LOCUS       NM_002280               1768 bp    mRNA    linear   PRI 12-JUN-2024
DEFINITION  Homo sapiens keratin 35 (KRT35), mRNA.
ACCESSION   NM_002280 XM_011524794
VERSION     NM_002280.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1768)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 1768)
  AUTHORS   Pieragostino,D., Agnifili,L., Fasanella,V., D'Aguanno,S.,
            Mastropasqua,R., Di Ilio,C., Sacchetta,P., Urbani,A. and Del
            Boccio,P.
  TITLE     Shotgun proteomics reveals specific modulated protein patterns in
            tears of patients with primary open angle glaucoma naive to therapy
  JOURNAL   Mol Biosyst 9 (6), 1108-1116 (2013)
   PUBMED   23580065
REFERENCE   3  (bases 1 to 1768)
  AUTHORS   Gilon,M., Sher,N., Cohen,S. and Gat,U.
  TITLE     Transcriptional activation of a subset of hair keratin genes by the
            NF-kappaB effector p65/RelA
  JOURNAL   Differentiation 76 (5), 518-530 (2008)
   PUBMED   18021261
  REMARK    GeneRIF: p65 induces transcriptional activation of Ha5. It is
            co-expressed with it & may mediate the NF-kappaB pathway's
            activity. There are major NF-kappaB/RelA binding sites in its
            regulatory region; p65 binds directly to these sites.
REFERENCE   4  (bases 1 to 1768)
  AUTHORS   Schweizer,J., Bowden,P.E., Coulombe,P.A., Langbein,L., Lane,E.B.,
            Magin,T.M., Maltais,L., Omary,M.B., Parry,D.A., Rogers,M.A. and
            Wright,M.W.
  TITLE     New consensus nomenclature for mammalian keratins
  JOURNAL   J Cell Biol 174 (2), 169-174 (2006)
   PUBMED   16831889
REFERENCE   5  (bases 1 to 1768)
  AUTHORS   Cribier,B., Peltre,B., Grosshans,E., Langbein,L. and Schweizer,J.
  TITLE     On the regulation of hair keratin expression: lessons from studies
            in pilomatricomas
  JOURNAL   J Invest Dermatol 122 (5), 1078-1083 (2004)
   PUBMED   15140206
  REMARK    GeneRIF: the co-expression of hair keratin hHa5 with its regulatory
            nuclear homeoprotein HOXC13 in matrix cells of the hair follicle is
            maintained in lower transitional cells of pilomatricomas
REFERENCE   6  (bases 1 to 1768)
  AUTHORS   Langbein,L., Rogers,M.A., Winter,H., Praetzel,S., Beckhaus,U.,
            Rackwitz,H.R. and Schweizer,J.
  TITLE     The catalog of human hair keratins. I. Expression of the nine type
            I members in the hair follicle
  JOURNAL   J Biol Chem 274 (28), 19874-19884 (1999)
   PUBMED   10391933
REFERENCE   7  (bases 1 to 1768)
  AUTHORS   Rogers,M.A., Winter,H., Wolf,C., Heck,M. and Schweizer,J.
  TITLE     Characterization of a 190-kilobase pair domain of human type I hair
            keratin genes
  JOURNAL   J Biol Chem 273 (41), 26683-26691 (1998)
   PUBMED   9756910
REFERENCE   8  (bases 1 to 1768)
  AUTHORS   Rogers,M.A., Winter,H., Langbein,L., Krieg,T. and Schweizer,J.
  TITLE     Genomic characterization of the human type I cuticular hair keratin
            hHa2 and identification of an adjacent novel type I hair keratin
            gene hHa5
  JOURNAL   J Invest Dermatol 107 (4), 633-638 (1996)
   PUBMED   8823373
REFERENCE   9  (bases 1 to 1768)
  AUTHORS   Yu,J., Yu,D.W., Checkla,D.M., Freedberg,I.M. and Bertolino,A.P.
  TITLE     Human hair keratins
  JOURNAL   J Invest Dermatol 101 (1 Suppl), 56S-59S (1993)
   PUBMED   7686952
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff in
            collaboration with Michael Rogers. The reference sequence was
            derived from AC019349.28.
            This sequence is a reference standard in the RefSeqGene project.
            
            On or before Oct 19, 2020 this sequence version replaced
            XM_011524794.1, NM_002280.5.
            
            Summary: The protein encoded by this gene is a member of the
            keratin gene family. This type I hair keratin is an acidic protein
            which heterodimerizes with type II keratins to form hair and nails.
            The type I hair keratins are clustered in a region of chromosome
            17q12-q21 and have the same direction of transcription. [provided
            by RefSeq, Jul 2008].
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA1968832, SAMEA1968968
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000246639.7/ ENSP00000246639.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-525               AC019349.28        116984-117508
            526-608             AC019349.28        118354-118436
            609-765             AC019349.28        118632-118788
            766-927             AC019349.28        119140-119301
            928-1053            AC019349.28        119649-119774
            1054-1274           AC019349.28        120397-120617
            1275-1768           AC019349.28        120932-121425
FEATURES             Location/Qualifiers
     source          1..1768
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q21.2"
     gene            1..1768
                     /gene="KRT35"
                     /gene_synonym="Ha-5; HA5; hHa5; K35; KRTHA5"
                     /note="keratin 35"
                     /db_xref="GeneID:3886"
                     /db_xref="HGNC:HGNC:6453"
                     /db_xref="MIM:602764"
     exon            1..525
                     /gene="KRT35"
                     /gene_synonym="Ha-5; HA5; hHa5; K35; KRTHA5"
                     /inference="alignment:Splign:2.1.0"
     CDS             55..1422
                     /gene="KRT35"
                     /gene_synonym="Ha-5; HA5; hHa5; K35; KRTHA5"
                     /note="keratin, hair, acidic, 5; hard keratin, type I, 5;
                     HHa5 hair keratin type I intermediate filament; hair
                     keratin, type I Ha5; keratin 35, type I"
                     /codon_start=1
                     /product="keratin, type I cuticular Ha5"
                     /protein_id="NP_002271.3"
                     /db_xref="CCDS:CCDS11394.2"
                     /db_xref="GeneID:3886"
                     /db_xref="HGNC:HGNC:6453"
                     /db_xref="MIM:602764"
                     /translation="MASKCLKAGFSSGSLKSPGGASGGSTRVSAMYSSSSCKLPSLSP
                     VARSFSACSVGLGRSSYRATSCLPALCLPAGGFATSYSGGGGWFGEGILTGNEKETMQ
                     SLNDRLAGYLEKVRQLEQENASLESRIREWCEQQVPYMCPDYQSYFRTIEELQKKTLC
                     SKAENARLVVEIDNAKLAADDFRTKYETEVSLRQLVESDINGLRRILDDLTLCKSDLE
                     AQVESLKEELLCLKKNHEEEVNSLRCQLGDRLNVEVDAAPPVDLNRVLEEMRCQYETL
                     VENNRRDAEDWLDTQSEELNQQVVSSSEQLQSCQAEIIELRRTVNALEIELQAQHSMR
                     DALESTLAETEARYSSQLAQMQCMITNVEAQLAEIRADLERQNQEYQVLLDVRARLEC
                     EINTYRGLLESEDSKLPCNPCAPDYSPSKSCLPCLPAASCGPSAARTNCSPRPICVPC
                     PGGRF"
     exon            526..608
                     /gene="KRT35"
                     /gene_synonym="Ha-5; HA5; hHa5; K35; KRTHA5"
                     /inference="alignment:Splign:2.1.0"
     exon            609..765
                     /gene="KRT35"
                     /gene_synonym="Ha-5; HA5; hHa5; K35; KRTHA5"
                     /inference="alignment:Splign:2.1.0"
     exon            766..927
                     /gene="KRT35"
                     /gene_synonym="Ha-5; HA5; hHa5; K35; KRTHA5"
                     /inference="alignment:Splign:2.1.0"
     exon            928..1053
                     /gene="KRT35"
                     /gene_synonym="Ha-5; HA5; hHa5; K35; KRTHA5"
                     /inference="alignment:Splign:2.1.0"
     exon            1054..1274
                     /gene="KRT35"
                     /gene_synonym="Ha-5; HA5; hHa5; K35; KRTHA5"
                     /inference="alignment:Splign:2.1.0"
     exon            1275..1768
                     /gene="KRT35"
                     /gene_synonym="Ha-5; HA5; hHa5; K35; KRTHA5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctttggggtg tctggcctca gagacctatc aattgcatct gagttgcagg ggccatggct
       61 tccaaatgcc tcaaggccgg cttctcttct gggtctctca agagcccagg aggggccagt
      121 gggggctcca ctcgtgtgtc cgcaatgtac tccagcagct cttgcaagct tccaagtctc
      181 tcccctgtgg ccagaagttt ctctgcctgc tcagtgggtc tgggcagaag cagctacagg
      241 gccaccagct gcctccctgc tctctgcctc cctgctggag gcttcgctac cagctacagt
      301 gggggtgggg gctggtttgg ggagggcatc ctcactggca atgagaagga gaccatgcaa
      361 tccctgaacg accgcctggc cggctacctg gagaaggtgc gtcagctgga gcaggagaac
      421 gccagcctgg agagccgcat ccgtgagtgg tgtgagcagc aggtccccta catgtgccct
      481 gactaccagt cctacttccg gaccatcgag gagctccaga agaagactct atgcagcaag
      541 gctgagaatg ccaggctggt ggtggagatt gacaatgcca aattggctgc agatgacttc
      601 aggaccaagt atgagacgga ggtgtccctg cggcagctgg tggagtcaga catcaacggc
      661 ctgcgcagga tcctggatga cctgaccctg tgcaagtctg acctggaggc ccaggtggag
      721 tccctgaagg aggagctgct ctgcctgaag aagaaccatg aggaggaagt gaactcactg
      781 cgctgccaac ttggtgaccg cctcaatgtt gaggtggacg ctgccccacc tgttgacctg
      841 aaccgagttc tggaggagat gaggtgccag tatgaaaccc tggtggagaa taaccgccgg
      901 gatgctgaag actggttgga cacccagagt gaggagctga accagcaggt ggtgtccagc
      961 tcagagcagt tgcagtcctg ccaggcagag atcatcgagc tgagacgcac ggtcaacgcc
     1021 ctggagattg agctgcaggc tcagcacagc atgagagatg ctttggaatc caccctggca
     1081 gagacggagg cccgctatag ctcccagctg gcccagatgc agtgcatgat caccaacgtg
     1141 gaggcccagc tggccgagat ccgggctgac ctggagcggc agaaccagga gtaccaggtg
     1201 ctgctggacg tccgggcccg gctggagtgt gagatcaaca cgtaccgggg cctgctggag
     1261 agtgaggaca gcaagctccc ctgtaaccca tgtgcacctg actactcacc ctccaagtca
     1321 tgccttccct gtcttcctgc ggcctcctgc ggtcctagtg cagcccgcac aaactgcagc
     1381 ccccgcccca tttgtgtgcc ctgcccaggg ggtcggttct gagagcgggt gacccagatg
     1441 gccatggcta ttgtctccag ggcttgaact tggcctctac ccaaacttaa cccttgtagc
     1501 ccaatcccct ctcttcgcgc agagcccagg cccagggtct ggctgaaaag gctttctgca
     1561 aatacatgcc ctaaagtttc tcagagcctg tcacaaaggc cggctgcccc caaaggtctc
     1621 aactcctcat catttcaatg ggtgccaggg tctctgttct caggctgcct cctgggtcag
     1681 gttttccttc taggtgctgt tccggtggat tctgaaatgc agtagagggc ttttgttggc
     1741 agaacaataa agtgcatttg ctcaggcc
//
