LOCUS       NM_002278               2005 bp    mRNA    linear   PRI 02-JUN-2024
DEFINITION  Homo sapiens keratin 32 (KRT32), mRNA.
ACCESSION   NM_002278
VERSION     NM_002278.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2005)
  AUTHORS   Kim,D.K., Weller,B., Lin,C.W., Sheykhkarimli,D., Knapp,J.J.,
            Dugied,G., Zanzoni,A., Pons,C., Tofaute,M.J., Maseko,S.B.,
            Spirohn,K., Laval,F., Lambourne,L., Kishore,N., Rayhan,A.,
            Sauer,M., Young,V., Halder,H., la Rosa,N.M., Pogoutse,O.,
            Strobel,A., Schwehn,P., Li,R., Rothballer,S.T., Altmann,M.,
            Cassonnet,P., Cote,A.G., Vergara,L.E., Hazelwood,I., Liu,B.B.,
            Nguyen,M., Pandiarajan,R., Dohai,B., Coloma,P.A.R., Poirson,J.,
            Giuliana,P., Willems,L., Taipale,M., Jacob,Y., Hao,T., Hill,D.E.,
            Brun,C., Twizere,J.C., Krappmann,D., Heinig,M., Falter,C., Aloy,P.,
            Demeret,C., Vidal,M., Calderwood,M.A., Roth,F.P. and
            Falter-Braun,P.
  TITLE     A proteome-scale map of the SARS-CoV-2-human contactome
  JOURNAL   Nat Biotechnol 41 (1), 140-149 (2023)
   PUBMED   36217029
REFERENCE   2  (bases 1 to 2005)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 2005)
  AUTHORS   Schweizer,J., Bowden,P.E., Coulombe,P.A., Langbein,L., Lane,E.B.,
            Magin,T.M., Maltais,L., Omary,M.B., Parry,D.A., Rogers,M.A. and
            Wright,M.W.
  TITLE     New consensus nomenclature for mammalian keratins
  JOURNAL   J Cell Biol 174 (2), 169-174 (2006)
   PUBMED   16831889
REFERENCE   4  (bases 1 to 2005)
  AUTHORS   Adkins,J.N., Varnum,S.M., Auberry,K.J., Moore,R.J., Angell,N.H.,
            Smith,R.D., Springer,D.L. and Pounds,J.G.
  TITLE     Toward a human blood serum proteome: analysis by multidimensional
            separation coupled with mass spectrometry
  JOURNAL   Mol Cell Proteomics 1 (12), 947-955 (2002)
   PUBMED   12543931
REFERENCE   5  (bases 1 to 2005)
  AUTHORS   Langbein,L., Rogers,M.A., Winter,H., Praetzel,S., Beckhaus,U.,
            Rackwitz,H.R. and Schweizer,J.
  TITLE     The catalog of human hair keratins. I. Expression of the nine type
            I members in the hair follicle
  JOURNAL   J Biol Chem 274 (28), 19874-19884 (1999)
   PUBMED   10391933
REFERENCE   6  (bases 1 to 2005)
  AUTHORS   Rogers,M.A., Winter,H., Langbein,L., Krieg,T. and Schweizer,J.
  TITLE     Genomic characterization of the human type I cuticular hair keratin
            hHa2 and identification of an adjacent novel type I hair keratin
            gene hHa5
  JOURNAL   J Invest Dermatol 107 (4), 633-638 (1996)
   PUBMED   8823373
REFERENCE   7  (bases 1 to 2005)
  AUTHORS   Rogers,M.A., Nischt,R., Korge,B., Krieg,T., Fink,T.M., Lichter,P.,
            Winter,H. and Schweizer,J.
  TITLE     Sequence data and chromosomal localization of human type I and type
            II hair keratin genes
  JOURNAL   Exp Cell Res 220 (2), 357-362 (1995)
   PUBMED   7556444
REFERENCE   8  (bases 1 to 2005)
  AUTHORS   Yu,J., Yu,D.W., Checkla,D.M., Freedberg,I.M. and Bertolino,A.P.
  TITLE     Human hair keratins
  JOURNAL   J Invest Dermatol 101 (1 Suppl), 56S-59S (1993)
   PUBMED   7686952
  REMARK    Review article
REFERENCE   9  (bases 1 to 2005)
  AUTHORS   Heid,H.W., Moll,I. and Franke,W.W.
  TITLE     Patterns of expression of trichocytic and epithelial cytokeratins
            in mammalian tissues. I. Human and bovine hair follicles
  JOURNAL   Differentiation 37 (2), 137-157 (1988)
   PUBMED   2456239
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff in
            collaboration with Michael Rogers. The reference sequence was
            derived from AC019349.28, X81419.1 and AI190798.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Oct 23, 2006 this sequence version replaced NM_002278.2.
            
            Summary: The protein encoded by this gene is a member of the
            keratin gene family. As a type I hair keratin, it is an acidic
            protein which heterodimerizes with type II keratins to form hair
            and nails. The type I hair keratins are clustered in a region of
            chromosome 17q12-q21 and have the same direction of transcription.
            [provided by RefSeq, Jul 2008].
            
            ##Evidence-Data-START##
            Transcript exon combination :: X81419.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2147975, SAMEA2156670
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000225899.4/ ENSP00000225899.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-161               AC019349.28        130749-130909
            162-513             X81419.1           1-352
            514-515             AC019349.28        131262-131263
            516-1140            X81419.1           355-979
            1141-1267           AC019349.28        135168-135294
            1268-1339           X81419.1           1107-1178
            1340-1341           AC019349.28        137957-137958
            1342-1707           X81419.1           1181-1546
            1708-2005           AI190798.1         1-298               c
FEATURES             Location/Qualifiers
     source          1..2005
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q21.2"
     gene            1..2005
                     /gene="KRT32"
                     /gene_synonym="HA2; hHa2; HKA2; KRTHA2"
                     /note="keratin 32"
                     /db_xref="GeneID:3882"
                     /db_xref="HGNC:HGNC:6449"
                     /db_xref="MIM:602760"
     exon            1..529
                     /gene="KRT32"
                     /gene_synonym="HA2; hHa2; HKA2; KRTHA2"
                     /inference="alignment:Splign:2.1.0"
     CDS             62..1408
                     /gene="KRT32"
                     /gene_synonym="HA2; hHa2; HKA2; KRTHA2"
                     /note="keratin, hair, acidic, 2; type I cuticular hair
                     keratin; hard keratin, type I, 2; K32; hair keratin, type
                     I Ha2; keratin 32, type I"
                     /codon_start=1
                     /product="keratin, type I cuticular Ha2"
                     /protein_id="NP_002269.3"
                     /db_xref="CCDS:CCDS11393.1"
                     /db_xref="GeneID:3882"
                     /db_xref="HGNC:HGNC:6449"
                     /db_xref="MIM:602760"
                     /translation="MTSSCCVTNNLQASLKSCPRPASVCSSGVNCRPELCLGYVCQPM
                     ACLPSVCLPTTFRPASCLSKTYLSSSCQAASGISGSMGPGSWYSEGAFNGNEKETMQF
                     LNDRLASYLTRVRQLEQENAELESRIQEASHSQVLTMTPDYQSHFRTIEELQQKILCT
                     KAENARMVVNIDNAKLAADDFRAKYEAELAMRQLVEADINGLRRILDDLTLCKADLEA
                     QVESLKEELMCLKKNHEEEVGSLRCQLGDRLNIEVDAAPPVDLTRVLEEMRCQYEAMV
                     EANRRDVEEWFNMQMEELNQQVATSSEQLQNYQSDIIDLRRTVNTLEIELQAQHSLRD
                     SLENTLTESEARYSSQLAQMQCMITNVEAQLAEIRADLERQNQEYQVLLDVRARLEGE
                     INTYRSLLENEDCKLPCNPCSTPSCTTCVPSPCVPRTVCVPRTVGMPCSPCPQGRY"
     exon            530..612
                     /gene="KRT32"
                     /gene_synonym="HA2; hHa2; HKA2; KRTHA2"
                     /inference="alignment:Splign:2.1.0"
     exon            613..769
                     /gene="KRT32"
                     /gene_synonym="HA2; hHa2; HKA2; KRTHA2"
                     /inference="alignment:Splign:2.1.0"
     exon            770..931
                     /gene="KRT32"
                     /gene_synonym="HA2; hHa2; HKA2; KRTHA2"
                     /inference="alignment:Splign:2.1.0"
     exon            932..1057
                     /gene="KRT32"
                     /gene_synonym="HA2; hHa2; HKA2; KRTHA2"
                     /inference="alignment:Splign:2.1.0"
     exon            1058..1278
                     /gene="KRT32"
                     /gene_synonym="HA2; hHa2; HKA2; KRTHA2"
                     /inference="alignment:Splign:2.1.0"
     exon            1279..2005
                     /gene="KRT32"
                     /gene_synonym="HA2; hHa2; HKA2; KRTHA2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1679..1684
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KRT32"
                     /gene_synonym="HA2; hHa2; HKA2; KRTHA2"
                     /note="hexamer: AATAGA"
     polyA_site      1707
                     /gene="KRT32"
                     /gene_synonym="HA2; hHa2; HKA2; KRTHA2"
                     /note="major polyA site"
ORIGIN      
        1 ggcggcatgg ggtctgtaga catccaggta gctgtggctg aggagaaagg gcctctccaa
       61 catgacatcc tcctgctgtg tcaccaacaa cttgcaagcc tctctcaaga gctgcccccg
      121 gcctgcctcg gtctgttcca gcggcgtgaa ctgccggcct gagctgtgcc tgggctatgt
      181 ctgccagccc atggcatgcc tgccttcggt ctgcctgccc accaccttcc ggccagccag
      241 ctgcctctcc aaaacctatc tatccagttc ctgccaggca gccagtggca tctccggctc
      301 catgggcccc ggcagctggt acagcgaagg ggccttcaat ggcaatgaga aggaaaccat
      361 gcagttcctt aacgaccgcc tggccagcta cctgacgagg gtgcggcagc tggagcagga
      421 gaatgcggag ctggagagca ggatccaaga ggcctctcac tcccaggtgc tcaccatgac
      481 tcctgactac cagtctcatt tcaggaccat tgaggagctc cagcagaaga ttctgtgtac
      541 caaggcagag aatgccagga tggttgtgaa cattgataat gccaaactgg ctgccgatga
      601 cttcagggcc aagtacgagg cagagctggc catgcggcag ctggtggagg ccgacatcaa
      661 tggcctgcgc aggatcctgg atgatctcac tctgtgcaag gctgacctgg aggcccaggt
      721 tgagtccctg aaggaggagc tgatgtgcct caaaaagaac catgaggagg aagtcggttc
      781 ccttcgatgc cagcttgggg accgccttaa catcgaggtg gacgctgcac ccccggtgga
      841 cctgaccagg gtgctggagg agatgcggtg tcagtacgag gccatggtgg aggccaaccg
      901 cagggacgtg gaggaatggt tcaatatgca gatggaggag cttaaccaac aggtggccac
      961 aagctctgag cagcttcaga actaccagtc agacatcatt gacctgagac gcacggtcaa
     1021 cacgctggag atcgagctgc aggcccagca cagcctgagg gactccctgg aaaacacgct
     1081 gacggagagt gaggcccgct acagctccca gctggcccag atgcagtgca tgatcaccaa
     1141 cgttgaggcc cagctggctg agatccgggc tgacctggag cggcagaacc aggagtacca
     1201 ggtgctgctg gacgtccggg cccggctgga gggcgagatc aacacgtacc ggagcctgct
     1261 ggagaacgag gactgcaagc tgccctgtaa cccatgctcc actccttcct gcaccacctg
     1321 tgtgccctcc ccatgcgtgc cccgcaccgt ctgtgtgcca cgcactgttg gcatgccttg
     1381 ctcaccctgc ccccagggcc gctactgaag tccctttgtg ccagtggatc ctggagggcc
     1441 tggggctggg cagcctggta ttcagtggcc accagaagag cagggccagc cccggtcagc
     1501 aaggaagacc ctgagcagga ccgtggatca cctgcaacaa gctctgatac tccaggggat
     1561 acttaagccc tcatcacttc aaaactgcct cttttttcca tgggtgaact gttctctttg
     1621 gtgatgtttc tggttgtctg tgctgcctca aagagcgtgt gttcttagtt aactggcaaa
     1681 tagagctgta ctcagtggcc ttgcaaacat gtctgtctct gtttgtcact tacgctgctg
     1741 catccacaag ccaatcctac tcaattgggc ttaagaggaa cgtgggcaaa ttctgtattt
     1801 atttttatgc tccttctgct tccatagagg cttgagaggt gttcactaaa agggcccgca
     1861 tgccataaac cagttaaaac taatcaatta ctctagagcc aagtaataaa agaataaaga
     1921 gaggagggag ataattatgc cagaaaccta ggccaaatta ctgtaattga gaatcatatc
     1981 ataataaacc cacccctaaa tctca
//
