LOCUS       NM_005556               1625 bp    mRNA    linear   PRI 11-SEP-2024
DEFINITION  Homo sapiens keratin 7 (KRT7), mRNA.
ACCESSION   NM_005556
VERSION     NM_005556.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1625)
  AUTHORS   Ismael,A.T., Abdulhameed,R.A., Jalal,J.A., Tawfeeq,R.D., Ommar,A.
            and Jalal,A.
  TITLE     Expression of cytokeratin 7/20 and Ki67 in Helicobacter
            pylori-associated gastritis and intestinal metaplasia
  JOURNAL   J Infect Dev Ctries 18 (7), 1032-1040 (2024)
   PUBMED   39078783
  REMARK    GeneRIF: Expression of cytokeratin 7/20 and Ki67 in Helicobacter
            pylori-associated gastritis and intestinal metaplasia.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1625)
  AUTHORS   Wang,S., Li,H., Li,M., Liu,X., Yu,S., Huang,H. and Wang,X.
  TITLE     Role of the KRT7 Biomarker in Immune Infiltration and Paclitaxel
            Resistance in Ovarian
  JOURNAL   Altern Ther Health Med 29 (5), 132-140 (2023)
   PUBMED   37023314
  REMARK    GeneRIF: Role of the KRT7 Biomarker in Immune Infiltration and
            Paclitaxel Resistance in Ovarian.
REFERENCE   3  (bases 1 to 1625)
  AUTHORS   Polari,L., Tenhami,M., Anttila,S., Helenius,T., Kujari,H.,
            Kallajoki,M., Voutilainen,M. and Toivola,D.M.
  TITLE     Colonocyte keratin 7 is expressed de novo in inflammatory bowel
            diseases and associated with pathological changes and
            drug-resistance
  JOURNAL   Sci Rep 12 (1), 22213 (2022)
   PUBMED   36564440
  REMARK    GeneRIF: Colonocyte keratin 7 is expressed de novo in inflammatory
            bowel diseases and associated with pathological changes and
            drug-resistance.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1625)
  AUTHORS   Liu,H.L., Yang,A.Y., Xiong,Q.F., Zhong,Y.D., Liu,D.X., Huang,P.,
            Feng,X.N., Zhang,Y. and Yang,Y.F.
  TITLE     Aberrant cytokeratin 7 expression by hepatocytes can predict the
            ductopenia grade in primary biliary cholangitis
  JOURNAL   BMC Gastroenterol 22 (1), 443 (2022)
   PUBMED   36324070
  REMARK    GeneRIF: Aberrant cytokeratin 7 expression by hepatocytes can
            predict the ductopenia grade in primary biliary cholangitis.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1625)
  AUTHORS   Yu,Z., Ding,J., Pang,H., Fang,H., He,F., Xu,C., Li,X. and Ren,K.
  TITLE     A triple-classification for differentiating renal oncocytoma from
            renal cell carcinoma subtypes and CK7 expression evaluation: a
            radiomics analysis
  JOURNAL   BMC Urol 22 (1), 147 (2022)
   PUBMED   36096829
  REMARK    GeneRIF: A triple-classification for differentiating renal
            oncocytoma from renal cell carcinoma subtypes and CK7 expression
            evaluation: a radiomics analysis.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1625)
  AUTHORS   Gress,T.M., Muller-Pillasch,F., Geng,M., Zimmerhackl,F.,
            Zehetner,G., Friess,H., Buchler,M., Adler,G. and Lehrach,H.
  TITLE     A pancreatic cancer-specific expression profile
  JOURNAL   Oncogene 13 (8), 1819-1830 (1996)
   PUBMED   8895530
REFERENCE   7  (bases 1 to 1625)
  AUTHORS   Rosenberg,M., Fuchs,E., Le Beau,M.M., Eddy,R.L. and Shows,T.B.
  TITLE     Three epidermal and one simple epithelial type II keratin genes map
            to human chromosome 12
  JOURNAL   Cytogenet Cell Genet 57 (1), 33-38 (1991)
   PUBMED   1713141
REFERENCE   8  (bases 1 to 1625)
  AUTHORS   Glass,C. and Fuchs,E.
  TITLE     Isolation, sequence, and differential expression of a human K7 gene
            in simple epithelial cells
  JOURNAL   J Cell Biol 107 (4), 1337-1350 (1988)
   PUBMED   2459129
REFERENCE   9  (bases 1 to 1625)
  AUTHORS   Ramaekers,F., Huysmans,A., Schaart,G., Moesker,O. and Vooijs,P.
  TITLE     Tissue distribution of keratin 7 as monitored by a monoclonal
            antibody
  JOURNAL   Exp Cell Res 170 (1), 235-249 (1987)
   PUBMED   2436934
REFERENCE   10 (bases 1 to 1625)
  AUTHORS   Glass,C., Kim,K.H. and Fuchs,E.
  TITLE     Sequence and expression of a human type II mesothelial keratin
  JOURNAL   J Cell Biol 101 (6), 2366-2373 (1985)
   PUBMED   2415537
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff in
            collaboration with Michael Rogers. The reference sequence was
            derived from AC021066.37, BE744321.1, BE740515.1 and BC002700.2.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_005556.3.
            
            Summary: The protein encoded by this gene is a member of the
            keratin gene family. The type II cytokeratins consist of basic or
            neutral proteins which are arranged in pairs of heterotypic keratin
            chains coexpressed during differentiation of simple and stratified
            epithelial tissues. This type II cytokeratin is specifically
            expressed in the simple epithelia lining the cavities of the
            internal organs and in the gland ducts and blood vessels. The genes
            encoding the type II cytokeratins are clustered in a region of
            chromosome 12q12-q13. Alternative splicing may result in several
            transcript variants; however, not all variants have been fully
            described. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK025881.1, BC002700.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1968832
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000331817.6/ ENSP00000329243.5
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-378               AC021066.37        48582-48959         c
            379-978             BE744321.1         29-628
            979-1453            BE740515.1         183-657
            1454-1625           BC002700.2         1442-1613
FEATURES             Location/Qualifiers
     source          1..1625
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q13.13"
     gene            1..1625
                     /gene="KRT7"
                     /gene_synonym="CK7; K2C7; K7; SCL"
                     /note="keratin 7"
                     /db_xref="GeneID:3855"
                     /db_xref="HGNC:HGNC:6445"
                     /db_xref="MIM:148059"
     exon            1..378
                     /gene="KRT7"
                     /gene_synonym="CK7; K2C7; K7; SCL"
                     /inference="alignment:Splign:2.1.0"
     CDS             55..1464
                     /gene="KRT7"
                     /gene_synonym="CK7; K2C7; K7; SCL"
                     /note="cytokeratin 7; sarcolectin; keratin, 55K type II
                     cytoskeletal; type II mesothelial keratin K7; keratin,
                     simple epithelial type I, K7; CK-7; type-II keratin Kb7;
                     keratin 7, type II"
                     /codon_start=1
                     /product="keratin, type II cytoskeletal 7"
                     /protein_id="NP_005547.3"
                     /db_xref="CCDS:CCDS8822.1"
                     /db_xref="GeneID:3855"
                     /db_xref="HGNC:HGNC:6445"
                     /db_xref="MIM:148059"
                     /translation="MSIHFSSPVFTSRSAAFSGRGAQVRLSSARPGGLGSSSLYGLGA
                     SRPRVAVRSAYGGPVGAGIREVTINQSLLAPLRLDADPSLQRVRQEESEQIKTLNNKF
                     ASFIDKVRFLEQQNKLLETKWTLLQEQKSAKSSRLPDIFEAQIAGLRGQLEALQVDGG
                     RLEAELRSMQDVVEDFKNKYEDEINHRTAAENEFVVLKKDVDAAYMSKVELEAKVDAL
                     NDEINFLRTLNETELTELQSQISDTSVVLSMDNSRSLDLDGIIAEVKAQYEEMAKCSR
                     AEAEAWYQTKFETLQAQAGKHGDDLRNTRNEISEMNRAIQRLQAEIDNIKNQRAKLEA
                     AIAEAEERGELALKDARAKQEELEAALQRGKQDMARQLREYQELMSVKLALDIEIATY
                     RKLLEGEESRLAGDGVGAVNISVMNSTGGSSSGGGIGLTLGGTMGSNALSFSSSAGPG
                     LLKAYSIRTASASRRSARD"
     exon            379..590
                     /gene="KRT7"
                     /gene_synonym="CK7; K2C7; K7; SCL"
                     /inference="alignment:Splign:2.1.0"
     exon            591..651
                     /gene="KRT7"
                     /gene_synonym="CK7; K2C7; K7; SCL"
                     /inference="alignment:Splign:2.1.0"
     exon            652..747
                     /gene="KRT7"
                     /gene_synonym="CK7; K2C7; K7; SCL"
                     /inference="alignment:Splign:2.1.0"
     exon            748..912
                     /gene="KRT7"
                     /gene_synonym="CK7; K2C7; K7; SCL"
                     /inference="alignment:Splign:2.1.0"
     exon            913..1038
                     /gene="KRT7"
                     /gene_synonym="CK7; K2C7; K7; SCL"
                     /inference="alignment:Splign:2.1.0"
     exon            1039..1259
                     /gene="KRT7"
                     /gene_synonym="CK7; K2C7; K7; SCL"
                     /inference="alignment:Splign:2.1.0"
     exon            1260..1294
                     /gene="KRT7"
                     /gene_synonym="CK7; K2C7; K7; SCL"
                     /inference="alignment:Splign:2.1.0"
     exon            1295..1625
                     /gene="KRT7"
                     /gene_synonym="CK7; K2C7; K7; SCL"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1590..1595
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KRT7"
                     /gene_synonym="CK7; K2C7; K7; SCL"
                     /note="hexamer: AATAAA"
     polyA_site      1625
                     /gene="KRT7"
                     /gene_synonym="CK7; K2C7; K7; SCL"
                     /note="major polyA site"
ORIGIN      
        1 agcgagtgcg cgctcctcct cgcccgccgc taggtccatc ccggcccagc caccatgtcc
       61 atccacttca gctccccggt attcacctcg cgctcagccg ccttctcggg ccgcggcgcc
      121 caggtgcgcc tgagctccgc tcgccccggc ggccttggca gcagcagcct ctacggcctc
      181 ggcgcctcac ggccgcgcgt ggccgtgcgc tctgcctatg ggggcccggt gggcgccggc
      241 atccgcgagg tcaccattaa ccagagcctg ctggccccgc tgcggctgga cgccgacccc
      301 tccctccagc gggtgcgcca ggaggagagc gagcagatca agaccctcaa caacaagttt
      361 gcctccttca tcgacaaggt gcggtttctg gagcagcaga acaagctgct ggagaccaag
      421 tggacgctgc tgcaggagca gaagtcggcc aagagcagcc gcctcccaga catctttgag
      481 gcccagattg ctggccttcg gggtcagctt gaggcactgc aggtggatgg gggccgcctg
      541 gaggcggagc tgcggagcat gcaggatgtg gtggaggact tcaagaataa gtacgaagat
      601 gaaattaacc accgcacagc tgctgagaat gagtttgtgg tgctgaagaa ggatgtggat
      661 gctgcctaca tgagcaaggt ggagctggag gccaaggtgg atgccctgaa tgatgagatc
      721 aacttcctca ggaccctcaa tgagacggag ttgacagagc tgcagtccca gatctccgac
      781 acatctgtgg tgctgtccat ggacaacagt cgctccctgg acctggacgg catcatcgct
      841 gaggtcaagg cgcagtatga ggagatggcc aaatgcagcc gggctgaggc tgaagcctgg
      901 taccagacca agtttgagac cctccaggcc caggctggga agcatgggga cgacctccgg
      961 aatacccgga atgagatttc agagatgaac cgggccatcc agaggctgca ggctgagatc
     1021 gacaacatca agaaccagcg tgccaagttg gaggccgcca ttgccgaggc tgaggagcgt
     1081 ggggagctgg cgctcaagga tgctcgtgcc aagcaggagg agctggaagc cgccctgcag
     1141 cggggcaagc aggatatggc acggcagctg cgtgagtacc aggaactcat gagcgtgaag
     1201 ctggccctgg acatcgagat cgccacctac cgcaagctgc tggagggcga ggagagccgg
     1261 ttggctggag atggagtggg agccgtgaat atctctgtga tgaattccac tggtggcagt
     1321 agcagtggcg gtggcattgg gctgaccctc gggggaacca tgggcagcaa tgccctgagc
     1381 ttctccagca gtgcgggtcc tgggctcctg aaggcttatt ccatccggac cgcatccgcc
     1441 agtcgcagga gtgcccgcga ctgagccgcc tcccaccact ccactcctcc agccaccacc
     1501 cacaatcaca agaagattcc cacccctgcc tcccatgcct ggtcccaaga cagtgagaca
     1561 gtctggaaag tgatgtcaga atagcttcca ataaagcagc ctcattctga ggcctgagtg
     1621 atcca
//
