LOCUS       NM_003770               1743 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens keratin 37 (KRT37), mRNA.
ACCESSION   NM_003770
VERSION     NM_003770.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1743)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 1743)
  AUTHORS   Schweizer,J., Bowden,P.E., Coulombe,P.A., Langbein,L., Lane,E.B.,
            Magin,T.M., Maltais,L., Omary,M.B., Parry,D.A., Rogers,M.A. and
            Wright,M.W.
  TITLE     New consensus nomenclature for mammalian keratins
  JOURNAL   J Cell Biol 174 (2), 169-174 (2006)
   PUBMED   16831889
REFERENCE   3  (bases 1 to 1743)
  AUTHORS   Rogers,M.A., Winter,H., Langbein,L., Bleiler,R. and Schweizer,J.
  TITLE     The human type I keratin gene family: characterization of new hair
            follicle specific members and evaluation of the chromosome 17q21.2
            gene domain
  JOURNAL   Differentiation 72 (9-10), 527-540 (2004)
   PUBMED   15617563
REFERENCE   4  (bases 1 to 1743)
  AUTHORS   Langbein,L., Rogers,M.A., Winter,H., Praetzel,S., Beckhaus,U.,
            Rackwitz,H.R. and Schweizer,J.
  TITLE     The catalog of human hair keratins. I. Expression of the nine type
            I members in the hair follicle
  JOURNAL   J Biol Chem 274 (28), 19874-19884 (1999)
   PUBMED   10391933
REFERENCE   5  (bases 1 to 1743)
  AUTHORS   Rogers,M.A., Winter,H., Wolf,C., Heck,M. and Schweizer,J.
  TITLE     Characterization of a 190-kilobase pair domain of human type I hair
            keratin genes
  JOURNAL   J Biol Chem 273 (41), 26683-26691 (1998)
   PUBMED   9756910
REFERENCE   6  (bases 1 to 1743)
  AUTHORS   Yu,J., Yu,D.W., Checkla,D.M., Freedberg,I.M. and Bertolino,A.P.
  TITLE     Human hair keratins
  JOURNAL   J Invest Dermatol 101 (1 Suppl), 56S-59S (1993)
   PUBMED   7686952
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff in
            collaboration with Michael Rogers. The reference sequence was
            derived from AC003958.3.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_003770.4.
            
            Summary: The protein encoded by this gene is a member of the
            keratin gene family. As a type I hair keratin, it is an acidic
            protein which heterodimerizes with type II keratins to form hair
            and nails. The type I hair keratins are clustered in a region of
            chromosome 17q12-q21 and have the same direction of transcription.
            [provided by RefSeq, Jul 2008].
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ786655.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMEA1965299,
                                           SAMEA2155974 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000225550.4/ ENSP00000225550.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 5' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-554               AC003958.3         8351-8904
            555-637             AC003958.3         9092-9174
            638-794             AC003958.3         10002-10158
            795-956             AC003958.3         10502-10663
            957-1082            AC003958.3         10742-10867
            1083-1303           AC003958.3         11349-11569
            1304-1743           AC003958.3         11950-12389
FEATURES             Location/Qualifiers
     source          1..1743
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q21.2"
     gene            1..1743
                     /gene="KRT37"
                     /gene_synonym="HA7; K37; KRTHA7"
                     /note="keratin 37"
                     /db_xref="GeneID:8688"
                     /db_xref="HGNC:HGNC:6455"
                     /db_xref="MIM:604541"
     exon            1..554
                     /gene="KRT37"
                     /gene_synonym="HA7; K37; KRTHA7"
                     /inference="alignment:Splign:2.1.0"
     CDS             63..1412
                     /gene="KRT37"
                     /gene_synonym="HA7; K37; KRTHA7"
                     /note="keratin, hair, acidic, 7; hair keratin, type I Ha7;
                     keratin 37, type I"
                     /codon_start=1
                     /product="keratin, type I cuticular Ha7"
                     /protein_id="NP_003761.3"
                     /db_xref="CCDS:CCDS32653.1"
                     /db_xref="GeneID:8688"
                     /db_xref="HGNC:HGNC:6455"
                     /db_xref="MIM:604541"
                     /translation="MTSFYSTSSCPLGCTMAPGARNVFVSPIDVGCQPVAEANAASMC
                     LLANVAHANRVRVGSTPLGRPSLCLPPTSHTACPLPGTCHIPGNIGICGAYGKNTLNG
                     HEKETMKFLNDRLANYLEKVRQLEQENAELETTLLERSKCHESTVCPDYQSYFRTIEE
                     LQQKILCSKAENARLIVQIDNAKLAADDFRIKLESERSLHQLVEADKCGTQKLLDDAT
                     LAKADLEAQQESLKEEQLSLKSNHEQEVKILRSQLGEKFRIELDIEPTIDLNRVLGEM
                     RAQYEAMVETNHQDVEQWFQAQSEGISLQAMSCSEELQCCQSEILELRCTVNALEVER
                     QAQHTLKDCLQNSLCEAEDRYGTELAQMQSLISNLEEQLSEIRADLERQNQEYQVLLD
                     VKARLENEIATYRNLLESEDCKLPCNPCSTPASCTSCPSCGPVTGGSPSGHGASMGR"
     exon            555..637
                     /gene="KRT37"
                     /gene_synonym="HA7; K37; KRTHA7"
                     /inference="alignment:Splign:2.1.0"
     exon            638..794
                     /gene="KRT37"
                     /gene_synonym="HA7; K37; KRTHA7"
                     /inference="alignment:Splign:2.1.0"
     exon            795..956
                     /gene="KRT37"
                     /gene_synonym="HA7; K37; KRTHA7"
                     /inference="alignment:Splign:2.1.0"
     exon            957..1082
                     /gene="KRT37"
                     /gene_synonym="HA7; K37; KRTHA7"
                     /inference="alignment:Splign:2.1.0"
     exon            1083..1303
                     /gene="KRT37"
                     /gene_synonym="HA7; K37; KRTHA7"
                     /inference="alignment:Splign:2.1.0"
     exon            1304..1743
                     /gene="KRT37"
                     /gene_synonym="HA7; K37; KRTHA7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1721..1726
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KRT37"
                     /gene_synonym="HA7; K37; KRTHA7"
                     /note="hexamer: AATAAA"
     polyA_site      1743
                     /gene="KRT37"
                     /gene_synonym="HA7; K37; KRTHA7"
                     /note="major polyA site"
ORIGIN      
        1 agtctcagtg gctcagcctt cccagctgat ctgaagctcc tgtgcagcct cagccctaca
       61 ccatgacctc cttctacagc acctcctcat gccctctggg ttgcaccatg gctcctggag
      121 caagaaatgt ctttgtctct cctatcgatg ttgggtgcca gcctgtggca gaggccaatg
      181 ctgcctccat gtgcctcttg gccaacgtgg cacacgccaa cagagtccgt gtggggtcga
      241 ctcccctggg ccgccccagc ctctgtctgc ccccaaccag tcacactgct tgtcccttgc
      301 cagggacctg tcacattccc ggcaacatcg gaatctgtgg ggcctacggc aaaaacaccc
      361 tgaatggcca tgagaaggag accatgaagt tcctgaatga ccgcctggcc aactacctgg
      421 agaaggtgcg ccagctggag caggagaatg cagagctgga gaccacactc ctcgagagga
      481 gcaagtgcca cgagtccacc gtgtgccccg actaccagtc ctacttccgt acaatcgagg
      541 agctccagca gaagatcctg tgcagcaagg ctgagaatgc caggctgatt gtacaaattg
      601 acaacgcgaa gctggctgct gatgacttta ggatcaagct ggagagtgag cgctcccttc
      661 accagctggt ggaggcggac aagtgcggga cgcagaagct cctggatgac gcgaccctgg
      721 ccaaggccga cctggaggcc cagcaggagt ccctgaagga ggagcagctc tccctcaaga
      781 gcaaccacga gcaggaagta aagattctga ggagtcagct gggggagaag ttccggatcg
      841 agctggacat tgagcccacc attgacctga acagggtgtt gggggagatg cgggctcagt
      901 acgaggccat ggtggagacc aaccaccagg atgtggaaca gtggttccaa gcccagtctg
      961 aaggcatcag cctgcaggcc atgtcctgct ccgaggagct gcagtgctgc cagtcggaga
     1021 tcctggagct gagatgcacg gtgaatgccc tggaggtgga gcgccaagcc cagcacacct
     1081 tgaaggactg tctgcagaac tccctgtgtg aagcggagga ccgctacggc acagagctgg
     1141 cccagatgca gagcctcatt agcaacttgg aagagcagtt gtctgagatc cgggccgacc
     1201 tggagcggca gaaccaggag taccaggtgc tgctggacgt gaaggcccgg ttggagaacg
     1261 agattgccac ataccggaac cttctggaga gcgaggactg caaactcccc tgcaatccct
     1321 gttccacgcc tgcctcctgt acttcttgtc caagctgtgg ccctgtcacc ggtgggtctc
     1381 cctctggcca tggagccagc atggggagat gattctgaag gcccgagtta ggagattgag
     1441 gctggttgca ctggggtcag gagtgccctc accttgccca gtcttccttc aagactagac
     1501 tcactgaggc attttcccta aatcaaccgg tagcagatac ttccaaggag tggctccctg
     1561 cctatgcctc taagctgtat tttttgttgt tgctaaaatg ttgtaattat cttccatgaa
     1621 agcaattatt tttcctggtg tctcttcttg gtacttttag ttctattcca gtgtttcaga
     1681 atctccaaaa atgtaactgg gttccctgca ttaaatggtc aataaacctc cttcctgcac
     1741 caa
//
