LOCUS       NM_175078               3366 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens keratin 77 (KRT77), mRNA.
ACCESSION   NM_175078 XM_370694
VERSION     NM_175078.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3366)
  AUTHORS   Hinbest,A.J., Eldirany,S.A., Ho,M. and Bunick,C.G.
  TITLE     Molecular Modeling of Pathogenic Mutations in the Keratin 1B Domain
  JOURNAL   Int J Mol Sci 21 (18), 6641 (2020)
   PUBMED   32927888
  REMARK    GeneRIF: Molecular Modeling of Pathogenic Mutations in the Keratin
            1B Domain.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3366)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 3366)
  AUTHORS   Schweizer,J., Bowden,P.E., Coulombe,P.A., Langbein,L., Lane,E.B.,
            Magin,T.M., Maltais,L., Omary,M.B., Parry,D.A., Rogers,M.A. and
            Wright,M.W.
  TITLE     New consensus nomenclature for mammalian keratins
  JOURNAL   J Cell Biol 174 (2), 169-174 (2006)
   PUBMED   16831889
REFERENCE   4  (bases 1 to 3366)
  AUTHORS   Scherer,S.E., Muzny,D.M., Buhay,C.J., Chen,R., Cree,A., Ding,Y.,
            Dugan-Rocha,S., Gill,R., Gunaratne,P., Harris,R.A., Hawes,A.C.,
            Hernandez,J., Hodgson,A.V., Hume,J., Jackson,A., Khan,Z.M.,
            Kovar-Smith,C., Lewis,L.R., Lozado,R.J., Metzker,M.L.,
            Milosavljevic,A., Miner,G.R., Montgomery,K.T., Morgan,M.B.,
            Nazareth,L.V., Scott,G., Sodergren,E., Song,X.Z., Steffen,D.,
            Lovering,R.C., Wheeler,D.A., Worley,K.C., Yuan,Y., Zhang,Z.,
            Adams,C.Q., Ansari-Lari,M.A., Ayele,M., Brown,M.J., Chen,G.,
            Chen,Z., Clerc-Blankenburg,K.P., Davis,C., Delgado,O., Dinh,H.H.,
            Draper,H., Gonzalez-Garay,M.L., Havlak,P., Jackson,L.R.,
            Jacob,L.S., Kelly,S.H., Li,L., Li,Z., Liu,J., Liu,W., Lu,J.,
            Maheshwari,M., Nguyen,B.V., Okwuonu,G.O., Pasternak,S., Perez,L.M.,
            Plopper,F.J., Santibanez,J., Shen,H., Tabor,P.E., Verduzco,D.,
            Waldron,L., Wang,Q., Williams,G.A., Zhang,J., Zhou,J., Allen,C.C.,
            Amin,A.G., Anyalebechi,V., Bailey,M., Barbaria,J.A., Bimage,K.E.,
            Bryant,N.P., Burch,P.E., Burkett,C.E., Burrell,K.L., Calderon,E.,
            Cardenas,V., Carter,K., Casias,K., Cavazos,I., Cavazos,S.R.,
            Ceasar,H., Chacko,J., Chan,S.N., Chavez,D., Christopoulos,C.,
            Chu,J., Cockrell,R., Cox,C.D., Dang,M., Dathorne,S.R., David,R.,
            Davis,C.M., Davy-Carroll,L., Deshazo,D.R., Donlin,J.E., D'Souza,L.,
            Eaves,K.A., Simons,R., Emery-Cohen,A.J., Escotto,M., Flagg,N.,
            Forbes,L.D., Gabisi,A.M., Garza,M., Hamilton,C., Henderson,N.,
            Hernandez,O., Hines,S., Hogues,M.E., Huang,M., Idlebird,D.G.,
            Johnson,R., Jolivet,A., Jones,S., Kagan,R., King,L.M., Leal,B.,
            Lebow,H., Lee,S., LeVan,J.M., Lewis,L.C., London,P.,
            Lorensuhewa,L.M., Loulseged,H., Lovett,D.A., Lucier,A.,
            Lucier,R.L., Ma,J., Madu,R.C., Mapua,P., Martindale,A.D.,
            Martinez,E., Massey,E., Mawhiney,S., Meador,M.G., Mendez,S.,
            Mercado,C., Mercado,I.C., Merritt,C.E., Miner,Z.L., Minja,E.,
            Mitchell,T., Mohabbat,F., Mohabbat,K., Montgomery,B., Moore,N.,
            Morris,S., Munidasa,M., Ngo,R.N., Nguyen,N.B., Nickerson,E.,
            Nwaokelemeh,O.O., Nwokenkwo,S., Obregon,M., Oguh,M., Oragunye,N.,
            Oviedo,R.J., Parish,B.J., Parker,D.N., Parrish,J., Parks,K.L.,
            Paul,H.A., Payton,B.A., Perez,A., Perrin,W., Pickens,A.,
            Primus,E.L., Pu,L.L., Puazo,M., Quiles,M.M., Quiroz,J.B.,
            Rabata,D., Reeves,K., Ruiz,S.J., Shao,H., Sisson,I., Sonaike,T.,
            Sorelle,R.P., Sutton,A.E., Svatek,A.F., Svetz,L.A., Tamerisa,K.S.,
            Taylor,T.R., Teague,B., Thomas,N., Thorn,R.D., Trejos,Z.Y.,
            Trevino,B.K., Ukegbu,O.N., Urban,J.B., Vasquez,L.I., Vera,V.A.,
            Villasana,D.M., Wang,L., Ward-Moore,S., Warren,J.T., Wei,X.,
            White,F., Williamson,A.L., Wleczyk,R., Wooden,H.S., Wooden,S.H.,
            Yen,J., Yoon,L., Yoon,V., Zorrilla,S.E., Nelson,D.,
            Kucherlapati,R., Weinstock,G. and Gibbs,R.A.
  CONSRTM   Baylor College of Medicine Human Genome Sequencing Center Sequence
            Production Team
  TITLE     The finished DNA sequence of human chromosome 12
  JOURNAL   Nature 440 (7082), 346-351 (2006)
   PUBMED   16541075
REFERENCE   5  (bases 1 to 3366)
  AUTHORS   Langbein,L., Rogers,M.A., Praetzel,S., Cribier,B., Peltre,B.,
            Gassler,N. and Schweizer,J.
  TITLE     Characterization of a novel human type II epithelial keratin K1b,
            specifically expressed in eccrine sweat glands
  JOURNAL   J Invest Dermatol 125 (3), 428-444 (2005)
   PUBMED   16117782
  REMARK    GeneRIF: Epithelial keratin, K1b, is exclusively expressed in
            luminal duct cells of eccrine sweat glands.
REFERENCE   6  (bases 1 to 3366)
  AUTHORS   Rogers,M.A., Edler,L., Winter,H., Langbein,L., Beckmann,I. and
            Schweizer,J.
  TITLE     Characterization of new members of the human type II keratin gene
            family and a general evaluation of the keratin gene domain on
            chromosome 12q13.13
  JOURNAL   J Invest Dermatol 124 (3), 536-544 (2005)
   PUBMED   15737194
REFERENCE   7  (bases 1 to 3366)
  AUTHORS   Hesse,M., Magin,T.M. and Weber,K.
  TITLE     Genes for intermediate filament proteins and the draft sequence of
            the human genome: novel keratin genes and a surprisingly high
            number of pseudogenes related to keratin genes 8 and 18
  JOURNAL   J Cell Sci 114 (Pt 14), 2569-2575 (2001)
   PUBMED   11683385
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC055716.24 and BC122558.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_175078.2.
            
            Summary: Keratins are intermediate filament proteins responsible
            for the structural integrity of epithelial cells and are subdivided
            into epithelial keratins and hair keratins. This gene encodes an
            epithelial keratin that is expressed in the skin and eccrine sweat
            glands. The type II keratins are clustered in a region of
            chromosome 12q13.[provided by RefSeq, Jun 2009].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because transcript sequence consistent with
            the reference genome assembly was not available for all regions of
            the RefSeq transcript. The extent of this transcript is supported
            by transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ564104.1, BC122558.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145893, SAMEA2147596
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000341809.8/ ENSP00000342710.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-61                AC055716.24        55110-55170         c
            62-396              AC055716.24        54775-55109         c
            397-1686            BC122558.1         336-1625
            1687-3366           AC055716.24        41272-42951         c
FEATURES             Location/Qualifiers
     source          1..3366
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q13.13"
     gene            1..3366
                     /gene="KRT77"
                     /gene_synonym="K1B; KRT1B"
                     /note="keratin 77"
                     /db_xref="GeneID:374454"
                     /db_xref="HGNC:HGNC:20411"
                     /db_xref="MIM:611158"
     exon            1..633
                     /gene="KRT77"
                     /gene_synonym="K1B; KRT1B"
                     /inference="alignment:Splign:2.1.0"
     CDS             91..1827
                     /gene="KRT77"
                     /gene_synonym="K1B; KRT1B"
                     /note="keratin 1B; K77; CK-1B; cytokeratin-1B; type-II
                     keratin Kb39; keratin 77, type II"
                     /codon_start=1
                     /product="keratin, type II cytoskeletal 1b"
                     /protein_id="NP_778253.2"
                     /db_xref="CCDS:CCDS8837.1"
                     /db_xref="GeneID:374454"
                     /db_xref="HGNC:HGNC:20411"
                     /db_xref="MIM:611158"
                     /translation="MSHQFSSQSAFSSMSRRVYSTSSSAGSGGGSPAVGSVCYARGRC
                     GGGGYGIHGRGFGSRSLYNLGGSRSISINLMGRSTSGFCQGGGVGGFGGGRGFGVGST
                     GAGGFGGGGFGGAGFGTSNFGLGGFGPYCPPGGIQEVTINQSLLEPLHLEVDPEIQRI
                     KTQEREQIMVLNNKFASFIDKVRFLEQQNQVLQTKWELLQQVNTSTGTNNLEPLLENY
                     IGDLRRQVDLLSAEQMRQNAEVRSMQDVVEDYKSKYEDEINKRTGSENDFVVLKKDVD
                     AAYVSKVDLESRVDTLTGEVNFLKYLFLTELSQVQTHISDTNVILSMDNNRSLDLDSI
                     IDAVRTQYELIAQRSKDEAEALYQTKYQELQITAGRHGDDLKNSKMEIAELNRTVQRL
                     QAEISNVKKQIEQMQSLISDAEERGEQALQDAWQKLQDLEEALQQSKEELARLLRDYQ
                     AMLGVKLSLDVEIATYRQLLEGEESRMSGELQSHVSISVQNSQVSVNGGAGGGGSYGS
                     GGYGGGSGGGYGGGRSYRGGGARGRSGGGYGSGCGGGGGSYGGSGRSGRGSSRVQIIQ
                     TSTNTSHRRILE"
     exon            634..848
                     /gene="KRT77"
                     /gene_synonym="K1B; KRT1B"
                     /inference="alignment:Splign:2.1.0"
     exon            849..909
                     /gene="KRT77"
                     /gene_synonym="K1B; KRT1B"
                     /inference="alignment:Splign:2.1.0"
     exon            910..1005
                     /gene="KRT77"
                     /gene_synonym="K1B; KRT1B"
                     /inference="alignment:Splign:2.1.0"
     exon            1006..1170
                     /gene="KRT77"
                     /gene_synonym="K1B; KRT1B"
                     /inference="alignment:Splign:2.1.0"
     exon            1171..1296
                     /gene="KRT77"
                     /gene_synonym="K1B; KRT1B"
                     /inference="alignment:Splign:2.1.0"
     exon            1297..1517
                     /gene="KRT77"
                     /gene_synonym="K1B; KRT1B"
                     /inference="alignment:Splign:2.1.0"
     exon            1518..1552
                     /gene="KRT77"
                     /gene_synonym="K1B; KRT1B"
                     /inference="alignment:Splign:2.1.0"
     exon            1553..3366
                     /gene="KRT77"
                     /gene_synonym="K1B; KRT1B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3343..3348
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KRT77"
                     /gene_synonym="K1B; KRT1B"
                     /note="hexamer: AATAAA"
     polyA_site      3366
                     /gene="KRT77"
                     /gene_synonym="K1B; KRT1B"
                     /note="major polyA site"
ORIGIN      
        1 aaaggagtca gagctccttt cctctctggt ctctgcctcc ttcctgccag gctctttctc
       61 ttgcctgctt ctctggatgc tccagcaaac atgagccacc aatttagttc tcagtccgcg
      121 tttagttcaa tgagcaggcg ggtttatagt accagctctt ctgcaggctc tggtggtggg
      181 agtccggcag tgggttctgt gtgttatgct cgagggaggt gtggtggtgg tggatatggg
      241 atccatggaa gggggtttgg ctctaggagc ctctacaatc tgggtggcag tagaagcatc
      301 tccattaatc taatggggag gagcaccagt ggtttctgcc agggtggggg agtaggggga
      361 tttggagggg gcagaggctt tggggttggc agcaccgggg ctggtggctt tggaggaggt
      421 ggttttgggg gtgctggatt tgggactagc aattttgggc ttgggggctt tggtccttat
      481 tgtcctcctg ggggcatcca agaggtgacc attaaccaga gcctcctaga gccacttcac
      541 ctggaggtgg accctgaaat tcagaggatc aagacccagg agcgggagca gattatggtt
      601 ctcaacaaca agtttgcctc cttcattgac aaggtgcgat tcctggagca gcagaaccag
      661 gtgctacaaa caaaatggga gttgctgcag caggtgaaca cctcaactgg aaccaacaac
      721 ctggagcccc tcttggagaa ctacatcggt gacctgcgga ggcaggtgga tttgctcagt
      781 gcggagcaga tgcgccagaa cgcggaggtc aggagcatgc aggatgtcgt ggaggactac
      841 aagagcaagt atgaggatga aatcaacaag aggactggca gcgagaatga ctttgtcgtc
      901 ctgaagaagg atgtggatgc tgcttatgtg agcaaagtgg acctggagtc cagggtggac
      961 actctgactg gggaggtcaa tttcttgaaa tatttatttt tgacggagct gtctcaggtg
     1021 cagactcaca tcagcgacac caacgtcatc ctgtccatgg acaataaccg ttccctggac
     1081 ctggacagca tcatcgatgc agtgcggacc cagtatgaac tgattgcaca gaggagcaag
     1141 gacgaggccg aagccctgta ccagaccaag taccaggagc tccagatcac ggcagggaga
     1201 catggagacg acctgaagaa cagcaagatg gagattgcag agctcaaccg caccgtccag
     1261 aggctgcagg cagagatcag caacgtgaag aagcagattg aacagatgca gtcactcatt
     1321 tcggatgctg aggagagagg cgagcaggcc ctccaggatg cgtggcagaa gctgcaggac
     1381 ctggaggagg ccctgcagca gtccaaggag gagctggccc ggctgctgcg tgactaccag
     1441 gccatgctgg gggtcaagct gtccctggat gtggagatcg ccacctaccg ccagctgctg
     1501 gagggcgagg agagcaggat gtcaggagag ctgcagagcc atgtgagcat ctccgtgcag
     1561 aacagccagg tgagcgtcaa cggcggcgcg ggaggcggcg gcagctacgg ctcaggaggc
     1621 tacggcggcg gcagcggtgg gggctatggc ggcggaagaa gctaccgcgg aggcggggca
     1681 cgaggcagga gtggaggcgg ttatggcagc ggctgcggcg gcggtggcgg gagctacgga
     1741 gggagcggca gaagcggccg cggatcctcg cgcgtgcaga tcatccagac ctccaccaac
     1801 acctcccaca ggcggatctt ggagtagagg cctcgtttct gccacacatc acgcctgccc
     1861 ctcaccgccc tctcctcaaa ctcctcccct ccacgccctt cctgatcccc tctcattcac
     1921 ttttcttaat gggtctcagc aattttgcca ataaattcga ctctaatggg ggaagcaggg
     1981 tggataagtc caaacagcag atctctcttt ggagggcact ggcttgcagt cagattcaca
     2041 gctaggcaca ttctcactca gaccccgctc tgctggccct gctgctgttc ctgctcccac
     2101 ctttttggaa gatcggtagc ccagggtgag cacaaacatt ccagttagag gcagaggctg
     2161 cgtgagttgg caaggtaggg agaagtcatt gttatcattc ctctgcctcc aagtagaatg
     2221 cccttatgcc ccagttcaag ccactgcagc taagtattaa tccccagtgc taaaagatac
     2281 caggcatcta gtttagcaat ggagggaaac agaaacagcc tgtagagagc atcgacaagg
     2341 cgcataatgg agagttggta tctcaacccc aagctccctt tgctgtacct gggctgctct
     2401 gtgaacaaga atccacgccc ccctgccctg ctggggacca cataatgatc cctttggggg
     2461 aagttgctga ttgcagggca agctagcttg gtaaggaaaa cctctgcacc agcggcctat
     2521 tcctgcctct tggtccatag cctcatacac tcatgttgat ggatagtata gatttgctgc
     2581 ccacaccaga tatctgtaag gcatcactgt cctgattctg aacctctgtt tcaggaagca
     2641 ttctcccctg tgtaaacaac tcaaggtgga agtatttcag agggcatagg gtcatgaatc
     2701 cttacccaaa ggaagcctgt tttagcagtg gatgcaggag ttgatgaaca gacaagcaag
     2761 ttctgcttct gtcctgtttc ctcctgacag ctccattctt ttgaagcctg acccttccta
     2821 agctctgcat cataaccact ctgagaattg ccccattggg tgggcatgtg aagcccagct
     2881 ctgttccatc caggtgcctc gggcctgagg agtctgagga tctgacttgg gtcttggaag
     2941 ggttccaacc ccaagtcagt caggaagctg cccatttttt tgcaaggcat tttaatgccc
     3001 tttcccagac ctctctagtc cctcctgcct tctgttctct gtagctgtga gccctttgtg
     3061 agaatatgac tcttaatttt gaatcttatg taagaggctt gagatgtgct ggagagggca
     3121 ggaagaggaa agtatcaggc cttgagagag ggaatgtagc tttgcttcta tgatctggag
     3181 tcaccttcac ttgctagctg agtcctaaca caacttccaa gtccatgatt ctcttggggc
     3241 attggatggg ctcagtgtgg gtctcttagg ctgttcttgt gacttcatca tttcctggtt
     3301 caaagttgta ctgtcaaggg gcagcatttc tggtatttct ataataaatt tttctgtgat
     3361 ctcaaa
//
