LOCUS       NM_002279               1616 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens keratin 33B (KRT33B), mRNA.
ACCESSION   NM_002279
VERSION     NM_002279.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1616)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 1616)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 1616)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1616)
  AUTHORS   Yang,X., Coulombe-Huntington,J., Kang,S., Sheynkman,G.M., Hao,T.,
            Richardson,A., Sun,S., Yang,F., Shen,Y.A., Murray,R.R., Spirohn,K.,
            Begg,B.E., Duran-Frigola,M., MacWilliams,A., Pevzner,S.J.,
            Zhong,Q., Wanamaker,S.A., Tam,S., Ghamsari,L., Sahni,N., Yi,S.,
            Rodriguez,M.D., Balcha,D., Tan,G., Costanzo,M., Andrews,B.,
            Boone,C., Zhou,X.J., Salehi-Ashtiani,K., Charloteaux,B., Chen,A.A.,
            Calderwood,M.A., Aloy,P., Roth,F.P., Hill,D.E., Iakoucheva,L.M.,
            Xia,Y. and Vidal,M.
  TITLE     Widespread Expansion of Protein Interaction Capabilities by
            Alternative Splicing
  JOURNAL   Cell 164 (4), 805-817 (2016)
   PUBMED   26871637
REFERENCE   5  (bases 1 to 1616)
  AUTHORS   Rogers,M.A., Winter,H., Langbein,L., Bleiler,R. and Schweizer,J.
  TITLE     The human type I keratin gene family: characterization of new hair
            follicle specific members and evaluation of the chromosome 17q21.2
            gene domain
  JOURNAL   Differentiation 72 (9-10), 527-540 (2004)
   PUBMED   15617563
REFERENCE   6  (bases 1 to 1616)
  AUTHORS   Cribier,B., Peltre,B., Langbein,L., Winter,H., Schweizer,J. and
            Grosshans,E.
  TITLE     Expression of type I hair keratins in follicular tumours
  JOURNAL   Br J Dermatol 144 (5), 977-982 (2001)
   PUBMED   11359384
REFERENCE   7  (bases 1 to 1616)
  AUTHORS   Langbein,L., Rogers,M.A., Winter,H., Praetzel,S., Beckhaus,U.,
            Rackwitz,H.R. and Schweizer,J.
  TITLE     The catalog of human hair keratins. I. Expression of the nine type
            I members in the hair follicle
  JOURNAL   J Biol Chem 274 (28), 19874-19884 (1999)
   PUBMED   10391933
REFERENCE   8  (bases 1 to 1616)
  AUTHORS   Rogers,M.A., Winter,H., Wolf,C., Heck,M. and Schweizer,J.
  TITLE     Characterization of a 190-kilobase pair domain of human type I hair
            keratin genes
  JOURNAL   J Biol Chem 273 (41), 26683-26691 (1998)
   PUBMED   9756910
REFERENCE   9  (bases 1 to 1616)
  AUTHORS   Rogers,M.A., Schweizer,J., Kreig,T. and Winter,H.
  TITLE     A novel human type I hair keratin gene: evidence for two keratin
            hHa3 isoforms
  JOURNAL   Mol Biol Rep 20 (3), 155-161 (1994)
   PUBMED   7565656
REFERENCE   10 (bases 1 to 1616)
  AUTHORS   Yu,J., Yu,D.W., Checkla,D.M., Freedberg,I.M. and Bertolino,A.P.
  TITLE     Human hair keratins
  JOURNAL   J Invest Dermatol 101 (1 Suppl), 56S-59S (1993)
   PUBMED   7686952
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff in
            collaboration with Michael Rogers. The reference sequence was
            derived from AC003958.3 and BC009971.2.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_002279.4.
            
            Summary: This gene encodes a member of the keratin gene family.
            This gene is one of multiple type I hair keratin genes that are
            clustered in a region of chromosome 17q12-q21 and have the same
            direction of transcription. As a type I hair keratin, the encoded
            protein is an acidic protein which heterodimerizes with type II
            keratins to form hair and nails. There are two isoforms of this
            protein, encoded by two separate genes, keratin 33A and keratin
            33B. [provided by RefSeq, May 2012].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC009971.2, X82634.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMEA1968968,
                                           SAMEA2147975 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000251646.8/ ENSP00000251646.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-13                AC003958.3         63123-63135
            14-1616             BC009971.2         1-1603
FEATURES             Location/Qualifiers
     source          1..1616
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q21.2"
     gene            1..1616
                     /gene="KRT33B"
                     /gene_synonym="Ha-3II; HA3II; hHa3-II; K33B; KRTHA3A;
                     KRTHA3B"
                     /note="keratin 33B"
                     /db_xref="GeneID:3884"
                     /db_xref="HGNC:HGNC:6451"
                     /db_xref="MIM:602762"
     exon            1..411
                     /gene="KRT33B"
                     /gene_synonym="Ha-3II; HA3II; hHa3-II; K33B; KRTHA3A;
                     KRTHA3B"
                     /inference="alignment:Splign:2.1.0"
     CDS             64..1278
                     /gene="KRT33B"
                     /gene_synonym="Ha-3II; HA3II; hHa3-II; K33B; KRTHA3A;
                     KRTHA3B"
                     /note="keratin, hair, acidic, 3B; type I hair keratin 3B;
                     hard keratin, type I, 3II; hair keratin, type I Ha3-II;
                     keratin 33B, type I"
                     /codon_start=1
                     /product="keratin, type I cuticular Ha3-II"
                     /protein_id="NP_002270.1"
                     /db_xref="CCDS:CCDS11389.1"
                     /db_xref="GeneID:3884"
                     /db_xref="HGNC:HGNC:6451"
                     /db_xref="MIM:602762"
                     /translation="MPYNFCLPSLSCRTSCSSRPCVPPSCHGYTLPGACNIPANVSNC
                     NWFCEGSFNGSEKETMQFLNDRLASYLEKVRQLERDNAELENLIRERSQQQEPLLCPS
                     YQSYFKTIEELQQKILCSKSENARLVVQIDNAKLAADDFRTKYQTEQSLRQLVESDIN
                     SLRRILDELTLCRSDLEAQMESLKEELLSLKQNHEQEVNTLRCQLGDRLNVEVDAAPA
                     VDLNQVLNETRNQYEALVETNRREVEQWFATQTEELNKQVVSSSEQLQSYQAEIIELR
                     RTVNALEIELQAQHNLRYSLENTLTESEARYSSQLSQVQSLITNVESQLAEIRSDLER
                     QNQEYQVLLDVRARLECEINTYRSLLESEDCKLPSNPCATTNACEKPIGSCVTNPCGP
                     RSRCGPCNTFGY"
     exon            412..494
                     /gene="KRT33B"
                     /gene_synonym="Ha-3II; HA3II; hHa3-II; K33B; KRTHA3A;
                     KRTHA3B"
                     /inference="alignment:Splign:2.1.0"
     exon            495..651
                     /gene="KRT33B"
                     /gene_synonym="Ha-3II; HA3II; hHa3-II; K33B; KRTHA3A;
                     KRTHA3B"
                     /inference="alignment:Splign:2.1.0"
     exon            652..813
                     /gene="KRT33B"
                     /gene_synonym="Ha-3II; HA3II; hHa3-II; K33B; KRTHA3A;
                     KRTHA3B"
                     /inference="alignment:Splign:2.1.0"
     exon            814..939
                     /gene="KRT33B"
                     /gene_synonym="Ha-3II; HA3II; hHa3-II; K33B; KRTHA3A;
                     KRTHA3B"
                     /inference="alignment:Splign:2.1.0"
     exon            940..1160
                     /gene="KRT33B"
                     /gene_synonym="Ha-3II; HA3II; hHa3-II; K33B; KRTHA3A;
                     KRTHA3B"
                     /inference="alignment:Splign:2.1.0"
     exon            1161..1616
                     /gene="KRT33B"
                     /gene_synonym="Ha-3II; HA3II; hHa3-II; K33B; KRTHA3A;
                     KRTHA3B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1593..1598
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KRT33B"
                     /gene_synonym="Ha-3II; HA3II; hHa3-II; K33B; KRTHA3A;
                     KRTHA3B"
                     /note="hexamer: AATAAA"
     polyA_site      1616
                     /gene="KRT33B"
                     /gene_synonym="Ha-3II; HA3II; hHa3-II; K33B; KRTHA3A;
                     KRTHA3B"
                     /note="major polyA site"
ORIGIN      
        1 atcccaggga aaaggaatca ggttttgaaa ctgacttcca gagctccact gcctccctgc
       61 accatgccct acaacttctg cctgcccagc ctgagctgcc gcaccagctg ctcctcccgg
      121 ccctgtgtgc cccccagctg ccacggctac accctgcccg gggcctgcaa catccctgcc
      181 aatgtgagca actgcaactg gttctgcgag ggctccttca atggcagcga gaaggagact
      241 atgcagttcc tgaacgaccg cctggccagc tacctggaga aggtgcgtca gctggagcgg
      301 gacaacgcgg agctggagaa cctcatccgg gagcggtctc agcagcagga gcccttgctg
      361 tgccccagct accagtccta cttcaagacc attgaggagc tccagcagaa gatcctgtgc
      421 agcaagtctg agaatgccag gctggtggtg cagatcgaca atgccaagct ggctgcagat
      481 gacttcagaa ccaagtacca gacggagcag tccctgcggc agctggtgga gtccgacatc
      541 aacagcctgc gcaggattct ggatgagctg accctgtgca ggtctgacct ggaggcccag
      601 atggagtccc tgaaggagga gctgctgtcc ctcaagcaga accatgagca ggaagtcaac
      661 accttgcgct gccagcttgg agaccgcctc aacgtggagg tggacgctgc tcccgctgtg
      721 gacctgaacc aggtcctgaa cgagaccagg aatcagtatg aggccctggt ggaaaccaac
      781 cgcagggaag tggagcaatg gttcgccacg cagaccgagg agctgaacaa gcaggtggta
      841 tccagctcgg agcagctgca gtcctaccag gcggagatca tcgagctgag acgcacagtc
      901 aatgccctgg agatcgagct gcaggcccag cacaacctgc gatactctct ggaaaacacg
      961 ctgacagaga gcgaggcccg ctacagctcc cagctgtccc aggtgcagag cctgatcacc
     1021 aacgtggagt cccagctggc ggagatccgc agtgacctgg agcggcagaa ccaggagtat
     1081 caggtgctgc tggacgtgcg ggcgcggctg gagtgtgaga tcaacacata ccggagcctg
     1141 ctggagagcg aggactgcaa gctgccctcc aacccctgcg ccaccaccaa tgcatgtgaa
     1201 aagcccattg gatcctgtgt caccaatcct tgtggtcctc gttcccgctg tgggccttgc
     1261 aacacctttg ggtactagat accctggggc cagcagaagt atagcatgaa gacagaacta
     1321 ccatcggtgg gccagttctg cctctctgac aaccatcagc caccggaccc caccccgagg
     1381 catcaccaca aatcatggtc tggaaggaga acaaatgccc agcgtttggg tctgactctg
     1441 agcctagggc tacttgatcc tcctcacccc aggtccctct cctgtagtca gtctgagttc
     1501 tgatggtcag aggttggagc tgtgacagtg gcatacgagg tgttttgttc tctctgctgc
     1561 ttctaccttt attgcagttc cccaaatcgc ctaataaact ttcctcttgc aaagca
//
