LOCUS       NP_005545                564 aa            linear   PRI 27-APR-2025
DEFINITION  keratin, type II cytoskeletal 6A [Homo sapiens].
ACCESSION   NP_005545 NP_490596
VERSION     NP_005545.1
DBSOURCE    REFSEQ: accession NM_005554.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 564)
  AUTHORS   Harada-Kagitani,S., Kouchi,Y., Shinomiya,Y., Kodama,M., Ohira,G.,
            Matsubara,H., Ikeda,J.I. and Kishimoto,T.
  TITLE     Keratin 6A Is Expressed at the Invasive Front and Enhances the
            Progression of Colorectal Cancer
  JOURNAL   Lab Invest 104 (7), 102075 (2024)
   PUBMED   38729352
  REMARK    GeneRIF: Keratin 6A Is Expressed at the Invasive Front and Enhances
            the Progression of Colorectal Cancer.
REFERENCE   2  (residues 1 to 564)
  AUTHORS   Shinomiya,Y., Kouchi,Y., Harada-Kagitani,S., Ishige,T., Takano,S.,
            Ohtsuka,M., Ikeda,J.I. and Kishimoto,T.
  TITLE     ECM1 and KRT6A are involved in tumor progression and
            chemoresistance in the effect of dexamethasone on pancreatic cancer
  JOURNAL   Cancer Sci 115 (6), 1948-1963 (2024)
   PUBMED   38613239
  REMARK    GeneRIF: ECM1 and KRT6A are involved in tumor progression and
            chemoresistance in the effect of dexamethasone on pancreatic
            cancer.
REFERENCE   3  (residues 1 to 564)
  AUTHORS   Michalak-Micka,K., Tenini,C., Bottcher-Haberzeth,S., Mazzone,L.,
            Pontiggia,L., Klar,A.S., Moehrlen,U. and Biedermann,T.
  TITLE     The expression pattern of cytokeratin 6a in epithelial cells of
            different origin in dermo-epidermal skin substitutes in vivo
  JOURNAL   Biotechnol J 19 (1), e2300246 (2024)
   PUBMED   37766482
  REMARK    GeneRIF: The expression pattern of cytokeratin 6a in epithelial
            cells of different origin in dermo-epidermal skin substitutes in
            vivo.
REFERENCE   4  (residues 1 to 564)
  AUTHORS   Li,Y. and Wu,Q.
  TITLE     KRT6A Inhibits IL-1beta-Mediated Pyroptosis of Keratinocytes via
            Blocking IL-17 Signaling
  JOURNAL   Crit Rev Eukaryot Gene Expr 34 (4), 1-11 (2024)
   PUBMED   38505868
  REMARK    GeneRIF: KRT6A Inhibits IL-1beta-Mediated Pyroptosis of
            Keratinocytes via Blocking IL-17 Signaling.
REFERENCE   5  (residues 1 to 564)
  AUTHORS   Tam,C., Mun,J.J., Evans,D.J. and Fleiszig,S.M.
  TITLE     Cytokeratins mediate epithelial innate defense through their
            antimicrobial properties
  JOURNAL   J Clin Invest 122 (10), 3665-3677 (2012)
   PUBMED   23006328
  REMARK    GeneRIF: Keratin-derived antimicrobial peptides (KDAMPs) and their
            synthetic analogs exhibit antimicrobial activity against bacterial
            pathogens.
REFERENCE   6  (residues 1 to 564)
  AUTHORS   Takahashi,K., Paladini,R.D. and Coulombe,P.A.
  TITLE     Cloning and characterization of multiple human genes and cDNAs
            encoding highly related type II keratin 6 isoforms
  JOURNAL   J Biol Chem 270 (31), 18581-18592 (1995)
   PUBMED   7543104
REFERENCE   7  (residues 1 to 564)
  AUTHORS   Kouklis,P.D., Hutton,E. and Fuchs,E.
  TITLE     Making a connection: direct binding between keratin intermediate
            filaments and desmosomal proteins
  JOURNAL   J Cell Biol 127 (4), 1049-1060 (1994)
   PUBMED   7525601
REFERENCE   8  (residues 1 to 564)
  AUTHORS   Smith,F.J.D., Hansen,C.D., Hull,P.R., Kaspar,R.L., McLean,W.H.I.,
            O'Toole,E. and Sprecher,E.
  TITLE     Pachyonychia Congenita
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301457
REFERENCE   9  (residues 1 to 564)
  AUTHORS   Rosenberg,M., Fuchs,E., Le Beau,M.M., Eddy,R.L. and Shows,T.B.
  TITLE     Three epidermal and one simple epithelial type II keratin genes map
            to human chromosome 12
  JOURNAL   Cytogenet Cell Genet 57 (1), 33-38 (1991)
   PUBMED   1713141
REFERENCE   10 (residues 1 to 564)
  AUTHORS   Hanukoglu,I. and Fuchs,E.
  TITLE     The cDNA sequence of a Type II cytoskeletal keratin reveals
            constant and variable structural domains among keratins
  JOURNAL   Cell 33 (3), 915-924 (1983)
   PUBMED   6191871
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff in
            collaboration with Michael Rogers. The reference sequence was
            derived from DA451441.1 and BC008807.2.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Feb 27, 2007 this sequence version replaced NP_490596.1.
            
            Summary: The protein encoded by this gene is a member of the
            keratin gene family. The type II cytokeratins consist of basic or
            neutral proteins which are arranged in pairs of heterotypic keratin
            chains coexpressed during differentiation of simple and stratified
            epithelial tissues. As many as six of this type II cytokeratin
            (KRT6) have been identified; the multiplicity of the genes is
            attributed to successive gene duplication events. The genes are
            expressed with family members KRT16 and/or KRT17 in the filiform
            papillae of the tongue, the stratified epithelial lining of oral
            mucosa and esophagus, the outer root sheath of hair follicles, and
            the glandular epithelia. This KRT6 gene in particular encodes the
            most abundant isoform. Mutations in these genes have been
            associated with pachyonychia congenita. In addition, peptides from
            the C-terminal region of the protein have antimicrobial activity
            against bacterial pathogens. The type II cytokeratins are clustered
            in a region of chromosome 12q12-q13. [provided by RefSeq, Oct
            2014].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC008807.2, ERR279848.4870.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2147975, SAMEA2156670
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match                 :: ENST00000330722.7/
                                                  ENSP00000369317.3
            Protein has antimicrobial activity :: PMID: 23006328
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..564
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q13.13"
     Protein         1..564
                     /product="keratin, type II cytoskeletal 6A"
                     /note="keratin, epidermal type II, K6A; cytokeratin 6A;
                     cytokeratin 6C; cytokeratin 6D; type-II keratin Kb6;
                     keratin 6A, type II"
                     /calculated_mol_wt=59914
     Region          1..23
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P02538.3)"
     Region          2..162
                     /region_name="Head"
                     /note="propagated from UniProtKB/Swiss-Prot (P02538.3)"
     Site            2
                     /site_type="acetylation"
                     /note="N-acetylalanine. /evidence=ECO:0000269|Ref.4;
                     propagated from UniProtKB/Swiss-Prot (P02538.3)"
     Region          <59..159
                     /region_name="Keratin_2_head"
                     /note="Keratin type II head; pfam16208"
                     /db_xref="CDD:465068"
     Region          162..475
                     /region_name="Filament"
                     /note="Intermediate filament protein; pfam00038"
                     /db_xref="CDD:459643"
     Region          163..198
                     /region_name="Coil 1A"
                     /note="propagated from UniProtKB/Swiss-Prot (P02538.3)"
     Region          199..217
                     /region_name="Linker 1"
                     /note="propagated from UniProtKB/Swiss-Prot (P02538.3)"
     Region          218..309
                     /region_name="Coil 1B"
                     /note="propagated from UniProtKB/Swiss-Prot (P02538.3)"
     Region          310..333
                     /region_name="Linker 12"
                     /note="propagated from UniProtKB/Swiss-Prot (P02538.3)"
     Region          334..472
                     /region_name="Coil 2"
                     /note="propagated from UniProtKB/Swiss-Prot (P02538.3)"
     Site            414
                     /site_type="other"
                     /note="Stutter; propagated from UniProtKB/Swiss-Prot
                     (P02538.3)"
     Region          473..564
                     /region_name="Tail"
                     /note="propagated from UniProtKB/Swiss-Prot (P02538.3)"
     CDS             1..564
                     /gene="KRT6A"
                     /gene_synonym="CK-6C; CK-6E; CK6A; CK6C; CK6D; K6A; K6C;
                     K6D; KRT6C; KRT6D; PC3"
                     /coded_by="NM_005554.4:70..1764"
                     /db_xref="CCDS:CCDS41786.1"
                     /db_xref="GeneID:3853"
                     /db_xref="HGNC:HGNC:6443"
                     /db_xref="MIM:148041"
ORIGIN      
        1 maststtirs hsssrrgfsa nsarlpgvsr sgfssvsvsr srgsgglgga cggagfgsrs
       61 lyglggskri sigggscais ggygsraggs ygfggagsgf gfgggagigf glgggaglag
      121 gfggpgfpvc ppggiqevtv nqslltplnl qidptiqrvr aeereqiktl nnkfasfidk
      181 vrfleqqnkv letkwtllqe qgtktvrqnl eplfeqyinn lrrqldsivg ergrldselr
      241 gmqdlvedfk nkyedeinkr taaenefvtl kkdvdaaymn kvelqakadt ltdeinflra
      301 lydaelsqmq thisdtsvvl smdnnrnldl dsiiaevkaq yeeiaqrsra eaeswyqtky
      361 eelqvtagrh gddlrntkqe iaeinrmiqr lrseidhvkk qcanlqaaia daeqrgemal
      421 kdaknklegl edalqkakqd larllkeyqe lmnvklaldv eiatyrklle geecrlngeg
      481 vgqvnisvvq stvssgygga sgvgsglglg ggssysygsg lgvgggfsss sgraigggls
      541 svgggsstik ytttssssrk sykh
//
