LOCUS       NM_015848               2529 bp    mRNA    linear   PRI 03-APR-2024
DEFINITION  Homo sapiens keratin 76 (KRT76), mRNA.
ACCESSION   NM_015848
VERSION     NM_015848.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2529)
  AUTHORS   Nelke,C., Muntefering,T., Cengiz,D., Theissen,L., Dobelmann,V.,
            Schroeter,C.B., Block,H., Preusse,C., Michels,A.P.E.,
            Lichtenberg,S., Pawlitzki,M., Pfeuffer,S., Huntemann,N.,
            Zarbock,A., Briese,T., Kittl,C., Dittmayer,C., Budde,T.,
            Lundberg,I.E., Stenzel,W., Meuth,S.G. and Ruck,T.
  TITLE     K2P2.1 is a regulator of inflammatory cell responses in idiopathic
            inflammatory myopathies
  JOURNAL   J Autoimmun 142, 103136 (2024)
   PUBMED   37935063
  REMARK    GeneRIF: K2P2.1 is a regulator of inflammatory cell responses in
            idiopathic inflammatory myopathies.
REFERENCE   2  (bases 1 to 2529)
  AUTHORS   Benz,C., Ali,M., Krystkowiak,I., Simonetti,L., Sayadi,A.,
            Mihalic,F., Kliche,J., Andersson,E., Jemth,P., Davey,N.E. and
            Ivarsson,Y.
  TITLE     Proteome-scale mapping of binding sites in the unstructured regions
            of the human proteome
  JOURNAL   Mol Syst Biol 18 (1), e10584 (2022)
   PUBMED   35044719
REFERENCE   3  (bases 1 to 2529)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 2529)
  AUTHORS   Sequeira,I., Neves,J.F., Carrero,D., Peng,Q., Palasz,N.,
            Liakath-Ali,K., Lord,G.M., Morgan,P.R., Lombardi,G. and Watt,F.M.
  TITLE     Immunomodulatory role of Keratin 76 in oral and gastric cancer
  JOURNAL   Nat Commun 9 (1), 3437 (2018)
   PUBMED   30143634
  REMARK    GeneRIF: Data shows that immunomodulatory role of Keratin 76 in
            oral and gastric cancer.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2529)
  AUTHORS   de Mateo,S., Castillo,J., Estanyol,J.M., Ballesca,J.L. and Oliva,R.
  TITLE     Proteomic characterization of the human sperm nucleus
  JOURNAL   Proteomics 11 (13), 2714-2726 (2011)
   PUBMED   21630459
REFERENCE   6  (bases 1 to 2529)
  AUTHORS   Behrends,C., Sowa,M.E., Gygi,S.P. and Harper,J.W.
  TITLE     Network organization of the human autophagy system
  JOURNAL   Nature 466 (7302), 68-76 (2010)
   PUBMED   20562859
REFERENCE   7  (bases 1 to 2529)
  AUTHORS   Schweizer,J., Bowden,P.E., Coulombe,P.A., Langbein,L., Lane,E.B.,
            Magin,T.M., Maltais,L., Omary,M.B., Parry,D.A., Rogers,M.A. and
            Wright,M.W.
  TITLE     New consensus nomenclature for mammalian keratins
  JOURNAL   J Cell Biol 174 (2), 169-174 (2006)
   PUBMED   16831889
REFERENCE   8  (bases 1 to 2529)
  AUTHORS   Rogers,M.A., Edler,L., Winter,H., Langbein,L., Beckmann,I. and
            Schweizer,J.
  TITLE     Characterization of new members of the human type II keratin gene
            family and a general evaluation of the keratin gene domain on
            chromosome 12q13.13
  JOURNAL   J Invest Dermatol 124 (3), 536-544 (2005)
   PUBMED   15737194
REFERENCE   9  (bases 1 to 2529)
  AUTHORS   Collin,C., Ouhayoun,J.P., Grund,C. and Franke,W.W.
  TITLE     Suprabasal marker proteins distinguishing keratinizing squamous
            epithelia: cytokeratin 2 polypeptides of oral masticatory
            epithelium and epidermis are different
  JOURNAL   Differentiation 51 (2), 137-148 (1992)
   PUBMED   1282112
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK299390.1 and M99063.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jul 9, 2009 this sequence version replaced NM_015848.3.
            
            Summary: Keratins are intermediate filament proteins responsible
            for the structural integrity of epithelial cells and are subdivided
            into epithelial keratins and hair keratins. The type II keratins
            are clustered in a region of chromosome 12q13. [provided by RefSeq,
            Jun 2009].
            
            ##Evidence-Data-START##
            Transcript exon combination :: M99063.1, AK299390.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000332411.2/ ENSP00000330101.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-24                AK299390.1         1-24
            25-1128             M99063.1           2-1105
            1129-2375           AK299390.1         1129-2375
            2376-2529           M99063.1           2353-2506
FEATURES             Location/Qualifiers
     source          1..2529
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q13.13"
     gene            1..2529
                     /gene="KRT76"
                     /gene_synonym="HUMCYT2A; KRT2B; KRT2P"
                     /note="keratin 76"
                     /db_xref="GeneID:51350"
                     /db_xref="HGNC:HGNC:24430"
                     /db_xref="MIM:616671"
     exon            1..654
                     /gene="KRT76"
                     /gene_synonym="HUMCYT2A; KRT2B; KRT2P"
                     /inference="alignment:Splign:2.1.0"
     CDS             55..1971
                     /gene="KRT76"
                     /gene_synonym="HUMCYT2A; KRT2B; KRT2P"
                     /note="cytokeratin 2; keratin 2p; K2P; K76; CK-2P;
                     cytokeratin-2P; type-II keratin Kb9; keratin 76, type II"
                     /codon_start=1
                     /product="keratin, type II cytoskeletal 2 oral"
                     /protein_id="NP_056932.2"
                     /db_xref="CCDS:CCDS8838.1"
                     /db_xref="GeneID:51350"
                     /db_xref="HGNC:HGNC:24430"
                     /db_xref="MIM:616671"
                     /translation="MNRQVCKKSFSGRSQGFSGRSAVVSGSSRMSCVARSGGAGGGAC
                     GFRSGAGSFGSRSLYNLGSNKSISISVAAGSSRAGGFGGGRSSCGFAGGYGGGFGGSY
                     GGGFGGGRGVGSGFGGAGGFGGAGGFGGPGVFGGPGSFGGPGGFGPGGFPGGIQEVIV
                     NQSLLQPLNVEIDPQIGQVKAQEREQIKTLNNKFASFIDKVRFLEQQNKVLETKWELL
                     QQQTTGSGPSSLEPCFESYISFLCKQLDSLLGERGNLEGELKSMQDLVEDFKKKYEDE
                     INKRTAAENEFVGLKKDVDAAFMNKVELQAKVDSLTDEVSFLRTLYEMELSQMQSHAS
                     DTSVVLSMDNNRCLDLGSIIAEVRAQYEEIAQRSKSEAEALYQTKLGELQTTAGRHGD
                     DLRNTKSEIMELNRMIQRLRAEIENVKKQNANLQTAIAEAEQRGEMALKDANAKLQDL
                     QTALQKAKDDLARLLRDYQELMNVKLALDVEIATYRKLLEGEECRMSGECQSAVCISV
                     VSNVTSTSGSSGSSRGVFGGVSGSGSGGYKGGSSSSSSSGYGVSGGSGSGYGGVSSGS
                     TGGRGSSGSYQSSSSGSRLGGAGSISVSHSGMGSSSGSIQTSGGSGYKSGGGGSTSIR
                     FSQTTSSSQHSSTK"
     exon            655..869
                     /gene="KRT76"
                     /gene_synonym="HUMCYT2A; KRT2B; KRT2P"
                     /inference="alignment:Splign:2.1.0"
     exon            870..930
                     /gene="KRT76"
                     /gene_synonym="HUMCYT2A; KRT2B; KRT2P"
                     /inference="alignment:Splign:2.1.0"
     exon            931..1026
                     /gene="KRT76"
                     /gene_synonym="HUMCYT2A; KRT2B; KRT2P"
                     /inference="alignment:Splign:2.1.0"
     exon            1027..1191
                     /gene="KRT76"
                     /gene_synonym="HUMCYT2A; KRT2B; KRT2P"
                     /inference="alignment:Splign:2.1.0"
     exon            1192..1317
                     /gene="KRT76"
                     /gene_synonym="HUMCYT2A; KRT2B; KRT2P"
                     /inference="alignment:Splign:2.1.0"
     exon            1318..1538
                     /gene="KRT76"
                     /gene_synonym="HUMCYT2A; KRT2B; KRT2P"
                     /inference="alignment:Splign:2.1.0"
     exon            1539..1573
                     /gene="KRT76"
                     /gene_synonym="HUMCYT2A; KRT2B; KRT2P"
                     /inference="alignment:Splign:2.1.0"
     exon            1574..2529
                     /gene="KRT76"
                     /gene_synonym="HUMCYT2A; KRT2B; KRT2P"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2509..2514
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KRT76"
                     /gene_synonym="HUMCYT2A; KRT2B; KRT2P"
     polyA_site      2529
                     /gene="KRT76"
                     /gene_synonym="HUMCYT2A; KRT2B; KRT2P"
ORIGIN      
        1 atccctctca gctcttgcta agtgatcact agcttgcctc caagctctct cactatgaac
       61 agacaagttt gcaagaaatc cttcagtggc aggagccagg gtttctctgg ccgctctgct
      121 gtggtctccg gcagcagcag gatgagctgt gtggcccgct ctgggggagc tggtggaggg
      181 gcctgtggct tcaggagcgg agcaggcagc tttggcagtc gcagcctcta caacctgggc
      241 agcaacaaga gcatctccat cagcgtggca gctggcagct cccgggctgg aggctttggg
      301 ggagggcgga gcagctgtgg ctttgcaggt ggctatggag gtggctttgg gggcagctat
      361 ggtggtggct ttggtggtgg cagaggagta ggtagtggtt ttggaggggc tggtggcttt
      421 ggtggagctg gtggctttgg tggtcctggt gtatttggtg ggcctggcag ctttggtggt
      481 cctggtggct ttggccctgg gggctttcct gggggaattc aggaagtgat tgtaaaccag
      541 agtctcctgc agcccctcaa tgtggagatc gacccccaga ttgggcaagt aaaggcccag
      601 gagcgggaac agatcaagac cctcaacaac aagtttgcct ccttcatcga caaggtgcgg
      661 ttcctggaac agcagaacaa ggtcctggag accaagtggg aactgctcca gcagcagacc
      721 acaggctcag ggcccagcag cctggagcct tgttttgaat cctacatcag cttcctatgc
      781 aagcagctag attcacttct aggggagagg gggaacctgg agggagagct gaaaagcatg
      841 caggacctgg tggaagactt caaaaagaag tatgaagatg aaatcaacaa acgcactgcc
      901 gcagagaatg agtttgtggg gctcaagaag gatgtggatg cggctttcat gaacaaggtg
      961 gagctgcagg ccaaagtgga cagcctgaca gatgaagtca gcttcctgag gaccctctat
     1021 gagatggagc tgtcccagat gcaaagccat gccagtgaca cgtctgtggt tctgtccatg
     1081 gacaacaacc gctgcctgga cctgggcagc atcattgccg aggtccgcgc ccagtatgag
     1141 gagattgccc agaggagcaa gtctgaagct gaggccctgt accagaccaa gcttggggag
     1201 ctgcagacca cagctggcag gcatggggat gacctgagga acaccaagag tgagatcatg
     1261 gagctcaaca ggatgatcca gaggctacgg gctgagattg aaaatgtcaa gaagcagaat
     1321 gccaacctgc agacggcaat tgcagaggct gagcagcgtg gagagatggc cctcaaggac
     1381 gccaatgcca agctccaaga cttgcagact gccctacaga aggctaagga tgacctggct
     1441 cggctcctgc gtgactacca ggagctgatg aacgtcaagc tggccctgga tgtggagatt
     1501 gccacctacc gcaagctgct ggagggagag gagtgcagga tgtctggaga atgtcagagt
     1561 gccgtgtgca tttcagtggt cagcaatgtc accagcacaa gtggcagctc tggcagtagc
     1621 cgtggagttt ttggaggggt cagtggcagt ggcagtggtg gctacaaagg cggcagcagc
     1681 agcagcagca gcagtggcta tggagtcagt ggcggcagcg gcagtggcta tggaggggtc
     1741 agcagtggca gcactggggg caggggtagc agcgggagct accagagcag cagtagtggg
     1801 agcaggctcg gcggtgcagg tagcatctcc gtgagccaca gtggaatggg ctccagctct
     1861 ggcagcatcc agacttctgg aggaagtggc tacaagtctg gtggtggagg cagcaccagt
     1921 atccgcttct cccagaccac gagctcaagc cagcatagct ccaccaagtg atctactgtt
     1981 ccaaatctct ataaccacct gcttcccact cagcctgcaa tagtgtttcc cactctctgc
     2041 ttggcatcaa tagatgcata agggtcaacc acatttttcc tcaagttccc tggagaagaa
     2101 gctgaactcc tggtttctcc atccccatga ccttcccagg gccatggagg tcctgctgct
     2161 ggtctgggat gatgatgccc ctggaaacct tcctgcaatg gccccttact ttggacagca
     2221 acccctgagc ccaagccagt tttggccttc acagcctggc ctgttcccac tctggcccat
     2281 ctccctttct tactgggagt tggagatttg aagccagtca tctcagcact gtctgaggag
     2341 ggcagagcca tgggttctgt gctggagggt gcacggccaa gatctccaga ctgctggttc
     2401 ccagggaacc ctccctacat ctgggcttca gatcctgact cccttctgtc ccctaattcc
     2461 ctgagctgta gatcctctgg tgatgagtat gttgcacttt cttttctcaa taaattgcac
     2521 tgaacttca
//
