LOCUS       NM_000424               2238 bp    mRNA    linear   PRI 04-OCT-2024
DEFINITION  Homo sapiens keratin 5 (KRT5), mRNA.
ACCESSION   NM_000424
VERSION     NM_000424.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2238)
  AUTHORS   Hewitt,R.J., Puttur,F., Gaboriau,D.C.A., Fercoq,F., Fresquet,M.,
            Traves,W.J., Yates,L.L., Walker,S.A., Molyneaux,P.L., Kemp,S.V.,
            Nicholson,A.G., Rice,A., Roberts,E., Lennon,R., Carlin,L.M.,
            Byrne,A.J., Maher,T.M. and Lloyd,C.M.
  TITLE     Lung extracellular matrix modulates KRT5+ basal cell activity in
            pulmonary fibrosis
  JOURNAL   Nat Commun 14 (1), 6039 (2023)
   PUBMED   37758700
  REMARK    GeneRIF: Lung extracellular matrix modulates KRT5[+] basal cell
            activity in pulmonary fibrosis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2238)
  AUTHORS   Sun,L., Wang,D., Chen,Z. and Zhu,X.
  TITLE     TRIM29 knockdown prevented the colon cancer progression through
            decreasing the ubiquitination levels of KRT5
  JOURNAL   Open Life Sci 18 (1), 20220711 (2023)
   PUBMED   37671092
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2238)
  AUTHORS   Thomsen,C., Blok-Husum,L., Georgsen,J.B., Steiniche,T. and
            Vyberg,M.
  TITLE     Keratin 5 in Lung Cancer Specimens: Comparison of Four Antibody
            Clones and KRT5 mRNA-ISH
  JOURNAL   Appl Immunohistochem Mol Morphol 31 (6), 347-353 (2023)
   PUBMED   37212698
  REMARK    GeneRIF: Keratin 5 in Lung Cancer Specimens: Comparison of Four
            Antibody Clones and KRT5 mRNA-ISH.
REFERENCE   4  (bases 1 to 2238)
  AUTHORS   Jia,W., Zhang,Y., Wang,X., Luo,L., Sun,H., Jiang,Y., Wang,J.,
            Mao,Q., Guo,Y., Kong,L., Mo,R. and Li,C.
  TITLE     KRT5 mutation regulate melanin metabolism through notch signalling
            pathway between keratinocytes and melanocytes
  JOURNAL   Exp Dermatol 32 (6), 752-765 (2023)
   PUBMED   36809573
  REMARK    GeneRIF: KRT5 mutation regulate melanin metabolism through notch
            signalling pathway between keratinocytes and melanocytes.
REFERENCE   5  (bases 1 to 2238)
  AUTHORS   Terada,K., Yoshizawa,A., Sumiyoshi,S., Rokutan-Kurata,M.,
            Nakajima,N., Hamaji,M., Sonobe,M., Menju,T., Date,H. and Haga,H.
  TITLE     Clinicopathological features of cytokeratin 5-positive pulmonary
            adenocarcinoma
  JOURNAL   Histopathology 82 (3), 439-453 (2023)
   PUBMED   36239561
  REMARK    GeneRIF: Clinicopathological features of cytokeratin 5-positive
            pulmonary adenocarcinoma.
REFERENCE   6  (bases 1 to 2238)
  AUTHORS   So,J.Y. and Teng,J.
  TITLE     Epidermolysis Bullosa Simplex
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301543
REFERENCE   7  (bases 1 to 2238)
  AUTHORS   Ohtsuki,M., Tomic-Canic,M., Freedberg,I.M. and Blumenberg,M.
  TITLE     Regulation of epidermal keratin expression by retinoic acid and
            thyroid hormone
  JOURNAL   J Dermatol 19 (11), 774-780 (1992)
   PUBMED   1284070
REFERENCE   8  (bases 1 to 2238)
  AUTHORS   Tavakkol,A., Griffiths,C.E., Keane,K.M., Palmer,R.D. and
            Voorhees,J.J.
  TITLE     Cellular localization of mRNA for cellular retinoic acid-binding
            protein II and nuclear retinoic acid receptor-gamma 1 in retinoic
            acid-treated human skin
  JOURNAL   J Invest Dermatol 99 (2), 146-150 (1992)
   PUBMED   1378478
REFERENCE   9  (bases 1 to 2238)
  AUTHORS   Lane,E.B., Rugg,E.L., Navsaria,H., Leigh,I.M., Heagerty,A.H.,
            Ishida-Yamamoto,A. and Eady,R.A.
  TITLE     A mutation in the conserved helix termination peptide of keratin 5
            in hereditary skin blistering
  JOURNAL   Nature 356 (6366), 244-246 (1992)
   PUBMED   1372711
REFERENCE   10 (bases 1 to 2238)
  AUTHORS   Rosenberg,M., Fuchs,E., Le Beau,M.M., Eddy,R.L. and Shows,T.B.
  TITLE     Three epidermal and one simple epithelial type II keratin genes map
            to human chromosome 12
  JOURNAL   Cytogenet Cell Genet 57 (1), 33-38 (1991)
   PUBMED   1713141
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff in
            collaboration with Michael Rogers. The reference sequence was
            derived from M21389.1 and BC071906.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_000424.3.
            
            Summary: The protein encoded by this gene is a member of the
            keratin gene family. The type II cytokeratins consist of basic or
            neutral proteins which are arranged in pairs of heterotypic keratin
            chains coexpressed during differentiation of simple and stratified
            epithelial tissues. This type II cytokeratin is specifically
            expressed in the basal layer of the epidermis with family member
            KRT14. Mutations in these genes have been associated with a complex
            of diseases termed epidermolysis bullosa simplex. The type II
            cytokeratins are clustered in a region of chromosome 12q12-q13.
            [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC024292.1, M21389.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145893, SAMEA2147596
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000252242.9/ ENSP00000252242.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-334               M21389.1           294-627
            335-727             BC071906.1         319-711
            728-1256            M21389.1           1021-1549
            1257-1679           BC071906.1         1241-1663
            1680-2236           M21389.1           1973-2529
            2237-2238           BC071906.1         2221-2222
FEATURES             Location/Qualifiers
     source          1..2238
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q13.13"
     gene            1..2238
                     /gene="KRT5"
                     /gene_synonym="CK5; DDD; DDD1; EBS1; EBS2; EBS2A; EBS2B;
                     EBS2C; EBS2D; EBS2E; EBS2F; K5; KRT5A"
                     /note="keratin 5"
                     /db_xref="GeneID:3852"
                     /db_xref="HGNC:HGNC:6442"
                     /db_xref="MIM:148040"
     exon            1..653
                     /gene="KRT5"
                     /gene_synonym="CK5; DDD; DDD1; EBS1; EBS2; EBS2A; EBS2B;
                     EBS2C; EBS2D; EBS2E; EBS2F; K5; KRT5A"
                     /inference="alignment:Splign:2.1.0"
     CDS             99..1871
                     /gene="KRT5"
                     /gene_synonym="CK5; DDD; DDD1; EBS1; EBS2; EBS2A; EBS2B;
                     EBS2C; EBS2D; EBS2E; EBS2F; K5; KRT5A"
                     /note="keratin 5 (epidermolysis bullosa simplex,
                     Dowling-Meara/Kobner/Weber-Cockayne types); keratin 5,
                     type II; epidermolysis bullosa simplex 2
                     Dowling-Meara/Kobner/Weber-Cockayne types; 58 kda
                     cytokeratin; CK-5; cytokeratin-5; type-II keratin Kb5"
                     /codon_start=1
                     /product="keratin, type II cytoskeletal 5"
                     /protein_id="NP_000415.2"
                     /db_xref="CCDS:CCDS8830.1"
                     /db_xref="GeneID:3852"
                     /db_xref="HGNC:HGNC:6442"
                     /db_xref="MIM:148040"
                     /translation="MSRQSSVSFRSGGSRSFSTASAITPSVSRTSFTSVSRSGGGGGG
                     GFGRVSLAGACGVGGYGSRSLYNLGGSKRISISTSGGSFRNRFGAGAGGGYGFGGGAG
                     SGFGFGGGAGGGFGLGGGAGFGGGFGGPGFPVCPPGGIQEVTVNQSLLTPLNLQIDPS
                     IQRVRTEEREQIKTLNNKFASFIDKVRFLEQQNKVLDTKWTLLQEQGTKTVRQNLEPL
                     FEQYINNLRRQLDSIVGERGRLDSELRNMQDLVEDFKNKYEDEINKRTTAENEFVMLK
                     KDVDAAYMNKVELEAKVDALMDEINFMKMFFDAELSQMQTHVSDTSVVLSMDNNRNLD
                     LDSIIAEVKAQYEEIANRSRTEAESWYQTKYEELQQTAGRHGDDLRNTKHEISEMNRM
                     IQRLRAEIDNVKKQCANLQNAIADAEQRGELALKDARNKLAELEEALQKAKQDMARLL
                     REYQELMNTKLALDVEIATYRKLLEGEECRLSGEGVGPVNISVVTSSVSSGYGSGSGY
                     GGGLGGGLGGGLGGGLAGGSSGSYYSSSSGGVGLGGGLSVGGSGFSASSGRGLGVGFG
                     SGGGSSSSVKFVSTTSSSRKSFKS"
     exon            654..868
                     /gene="KRT5"
                     /gene_synonym="CK5; DDD; DDD1; EBS1; EBS2; EBS2A; EBS2B;
                     EBS2C; EBS2D; EBS2E; EBS2F; K5; KRT5A"
                     /inference="alignment:Splign:2.1.0"
     exon            869..929
                     /gene="KRT5"
                     /gene_synonym="CK5; DDD; DDD1; EBS1; EBS2; EBS2A; EBS2B;
                     EBS2C; EBS2D; EBS2E; EBS2F; K5; KRT5A"
                     /inference="alignment:Splign:2.1.0"
     exon            930..1025
                     /gene="KRT5"
                     /gene_synonym="CK5; DDD; DDD1; EBS1; EBS2; EBS2A; EBS2B;
                     EBS2C; EBS2D; EBS2E; EBS2F; K5; KRT5A"
                     /inference="alignment:Splign:2.1.0"
     exon            1026..1190
                     /gene="KRT5"
                     /gene_synonym="CK5; DDD; DDD1; EBS1; EBS2; EBS2A; EBS2B;
                     EBS2C; EBS2D; EBS2E; EBS2F; K5; KRT5A"
                     /inference="alignment:Splign:2.1.0"
     exon            1191..1316
                     /gene="KRT5"
                     /gene_synonym="CK5; DDD; DDD1; EBS1; EBS2; EBS2A; EBS2B;
                     EBS2C; EBS2D; EBS2E; EBS2F; K5; KRT5A"
                     /inference="alignment:Splign:2.1.0"
     exon            1317..1537
                     /gene="KRT5"
                     /gene_synonym="CK5; DDD; DDD1; EBS1; EBS2; EBS2A; EBS2B;
                     EBS2C; EBS2D; EBS2E; EBS2F; K5; KRT5A"
                     /inference="alignment:Splign:2.1.0"
     exon            1538..1572
                     /gene="KRT5"
                     /gene_synonym="CK5; DDD; DDD1; EBS1; EBS2; EBS2A; EBS2B;
                     EBS2C; EBS2D; EBS2E; EBS2F; K5; KRT5A"
                     /inference="alignment:Splign:2.1.0"
     exon            1573..2238
                     /gene="KRT5"
                     /gene_synonym="CK5; DDD; DDD1; EBS1; EBS2; EBS2A; EBS2B;
                     EBS2C; EBS2D; EBS2E; EBS2F; K5; KRT5A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2216..2221
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KRT5"
                     /gene_synonym="CK5; DDD; DDD1; EBS1; EBS2; EBS2A; EBS2B;
                     EBS2C; EBS2D; EBS2E; EBS2F; K5; KRT5A"
                     /note="hexamer: AATAAA"
     polyA_site      2238
                     /gene="KRT5"
                     /gene_synonym="CK5; DDD; DDD1; EBS1; EBS2; EBS2A; EBS2B;
                     EBS2C; EBS2D; EBS2E; EBS2F; K5; KRT5A"
                     /note="major polyA site"
ORIGIN      
        1 aacagagcca ccttctgcgt cctgctgagc tctgttctct ccagcacctc ccaacccact
       61 agtgcctggt tctcttgctc caccaggaac aagccaccat gtctcgccag tcaagtgtgt
      121 ccttccggag cgggggcagt cgtagcttca gcaccgcctc tgccatcacc ccgtctgtct
      181 cccgcaccag cttcacctcc gtgtcccggt ccgggggtgg cggtggtggt ggcttcggca
      241 gggtcagcct tgcgggtgct tgtggagtgg gtggctatgg cagccggagc ctctacaacc
      301 tggggggctc caagaggata tccatcagca ctagtggtgg cagcttcagg aaccggtttg
      361 gtgctggtgc tggaggcggc tatggctttg gaggtggtgc cggtagtgga tttggtttcg
      421 gcggtggagc tggtggtggc tttgggctcg gtggcggagc tggctttgga ggtggcttcg
      481 gtggccctgg ctttcctgtc tgccctcctg gaggtatcca agaggtcact gtcaaccaga
      541 gtctcctgac tcccctcaac ctgcaaatcg accccagcat ccagagggtg aggaccgagg
      601 agcgcgagca gatcaagacc ctcaacaata agtttgcctc cttcatcgac aaggtgcggt
      661 tcctggagca gcagaacaag gttctggaca ccaagtggac cctgctgcag gagcagggca
      721 ccaagactgt gaggcagaac ctggagccgt tgttcgagca gtacatcaac aacctcagga
      781 ggcagctgga cagcatcgtg ggggaacggg gccgcctgga ctcagagctg agaaacatgc
      841 aggacctggt ggaagacttc aagaacaagt atgaggatga aatcaacaag cgtaccactg
      901 ctgagaatga gtttgtgatg ctgaagaagg atgtagatgc tgcctacatg aacaaggtgg
      961 agctggaggc caaggttgat gcactgatgg atgagattaa cttcatgaag atgttctttg
     1021 atgcggagct gtcccagatg cagacgcatg tctctgacac ctcagtggtc ctctccatgg
     1081 acaacaaccg caacctggac ctggatagca tcatcgctga ggtcaaggcc cagtatgagg
     1141 agattgccaa ccgcagccgg acagaagccg agtcctggta tcagaccaag tatgaggagc
     1201 tgcagcagac agctggccgg catggcgatg acctccgcaa caccaagcat gagatctctg
     1261 agatgaaccg gatgatccag aggctgagag ccgagattga caatgtcaag aaacagtgcg
     1321 ccaatctgca gaacgccatt gcggatgccg agcagcgtgg ggagctggcc ctcaaggatg
     1381 ccaggaacaa gctggccgag ctggaggagg ccctgcagaa ggccaagcag gacatggccc
     1441 ggctgctgcg tgagtaccag gagctcatga acaccaagct ggccctggac gtggagatcg
     1501 ccacttaccg caagctgctg gagggcgagg aatgcagact cagtggagaa ggagttggac
     1561 cagtcaacat ctctgttgtc acaagcagtg tttcctctgg atatggcagt ggcagtggct
     1621 atggcggtgg cctcggtgga ggtcttggcg gcggcctcgg tggaggtctt gccggaggta
     1681 gcagtggaag ctactactcc agcagcagtg ggggtgtcgg cctaggtggt gggctcagtg
     1741 tggggggctc tggcttcagt gcaagcagtg gccgagggct gggggtgggc tttggcagtg
     1801 gcgggggtag cagctccagc gtcaaatttg tctccaccac ctcctcctcc cggaagagct
     1861 tcaagagcta agaacctgct gcaagtcact gccttccaag tgcagcaacc cagcccatgg
     1921 agattgcctc ttctaggcag ttgctcaagc catgttttat ccttttctgg agagtagtct
     1981 agaccaagcc aattgcagaa ccacattctt tggttcccag gagagcccca ttcccagccc
     2041 ctggtctccc gtgccgcagt tctatattct gcttcaaatc agccttcagg tttcccacag
     2101 catggcccct gctgacacga gaacccaaag ttttcccaaa tctaaatcat caaaacagaa
     2161 tccccacccc aatcccaaat tttgttttgg ttctaactac ctccagaatg tgttcaataa
     2221 aatgctttta taatataa
//
