LOCUS       NM_001386014            1635 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens keratin 34 (KRT34), mRNA.
ACCESSION   NM_001386014
VERSION     NM_001386014.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1635)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 1635)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 1635)
  AUTHORS   Pereira,R., Barbosa,T., Alves,A., Santos,R., Oliveira,J. and
            Sousa,M.
  TITLE     Unveiling the genetic etiology of primary ciliary dyskinesia: When
            standard genetic approach is not enough
  JOURNAL   Adv Med Sci 65 (1), 1-11 (2020)
   PUBMED   31835165
  REMARK    GeneRIF: Unveiling the genetic etiology of primary ciliary
            dyskinesia: When standard genetic approach is not enough.
REFERENCE   4  (bases 1 to 1635)
  AUTHORS   Bachurska,S.Y., Staykov,D.G., Bakardzhiev,I.V., Antonov,P.A. and
            Belovezhdov,V.T.
  TITLE     Diagnostic Value of ERG in Prostate Needle Biopsies Containing
            Minute Cancer Foci
  JOURNAL   Folia Med (Plovdiv) 59 (1), 84-90 (2017)
   PUBMED   28384107
  REMARK    GeneRIF: 95 of the prostate carcinoma biopsies demonstrated lack of
            cytokeratin 34betaE12 expression and only 3 cases showed weak
            patchy staining.
REFERENCE   5  (bases 1 to 1635)
  AUTHORS   Jain,D., Gupta,S., Marwah,N., Kalra,R., Gupta,V., Gill,M., Jain,N.,
            Lal,S. and Sen,R.
  TITLE     Evaluation of role of alpha-methyl acyl-coenzyme A racemase/P504S
            and high molecular weight cytokeratin in diagnosing prostatic
            lesions
  JOURNAL   J Cancer Res Ther 13 (1), 21-25 (2017)
   PUBMED   28508828
  REMARK    GeneRIF: As an adjunct to biopsy, AMACR and HMWCK have value for
            resolving diagnostically challenging cases
REFERENCE   6  (bases 1 to 1635)
  AUTHORS   Raica,M., Zylis,D. and Cimpean,A.M.
  TITLE     Cytokeratin 20, 34betaE12 and overexpression of HER-2/neu in urine
            cytology as predictors of recurrences in superficial urothelial
            carcinoma
  JOURNAL   Rom J Morphol Embryol 46 (1), 11-15 (2005)
   PUBMED   16286979
  REMARK    GeneRIF: Overexpressed in recurrent superficial urothelial
            carcinoma.
REFERENCE   7  (bases 1 to 1635)
  AUTHORS   Langbein,L., Rogers,M.A., Winter,H., Praetzel,S., Beckhaus,U.,
            Rackwitz,H.R. and Schweizer,J.
  TITLE     The catalog of human hair keratins. I. Expression of the nine type
            I members in the hair follicle
  JOURNAL   J Biol Chem 274 (28), 19874-19884 (1999)
   PUBMED   10391933
REFERENCE   8  (bases 1 to 1635)
  AUTHORS   Rogers,M.A., Winter,H., Wolf,C., Heck,M. and Schweizer,J.
  TITLE     Characterization of a 190-kilobase pair domain of human type I hair
            keratin genes
  JOURNAL   J Biol Chem 273 (41), 26683-26691 (1998)
   PUBMED   9756910
REFERENCE   9  (bases 1 to 1635)
  AUTHORS   Yu,J., Yu,D.W., Checkla,D.M., Freedberg,I.M. and Bertolino,A.P.
  TITLE     Human hair keratins
  JOURNAL   J Invest Dermatol 101 (1 Suppl), 56S-59S (1993)
   PUBMED   7686952
  REMARK    Review article
REFERENCE   10 (bases 1 to 1635)
  AUTHORS   Heid,H.W., Werner,E. and Franke,W.W.
  TITLE     The complement of native alpha-keratin polypeptides of hair-forming
            cells: a subset of eight polypeptides that differ from epithelial
            cytokeratins
  JOURNAL   Differentiation 32 (2), 101-119 (1986)
   PUBMED   2431943
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC003958.3.
            This sequence is a reference standard in the RefSeqGene project.
            
            Summary: The protein encoded by this gene is a member of the
            keratin gene family. As a type I hair keratin, it is an acidic
            protein which heterodimerizes with type II keratins to form hair
            and nails. The type I hair keratins are clustered in a region of
            chromosome 17q12-q21 and have the same direction of transcription.
            [provided by RefSeq, Jul 2008].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038195.1043696.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2148874, SAMEA2151119
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000394001.3/ ENSP00000377570.3
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-408               AC003958.3         50630-51037
            409-491             AC003958.3         51141-51223
            492-648             AC003958.3         51724-51880
            649-810             AC003958.3         53205-53366
            811-936             AC003958.3         53458-53583
            937-1157            AC003958.3         53760-53980
            1158-1635           AC003958.3         54790-55267
FEATURES             Location/Qualifiers
     source          1..1635
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q21.2"
     gene            1..1635
                     /gene="KRT34"
                     /gene_synonym="Ha-4; HA4; hHa4; K34; KRTHA4"
                     /note="keratin 34"
                     /db_xref="GeneID:3885"
                     /db_xref="HGNC:HGNC:6452"
                     /db_xref="MIM:602763"
     exon            1..408
                     /gene="KRT34"
                     /gene_synonym="Ha-4; HA4; hHa4; K34; KRTHA4"
                     /inference="alignment:Splign:2.1.0"
     CDS             61..1245
                     /gene="KRT34"
                     /gene_synonym="Ha-4; HA4; hHa4; K34; KRTHA4"
                     /note="keratin, hair, acidic, 4; hard keratin, type I, 4;
                     hair keratin, type I Ha4; keratin 34, type I"
                     /codon_start=1
                     /product="keratin, type I cuticular Ha4"
                     /protein_id="NP_001372943.1"
                     /db_xref="CCDS:CCDS11390.2"
                     /db_xref="GeneID:3885"
                     /db_xref="HGNC:HGNC:6452"
                     /db_xref="MIM:602763"
                     /translation="MSYSCCLPSLGCRTSCSSRPCVPPSCHGYTLPGACNIPANVSNC
                     NWFCEGSFNGSEKETMQFLNDRLASYLEKVRQLERDNAELEKLIQERSQQQEPLLCPS
                     YQSYFKTIEELQQKILCAKAENARLVVNIDNAKLASDDFRSKYQTEQSLRLLVESDIN
                     SIRRILDELTLCKSDLESQVESLREELICLKKNHEEEVNTLRSQLGDRLNVEVDTAPT
                     VDLNQVLNETRSQYEALVEINRREVEQWFATQTEELNKQVVSSSEQLQSCQAEIIELR
                     RTVNALEIELQAQHNLRDSLENTLTESEAHYSSQLSQVQSLITNVESQLAEIRCDLER
                     QNQEYQVLLDVRARLECEINTYRSLLESEDCKLPCNPCATTNASGNSCGPCGTSQKGC
                     CN"
     exon            409..491
                     /gene="KRT34"
                     /gene_synonym="Ha-4; HA4; hHa4; K34; KRTHA4"
                     /inference="alignment:Splign:2.1.0"
     exon            492..648
                     /gene="KRT34"
                     /gene_synonym="Ha-4; HA4; hHa4; K34; KRTHA4"
                     /inference="alignment:Splign:2.1.0"
     exon            649..810
                     /gene="KRT34"
                     /gene_synonym="Ha-4; HA4; hHa4; K34; KRTHA4"
                     /inference="alignment:Splign:2.1.0"
     exon            811..936
                     /gene="KRT34"
                     /gene_synonym="Ha-4; HA4; hHa4; K34; KRTHA4"
                     /inference="alignment:Splign:2.1.0"
     exon            937..1157
                     /gene="KRT34"
                     /gene_synonym="Ha-4; HA4; hHa4; K34; KRTHA4"
                     /inference="alignment:Splign:2.1.0"
     exon            1158..1635
                     /gene="KRT34"
                     /gene_synonym="Ha-4; HA4; hHa4; K34; KRTHA4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1611..1616
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KRT34"
                     /gene_synonym="Ha-4; HA4; hHa4; K34; KRTHA4"
                     /note="hexamer: AATAAA"
     polyA_site      1635
                     /gene="KRT34"
                     /gene_synonym="Ha-4; HA4; hHa4; K34; KRTHA4"
                     /note="major polyA site"
ORIGIN      
        1 aaacctgccc acatccacct ccagcagctt acctgctttt ccattacctg ttccagcacc
       61 atgtcttaca gttgttgcct gcccagcctg ggctgccgca ccagctgctc ctcccggccc
      121 tgcgtgcccc ccagctgcca cggctacacc ctgcctgggg cctgcaacat ccccgccaat
      181 gtgagcaact gcaactggtt ctgtgagggc tccttcaatg gcagcgagaa ggagactatg
      241 cagttcctga acgaccgcct ggccagctac ctggagaagg tgcgtcagct ggagcgggac
      301 aacgcggagc tggagaaact catccaggag cggtcccagc agcaggagcc cttgctgtgc
      361 cccagctacc agtcctactt caagaccatt gaggagctcc agcagaagat tctgtgtgcc
      421 aaggctgaga atgccaggct ggtggtgaac attgacaatg ccaagctggc ctctgacgac
      481 ttcagaagca agtaccagac ggagcagtcc ctgaggctgt tggtggagtc ggacatcaac
      541 agcatacgca ggatcctgga tgagctgacc ctctgcaagt ctgacctgga gtcccaggtg
      601 gagtccctga gggaggagct gatctgcttg aagaagaacc atgaggagga ggttaacacc
      661 ctgcgctccc agcttggaga ccgcctcaac gtggaggtgg acactgcccc cactgtggac
      721 ctgaaccagg tcctgaacga gaccaggagt cagtatgagg ctctggtgga aattaaccgc
      781 agggaagtgg agcaatggtt cgccacgcag accgaggagc tgaacaagca ggtggtatcc
      841 agctcagagc agctgcagtc ctgccaggcg gagatcatcg agctgagacg cacagtcaac
      901 gccctggaga tcgagctgca ggcccagcac aacctgcgag actctctgga aaacacgctg
      961 acggagagcg aggcccacta cagctcccag ctgtcccagg tgcagagcct gatcaccaac
     1021 gtggagtctc agctggcaga gatccgctgt gacctggagc ggcagaacca ggagtaccag
     1081 gtgctgctgg acgtgcgtgc ccggctggag tgtgagatca acacgtaccg gagcctcctg
     1141 gagagtgagg actgcaagct cccctgcaac ccatgcgcca ccaccaatgc tagtggcaac
     1201 tcctgtggac cctgtggcac ctctcaaaag ggttgctgta attgaaaagc ttgtatcctc
     1261 tttgaagaca tctacaaagc catttagatc aaccacagga aggatcctca agtcctgact
     1321 tttctggagc tcagctgaca tcaagaaacc tcatcttgcc tctatgttat ttctagaatg
     1381 ctgaaaagct ttcctgaccc aagcaaagac acacatcatc aacttccaat gtctggacaa
     1441 ctccttcctg ttgagggtcg agcctgtttg tttctaaaga tgttcagctc cctgtaatct
     1501 gagctccagt tactacttaa ggtgtttcct gaacgtacta ctgcatttcc tgttttcctt
     1561 ttttctttgg cattctctgg aatgcaagga ggagacttca tttacttccc aataaacttc
     1621 atttctctgg cataa
//
