LOCUS       NP_542785                511 aa            linear   PRI 27-APR-2025
DEFINITION  keratin, type II cytoskeletal 72 isoform 1 [Homo sapiens].
ACCESSION   NP_542785
VERSION     NP_542785.1
DBSOURCE    REFSEQ: accession NM_080747.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 511)
  AUTHORS   Jiang,Z., Hou,Z., Liu,W., Yu,Z., Liang,Z. and Chen,S.
  TITLE     circ-Keratin 6c Promotes Malignant Progression and Immune Evasion
            of Colorectal Cancer through microRNA-485-3p/Programmed Cell Death
            Receptor Ligand 1 Axis
  JOURNAL   J Pharmacol Exp Ther 377 (3), 358-367 (2021)
   PUBMED   33771844
  REMARK    GeneRIF: circ-Keratin 6c Promotes Malignant Progression and Immune
            Evasion of Colorectal Cancer through microRNA-485-3p/Programmed
            Cell Death Receptor Ligand 1 Axis.
REFERENCE   2  (residues 1 to 511)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (residues 1 to 511)
  AUTHORS   Gao,L., Dou,J., Zhang,B., Zeng,J., Cheng,Q., Lei,L., Tan,L.,
            Zeng,Q., Ding,S., Guo,A., Cheng,H., Yang,C., Luo,Z. and Lu,J.
  TITLE     Ozone therapy promotes the differentiation of basal keratinocytes
            via increasing Tp63-mediated transcription of KRT10 to improve
            psoriasis
  JOURNAL   J Cell Mol Med 24 (8), 4819-4829 (2020)
   PUBMED   32168425
  REMARK    GeneRIF: Ozone therapy promotes the differentiation of basal
            keratinocytes via increasing Tp63-mediated transcription of KRT10
            to improve psoriasis.
REFERENCE   4  (residues 1 to 511)
  AUTHORS   Nakai,T., Ichihara,S., Kada,A., Ito,N., Moritani,S., Kawasaki,T.,
            Uchiyama,T., Itami,H., Morita,K., Takano,M., Takeda,M.,
            Hatakeyama,K. and Ohbayashi,C.
  TITLE     The unique luminal staining pattern of cytokeratin 5/6 in adenoid
            cystic carcinoma of the breast may aid in differentiating it from
            its mimickers
  JOURNAL   Virchows Arch 469 (2), 213-222 (2016)
   PUBMED   27240462
  REMARK    GeneRIF: the luminal cells of adenoid cystic carcinoma show a
            unique aberrant staining pattern for cytokeratin 5/6 that may aid
            in the differential diagnosis
REFERENCE   5  (residues 1 to 511)
  AUTHORS   Koo,J.S., Kim,M.J., Kim,E.K. and Park,B.W.
  TITLE     Comparison of immunohistochemical staining in breast papillary
            neoplasms of cytokeratin 5/6 and p63 in core needle biopsies and
            surgical excisions
  JOURNAL   Appl Immunohistochem Mol Morphol 20 (2), 108-115 (2012)
   PUBMED   22553810
  REMARK    GeneRIF: the results of CK5/6 and p63 in CNBs of papillary
            neoplasms were mostly representative of the final results for CK5/6
            and p63 in subsequent surgical excisions, excisional biopsy is
            required for definitive subtyping
REFERENCE   6  (residues 1 to 511)
  AUTHORS   Boran,C., Kandirali,E., Yilmaz,F., Serin,E. and Akyol,M.
  TITLE     Reliability of the 34betaE12, keratin 5/6, p63, bcl-2, and AMACR in
            the diagnosis of prostate carcinoma
  JOURNAL   Urol Oncol 29 (6), 614-623 (2011)
   PUBMED   20189848
  REMARK    GeneRIF: we suggest that keratin 5/6 and bcl-2 should not be used
            to identify benign glands in prostate biopsy
REFERENCE   7  (residues 1 to 511)
  AUTHORS   Bertheau,P., Turpin,E., Rickman,D.S., Espie,M., de Reynies,A.,
            Feugeas,J.P., Plassa,L.F., Soliman,H., Varna,M., de Roquancourt,A.,
            Lehmann-Che,J., Beuzard,Y., Marty,M., Misset,J.L., Janin,A. and de
            The,H.
  TITLE     Exquisite sensitivity of TP53 mutant and basal breast cancers to a
            dose-dense epirubicin-cyclophosphamide regimen
  JOURNAL   PLoS Med 4 (3), e90 (2007)
   PUBMED   17388661
REFERENCE   8  (residues 1 to 511)
  AUTHORS   Schweizer,J., Bowden,P.E., Coulombe,P.A., Langbein,L., Lane,E.B.,
            Magin,T.M., Maltais,L., Omary,M.B., Parry,D.A., Rogers,M.A. and
            Wright,M.W.
  TITLE     New consensus nomenclature for mammalian keratins
  JOURNAL   J Cell Biol 174 (2), 169-174 (2006)
   PUBMED   16831889
REFERENCE   9  (residues 1 to 511)
  AUTHORS   Langbein,L., Rogers,M.A., Praetzel,S., Winter,H. and Schweizer,J.
  TITLE     K6irs1, K6irs2, K6irs3, and K6irs4 represent the
            inner-root-sheath-specific type II epithelial keratins of the human
            hair follicle
  JOURNAL   J Invest Dermatol 120 (4), 512-522 (2003)
   PUBMED   12648212
REFERENCE   10 (residues 1 to 511)
  AUTHORS   Porter,R.M., Corden,L.D., Lunny,D.P., Smith,F.J., Lane,E.B. and
            McLean,W.H.
  TITLE     Keratin K6irs is specific to the inner root sheath of hair
            follicles in mice and humans
  JOURNAL   Br J Dermatol 145 (4), 558-568 (2001)
   PUBMED   11703281
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK293645.1, BC113686.1,
            AY033495.1 and BX089867.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            Summary: Keratins are intermediate filament proteins responsible
            for the structural integrity of epithelial cells. The type II
            keratins consist of basic or neutral proteins which are arranged in
            pairs of heterotypic keratin chains coexpressed during
            differentiation of simple and stratified epithelial tissues. This
            gene encodes a type II keratin that is specifically expressed in
            the inner root sheath of hair follicles. The type II keratins are
            clustered in a region of chromosome 12q12-q13. Multiple transcript
            variants encoding different isoforms have been found for this
            gene.[provided by RefSeq, Jun 2009].
            
            Transcript Variant: This variant (1) represents the predominant
            transcript and encodes the longer isoform (1). Variants 1 and 2
            encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC113686.1, SRR3476690.969423.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148874
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000293745.7/ ENSP00000293745.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..511
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q13.13"
     Protein         1..511
                     /product="keratin, type II cytoskeletal 72 isoform 1"
                     /note="keratin, type II cytoskeletal 72; keratin 6, inner
                     root sheath, 2; keratin protein K6irs; cytokeratin-72;
                     type-II keratin Kb35; type II inner root sheath-specific
                     keratin-K6irs2; keratin 72, type II"
                     /calculated_mol_wt=55746
     Region          1..124
                     /region_name="Head"
                     /note="propagated from UniProtKB/Swiss-Prot (Q14CN4.2)"
     Region          15..121
                     /region_name="Keratin_2_head"
                     /note="Keratin type II head; pfam16208"
                     /db_xref="CDD:465068"
     Region          124..437
                     /region_name="Filament"
                     /note="Intermediate filament protein; pfam00038"
                     /db_xref="CDD:459643"
     Region          125..160
                     /region_name="Coil 1A"
                     /note="propagated from UniProtKB/Swiss-Prot (Q14CN4.2)"
     Region          161..179
                     /region_name="Linker 1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q14CN4.2)"
     Region          180..271
                     /region_name="Coil 1B"
                     /note="propagated from UniProtKB/Swiss-Prot (Q14CN4.2)"
     Region          272..295
                     /region_name="Linker 12"
                     /note="propagated from UniProtKB/Swiss-Prot (Q14CN4.2)"
     Region          296..434
                     /region_name="Coil 2"
                     /note="propagated from UniProtKB/Swiss-Prot (Q14CN4.2)"
     Site            376
                     /site_type="other"
                     /note="Stutter; propagated from UniProtKB/Swiss-Prot
                     (Q14CN4.2)"
     Region          435..511
                     /region_name="Tail"
                     /note="propagated from UniProtKB/Swiss-Prot (Q14CN4.2)"
     Region          486..511
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q14CN4.2)"
     CDS             1..511
                     /gene="KRT72"
                     /gene_synonym="CK-72; K6irs; K6IRS2; K72; KRT6; KRT6IRS2"
                     /coded_by="NM_080747.3:12..1547"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS8833.1"
                     /db_xref="GeneID:140807"
                     /db_xref="HGNC:HGNC:28932"
                     /db_xref="MIM:608246"
ORIGIN      
        1 msrqlthfpr gerlgfsgcs avlsggigss sasfrarvkg sasfgsksls clggsrslal
       61 saaarrgggr lggfvgtafg saglgpkcps vcppggipqv tvnksllapl nvemdpeiqr
      121 vraqereqik alnnkfasfi dkvrfleqqn qvletkwnll qqldlnncrk nlepiyegyi
      181 snlqkqleml sgdgvrldse lrnmqdlved ykkryevein rrtaaenefv vlkkdvdaay
      241 mnkvelqakv dsltdeikff kclyegeitq iqshisdtsi vlsmdnnrdl dldsiiaevr
      301 aqyeeialks kaeaetlyqt kiqelqvtag qhgddlkltk aeiselnrli qrirseignv
      361 kkqcadleta iadaeqrgdc alkdarakld elegalhqak eelarmlrey qelvslklal
      421 dmeiatyrkl leseecrmsg eypnsvsisv isstnagagg agfsmgfgas ssysyktaaa
      481 dvktkgscgs elkdplakts gsscatkkas r
//
