LOCUS       NM_175834               2123 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens keratin 79 (KRT79), mRNA.
ACCESSION   NM_175834
VERSION     NM_175834.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2123)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 2123)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2123)
  AUTHORS   Chen,S., Fragoza,R., Klei,L., Liu,Y., Wang,J., Roeder,K., Devlin,B.
            and Yu,H.
  TITLE     An interactome perturbation framework prioritizes damaging missense
            mutations for developmental disorders
  JOURNAL   Nat Genet 50 (7), 1032-1040 (2018)
   PUBMED   29892012
REFERENCE   4  (bases 1 to 2123)
  AUTHORS   Veniaminova,N.A., Vagnozzi,A.N., Kopinke,D., Do,T.T.,
            Murtaugh,L.C., Maillard,I., Dlugosz,A.A., Reiter,J.F. and Wong,S.Y.
  TITLE     Keratin 79 identifies a novel population of migratory epithelial
            cells that initiates hair canal morphogenesis and regeneration
  JOURNAL   Development 140 (24), 4870-4880 (2013)
   PUBMED   24198274
  REMARK    GeneRIF: migratory keratinocytes express keratin 79 and stream out
            of the hair germ and into the epidermis prior to lumen formation in
            the embryo.
REFERENCE   5  (bases 1 to 2123)
  AUTHORS   Armour,S.M., Bennett,E.J., Braun,C.R., Zhang,X.Y., McMahon,S.B.,
            Gygi,S.P., Harper,J.W. and Sinclair,D.A.
  TITLE     A high-confidence interaction map identifies SIRT1 as a mediator of
            acetylation of USP22 and the SAGA coactivator complex
  JOURNAL   Mol Cell Biol 33 (8), 1487-1502 (2013)
   PUBMED   23382074
REFERENCE   6  (bases 1 to 2123)
  AUTHORS   Gonzalez-Begne,M., Lu,B., Han,X., Hagen,F.K., Hand,A.R.,
            Melvin,J.E. and Yates,J.R.
  TITLE     Proteomic analysis of human parotid gland exosomes by
            multidimensional protein identification technology (MudPIT)
  JOURNAL   J Proteome Res 8 (3), 1304-1314 (2009)
   PUBMED   19199708
REFERENCE   7  (bases 1 to 2123)
  AUTHORS   Rogers,M.A., Edler,L., Winter,H., Langbein,L., Beckmann,I. and
            Schweizer,J.
  TITLE     Characterization of new members of the human type II keratin gene
            family and a general evaluation of the keratin gene domain on
            chromosome 12q13.13
  JOURNAL   J Invest Dermatol 124 (3), 536-544 (2005)
   PUBMED   15737194
REFERENCE   8  (bases 1 to 2123)
  AUTHORS   Hesse,M., Magin,T.M. and Weber,K.
  TITLE     Genes for intermediate filament proteins and the draft sequence of
            the human genome: novel keratin genes and a surprisingly high
            number of pseudogenes related to keratin genes 8 and 18
  JOURNAL   J Cell Sci 114 (Pt 14), 2569-2575 (2001)
   PUBMED   11683385
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC107016.20, BC039148.1 and
            AJ564105.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_175834.2.
            
            Summary: Keratins are intermediate filament proteins responsible
            for the structural integrity of epithelial cells and are subdivided
            into epithelial keratins and hair keratins. This gene encodes an
            epithelial keratin that is expressed in skeletal muscle, skin and
            scalp. The type II keratins are clustered in a region of chromosome
            12q13.[provided by RefSeq, Jun 2009].
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC039148.1, AJ564105.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145893, SAMEA2147596
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000330553.6/ ENSP00000328358.5
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-18                AC107016.20        137277-137294
            19-292              BC039148.1         3-276
            293-1711            AJ564105.1         260-1678
            1712-2084           BC039148.1         1696-2068
            2085-2123           AC107016.20        150142-150180
FEATURES             Location/Qualifiers
     source          1..2123
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q13.13"
     gene            1..2123
                     /gene="KRT79"
                     /gene_synonym="K6L; KRT6L"
                     /note="keratin 79"
                     /db_xref="GeneID:338785"
                     /db_xref="HGNC:HGNC:28930"
                     /db_xref="MIM:611160"
     exon            1..528
                     /gene="KRT79"
                     /gene_synonym="K6L; KRT6L"
                     /inference="alignment:Splign:2.1.0"
     CDS             52..1659
                     /gene="KRT79"
                     /gene_synonym="K6L; KRT6L"
                     /note="keratin 6L; K79; CK-79; cytokeratin-79; type-II
                     keratin Kb38; keratin 79, type II"
                     /codon_start=1
                     /product="keratin, type II cytoskeletal 79"
                     /protein_id="NP_787028.1"
                     /db_xref="CCDS:CCDS8839.1"
                     /db_xref="GeneID:338785"
                     /db_xref="HGNC:HGNC:28930"
                     /db_xref="MIM:611160"
                     /translation="MRSSVSRQTYSTKGGFSSNSASGGSGSQARTSFSSVTVSRSSGS
                     GGGAHCGPGTGGFGSRSLYNLGGHKSISVSVAGGALLGRALGGFGFGSRAFMGQGAGR
                     QTFGPACPPGGIQEVTVNQSLLTPLHVEIDPEIQRVRTQEREQIKTLNNKFASFIDKV
                     RFLEQQNKVLETKWALLQEQGQNLGVTRNNLEPLFEAYLGSMRSTLDRLQSERGRLDS
                     ELRNVQDLVEDFKNKYEDEINKHTAAENEFVVLKKDVDAAYMGRMDLHGKVGTLTQEI
                     DFLQQLYEMELSQVQTHVSNTNVVLSMDNNRNLDLDSIIAEVKAQYELIAQRSRAEAE
                     AWYQTKYEELQVTAGKHGDNLRDTKNEIAELTRTIQRLQGEADAAKKQCQQLQTAIAE
                     AEQRGELALKDAQKKLGDLDVALHQAKEDLTRLLRDYQELMNVKLALDVEIATYRKLL
                     ESEESRMSGECPSAVSISVTGNSTTVCGGGAASFGGGISLGGSGGATKGGFSTNVGYS
                     TVKGGPVSAGTSILRKTTTVKTSSQRY"
     exon            529..749
                     /gene="KRT79"
                     /gene_synonym="K6L; KRT6L"
                     /inference="alignment:Splign:2.1.0"
     exon            750..810
                     /gene="KRT79"
                     /gene_synonym="K6L; KRT6L"
                     /inference="alignment:Splign:2.1.0"
     exon            811..906
                     /gene="KRT79"
                     /gene_synonym="K6L; KRT6L"
                     /inference="alignment:Splign:2.1.0"
     exon            907..1071
                     /gene="KRT79"
                     /gene_synonym="K6L; KRT6L"
                     /inference="alignment:Splign:2.1.0"
     exon            1072..1197
                     /gene="KRT79"
                     /gene_synonym="K6L; KRT6L"
                     /inference="alignment:Splign:2.1.0"
     exon            1198..1418
                     /gene="KRT79"
                     /gene_synonym="K6L; KRT6L"
                     /inference="alignment:Splign:2.1.0"
     exon            1419..1453
                     /gene="KRT79"
                     /gene_synonym="K6L; KRT6L"
                     /inference="alignment:Splign:2.1.0"
     exon            1454..2123
                     /gene="KRT79"
                     /gene_synonym="K6L; KRT6L"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2066..2071
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KRT79"
                     /gene_synonym="K6L; KRT6L"
                     /note="hexamer: AATAAA"
     polyA_site      2084
                     /gene="KRT79"
                     /gene_synonym="K6L; KRT6L"
                     /note="major polyA site"
     polyA_site      2123
                     /gene="KRT79"
                     /gene_synonym="K6L; KRT6L"
ORIGIN      
        1 acggcactcc cttcctgccc tctcatcctg ccctccggcc cctctgcagc tatgaggtcc
       61 tccgtctctc ggcaaacata ctccacaaaa gggggcttca gctccaactc tgccagcgga
      121 gggagtgggt cccaggcccg caccagcttc agctcagtga cggtgtctcg gagcagtggc
      181 agtggtggcg gggcccactg tggccccggc acaggtggct ttggcagccg aagcctctat
      241 aacttggggg gccacaagag tatctctgtc agtgtggccg gaggggcctt gttggggcgg
      301 gctctggggg gctttggctt tggcagcagg gcatttatgg gacagggggc tggcaggcag
      361 acgtttgggc ctgcttgtcc tcctgggggg atccaggagg tcactgtcaa ccagagcctg
      421 ctgacccccc tccatgtgga gattgacccc gagatccagc gagtgcgcac tcaggagcgg
      481 gagcagatca agaccctcaa caacaagttc gcctccttca tcgacaaggt gcggttcctg
      541 gagcaacaga ataaggtgct ggagaccaag tgggcactgc tgcaggagca gggccagaac
      601 ttgggtgtca ccaggaacaa cctggagccc ctctttgagg cctacctggg tagcatgcgg
      661 agcacgctgg acagacttca gagcgagcgg gggaggctgg actcagagct caggaacgtg
      721 caggaccttg tggaggactt caagaacaag tacgaggatg aaatcaacaa gcacactgct
      781 gcagagaacg agtttgtggt gctcaagaag gatgtggatg cagcatacat gggccggatg
      841 gatctgcatg gcaaagtggg caccttgacc caggagattg acttcctgca gcaactctat
      901 gaaatggagc tgagccaagt gcagacccac gtgtctaaca ccaatgtggt gctgtccatg
      961 gacaacaacc gcaacctgga cctggacagc atcatcgccg aggtcaaggc ccagtatgag
     1021 ctgattgccc agaggagccg ggctgaggcc gaggcctggt accagaccaa gtatgaggag
     1081 ctgcaggtga ctgctgggaa gcatggggac aacctgcggg acaccaagaa cgagattgct
     1141 gagctcaccc gcactatcca gaggctgcag ggggaggctg atgcagccaa gaagcagtgt
     1201 cagcagctgc agacggccat tgcggaagcg gagcagcgtg gggagctggc actcaaggat
     1261 gctcagaaga agcttgggga tctggatgtg gccctgcacc aggccaagga ggacctgaca
     1321 cggctgctgc gtgactacca ggagctgatg aatgtcaagc tggccctgga cgtggagatt
     1381 gccacctacc gcaagcttct ggagagcgag gagagcagga tgtctggaga atgtcccagt
     1441 gcagtcagca tttctgtgac tggcaactcc accactgtgt gcggaggtgg cgcagccagc
     1501 tttggaggtg gcatctccct gggtgggagt gggggggcca ccaagggtgg attcagcaca
     1561 aatgtgggct atagcaccgt caagggaggg ccagtctctg cgggcacctc catcctgcgg
     1621 aagaccacta cggtcaagac gtccagccag aggtattagc tgctgagccc tgcaagggcc
     1681 cctgcaatcc tgtccctgcc ctcctcaccc cacctctgct gtcctttcca gtcacttctc
     1741 aggagcagga acagccaggg gacctcagac ccagggtatt ttcataccag actatttgca
     1801 tcttgggaag cgctcaaatc tactcaggtt ttctccttgg tcctgcagta ggatgggagg
     1861 gaaggttaaa gttgccagct tgagtgatgt gcttgggtga cttgggggtg accttttgac
     1921 caccgagagg aggctgaatt tctcaagcca ttaggagaga gagaaattgg gagtggtccc
     1981 caaagaccct tcaacctccc cagtccccca ccagacccac cctctccctg aatctaccca
     2041 catccccctt ccctgtctgt gtctcaataa atggtgcaac tgcagctagc tgtctgtggc
     2101 tgcagtctgt cctgcctggg gaa
//
