LOCUS       NP_003762                467 aa            linear   PRI 30-APR-2025
DEFINITION  keratin, type I cuticular Ha6 [Homo sapiens].
ACCESSION   NP_003762
VERSION     NP_003762.1
DBSOURCE    REFSEQ: accession NM_003771.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 467)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (residues 1 to 467)
  AUTHORS   Boldrup,L., Gu,X., Coates,P.J., Norberg-Spaak,L., Fahraeus,R.,
            Laurell,G., Wilms,T. and Nylander,K.
  TITLE     Gene expression changes in tumor free tongue tissue adjacent to
            tongue squamous cell carcinoma
  JOURNAL   Oncotarget 8 (12), 19389-19402 (2017)
   PUBMED   28038473
  REMARK    GeneRIF: Low KRT36 expression is associated with tongue squamous
            cell carcinoma.
REFERENCE   3  (residues 1 to 467)
  AUTHORS   Schweizer,J., Bowden,P.E., Coulombe,P.A., Langbein,L., Lane,E.B.,
            Magin,T.M., Maltais,L., Omary,M.B., Parry,D.A., Rogers,M.A. and
            Wright,M.W.
  TITLE     New consensus nomenclature for mammalian keratins
  JOURNAL   J Cell Biol 174 (2), 169-174 (2006)
   PUBMED   16831889
REFERENCE   4  (residues 1 to 467)
  AUTHORS   Langbein,L., Rogers,M.A., Winter,H., Praetzel,S., Beckhaus,U.,
            Rackwitz,H.R. and Schweizer,J.
  TITLE     The catalog of human hair keratins. I. Expression of the nine type
            I members in the hair follicle
  JOURNAL   J Biol Chem 274 (28), 19874-19884 (1999)
   PUBMED   10391933
REFERENCE   5  (residues 1 to 467)
  AUTHORS   Rogers,M.A., Winter,H., Wolf,C., Heck,M. and Schweizer,J.
  TITLE     Characterization of a 190-kilobase pair domain of human type I hair
            keratin genes
  JOURNAL   J Biol Chem 273 (41), 26683-26691 (1998)
   PUBMED   9756910
REFERENCE   6  (residues 1 to 467)
  AUTHORS   Fuchs,E. and Weber,K.
  TITLE     Intermediate filaments: structure, dynamics, function, and disease
  JOURNAL   Annu Rev Biochem 63, 345-382 (1994)
   PUBMED   7979242
  REMARK    Review article
REFERENCE   7  (residues 1 to 467)
  AUTHORS   Yu,J., Yu,D.W., Checkla,D.M., Freedberg,I.M. and Bertolino,A.P.
  TITLE     Human hair keratins
  JOURNAL   J Invest Dermatol 101 (1 Suppl), 56S-59S (1993)
   PUBMED   7686952
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. This record has been curated by NCBI staff in
            collaboration with Michael Rogers. The reference sequence was
            derived from AC019349.28.
            This sequence is a reference standard in the RefSeqGene project.
            
            Summary: The protein encoded by this gene is a member of the
            keratin gene family. This type I hair keratin is an acidic protein
            which heterodimerizes with type II keratins to form hair and nails.
            The type I hair keratins are clustered in a region of chromosome
            17q12-q21 and have the same direction of transcription. [provided
            by RefSeq, Jul 2008].
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA1968968,
                              SAMEA2155628 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000328119.11/ ENSP00000329165.6
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..467
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q21.2"
     Protein         1..467
                     /product="keratin, type I cuticular Ha6"
                     /note="keratin, hair, acidic, 6; K36; hair keratin, type I
                     Ha6; keratin 36, type I"
                     /calculated_mol_wt=52116
     Region          1..93
                     /region_name="Head"
                     /note="propagated from UniProtKB/Swiss-Prot (O76013.1)"
     Region          92..403
                     /region_name="Filament"
                     /note="Intermediate filament protein; pfam00038"
                     /db_xref="CDD:459643"
     Region          94..128
                     /region_name="Coil 1A"
                     /note="propagated from UniProtKB/Swiss-Prot (O76013.1)"
     Region          129..139
                     /region_name="Linker 1"
                     /note="propagated from UniProtKB/Swiss-Prot (O76013.1)"
     Region          140..240
                     /region_name="Coil 1B"
                     /note="propagated from UniProtKB/Swiss-Prot (O76013.1)"
     Region          241..256
                     /region_name="Linker 12"
                     /note="propagated from UniProtKB/Swiss-Prot (O76013.1)"
     Region          257..400
                     /region_name="Coil 2"
                     /note="propagated from UniProtKB/Swiss-Prot (O76013.1)"
     Site            342
                     /site_type="other"
                     /note="Stutter; propagated from UniProtKB/Swiss-Prot
                     (O76013.1)"
     Region          401..467
                     /region_name="Tail"
                     /note="propagated from UniProtKB/Swiss-Prot (O76013.1)"
     CDS             1..467
                     /gene="KRT36"
                     /gene_synonym="HA6; hHa6; KRTHA6"
                     /coded_by="NM_003771.5:47..1450"
                     /db_xref="CCDS:CCDS11395.1"
                     /db_xref="GeneID:8689"
                     /db_xref="HGNC:HGNC:6454"
                     /db_xref="MIM:604540"
ORIGIN      
        1 matqtctptf stgsikglcg taggisrvss irsvgscrvp slagaagyis sarsglsglg
       61 sclpgsylss echtsgfvgs ggwfcegsfn gseketmqfl ndrlanylek vrqlerenae
      121 lesriqewye fqipyicpdy qsyfktiedf qqkilltkse narlvlqidn aklaaddfrt
      181 kyetelslrq lveadinglr rildeltlck adleaqvesl keelmclkkn heeevsvlrc
      241 qlgdrlnvev daappvdlnk iledmrcqye alvennrrdv eawfntqtee lnqqvvssse
      301 qlqccqteii elrrtvnale ielqaqhsmr nslestlaet earyssqlaq mqclisnvea
      361 qlseircdle rqnqeyqvll dvkarlegei atyrhllege dcklppqpca tackpvirvp
      421 svppvpcvps vpctpapqvg tqirtiteei rdgkvissre hvqsrpl
//
