LOCUS       NM_003771               1690 bp    mRNA    linear   PRI 10-JUN-2024
DEFINITION  Homo sapiens keratin 36 (KRT36), mRNA.
ACCESSION   NM_003771
VERSION     NM_003771.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1690)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 1690)
  AUTHORS   Boldrup,L., Gu,X., Coates,P.J., Norberg-Spaak,L., Fahraeus,R.,
            Laurell,G., Wilms,T. and Nylander,K.
  TITLE     Gene expression changes in tumor free tongue tissue adjacent to
            tongue squamous cell carcinoma
  JOURNAL   Oncotarget 8 (12), 19389-19402 (2017)
   PUBMED   28038473
  REMARK    GeneRIF: Low KRT36 expression is associated with tongue squamous
            cell carcinoma.
REFERENCE   3  (bases 1 to 1690)
  AUTHORS   Schweizer,J., Bowden,P.E., Coulombe,P.A., Langbein,L., Lane,E.B.,
            Magin,T.M., Maltais,L., Omary,M.B., Parry,D.A., Rogers,M.A. and
            Wright,M.W.
  TITLE     New consensus nomenclature for mammalian keratins
  JOURNAL   J Cell Biol 174 (2), 169-174 (2006)
   PUBMED   16831889
REFERENCE   4  (bases 1 to 1690)
  AUTHORS   Langbein,L., Rogers,M.A., Winter,H., Praetzel,S., Beckhaus,U.,
            Rackwitz,H.R. and Schweizer,J.
  TITLE     The catalog of human hair keratins. I. Expression of the nine type
            I members in the hair follicle
  JOURNAL   J Biol Chem 274 (28), 19874-19884 (1999)
   PUBMED   10391933
REFERENCE   5  (bases 1 to 1690)
  AUTHORS   Rogers,M.A., Winter,H., Wolf,C., Heck,M. and Schweizer,J.
  TITLE     Characterization of a 190-kilobase pair domain of human type I hair
            keratin genes
  JOURNAL   J Biol Chem 273 (41), 26683-26691 (1998)
   PUBMED   9756910
REFERENCE   6  (bases 1 to 1690)
  AUTHORS   Fuchs,E. and Weber,K.
  TITLE     Intermediate filaments: structure, dynamics, function, and disease
  JOURNAL   Annu Rev Biochem 63, 345-382 (1994)
   PUBMED   7979242
  REMARK    Review article
REFERENCE   7  (bases 1 to 1690)
  AUTHORS   Yu,J., Yu,D.W., Checkla,D.M., Freedberg,I.M. and Bertolino,A.P.
  TITLE     Human hair keratins
  JOURNAL   J Invest Dermatol 101 (1 Suppl), 56S-59S (1993)
   PUBMED   7686952
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. This record has been curated by NCBI staff in
            collaboration with Michael Rogers. The reference sequence was
            derived from AC019349.28.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Sep 17, 2020 this sequence version replaced NM_003771.4.
            
            Summary: The protein encoded by this gene is a member of the
            keratin gene family. This type I hair keratin is an acidic protein
            which heterodimerizes with type II keratins to form hair and nails.
            The type I hair keratins are clustered in a region of chromosome
            17q12-q21 and have the same direction of transcription. [provided
            by RefSeq, Jul 2008].
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA1968968,
                              SAMEA2155628 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000328119.11/ ENSP00000329165.6
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-505               AC019349.28        108225-108729
            506-588             AC019349.28        109411-109493
            589-745             AC019349.28        109736-109892
            746-907             AC019349.28        110398-110559
            908-1033            AC019349.28        110659-110784
            1034-1254           AC019349.28        110965-111185
            1255-1690           AC019349.28        111564-111999
FEATURES             Location/Qualifiers
     source          1..1690
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q21.2"
     gene            1..1690
                     /gene="KRT36"
                     /gene_synonym="HA6; hHa6; KRTHA6"
                     /note="keratin 36"
                     /db_xref="GeneID:8689"
                     /db_xref="HGNC:HGNC:6454"
                     /db_xref="MIM:604540"
     exon            1..505
                     /gene="KRT36"
                     /gene_synonym="HA6; hHa6; KRTHA6"
                     /inference="alignment:Splign:2.1.0"
     CDS             47..1450
                     /gene="KRT36"
                     /gene_synonym="HA6; hHa6; KRTHA6"
                     /note="keratin, hair, acidic, 6; K36; hair keratin, type I
                     Ha6; keratin 36, type I"
                     /codon_start=1
                     /product="keratin, type I cuticular Ha6"
                     /protein_id="NP_003762.1"
                     /db_xref="CCDS:CCDS11395.1"
                     /db_xref="GeneID:8689"
                     /db_xref="HGNC:HGNC:6454"
                     /db_xref="MIM:604540"
                     /translation="MATQTCTPTFSTGSIKGLCGTAGGISRVSSIRSVGSCRVPSLAG
                     AAGYISSARSGLSGLGSCLPGSYLSSECHTSGFVGSGGWFCEGSFNGSEKETMQFLND
                     RLANYLEKVRQLERENAELESRIQEWYEFQIPYICPDYQSYFKTIEDFQQKILLTKSE
                     NARLVLQIDNAKLAADDFRTKYETELSLRQLVEADINGLRRILDELTLCKADLEAQVE
                     SLKEELMCLKKNHEEEVSVLRCQLGDRLNVEVDAAPPVDLNKILEDMRCQYEALVENN
                     RRDVEAWFNTQTEELNQQVVSSSEQLQCCQTEIIELRRTVNALEIELQAQHSMRNSLE
                     STLAETEARYSSQLAQMQCLISNVEAQLSEIRCDLERQNQEYQVLLDVKARLEGEIAT
                     YRHLLEGEDCKLPPQPCATACKPVIRVPSVPPVPCVPSVPCTPAPQVGTQIRTITEEI
                     RDGKVISSREHVQSRPL"
     exon            506..588
                     /gene="KRT36"
                     /gene_synonym="HA6; hHa6; KRTHA6"
                     /inference="alignment:Splign:2.1.0"
     exon            589..745
                     /gene="KRT36"
                     /gene_synonym="HA6; hHa6; KRTHA6"
                     /inference="alignment:Splign:2.1.0"
     exon            746..907
                     /gene="KRT36"
                     /gene_synonym="HA6; hHa6; KRTHA6"
                     /inference="alignment:Splign:2.1.0"
     exon            908..1033
                     /gene="KRT36"
                     /gene_synonym="HA6; hHa6; KRTHA6"
                     /inference="alignment:Splign:2.1.0"
     exon            1034..1254
                     /gene="KRT36"
                     /gene_synonym="HA6; hHa6; KRTHA6"
                     /inference="alignment:Splign:2.1.0"
     exon            1255..1690
                     /gene="KRT36"
                     /gene_synonym="HA6; hHa6; KRTHA6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1657..1662
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KRT36"
                     /gene_synonym="HA6; hHa6; KRTHA6"
                     /note="hexamer: AATAAA"
     polyA_site      1690
                     /gene="KRT36"
                     /gene_synonym="HA6; hHa6; KRTHA6"
                     /note="major polyA site"
ORIGIN      
        1 agaacctgag ctccttgcta agctgcaacc ttcctctgct agcaccatgg ccacccagac
       61 ctgcacccct accttctcca ctgggtctat caagggcctc tgtggcacag caggcggcat
      121 ctctcgggtg tcctccatcc gttctgtggg ctcctgcagg gtccccagtc tcgccggtgc
      181 tgcagggtac atctcttctg ctaggtcggg cctctctggc cttgggagct gcttgcctgg
      241 ctcctacctg tcttctgagt gccacacctc tggctttgtg gggagcgggg gctggttctg
      301 cgagggctcc ttcaacggca gcgagaagga gactatgcag ttcctgaacg accgcctggc
      361 caactacctg gagaaggtgc gtcagctgga gcgggagaac gcggagctgg agagccgcat
      421 ccaggagtgg tacgagtttc agatcccata catctgccca gactaccagt cctacttcaa
      481 gaccatcgaa gatttccagc agaagatcct gctgactaag tctgagaatg ccaggctggt
      541 cctgcagatt gataatgcca agctggctgc tgacgacttc cggaccaagt atgagacaga
      601 gctgtctctg cggcagctag tggaggccga catcaacggc ctgcgtagga tcctggatga
      661 gctgaccctg tgcaaggctg acctggaggc tcaggtggag tccctgaagg aggagctgat
      721 gtgcctcaag aagaatcacg aggaggaagt cagtgtactc cgttgccaac ttggggaccg
      781 actgaatgtg gaggtggacg ctgctccccc agtggatctc aacaagatcc tggaggatat
      841 gagatgccag tacgaggccc tggtggagaa taaccgcaga gatgtggagg cctggttcaa
      901 cacccagact gaggagctga accagcaggt ggtgtccagc tcggagcagc tgcagtgctg
      961 ccagacggag atcatcgagc tgagacgtac ggtcaacgcg ctagagattg agctgcaggc
     1021 tcagcacagc atgcggaatt ccttggaatc caccctggcc gaaaccgagg cccgctacag
     1081 ctcccagctg gcccagatgc agtgcctgat cagcaacgtg gaggcccagc tgtctgagat
     1141 ccgctgcgac ctggagcggc agaaccagga gtaccaggtg ttactggacg tcaaggcccg
     1201 gctggagggc gagatcgcta cctaccgcca cctgctggag ggagaggact gcaagcttcc
     1261 tccccaacct tgtgccacgg catgcaagcc tgttattaga gttccttctg tccccccggt
     1321 gccctgtgtc ccctctgtgc cctgcacccc ggctccccag gttggcactc agatccgcac
     1381 catcaccgag gagatcagag atgggaaagt catctcctcc agggagcacg tgcagtcccg
     1441 cccgctgtga cagcccactt ggtccaccag ggcagggccc tgaccacagg aaggaggaca
     1501 cccctgtggc tcctggaggc ttaacgaccc tgcccttctc tagaggggtc cccctacgct
     1561 tagcaggttt ttctaccaaa acactccccg tattgtgttt ccggacttaa ctgtgctttt
     1621 acgccatgca aaaccaggtt tcctggaaat ttacccaata aagtgtgttc tcctggcata
     1681 gcaaactcaa
//
