LOCUS       NP_778253                578 aa            linear   PRI 27-APR-2025
DEFINITION  keratin, type II cytoskeletal 1b [Homo sapiens].
ACCESSION   NP_778253 XP_370694
VERSION     NP_778253.2
DBSOURCE    REFSEQ: accession NM_175078.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 578)
  AUTHORS   Hinbest,A.J., Eldirany,S.A., Ho,M. and Bunick,C.G.
  TITLE     Molecular Modeling of Pathogenic Mutations in the Keratin 1B Domain
  JOURNAL   Int J Mol Sci 21 (18), 6641 (2020)
   PUBMED   32927888
  REMARK    GeneRIF: Molecular Modeling of Pathogenic Mutations in the Keratin
            1B Domain.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 578)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (residues 1 to 578)
  AUTHORS   Schweizer,J., Bowden,P.E., Coulombe,P.A., Langbein,L., Lane,E.B.,
            Magin,T.M., Maltais,L., Omary,M.B., Parry,D.A., Rogers,M.A. and
            Wright,M.W.
  TITLE     New consensus nomenclature for mammalian keratins
  JOURNAL   J Cell Biol 174 (2), 169-174 (2006)
   PUBMED   16831889
REFERENCE   4  (residues 1 to 578)
  AUTHORS   Scherer,S.E., Muzny,D.M., Buhay,C.J., Chen,R., Cree,A., Ding,Y.,
            Dugan-Rocha,S., Gill,R., Gunaratne,P., Harris,R.A., Hawes,A.C.,
            Hernandez,J., Hodgson,A.V., Hume,J., Jackson,A., Khan,Z.M.,
            Kovar-Smith,C., Lewis,L.R., Lozado,R.J., Metzker,M.L.,
            Milosavljevic,A., Miner,G.R., Montgomery,K.T., Morgan,M.B.,
            Nazareth,L.V., Scott,G., Sodergren,E., Song,X.Z., Steffen,D.,
            Lovering,R.C., Wheeler,D.A., Worley,K.C., Yuan,Y., Zhang,Z.,
            Adams,C.Q., Ansari-Lari,M.A., Ayele,M., Brown,M.J., Chen,G.,
            Chen,Z., Clerc-Blankenburg,K.P., Davis,C., Delgado,O., Dinh,H.H.,
            Draper,H., Gonzalez-Garay,M.L., Havlak,P., Jackson,L.R.,
            Jacob,L.S., Kelly,S.H., Li,L., Li,Z., Liu,J., Liu,W., Lu,J.,
            Maheshwari,M., Nguyen,B.V., Okwuonu,G.O., Pasternak,S., Perez,L.M.,
            Plopper,F.J., Santibanez,J., Shen,H., Tabor,P.E., Verduzco,D.,
            Waldron,L., Wang,Q., Williams,G.A., Zhang,J., Zhou,J., Allen,C.C.,
            Amin,A.G., Anyalebechi,V., Bailey,M., Barbaria,J.A., Bimage,K.E.,
            Bryant,N.P., Burch,P.E., Burkett,C.E., Burrell,K.L., Calderon,E.,
            Cardenas,V., Carter,K., Casias,K., Cavazos,I., Cavazos,S.R.,
            Ceasar,H., Chacko,J., Chan,S.N., Chavez,D., Christopoulos,C.,
            Chu,J., Cockrell,R., Cox,C.D., Dang,M., Dathorne,S.R., David,R.,
            Davis,C.M., Davy-Carroll,L., Deshazo,D.R., Donlin,J.E., D'Souza,L.,
            Eaves,K.A., Simons,R., Emery-Cohen,A.J., Escotto,M., Flagg,N.,
            Forbes,L.D., Gabisi,A.M., Garza,M., Hamilton,C., Henderson,N.,
            Hernandez,O., Hines,S., Hogues,M.E., Huang,M., Idlebird,D.G.,
            Johnson,R., Jolivet,A., Jones,S., Kagan,R., King,L.M., Leal,B.,
            Lebow,H., Lee,S., LeVan,J.M., Lewis,L.C., London,P.,
            Lorensuhewa,L.M., Loulseged,H., Lovett,D.A., Lucier,A.,
            Lucier,R.L., Ma,J., Madu,R.C., Mapua,P., Martindale,A.D.,
            Martinez,E., Massey,E., Mawhiney,S., Meador,M.G., Mendez,S.,
            Mercado,C., Mercado,I.C., Merritt,C.E., Miner,Z.L., Minja,E.,
            Mitchell,T., Mohabbat,F., Mohabbat,K., Montgomery,B., Moore,N.,
            Morris,S., Munidasa,M., Ngo,R.N., Nguyen,N.B., Nickerson,E.,
            Nwaokelemeh,O.O., Nwokenkwo,S., Obregon,M., Oguh,M., Oragunye,N.,
            Oviedo,R.J., Parish,B.J., Parker,D.N., Parrish,J., Parks,K.L.,
            Paul,H.A., Payton,B.A., Perez,A., Perrin,W., Pickens,A.,
            Primus,E.L., Pu,L.L., Puazo,M., Quiles,M.M., Quiroz,J.B.,
            Rabata,D., Reeves,K., Ruiz,S.J., Shao,H., Sisson,I., Sonaike,T.,
            Sorelle,R.P., Sutton,A.E., Svatek,A.F., Svetz,L.A., Tamerisa,K.S.,
            Taylor,T.R., Teague,B., Thomas,N., Thorn,R.D., Trejos,Z.Y.,
            Trevino,B.K., Ukegbu,O.N., Urban,J.B., Vasquez,L.I., Vera,V.A.,
            Villasana,D.M., Wang,L., Ward-Moore,S., Warren,J.T., Wei,X.,
            White,F., Williamson,A.L., Wleczyk,R., Wooden,H.S., Wooden,S.H.,
            Yen,J., Yoon,L., Yoon,V., Zorrilla,S.E., Nelson,D.,
            Kucherlapati,R., Weinstock,G. and Gibbs,R.A.
  CONSRTM   Baylor College of Medicine Human Genome Sequencing Center Sequence
            Production Team
  TITLE     The finished DNA sequence of human chromosome 12
  JOURNAL   Nature 440 (7082), 346-351 (2006)
   PUBMED   16541075
REFERENCE   5  (residues 1 to 578)
  AUTHORS   Langbein,L., Rogers,M.A., Praetzel,S., Cribier,B., Peltre,B.,
            Gassler,N. and Schweizer,J.
  TITLE     Characterization of a novel human type II epithelial keratin K1b,
            specifically expressed in eccrine sweat glands
  JOURNAL   J Invest Dermatol 125 (3), 428-444 (2005)
   PUBMED   16117782
  REMARK    GeneRIF: Epithelial keratin, K1b, is exclusively expressed in
            luminal duct cells of eccrine sweat glands.
REFERENCE   6  (residues 1 to 578)
  AUTHORS   Rogers,M.A., Edler,L., Winter,H., Langbein,L., Beckmann,I. and
            Schweizer,J.
  TITLE     Characterization of new members of the human type II keratin gene
            family and a general evaluation of the keratin gene domain on
            chromosome 12q13.13
  JOURNAL   J Invest Dermatol 124 (3), 536-544 (2005)
   PUBMED   15737194
REFERENCE   7  (residues 1 to 578)
  AUTHORS   Hesse,M., Magin,T.M. and Weber,K.
  TITLE     Genes for intermediate filament proteins and the draft sequence of
            the human genome: novel keratin genes and a surprisingly high
            number of pseudogenes related to keratin genes 8 and 18
  JOURNAL   J Cell Sci 114 (Pt 14), 2569-2575 (2001)
   PUBMED   11683385
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC055716.24 and BC122558.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jul 10, 2008 this sequence version replaced NP_778253.1.
            
            Summary: Keratins are intermediate filament proteins responsible
            for the structural integrity of epithelial cells and are subdivided
            into epithelial keratins and hair keratins. This gene encodes an
            epithelial keratin that is expressed in the skin and eccrine sweat
            glands. The type II keratins are clustered in a region of
            chromosome 12q13.[provided by RefSeq, Jun 2009].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because transcript sequence consistent with
            the reference genome assembly was not available for all regions of
            the RefSeq transcript. The extent of this transcript is supported
            by transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ564104.1, BC122558.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145893, SAMEA2147596
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000341809.8/ ENSP00000342710.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..578
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q13.13"
     Protein         1..578
                     /product="keratin, type II cytoskeletal 1b"
                     /note="keratin 1B; K77; CK-1B; cytokeratin-1B; type-II
                     keratin Kb39; keratin 77, type II"
                     /calculated_mol_wt=61771
     Region          1..163
                     /region_name="Head"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7Z794.3)"
     Region          <56..160
                     /region_name="Keratin_2_head"
                     /note="Keratin type II head; pfam16208"
                     /db_xref="CDD:465068"
     Site            95
                     /site_type="methylation"
                     /note="Omega-N-methylarginine.
                     /evidence=ECO:0000250|UniProtKB:Q6IFZ6; propagated from
                     UniProtKB/Swiss-Prot (Q7Z794.3)"
     Region          163..476
                     /region_name="Filament"
                     /note="Intermediate filament protein; pfam00038"
                     /db_xref="CDD:459643"
     Region          164..200
                     /region_name="Coil 1A"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7Z794.3)"
     Region          201..219
                     /region_name="Linker 1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7Z794.3)"
     Region          220..311
                     /region_name="Coil 1B"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7Z794.3)"
     Region          312..335
                     /region_name="Linker 12"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7Z794.3)"
     Region          336..474
                     /region_name="Coil 2"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7Z794.3)"
     Site            418
                     /site_type="other"
                     /note="Stutter; propagated from UniProtKB/Swiss-Prot
                     (Q7Z794.3)"
     Region          475..578
                     /region_name="Tail"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7Z794.3)"
     Site            523
                     /site_type="methylation"
                     /note="Omega-N-methylarginine.
                     /evidence=ECO:0000250|UniProtKB:Q6IFZ6; propagated from
                     UniProtKB/Swiss-Prot (Q7Z794.3)"
     Region          547..578
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7Z794.3)"
     CDS             1..578
                     /gene="KRT77"
                     /gene_synonym="K1B; KRT1B"
                     /coded_by="NM_175078.3:91..1827"
                     /db_xref="CCDS:CCDS8837.1"
                     /db_xref="GeneID:374454"
                     /db_xref="HGNC:HGNC:20411"
                     /db_xref="MIM:611158"
ORIGIN      
        1 mshqfssqsa fssmsrrvys tsssagsggg spavgsvcya rgrcggggyg ihgrgfgsrs
       61 lynlggsrsi sinlmgrsts gfcqgggvgg fgggrgfgvg stgaggfggg gfggagfgts
      121 nfglggfgpy cppggiqevt inqslleplh levdpeiqri ktqereqimv lnnkfasfid
      181 kvrfleqqnq vlqtkwellq qvntstgtnn lepllenyig dlrrqvdlls aeqmrqnaev
      241 rsmqdvvedy kskyedeink rtgsendfvv lkkdvdaayv skvdlesrvd tltgevnflk
      301 ylfltelsqv qthisdtnvi lsmdnnrsld ldsiidavrt qyeliaqrsk deaealyqtk
      361 yqelqitagr hgddlknskm eiaelnrtvq rlqaeisnvk kqieqmqsli sdaeergeqa
      421 lqdawqklqd leealqqske elarllrdyq amlgvklsld veiatyrqll egeesrmsge
      481 lqshvsisvq nsqvsvngga ggggsygsgg ygggsgggyg ggrsyrggga rgrsgggygs
      541 gcgggggsyg gsgrsgrgss rvqiiqtstn tshrrile
//
