873
                     /gene="KRT80"
                     /gene_synonym="KB20"
                     /note="keratin 80"
                     /db_xref="GeneID:144501"
                     /db_xref="HGNC:HGNC:27056"
                     /db_xref="MIM:611161"
     exon            1..412
                     /gene="KRT80"
                     /gene_synonym="KB20"
                     /inference="alignment:Splign:2.1.0"
     CDS             113..1471
                     /gene="KRT80"
                     /gene_synonym="KB20"
                     /note="isoform K80 is encoded by transcript variant 1;
                     keratin, type II cytoskeletal 80; type II keratin; keratin
                     b20; CK-80; cytokeratin-80; type-II keratin Kb20; keratin
                     80, type II"
                     /codon_start=1
                     /product="keratin, type II cytoskeletal 80 isoform K80"
                     /protein_id="NP_872313.2"
                     /db_xref="CCDS:CCDS8821.2"
                     /db_xref="GeneID:144501"
                     /db_xref="HGNC:HGNC:27056"
                     /db_xref="MIM:611161"
                     /translation="MACRSCVVGFSSLSSCEVTPVGSPRPGTSGWDSCRAPGPGFSSR
                     SLTGCWSAGTISKVTVNPGLLVPLDVKLDPAVQQLKNQEKEEMKALNDKFASLIGKVQ
                     ALEQRNQLLETRWSFLQGQDSAIFDLGHLYEEYQGRLQEELRKVSQERGQLEANLLQV
                     LEKVEEFRIRYEDEISKRTDMEFTFVQLKKDLDAECLHRTELETKLKSLESFVELMKT
                     IYEQELKDLAAQVKDVSVTVGMDSRCHIDLSGIVEEVKAQYDAVAARSLEEAEAYSRS
                     QLEEQAARSAEYGSSLQSSRSEIADLNVRIQKLRSQILSVKSHCLKLEENIKTAEEQG
                     ELAFQDAKTKLAQLEAALQQAKQDMARQLRKYQELMNVKLALDIEIATYRKLVEGEEG
                     RMDSPSATVVSAVQSRCKTAASRSGLSKAPSRKKKGSKGPVIKITEMSEKYFSQESEV
                     SE"
     exon            413..621
                     /gene="KRT80"
                     /gene_synonym="KB20"
                     /inference="alignment:Splign:2.1.0"
     exon            622..682
                     /gene="KRT80"
                     /gene_synonym="KB20"
                     /inference="alignment:Splign:2.1.0"
     exon            683..778
                     /gene="KRT80"
                     /gene_synonym="KB20"
                     /inference="alignment:Splign:2.1.0"
     exon            779..943
                     /gene="KRT80"
                     /gene_synonym="KB20"
                     /inference="alignment:Splign:2.1.0"
     exon            944..1069
                     /gene="KRT80"
                     /gene_synonym="KB20"
                     /inference="alignment:Splign:2.1.0"
     exon            1070..1290
                     /gene="KRT80"
                     /gene_synonym="KB20"
                     /inference="alignment:Splign:2.1.0"
     exon            1291..1346
                     /gene="KRT80"
                     /gene_synonym="KB20"
                     /inference="alignment:Splign:2.1.0"
     exon            1347..3873
                     /gene="KRT80"
                     /gene_synonym="KB20"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3316..3321
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KRT80"
                     /gene_synonym="KB20"
                     /note="hexamer: AATAAA"
     polyA_site      3342
                     /gene="KRT80"
                     /gene_synonym="KB20"
                     /note="major polyA site"
     regulatory      3848..3853
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KRT80"
                     /gene_synonym="KB20"
                     /note="hexamer: AATAAA"
     polyA_site      3873
                     /gene="KRT80"
                     /gene_synonym="KB20"
                     /note="major polyA site"
ORIGIN      
        1 agtccccagc ccgccccagc tgtgaccaga gcaaccagag cctgccaccc gacgcaaccc
       61 caggctcact cgctcacccc cctgggccct cctgcttccg gccgggggca ccatggcctg
      121 ccgctcctgc gtggttggct tcagcagcct cagcagctgt gaggtgaccc cggtgggcag
      181 cccccggcct ggaacctcag gatgggacag ctgcagggcc cccgggccgg gcttcagctc
      241 ccgcagcctc acaggctgct ggtcggctgg cactatctcc aaggtgactg tgaaccccgg
      301 cctgctggtg cccctggatg tcaagttgga ccccgctgtt cagcagctga agaaccagga
      361 gaaggaggag atgaaggccc tcaatgataa atttgcctcc ctaattggca aggtgcaagc
      421 cctggaacag cgcaaccagc tgctggagac acgctggagc ttcctgcagg gccaggactc
      481 agccatcttc gacctcgggc atctctatga ggaatatcag ggccggctgc aggaggaact
      541 gcgcaaagtg agccaggagc gggggcagct ggaggccaac ctgctgcagg tgctggagaa
      601 ggttgaggag tttcgaatca ggtatgagga tgagatctcc aagcgcacag acatggagtt
      661 cacctttgtt cagctgaaga aggacctgga tgcagagtgt cttcatcgga ctgaactgga
      721 aaccaagtta aaaagcctgg agagcttcgt ggagttgatg aaaaccatct atgagcagga
      781 gctgaaggac ctggcagcac aggtgaagga tgtgtcggtg accgtcggca tggacagccg
      841 ctgccacatc gacctgagcg gcatcgtgga ggaggtgaag gcccagtatg acgccgtcgc
      901 ggctcgcagc ctggaggagg ccgaggcata ctctcggagc cagctggagg agcaggccgc
      961 ccgctcggcc gagtatggga gcagcctcca gagcagccgc agcgagatcg cggatctcaa
     1021 tgtgcgcatc cagaagctgc ggtcccagat cctctctgtc aagagccatt gcctgaaact
     1081 ggaggagaac atcaagacag ctgaggagca gggtgagctg gccttccagg atgccaagac
     1141 caagctggcc cagctggagg ccgccctgca gcaggccaag caggacatgg cgcggcagct
     1201 gcgcaagtac caggagctga tgaacgtcaa gctggccctg gacatcgaga tcgccaccta
     1261 caggaagctg gtggagggcg aggagggcag gatggactcg ccctcagcca ctgtggtcag
     1321 cgctgtgcag tccaggtgca aaaccgctgc ctccagatca ggcctctcca aggccccctc
     1381 ccgaaagaag aagggcagca aaggccccgt gatcaaaatc accgaaatgt cagagaagta
     1441 cttctcgcag gagtcggagg tctcagagta aggcggctgg accccaggaa ccccagggca
     1501 ctccactgca gcaggaggga cttaagctag actcaagaaa gcagcttgga gcctctaggt
     1561 tgagaagaga ggcaaaacct gatattgaac tgagagaggg gttcaaaact gactgtgttt
     1621 tgtgggctgc cagggtggga gaggagcatc accagctcct cagagccact ccgctccata
     1681 tcagtatctc acagtcccat ccttccaacc ttctggccag aggttttcct gatgggtgag
     1741 tcggaattag gggtcagttt tgtctccacc tcctcgctcc tctgaggctc ctcctccagc
     1801 atcaggctct gccaaggccc ctctgactct tgcccaatcc ttgaccttga ctcctatctc
     1861 aagccttgcc ttgtctctgc ctcggaactg ggactgggac tggctcatcc acctatgtgc
     1921 gggagccgag gaggacggcg tgggccctgt cctgtatctg gaattcctgg gaaggctggc
     1981 tgctgaagac cctcttggct ttcccgtgct ctttgggctc cccagagacc tgacagtatt
     2041 agggagtgaa gggaggaggg gccctggcta tttgggacct aagcctaggc cccagagatc
     2101 agcccgaaca cccgcatccc ttcctcctcc catgggtccc tcccagtagg cagtagtcag
     2161 aactggatgg gctgccccca gccagctccc agcagcttct ccggaagctg ctcttgccat
     2221 aatcaactcc ctgggagtgg aagccagatg gcagcttgag attgggcagg agcattcgat
     2281 cttcctttca cctccctgcc atgctggggt cctacccagc ctggatctga gctctgtgcc
     2341 cccagccggg ttgttcccag cctgagcacc gggctttggt gcaccaggcc ttggagaccc
     2401 ctggtcccac ccctgccgtg aagccccagg cccacttccc aagaatctca cttctcaggg
     2461 cctctgttct cctctccact gggccaaata gcctggccct cccctccttg gcattcatgg
     2521 gggagcccag gaacccccca cacctatggg gttagagctc ctcctttctt ctcactcctt
     2581 ccccttcctc cctccatgcc cactccccct gcctccagca ggccaggaag aaggcacagt
     2641 ccaggcaagt ctgggagctt ccaagccctt gaggtccagc tgtggggccc aaatgacagc
     2701 cttacaaggg ttctaccaga gaggaaaatt ccacatccca ccagaagaca ggggtgttgg
     2761 caggcatact cctatctcct cctcttggct ctcaatgctg aggcttgcag aggcatccca
     2821 gcggcaccag cctcccactg cacagcttcc ttccctcctt cactctcctc tcccctccct
     2881 gccccttgcc tcacctcctc ttctagactg cattagattc attcatctca tttgccagga
     2941 catgttggcc agaggtctgg gcccatccca ggcctcaagg ccctccaggc ctgtggggag
     3001 cactggaggg ttactgactc tctggccatg ggaactcaga gattctcatc cccaaagtcc
     3061 caaaagaggg tgctgattgg tgcttttcct caggctcttc attggtttcc aagggagcaa
     3121 atcctcagtg gggatacaag acatataaag tatatattat tttttcataa cttatgtggc
     3181 ttttaactta ttgcttccct tcctgtttct gcatgatcag tctgtatgta ctatctggaa
     3241 agataacaca tactccagcc acctcacctg attggctatc ttggggccat gtccccttct
     3301 tgctgccaca ggatgaataa agtgttgaga tttgtctatg gagaaagctg tgtgtctgtt
     3361 tttatctccc ctctcaggac cagtcagcca ctggtcaatc aggctgatca tggaacatta
     3421 ggaattctcc aattaaggga gaaaaagtcc agggacttag ttatatcttc agaccagtgc
     3481 agctggtaca cacaaagttc tcctgtctca ccatctgata tggtttggat gctcgtcccc
     3541 tccaaatctc atgttgaaat gtaattccca gtgttggaag tggagcctgg tgggaagtat
     3601 ttggatcatg agagaggatc cttcatgaat ggctcagcac catctccttg gtgatgagtg
     3661 agttctcact caattcacat agatatggtt gtttaaaaga gtctgagacc tctcccctct
     3721 ttctcgccat gtgatatgcc tgctccccct tcaccttccg cctttactgt aagcttcctg
     3781 aggccctcac cagaagctga gcaaatgttg gtgccatgcc agtacagcct gcagaattgt
     3841 gagccaaaat aaatgtcttt tctttataaa tta
//
