LOCUS       NM_004138               1303 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens keratin 33A (KRT33A), mRNA.
ACCESSION   NM_004138
VERSION     NM_004138.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1303)
  AUTHORS   Pieragostino,D., Agnifili,L., Fasanella,V., D'Aguanno,S.,
            Mastropasqua,R., Di Ilio,C., Sacchetta,P., Urbani,A. and Del
            Boccio,P.
  TITLE     Shotgun proteomics reveals specific modulated protein patterns in
            tears of patients with primary open angle glaucoma naive to therapy
  JOURNAL   Mol Biosyst 9 (6), 1108-1116 (2013)
   PUBMED   23580065
REFERENCE   2  (bases 1 to 1303)
  AUTHORS   Schweizer,J., Bowden,P.E., Coulombe,P.A., Langbein,L., Lane,E.B.,
            Magin,T.M., Maltais,L., Omary,M.B., Parry,D.A., Rogers,M.A. and
            Wright,M.W.
  TITLE     New consensus nomenclature for mammalian keratins
  JOURNAL   J Cell Biol 174 (2), 169-174 (2006)
   PUBMED   16831889
REFERENCE   3  (bases 1 to 1303)
  AUTHORS   Rogers,M.A., Winter,H., Langbein,L., Bleiler,R. and Schweizer,J.
  TITLE     The human type I keratin gene family: characterization of new hair
            follicle specific members and evaluation of the chromosome 17q21.2
            gene domain
  JOURNAL   Differentiation 72 (9-10), 527-540 (2004)
   PUBMED   15617563
REFERENCE   4  (bases 1 to 1303)
  AUTHORS   Langbein,L., Rogers,M.A., Winter,H., Praetzel,S., Beckhaus,U.,
            Rackwitz,H.R. and Schweizer,J.
  TITLE     The catalog of human hair keratins. I. Expression of the nine type
            I members in the hair follicle
  JOURNAL   J Biol Chem 274 (28), 19874-19884 (1999)
   PUBMED   10391933
REFERENCE   5  (bases 1 to 1303)
  AUTHORS   Rogers,M.A., Winter,H., Wolf,C., Heck,M. and Schweizer,J.
  TITLE     Characterization of a 190-kilobase pair domain of human type I hair
            keratin genes
  JOURNAL   J Biol Chem 273 (41), 26683-26691 (1998)
   PUBMED   9756910
REFERENCE   6  (bases 1 to 1303)
  AUTHORS   Rogers,M.A., Schweizer,J., Kreig,T. and Winter,H.
  TITLE     A novel human type I hair keratin gene: evidence for two keratin
            hHa3 isoforms
  JOURNAL   Mol Biol Rep 20 (3), 155-161 (1994)
   PUBMED   7565656
REFERENCE   7  (bases 1 to 1303)
  AUTHORS   Yu,J., Yu,D.W., Checkla,D.M., Freedberg,I.M. and Bertolino,A.P.
  TITLE     Human hair keratins
  JOURNAL   J Invest Dermatol 101 (1 Suppl), 56S-59S (1993)
   PUBMED   7686952
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff in
            collaboration with Michael Rogers. The reference sequence was
            derived from AC003958.3 and AJ633621.2.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_004138.3.
            
            Summary: This gene encodes a member of the keratin gene family.
            This gene is one of multiple type I hair keratin genes that are
            clustered in a region of chromosome 17q12-q21 and have the same
            direction of transcription. As a type I hair keratin, the encoded
            protein is an acidic protein which heterodimerizes with type II
            keratins to form hair and nails. There are two isoforms of this
            protein, encoded by two separate genes, keratin 33A and keratin
            33B. [provided by RefSeq, May 2012].
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ633621.2, BC069135.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148874
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000007735.4/ ENSP00000007735.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-16                AC003958.3         82108-82123
            17-341              AJ633621.2         1-325
            342-342             AC003958.3         82449-82449
            343-1303            AJ633621.2         327-1287
FEATURES             Location/Qualifiers
     source          1..1303
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q21.2"
     gene            1..1303
                     /gene="KRT33A"
                     /gene_synonym="Ha-3I; HA3I; hHa3-I; K33A; Krt1-3; KRTHA3A"
                     /note="keratin 33A"
                     /db_xref="GeneID:3883"
                     /db_xref="HGNC:HGNC:6450"
                     /db_xref="MIM:602761"
     exon            1..409
                     /gene="KRT33A"
                     /gene_synonym="Ha-3I; HA3I; hHa3-I; K33A; Krt1-3; KRTHA3A"
                     /inference="alignment:Splign:2.1.0"
     CDS             62..1276
                     /gene="KRT33A"
                     /gene_synonym="Ha-3I; HA3I; hHa3-I; K33A; Krt1-3; KRTHA3A"
                     /note="hard keratin, type I,3I; keratin, hair, acidic, 3A;
                     hair keratin, type I Ha3-I; keratin 33A, type I"
                     /codon_start=1
                     /product="keratin, type I cuticular Ha3-I"
                     /protein_id="NP_004129.2"
                     /db_xref="CCDS:CCDS11388.1"
                     /db_xref="GeneID:3883"
                     /db_xref="HGNC:HGNC:6450"
                     /db_xref="MIM:602761"
                     /translation="MSYSCGLPSLSCRTSCSSRPCVPPSCHGCTLPGACNIPANVSNC
                     NWFCEGSFNGSEKETMQFLNDRLASYLEKVRQLERDNAELENLIRERSQQQEPLVCAS
                     YQSYFKTIEELQQKILCSKSENARLVVQIDNAKLASDDFRTKYETELSLRQLVESDIN
                     GLRRILDELTLCRSDLEAQVESLKEELLCLKQNHEQEVNTLRCQLGDRLNVEVDAAPT
                     VDLNQVLNETRSQYEALVETNRREVEQWFATQTEELNKQVVSSSEQLQSYQAEIIELR
                     RTVNALEIELQAQHNLRDSLENTLTESEARYSSQLSQVQRLITNVESQLAEIRSDLER
                     QNQEYQVLLDVRARLECEINTYRSLLESEDCKLPSNPCATTNACDKSTGPCISNPCGL
                     RARCGPCNTFGY"
     exon            410..492
                     /gene="KRT33A"
                     /gene_synonym="Ha-3I; HA3I; hHa3-I; K33A; Krt1-3; KRTHA3A"
                     /inference="alignment:Splign:2.1.0"
     exon            493..649
                     /gene="KRT33A"
                     /gene_synonym="Ha-3I; HA3I; hHa3-I; K33A; Krt1-3; KRTHA3A"
                     /inference="alignment:Splign:2.1.0"
     exon            650..811
                     /gene="KRT33A"
                     /gene_synonym="Ha-3I; HA3I; hHa3-I; K33A; Krt1-3; KRTHA3A"
                     /inference="alignment:Splign:2.1.0"
     exon            812..937
                     /gene="KRT33A"
                     /gene_synonym="Ha-3I; HA3I; hHa3-I; K33A; Krt1-3; KRTHA3A"
                     /inference="alignment:Splign:2.1.0"
     exon            938..1158
                     /gene="KRT33A"
                     /gene_synonym="Ha-3I; HA3I; hHa3-I; K33A; Krt1-3; KRTHA3A"
                     /inference="alignment:Splign:2.1.0"
     exon            1159..1303
                     /gene="KRT33A"
                     /gene_synonym="Ha-3I; HA3I; hHa3-I; K33A; Krt1-3; KRTHA3A"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 accgctctac aacctggaga ttttggactc tgtcttcagc tggacactcc ctccctgcac
       61 catgtcttac agttgtggcc tgcccagcct gagctgccgc accagctgct cctcccggcc
      121 ctgtgtgccc cccagctgcc acggctgcac cctgcccggg gcctgcaaca tccccgccaa
      181 tgtgagcaac tgcaactggt tctgtgaggg ctccttcaat ggcagtgaga aggagaccat
      241 gcagttcctg aacgaccgcc tggccagcta cctggagaag gtgcgtcagc tggagcggga
      301 caacgcggag ctggagaacc tcatccggga gcggtcacag cagcaggagc ccttggtgtg
      361 tgccagctac cagtcctact tcaagaccat tgaggagctc cagcagaaga tcctgtgcag
      421 caagtctgag aatgccaggc ttgtggtgca gatcgacaat gccaagctgg cctcagatga
      481 cttcaggacc aaatatgaga ccgagctgtc cctgcggcag ctggtggagt cggacatcaa
      541 tggcctgcgc aggatcctgg atgagctgac cctgtgcagg tctgacctgg aggcccaggt
      601 ggagtccctg aaggaggagc tgctgtgcct caagcagaac catgagcagg aggttaacac
      661 cctgcgctgc cagcttggag accgcctcaa cgtggaggtg gacgctgctc ccactgtgga
      721 cctgaaccag gtcctgaatg agaccaggag tcagtatgag gccctggtgg aaaccaaccg
      781 cagggaagtg gagcaatggt tcgccacgca gaccgaggag ctgaacaagc aggtggtatc
      841 cagctcggag cagctgcagt cctaccaggc ggagatcatc gagctgagac gcacggtcaa
      901 tgccctggag atcgagctgc aggcccagca caacctgcga gactctctgg aaaacacgct
      961 gacagagagc gaggcccgct acagctccca gctgtcccag gtgcagagac tgatcaccaa
     1021 cgtggagtcc cagctggcgg agatccgcag tgacctggag cggcagaacc aggagtatca
     1081 ggtgctgctg gacgtgcggg cgcggctgga gtgtgagatc aacacgtacc ggagcctgct
     1141 ggagagcgag gactgcaagc tcccctccaa cccctgcgcc acaaccaatg catgtgacaa
     1201 gtccactggg ccctgtatct ctaatccctg tggcctacgt gctcggtgtg ggccttgcaa
     1261 cacatttggg tactagaggc cccacaacca ggaggagaag aaa
//
