LOCUS       NM_005555               2302 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens keratin 6B (KRT6B), mRNA.
ACCESSION   NM_005555
VERSION     NM_005555.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2302)
  AUTHORS   Feng,Y., Huang,Z., Song,L., Li,N., Li,X., Shi,H., Liu,R., Lu,F.,
            Han,X., Ding,Y., Ding,Y., Wang,J., Yang,J. and Jia,Z.
  TITLE     PDE3B regulates KRT6B and increases the sensitivity of bladder
            cancer cells to copper ionophores
  JOURNAL   Naunyn Schmiedebergs Arch Pharmacol 397 (7), 4911-4925 (2024)
   PUBMED   38165426
  REMARK    GeneRIF: PDE3B regulates KRT6B and increases the sensitivity of
            bladder cancer cells to copper ionophores.
REFERENCE   2  (bases 1 to 2302)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 2302)
  AUTHORS   Hashmi,A.A., Hussain,Z.F., Irfan,M., Edhi,M.M., Kanwal,S.,
            Faridi,N. and Khan,A.
  TITLE     Cytokeratin 5/6 expression in bladder cancer: association with
            clinicopathologic parameters and prognosis
  JOURNAL   BMC Res Notes 11 (1), 207 (2018)
   PUBMED   29587848
  REMARK    GeneRIF: Data indicate that cytokeratin 5/6 (CK5/6) is an
            independent prognostic biomarker in urothelial carcinoma and
            therefore can be used in the prognostic stratification of the
            patients with bladder cancer.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2302)
  AUTHORS   Duverger,O., Carlson,J.C., Karacz,C.M., Schwartz,M.E., Cross,M.A.,
            Marazita,M.L., Shaffer,J.R. and Morasso,M.I.
  TITLE     Genetic variants in pachyonychia congenita-associated keratins
            increase susceptibility to tooth decay
  JOURNAL   PLoS Genet 14 (1), e1007168 (2018)
   PUBMED   29357356
  REMARK    GeneRIF: Several missense polymorphisms in KRT6A, KRT6B and KRT6C
            that lead to a higher risk for dental caries.
            Erratum:[PLoS Genet. 2019 Jun 24;15(6):e1008230. doi:
            10.1371/journal.pgen.1008230.. PMID: 31233495]
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2302)
  AUTHORS   Hu,J., Zhang,L.C., Song,X., Lu,J.R. and Jin,Z.
  TITLE     KRT6 interacting with notch1 contributes to progression of renal
            cell carcinoma, and aliskiren inhibits renal carcinoma cell lines
            proliferation in vitro
  JOURNAL   Int J Clin Exp Pathol 8 (8), 9182-9188 (2015)
   PUBMED   26464664
  REMARK    GeneRIF: These results suggested that the upregulation of notch1
            and KRT6B might be involved in the development, progression and
            prognosis of human renal cell carcinoma
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2302)
  AUTHORS   Smith,F.J.D., Hansen,C.D., Hull,P.R., Kaspar,R.L., McLean,W.H.I.,
            O'Toole,E. and Sprecher,E.
  TITLE     Pachyonychia Congenita
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301457
REFERENCE   7  (bases 1 to 2302)
  AUTHORS   Rasmussen,H.H., van Damme,J., Puype,M., Gesser,B., Celis,J.E. and
            Vandekerckhove,J.
  TITLE     Microsequences of 145 proteins recorded in the two-dimensional gel
            protein database of normal human epidermal keratinocytes
  JOURNAL   Electrophoresis 13 (12), 960-969 (1992)
   PUBMED   1286667
REFERENCE   8  (bases 1 to 2302)
  AUTHORS   Suo,Z., Holm,R. and Nesland,J.M.
  TITLE     Squamous cell carcinomas, an immunohistochemical and
            ultrastructural study
  JOURNAL   Anticancer Res 12 (6B), 2025-2031 (1992)
   PUBMED   1284199
REFERENCE   9  (bases 1 to 2302)
  AUTHORS   Rosenberg,M., Fuchs,E., Le Beau,M.M., Eddy,R.L. and Shows,T.B.
  TITLE     Three epidermal and one simple epithelial type II keratin genes map
            to human chromosome 12
  JOURNAL   Cytogenet Cell Genet 57 (1), 33-38 (1991)
   PUBMED   1713141
REFERENCE   10 (bases 1 to 2302)
  AUTHORS   Tyner,A.L., Eichman,M.J. and Fuchs,E.
  TITLE     The sequence of a type II keratin gene expressed in human skin:
            conservation of structure among all intermediate filament genes
  JOURNAL   Proc Natl Acad Sci U S A 82 (14), 4683-4687 (1985)
   PUBMED   2410904
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff in
            collaboration with Michael Rogers. The reference sequence was
            derived from AC055736.20, BC034535.1 and BG679927.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_005555.3.
            
            Summary: The protein encoded by this gene is a member of the
            keratin gene family. The type II cytokeratins consist of basic or
            neutral proteins which are arranged in pairs of heterotypic keratin
            chains coexpressed during differentiation of simple and stratified
            epithelial tissues. As many as six of this type II cytokeratin
            (KRT6) have been identified; the multiplicity of the genes is
            attributed to successive gene duplication events. The genes are
            expressed with family members KRT16 and/or KRT17 in the filiform
            papillae of the tongue, the stratified epithelial lining of oral
            mucosa and esophagus, the outer root sheath of hair follicles, and
            the glandular epithelia. Mutations in these genes have been
            associated with pachyonychia congenita. The type II cytokeratins
            are clustered in a region of chromosome 12q12-q13. [provided by
            RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC034535.1, ERR279831.6271.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2147975 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000252252.4/ ENSP00000252252.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-20                AC055736.20        111644-111663
            21-1968             BC034535.1         1-1948
            1969-2015           BG679927.1         750-796
            2016-2302           BC034535.1         1995-2281
FEATURES             Location/Qualifiers
     source          1..2302
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q13.13"
     gene            1..2302
                     /gene="KRT6B"
                     /gene_synonym="CK-6B; CK6B; K6B; KRTL1; PC2; PC4"
                     /note="keratin 6B"
                     /db_xref="GeneID:3854"
                     /db_xref="HGNC:HGNC:6444"
                     /db_xref="MIM:148042"
     exon            1..608
                     /gene="KRT6B"
                     /gene_synonym="CK-6B; CK6B; K6B; KRTL1; PC2; PC4"
                     /inference="alignment:Splign:2.1.0"
     CDS             69..1763
                     /gene="KRT6B"
                     /gene_synonym="CK-6B; CK6B; K6B; KRTL1; PC2; PC4"
                     /note="keratin-like 1 (a type II keratin sequence);
                     keratin, epidermal, type II, K6B; cytokeratin 6B; type-II
                     keratin Kb10; keratin 6B, type II"
                     /codon_start=1
                     /product="keratin, type II cytoskeletal 6B"
                     /protein_id="NP_005546.2"
                     /db_xref="CCDS:CCDS8828.1"
                     /db_xref="GeneID:3854"
                     /db_xref="HGNC:HGNC:6444"
                     /db_xref="MIM:148042"
                     /translation="MASTSTTIRSHSSSRRGFSANSARLPGVSRSGFSSISVSRSRGS
                     GGLGGACGGAGFGSRSLYGLGGSKRISIGGGSCAISGGYGSRAGGSYGFGGAGSGFGF
                     GGGAGIGFGLGGGAGLAGGFGGPGFPVCPPGGIQEVTVNQSLLTPLNLQIDPAIQRVR
                     AEEREQIKTLNNKFASFIDKVRFLEQQNKVLDTKWTLLQEQGTKTVRQNLEPLFEQYI
                     NNLRRQLDNIVGERGRLDSELRNMQDLVEDLKNKYEDEINKRTAAENEFVTLKKDVDA
                     AYMNKVELQAKADTLTDEINFLRALYDAELSQMQTHISDTSVVLSMDNNRNLDLDSII
                     AEVKAQYEEIAQRSRAEAESWYQTKYEELQITAGRHGDDLRNTKQEIAEINRMIQRLR
                     SEIDHVKKQCANLQAAIADAEQRGEMALKDAKNKLEGLEDALQKAKQDLARLLKEYQE
                     LMNVKLALDVEIATYRKLLEGEECRLNGEGVGQVNISVVQSTVSSGYGGASGVGSGLG
                     LGGGSSYSYGSGLGVGGGFSSSSGRATGGGLSSVGGGSSTIKYTTTSSSSRKSYKH"
     exon            609..823
                     /gene="KRT6B"
                     /gene_synonym="CK-6B; CK6B; K6B; KRTL1; PC2; PC4"
                     /inference="alignment:Splign:2.1.0"
     exon            824..884
                     /gene="KRT6B"
                     /gene_synonym="CK-6B; CK6B; K6B; KRTL1; PC2; PC4"
                     /inference="alignment:Splign:2.1.0"
     exon            885..980
                     /gene="KRT6B"
                     /gene_synonym="CK-6B; CK6B; K6B; KRTL1; PC2; PC4"
                     /inference="alignment:Splign:2.1.0"
     exon            981..1145
                     /gene="KRT6B"
                     /gene_synonym="CK-6B; CK6B; K6B; KRTL1; PC2; PC4"
                     /inference="alignment:Splign:2.1.0"
     exon            1146..1271
                     /gene="KRT6B"
                     /gene_synonym="CK-6B; CK6B; K6B; KRTL1; PC2; PC4"
                     /inference="alignment:Splign:2.1.0"
     exon            1272..1492
                     /gene="KRT6B"
                     /gene_synonym="CK-6B; CK6B; K6B; KRTL1; PC2; PC4"
                     /inference="alignment:Splign:2.1.0"
     exon            1493..1527
                     /gene="KRT6B"
                     /gene_synonym="CK-6B; CK6B; K6B; KRTL1; PC2; PC4"
                     /inference="alignment:Splign:2.1.0"
     exon            1528..2302
                     /gene="KRT6B"
                     /gene_synonym="CK-6B; CK6B; K6B; KRTL1; PC2; PC4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2279..2284
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KRT6B"
                     /gene_synonym="CK-6B; CK6B; K6B; KRTL1; PC2; PC4"
                     /note="hexamer: AATAAA"
     polyA_site      2302
                     /gene="KRT6B"
                     /gene_synonym="CK-6B; CK6B; K6B; KRTL1; PC2; PC4"
                     /note="major polyA site"
ORIGIN      
        1 gtcctgcttc tcctccctct cgcctccagc ctctcacact ctcctaagcc ctctcatctc
       61 ctggaaccat ggccagcaca tccaccacca tcaggagcca cagcagcagc cgccggggtt
      121 tcagtgccaa ctcagccagg ctccctgggg tcagccgctc tggcttcagc agcatctccg
      181 tgtcccgctc caggggcagt ggtggcctgg gtggcgcatg tggaggagct ggctttggca
      241 gccgcagtct gtatggcctg gggggctcca agaggatctc cattggaggg ggcagctgtg
      301 ccatcagtgg cggctatggc agcagagccg gaggcagcta tggctttggt ggcgccggga
      361 gtggatttgg tttcggtggt ggagccggca ttggctttgg tctgggtggt ggagccggcc
      421 ttgctggtgg ctttgggggc cctggcttcc ctgtgtgccc ccctggaggc atccaagagg
      481 tcactgtcaa ccagagtctc ctgactcccc tcaacctgca aattgacccc gccatccagc
      541 gggtgcgggc cgaggagcgt gagcagatca agaccctcaa caacaagttt gcctccttca
      601 tcgacaaggt gcggttccta gagcagcaga acaaggttct ggacaccaag tggaccctgc
      661 tgcaggagca gggcaccaag actgtgaggc agaacctgga gccgttgttc gagcagtaca
      721 tcaacaacct caggaggcag ctggacaaca tcgtggggga acggggtcgt ctggactcgg
      781 agctgagaaa catgcaggac ctggtggagg acctcaagaa caaatatgag gatgaaatca
      841 acaagcgcac agcagcagag aatgaatttg tgactctgaa gaaggatgtg gatgctgcct
      901 acatgaacaa ggttgaactg caagccaagg cagacactct tacagatgag atcaacttcc
      961 tgagagcctt gtatgatgca gagctgtccc agatgcagac ccacatctca gacacatccg
     1021 tggtgctatc catggacaac aaccgcaacc tggacctgga cagcatcatc gctgaggtca
     1081 aggcccaata tgaggagatt gctcagagga gcagggctga ggctgagtcc tggtaccaga
     1141 caaagtacga ggagctgcag atcacagcag gcagacatgg ggacgacctg cgcaacacca
     1201 agcaggagat tgctgagatc aaccgcatga tccagaggct gagatctgag atcgaccacg
     1261 tcaagaagca gtgtgccaac ctacaggccg ccattgctga tgctgagcag cgtggggaga
     1321 tggccctcaa ggatgctaag aacaagctgg aagggctgga ggatgccctg cagaaggcca
     1381 agcaggacct ggcccggctg ctgaaggagt accaggagct gatgaacgtc aagctggccc
     1441 tggatgtgga gatcgccacc taccgcaagc tgctggaggg cgaggagtgc aggctgaatg
     1501 gcgaaggcgt tggacaagtc aacatctctg tagtgcagtc caccgtctcc agtggctatg
     1561 gcggtgccag cggtgtcggc agtggcttag gcctgggtgg aggaagcagc tactcctatg
     1621 gcagtggtct tggcgttgga ggcggcttta gttccagcag cggcagagcc actgggggtg
     1681 gcctcagctc tgttggaggc ggcagttcca ccatcaagta caccaccacc tcctcctcca
     1741 gcaggaagag ctacaagcac tgaagtgctg ccgccagctc tcagtcccac agctctcagg
     1801 cccctctctg gcagcagagc cctctcctca ggttgcttgt cctcccctgg cctccagtct
     1861 cccctgccct cccgggtaga gctgggatgc cctcactttt cttctcatca atacctgttc
     1921 cactgagctc ctgttgctta ccatcaagtc aacagttatc agcactcaga catgcgaatg
     1981 tcctttttag ttcccgtatt attacaggta tctgagtctg ccataattct gagaagaaaa
     2041 tgacctatat ccccataaga actgaaactc agtctaggtc cagctgcaga tgaggagtcc
     2101 tctctttaat tgctaaccat cctgcccatt atagctacac tcaggagttc tcatctgaca
     2161 agtcagttgt cctgatcttc tcttgcagtg tccctgaatg gcaagtgatg taccttctga
     2221 tgcagtctgc attcctgcac tgctttctct gctctctttg ccttcttttg ttctgttgaa
     2281 taaagcatat tgagaatgtg aa
//
